CAR-T and other adoptive cell therapies for B cell malignancies

Journal of the National Cancer Center - Tập 1 - Trang 88-96 - 2021
Peihua Lu1, Holly A. Hill2, Lucy J. Navsaria2, Michael L. Wang2
1Lu Daopei Hospital, Langfang, China
2Department of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center, Houston, USA

Tài liệu tham khảo

Jain, 2018, Long-term outcomes and mutation profiling of patients with mantle cell lymphoma (MCL) who discontinued ibrutinib, Br J Haematol, 183, 578, 10.1111/bjh.15567 Martin, 2016, Postibrutinib outcomes in patients with mantle cell lymphoma, Blood, 127, 1559, 10.1182/blood-2015-10-673145 Epperla, 2017, Predictive factors and outcomes for ibrutinib therapy in relapsed/refractory mantle cell lymphoma—a “real world” study, Hematol Oncol, 35, 528, 10.1002/hon.2380 Xu, 2019, Mechanisms of Relapse After CD19 CAR T-Cell Therapy for Acute Lymphoblastic Leukemia and Its Prevention and Treatment Strategies, Front Immunol, 10, 2664, 10.3389/fimmu.2019.02664 Jain, 2020, Genomic profiles and clinical outcomes of de novo blastoid/pleomorphic MCL are distinct from those of transformed MCL, Blood Adv, 4, 1038, 10.1182/bloodadvances.2019001396 Kochenderfer, 2013, Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors, Nat Rev Clin Oncol, 10, 267, 10.1038/nrclinonc.2013.46 Maude, 2016, Efficacy and Safety of CTL019 in the First US Phase II Multicenter Trial in Pediatric Relapsed/Refractory Acute Lymphoblastic Leukemia: Results of an Interim Analysis, Blood, 128, 10.1182/blood.V128.22.2801.2801 Schuster, 2019, Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma, N Engl J Med, 380, 45, 10.1056/NEJMoa1804980 Neelapu, 2017, Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma, N Engl J Med, 377, 2531, 10.1056/NEJMoa1707447 Wang, 2020, KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma, N Engl J Med, 382, 1331, 10.1056/NEJMoa1914347 Abramson, 2019, Pivotal Safety and Efficacy Results from Transcend NHL 001, a Multicenter Phase 1 Study of Lisocabtagene Maraleucel (liso-cel) in Relapsed/Refractory (R/R) Large B Cell Lymphomas, Blood, 134, 241, 10.1182/blood-2019-127508 George, 2020, Third-generation anti-CD19 chimeric antigen receptor T-cells incorporating a TLR2 domain for relapsed or refractory B-cell lymphoma: a phase I clinical trial protocol (ENABLE), BMJ Open, 10, e034629, 10.1136/bmjopen-2019-034629 Enblad, 2018, A Phase I/IIa Trial Using CD19-Targeted Third-Generation CAR T Cells for Lymphoma and Leukemia, Clin Cancer Res, 24, 6185, 10.1158/1078-0432.CCR-18-0426 Davila, 2014, Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia, Sci Transl Med, 6, 224ra25, 10.1126/scitranslmed.3008226 Hou, 2021, Navigating CAR-T cells through the solid-tumour microenvironment, Nat Rev Drug Discov, 20, 531, 10.1038/s41573-021-00189-2 Yu, 2019, Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity, Mol Cancer, 18, 125, 10.1186/s12943-019-1057-4 Ramos, 2018, In Vivo Fate and Activity of Second- versus Third-Generation CD19-Specific CAR-T Cells in B Cell Non-Hodgkin's Lymphomas, Mol Ther, 26, 2727, 10.1016/j.ymthe.2018.09.009 Schubert, 2019, Third-Generation CAR T Cells Targeting CD19 Are Associated with an Excellent Safety Profile and Might Improve Persistence of CAR T Cells in Treated Patients, Blood, 134, 51, 10.1182/blood-2019-125423 Wang, 2020, Efficacy and safety of CAR19/22 T-cell cocktail therapy in patients with refractory/relapsed