CD4+IL‐13+ cells in peripheral blood well correlates with the severity of atopic dermatitis in children

Allergy: European Journal of Allergy and Clinical Immunology - Tập 60 Số 3 - Trang 391-395 - 2005
Stefania La Grutta1, P. Richiusa2, Giuseppe Pizzolanti2, A Mattina2, Giovanni Battista Pajno3, Roberto Citarrella2, Giovanni Passalacqua4, Carla Giordano2
1Allergy Unit, Children Hospital -- ARNAS, Palermo, Italy.
2Laboratory of ImmunoEndocrinology, Endocrinology Section, Faculty of Medicine, Università di Palermo, Palermo
3Department of Pediatrics, Università di Messina, Messina
4Allergy and Respiratory Diseases, Department of Internal Medicine, Università di Genova, Genova, Italy

Tóm tắt

Background:  In atopic dermatitis (AD) a Th1/Th2 imbalance has been reported, and interleukin (IL)‐13 seems to play a pivotal role in the inflammatory network. We tried to assess the correlation between the immunological marker CD4+IL‐13+ and the clinical phase of extrinsic AD in children.Methods:  Twenty children with AD were studied. Assessed parameters were: clinical severity (SCORAD index), total serum immunoglobulin E (IgE), blood eosinophil count, and percentage of CD4+IFNγ+, CD4+IL‐4+, CD4+IL‐13+ T cells. Determinations were carried out in the acute phase and after clinical remission were achieved. Ten nonatopic‐matched children served as controls.Results:  At baseline, AD was mild in 25%, moderate in 50% and severe in 25% of children. In the acute phase a significant relationship between the eosinophil count and the SCORAD index was found (P = 0.0001). Blood CD4+IL‐4+ were significantly higher in the AD group (median 17.0, range: 13.7–21.4) than in controls (12.6, 6.4–17.2, P < 0.0001). CD4+IL‐13+ cells in the AD group well correlated (P = 0.0007) with SCORAD index. At remission, a significant correlation between SCORAD index and eosinophil count was found (P < 0.03) and the percentage of CD4+IL‐13+ cells globally decreased (P < 0.0001), while no difference was found among SCORAD classes.Conclusion:  This study confirms the Th2 profile predominance in the peripheral blood of children with AD, and evidences close relationship between the number of CD4+IL‐13+ T cells and the disease's severity.

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Thông tin xuất bản

Allergy: European Journal of Allergy and Clinical Immunology

Tập 60 Số 3

391-395

Thông tin tác giả