CCR5 inhibition in critical COVID-19 patients decreases inflammatory cytokines, increases CD8 T-cells, and decreases SARS-CoV2 RNA in plasma by day 14

International Journal of Infectious Diseases - Tập 103 - Trang 25-32 - 2021
Bruce K. Patterson1, Harish Seethamraju2, Kush Dhody3, Michael J. Corley4, Kazem Kazempour3, Jay Lalezari5, Alina P.S. Pang4, Christopher Sugai6, Eisa Mahyari7, Edgar B. Francisco1, Amruta Pise1, Hallison Rodrigues1, Helen L. Wu7, Gabriela M. Webb7, Byung S. Park7, Scott Kelly8, Nader Pourhassan8, Alina Lelic9, Lama Kdouh9, Monica Herrera10
1IncellDX, Menlo Park, CA, USA
2Montefiore Medical Center, New York, NY, USA
3Amarex Clinical Research LLC, Germantown, MD, USA
4Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine, New York, NY, USA
5Quest Clinical Research, San Francisco, CA, USA
6University of Hawaii, Honolulu, HI, USA,
7Vaccine & Gene Therapy Institute and Oregon National Primate Research Center, Oregon Health & Science University, Portland, OR, USA
8CytoDyn Inc., Vancouver, WA, USA
9Beckman Coulter, Miami, FL, USA
10Bio-Rad, Pleasanton, CA, USA

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