B-cell malignancies, Blood, 135, 17, 10.1182/blood.2019000017 Yang, 2019, Anti-CD19/CD22 Dual CAR-T Therapy for Refractory and Relapsed B-Cell Acute Lymphoblastic Leukemia, Blood, 134 Zhang, 2018, Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy, J Hematol Oncol, 11, 10.1186/s13045-018-0646-9 Han, 2019, Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy, J Hematol Oncol, 12, 128, 10.1186/s13045-019-0813-7 Pan, 2020, Sequential CD19-22 CAR T therapy induces sustained remission in children with r/r B-ALL, Blood, 135, 387, 10.1182/blood.2019003293 Zah, 2016, T Cells Expressing CD19/CD20 Bispecific Chimeric Antigen Receptors Prevent Antigen Escape by Malignant B Cells, Cancer Immunol Res, 4, 498, 10.1158/2326-6066.CIR-15-0231 Dai, 2020, Bispecific CAR-T cells targeting both CD19 and CD22 for therapy of adults with relapsed or refractory B cell acute lymphoblastic leukemia, J Hematol Oncol, 13, 30, 10.1186/s13045-020-00856-8 Cao, 2019, Anti-CD19 Chimeric Antigen Receptor T Cells in Combination With Nivolumab Are Safe and Effective Against Relapsed/Refractory B-Cell Non-hodgkin Lymphoma, Front Oncol, 9, 767, 10.3389/fonc.2019.00767 Liu, 2019, A phase I trial using CD19 CAR-T expressing PD-1/CD28 chimeric switch-receptor for refractory or relapsed B-cell lymphoma, J Clin Oncol, 37, 7557, 10.1200/JCO.2019.37.15_suppl.7557 Shah, 2020, Bispecific anti-CD20, anti-CD19 CAR T cells for relapsed B cell malignancies: a phase 1 dose escalation and expansion trial, Nat Med, 26, 1569, 10.1038/s41591-020-1081-3 Gattinoni, 2005, Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells, J Exp Med, 202, 907, 10.1084/jem.20050732 Corrigan-Curay, 2014, T-cell immunotherapy: looking forward, Mol Ther, 22, 1564, 10.1038/mt.2014.148 Neelapu, 2019, CAR-T efficacy: is conditioning the key?, Blood, 133, 1799, 10.1182/blood-2019-03-900928 Shah, 2021, KTE-X19 for relapsed or refractory adult B-cell acute lymphoblastic leukaemia: phase 2 results of the single-arm, open-label, multicentre ZUMA-3 study, Lancet, 398, 491, 10.1016/S0140-6736(21)01222-8 Maude, 2018, Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia, N Engl J Med, 378, 439, 10.1056/NEJMoa1709866 Yang, 2019, A Feasibility and Safety Study of a New CD19-Directed Fast CAR-T Therapy for Refractory and Relapsed B Cell Acute Lymphoblastic Leukemia, Blood, 134 Park, 2018, Long-Term Follow-up of CD19 CAR Therapy in Acute Lymphoblastic Leukemia, N Engl J Med, 378, 449, 10.1056/NEJMoa1709919 Abramson, 2020, Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study, The Lancet, 396, 839, 10.1016/S0140-6736(20)31366-0 Wang, 2019, Safety and preliminary efficacy in patients (pts) with relapsed/refractory (R/R) mantle cell lymphoma (MCL) receiving lisocabtagene maraleucel (Liso-cel) in TRANSCEND NHL 001, J Clin Oncol, 37, 7516, 10.1200/JCO.2019.37.15_suppl.7516 Jacobson, 2020, Interim analysis of ZUMA-5: A phase II study of axicabtagene ciloleucel (axi-cel) in patients (pts) with relapsed/refractory indolent non-Hodgkin lymphoma (R/R iNHL), J Clin Oncol, 38, 8008, 10.1200/JCO.2020.38.15_suppl.8008 Wang, 2017, Autologous T Cells Expressing CD30 Chimeric Antigen Receptors for Relapsed or Refractory Hodgkin Lymphoma: An Open-Label Phase I Trial, Clin Cancer Res, 23, 1156, 10.1158/1078-0432.CCR-16-1365 Ramos, 2020, Anti-CD30 CAR-T Cell Therapy in Relapsed and Refractory Hodgkin Lymphoma, J Clin Oncol, 38, 3794, 10.1200/JCO.20.01342 