CD4+Foxp3+ T cells, interleukin-35 (IL-35) and IL-10 in systemic lupus erythematosus patients: Relation to disease activity

Rekvig, 2014, Vlag. The pathogenesis and diagnosis of systemic lupus erythematosus: still not resolved, Semin Immunopathol, 36, 301, 10.1007/s00281-014-0428-6 Ma, 2013, Imbalance of different types of CD4+ forkhead box protein 3 (FoxP3) + T cells in patients with new-onset systemic lupus erythematosus, Clin ExpImmunol, 174, 345 Ohl, 2014, Regulatory T cells in systemic lupus erythematosus, Eur J Immunol, 45, 344, 10.1002/eji.201344280 Tselios, 2017, T Regulatory Cells in Systemic Lupus Erythematosus: Current Knowledge and Future Prospects, 123 Bonelli, 2014, CD4+CD25-Foxp3+ T cells: a marker for lupus nephritis?, Arthritis Res Ther, 16, R104, 10.1186/ar4553 El-Menoufy MA, El-Kak AA, Ahmed MA. Unusual CD4+CD28− T lymphocyte subset is implicated in the pathogenesis of early atherosclerosis in patients with rheumatoid arthritis. The Egyptian Rheumatologist. 2018;epub ahead or print. Abaza, 2013, Deficient or abundant but unable to fight? Estimation of circulating FoxP3+ T regulatory cells and their counteracting FoxP3− in rheumatoid arthritis and correlation with disease activity, Egyptian Rheumatologist., 35, 185, 10.1016/j.ejr.2013.03.005 Al-Zifzaf, 2015, FoxP3+T regulatory cells in Rheumatoid arthritis and the imbalance of the Treg/TH17 cytokine axis, Egyptian Rheumatologist., 37, 7, 10.1016/j.ejr.2014.06.004 Abbass, 2013, Association of FOXP3 regulatory gene expression with systemic lupus erythematosus disease activity among Egyptian patients, Egypt J Immunol., 20, 21 Elewa, 2014, The role of interleukins 4, 17 and interferon gamma as biomarkers in patients with Systemic Lupus Erythematosus and their correlation with disease activity, Egyptian Rheumatologist., 36, 21, 10.1016/j.ejr.2013.10.003 Azkalany, 2012, Clinical significance of serum TNFα and -308 G/A promoter polymorphism and serum Il-6 and -174 G/C promoter polymorphism in systemic lupus erythematosus patients, Egyptian Rheumatologist., 34, 119, 10.1016/j.ejr.2012.05.003 Talaat, 2015, Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity, Cytokine., 72, 146, 10.1016/j.cyto.2014.12.027 Collison, 2007, The inhibitory cytokine IL-35 contributes to regulatory T-cell function, Nature, 450, 566, 10.1038/nature06306 Pankratz, 2014, Human CD4+ HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo, FASEB J, 28, 3435, 10.1096/fj.14-251074 Tiemessen, 2007, CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages, Proc Natl Acad Sci USA, 104, 19446, 10.1073/pnas.0706832104 Ouyang, 2011, Regulation and functions of the IL-10 family of cytokines in inflammation and disease, Annu Rev Immunol, 29, 71, 10.1146/annurev-immunol-031210-101312 Atfy, 2009, Impact of CD4+CD25high regulatory T-cells and FoxP3 expression in the peripheral blood of patients with systemic lupus erythematosus, Egypt J Immunol., 16, 117 Petri, 2012, Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for SLE, Arthritis Rheum., 64, 2677, 10.1002/art.34473 Bombardier, 1992, Derivation of the SLEDAI. A disease activity index for lupus patients. The committee on prognosis studies in SLE, Arthritis Rheum., 35, 630, 10.1002/art.1780350606 Crispín, 2008, Novel molecular targets in the treatment of systemic lupus erythematosus, Autoimmun Rev, 7, 256, 10.1016/j.autrev.2007.11.020 Faddah, 2014, Lymphopenia and systemic lupus