Wang, 2018, Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor–Redirected T Cells Against Multiple Myeloma, Clin Cancer Res, 24, 106, 10.1158/1078-0432.CCR-17-0344 Bertilaccio, 2014, Combining CD23 chimeric antigen receptor immunotherapy and lenalidomide as a novel therapeutic strategy for chronic lymphocytic leukemia, Cytotherapy, 16, S35, 10.1016/j.jcyt.2014.01.119 Ruella, 2016, The Addition of the BTK Inhibitor Ibrutinib to Anti-CD19 Chimeric Antigen Receptor T Cells (CART19) Improves Responses against Mantle Cell Lymphoma, Clin Cancer Res, 22, 2684, 10.1158/1078-0432.CCR-15-1527 Qin, 2020, Antitumor Potency of an Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy, Lisocabtagene Maraleucel in Combination With Ibrutinib or Acalabrutinib, J Immunother, 43, 107, 10.1097/CJI.0000000000000307 Gauthier, 2020, Feasibility and efficacy of CD19-targeted CAR T cells with concurrent ibrutinib for CLL after ibrutinib failure, Blood, 135, 1650, 10.1182/blood.2019002936 Wang, 2020, KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma, N Engl J Med, 382, 1331, 10.1056/NEJMoa1914347 Lefebvre, 2019, 16207: Cardiovascular Effects of Chimeric Antigen Receptor T-Cell (CART Cell) Therapy in Adults, Circulation, 140 Chen, 2016, Measuring IL-6 and sIL-6R in serum from patients treated with tocilizumab and/or siltuximab following CAR T cell therapy, J Immunol Methods, 434, 1, 10.1016/j.jim.2016.03.005 Mehta, 2020, Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome, Lancet Rheumatol, 2, e358, 10.1016/S2665-9913(20)30096-5 Strati, 2020, Clinical efficacy of anakinra to mitigate CAR T-cell therapy–associated toxicity in large B-cell lymphoma, Blood Adv, 4, 3123, 10.1182/bloodadvances.2020002328 Jacobson, 2018, CD19 Chimeric Antigen Receptor Therapy for Refractory Aggressive B-Cell Lymphoma, J Clin Oncol, 37, 328, 10.1200/JCO.18.01457 Neelapu, 2018, Chimeric antigen receptor T-cell therapy — assessment and management of toxicities, Nat Rev Clin Oncol, 15, 47, 10.1038/nrclinonc.2017.148 Vitale, 2020, CAR T-Cell Therapy for B-Cell non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia: Clinical Trials and Real-World Experiences, Front Oncol, 10, 849, 10.3389/fonc.2020.00849 Topp, 2019, Earlier Steroid Use with Axicabtagene Ciloleucel (Axi-Cel) in Patients with Relapsed/Refractory Large B Cell Lymphoma, Blood, 134, 10.1182/blood-2019-126081 MLea, 2020, Management of a Patient with Mantle Cell Lymphoma who Developed Severe Neurotoxicity After tChimeric Antigen Receptor T-Cell Therapy in ZUMA-2, J Immunother Cancer, 8, e001114, 10.1136/jitc-2020-001114 Parker, 2020, Single-Cell Analyses Identify Brain Mural Cells Expressing CD19 as Potential Off-Tumor Targets for CAR-T Immunotherapies, Cell, 183, 10.1016/j.cell.2020.08.022 Duong, 2018, Two-Dimensional Regulation of CAR-T Cell Therapy with Orthogonal Switches, Mol Ther Oncolytics, 12, 124, 10.1016/j.omto.2018.12.009 Rezvani, 2017, Engineering Natural Killer Cells for Cancer Immunotherapy, Mol Ther, 25, 1769, 10.1016/j.ymthe.2017.06.012 Westin, 2019, Correlative Analyses of Patient and Clinical Characteristics Associated with Efficacy in Tisagenlecleucel-Treated Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients in the Juliet Trial, Blood, 134, 10.1182/blood-2019-129107 Dean, 2019, Association of high baseline metabolic tumor volume with response following axicabtagene ciloleucel in refractory large B-cell