erythematosus, a preliminary study: Correlation with clinical manifestations, disease activity and damage indices, Egypt. Rheumatol, 36, 125, 10.1016/j.ejr.2014.01.005 Martin, 2017, Systemic lupus erythematosus and lymphopenia: Clinical and pathophysiological features, Rev Med Interne., 38, 603, 10.1016/j.revmed.2017.01.005 Liu, 2013, Biomarkers in systemic lupus erythematosus: challenges and prospects for the future, Ther Adv Musculoskelet Dis, 5, 210, 10.1177/1759720X13485503 Suen, 2009, Altered homeostasis of CD4 (+) FoxP3+ regulatory T-cell subpopulations in systemic lupus erythematosus, Immunology, 127, 196, 10.1111/j.1365-2567.2008.02937.x Yates, 2008, Natural regulatory T cells: number and function are normal in the majority of patients with lupus nephritis, Clin Exp Immunol, 153, 44, 10.1111/j.1365-2249.2008.03665.x Azab, 2008, CD4+CD25+regulatory T cells (TREG) in systemic lupus erythematosus (SLE) patients: the possible influence of treatment with corticosteroids, Clin Immunol, 127, 151, 10.1016/j.clim.2007.12.010 Yan, 2008, Dysfunctional CD4+, CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells, Arthritis Rheum, 58, 801, 10.1002/art.23268 Suen, 2012, CD4DFoxP3D regulatory T-cells in human systemic lupus erythematosus, J Formos Med Assoc, 111, 465, 10.1016/j.jfma.2012.05.013 Zhang, 2008, Clinical significance of increased CD4+CD25-Foxp3? T cells in patients with new onset systemic lupus erythematosus, Ann Rheum Dis, 67, 1037, 10.1136/ard.2007.083543 Prado, 2013, Relationship between FOXP3 positive populations and cytokine production in systemic lupus erythematosus, Cytokine, 61, 90, 10.1016/j.cyto.2012.08.033 Qiu, 2013, Glucocorticoid downregulates expression of IL-12 family cytokines in systemic lupus erythematosus patients, Lupus, 22, 1011, 10.1177/0961203313498799 Cai, 2014, THU0555 Immunopathological Roles of the Novel Anti-Inflammatory Cytokine Interleukin-35 in Patients with Systemic Lupus Erythematosus, Ann Rheum Dis, 73, 372, 10.1136/annrheumdis-2014-eular.1022 Ouyang, 2014, Decreased interleukin 35 and CD4+ EBI3+ T cells in patients with active systemic lupus erythematosus, Am J Med Sci, 348, 156, 10.1097/MAJ.0000000000000215 Arora, 2012, Cytokine imbalance in systemic lupus erythematosus: a study on northern Indian subjects, Lupus, 21, 596, 10.1177/0961203311434937 Zhi-Chun, 2012, Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) mediates p38 mitogen-activated protein kinase activation and signal transduction in peripheral blood mononuclear cells from patients with lupus nephritis, Inflammation, 35, 935, 10.1007/s10753-011-9396-3 Chen, 2013, Analysis of immunoglobulin-like transcripts (ILTs) in lymphocytes with sHLA-G and IL10 from SLE patients, Clin Exp Med, 13, 135, 10.1007/s10238-012-0185-6 Dhir, 2009, Increased T-lymphocyte apoptosis in lupus correlates with disease activity and may be responsible for reduced T-cell frequency: a cross sectional and longitudinal study, Lupus, 18, 785, 10.1177/0961203309103152 Tselios, 2014, FRI0280 Cd4+cd25highfoxp3+ t regulatory cells as a biomarker of disease activity in systemic lupus erythematosus: a prospective study, Ann Rheum Dis, 72, A461 Chun, 2007, Cytokine IL-6 and IL-10 as Biomarkers in Systemic Lupus Erythematosus, J Clin Immunol, 27, 461, 10.1007/s10875-007-9104-0 Godsell, 2016, Clinical associations of IL-10 and IL-37 in systemic lupus erythematosus, Sci Rep, 6, 34604, 10.1038/srep34604