lymphoma, J Clin Oncol, 37, 7562, 10.1200/JCO.2019.37.15_suppl.7562 Wei, 2020, The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma, Signal Transduct Target Ther, 5, 134, 10.1038/s41392-020-00256-x Zhang, 2020, Point mutation in CD19 facilitates immune escape of B cell lymphoma from CAR-T cell therapy, J Immunother Cancer, 8, e001150, 10.1136/jitc-2020-001150 Locke, 2020, Tumor burden, inflammation, and product attributes determine outcomes of axicabtagene ciloleucel in large B-cell lymphoma, Blood Adv, 4, 4898, 10.1182/bloodadvances.2020002394 Jacobson, 2020, Axicabtagene Ciloleucel in the Non-Trial Setting: Outcomes and Correlates of Response, Resistance, and Toxicity, J Clin Oncol, 38, 3095, 10.1200/JCO.19.02103 Deng, 2020, Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas, Nat Med, 26, 1878, 10.1038/s41591-020-1061-7 Liu, 2020, Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors, N Engl J Med, 382, 545, 10.1056/NEJMoa1910607 Yamamoto, 2019, Developing neoantigen-targeted T cell-based treatments for solid tumors, Nat Med, 25, 1488, 10.1038/s41591-019-0596-y Chrusciel, 2020, Adoptive Cell Therapy-Harnessing Antigen-Specific T Cells to Target Solid Tumours, Cancers (Basel), 12, 10.3390/cancers12030683 Boon, 1996, Human tumor antigens recognized by T lymphocytes, J Exp Med, 183, 725, 10.1084/jem.183.3.725 Morris, 2016, Optimizing T-cell receptor gene therapy for hematologic malignancies, Blood, 127, 3305, 10.1182/blood-2015-11-629071 Garber, 2018, Driving T-cell immunotherapy to solid tumors, Nat Biotechnol, 36, 215, 10.1038/nbt.4090 Hughes, 2005, Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions, Hum Gene Ther, 16, 457, 10.1089/hum.2005.16.457 Rapoport, 2015, NY-ESO-1-specific TCR-engineered T cells mediate sustained antigen-specific antitumor effects in myeloma, Nat Med, 21, 914, 10.1038/nm.3910 D'Angelo, 2018, Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 (c259)T Cells in Synovial Sarcoma, Cancer Discov, 8, 944, 10.1158/2159-8290.CD-17-1417 Hunder, 2008, Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1, N Engl J Med, 358, 2698, 10.1056/NEJMoa0800251 Johnson, 2006, Gene transfer of tumor-reactive TCR confers both high avidity and tumor reactivity to nonreactive peripheral blood mononuclear cells and tumor-infiltrating lymphocytes, J Immunol, 177, 6548, 10.4049/jimmunol.177.9.6548 Deniger, 2016, Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System, Mol Ther, 24, 1078, 10.1038/mt.2016.51 Malekzadeh, 2020, Antigen Experienced T Cells from Peripheral Blood Recognize p53 Neoantigens, Clin Cancer Res, 26, 1267, 10.1158/1078-0432.CCR-19-1874 Mayr, 2006, MDM2 is recognized as a tumor-associated antigen in chronic lymphocytic leukemia by CD8+ autologous T lymphocytes, Exp Hematol, 34, 44, 10.1016/j.exphem.2005.09.016 Goodridge, 2019, FT596: Translation of First-of-Kind Multi-Antigen Targeted Off-the-Shelf CAR-NK Cell with Engineered Persistence for the Treatment of B Cell Malignancies, Blood, 134, 301, 10.1182/blood-2019-129319 Kloss, 2018, Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication, Mol Ther, 26, 1855, 10.1016/j.ymthe.2018.05.003 Tang, 2020, TGF-β inhibition via CRISPR promotes the long-term efficacy of CAR T cells against solid tumors, JCI Insight, 5, e133977, 10.1172/jci.insight.133977 Locke, 2019, Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial, Lancet Oncol, 20, 31, 10.1016/S1470-2045(18)30864-7