C-type lectins, fungi and Th17 responses

Korn, 2009, IL-17 and Th17 cells, Annu Rev Immunol, 27, 485, 10.1146/annurev.immunol.021908.132710 Curtis, 2009, Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens, Immunology, 126, 177, 10.1111/j.1365-2567.2008.03017.x Drickamer, 1999, C-type lectin-like domains, Curr Opin Struct Biol, 9, 585, 10.1016/S0959-440X(99)00009-3 Robinson, 2006, Myeloid C-type lectins in innate immunity, Nat Immunol, 7, 1258, 10.1038/ni1417 Zelensky, 2005, The C-type lectin-like domain superfamily, FEBS J, 272, 6179, 10.1111/j.1742-4658.2005.05031.x Reid, 2009, Pattern recognition: recent insights from Dectin-1, Curr Opin Immunol, 21, 30, 10.1016/j.coi.2009.01.003 Rand, 2009, Dectin-1 and inflammation-associated gene transcription and expression in mouse lungs by a toxic (1,3)-beta-d: glucan, Arch Toxicol Werner, 2009, Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus, J Immunol, 182, 4938, 10.4049/jimmunol.0804250 Ferwerda, 2009, Human dectin-1 deficiency and mucocutaneous fungal infections, N Engl J Med, 361, 1760, 10.1056/NEJMoa0901053 Gerosa, 2008, Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cells, J Exp Med, 205, 1447, 10.1084/jem.20071450 Dennehy, 2009, Reciprocal regulation of IL-23 and IL-12 following co-activation of Dectin-1 and TLR signaling pathways, Eur J Immunol, 39, 1379, 10.1002/eji.200838543 Leibundgut-Landmann, 2007, Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17, Nat Immunol, 8, 630, 10.1038/ni1460 Leibundgut-Landmann, 2008, Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses, Blood, 112, 4971, 10.1182/blood-2008-05-158469 Gringhuis, 2009, Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-kappaB activation through Raf-1 and Syk, Nat Immunol, 10.1038/ni.1692 Tassi, 2009, Requirement of phospholipase C-gamma2 (PLCgamma2) for Dectin-1-induced antigen presentation and induction of TH1/TH17 polarization, Eur J Immunol, 39, 1369, 10.1002/eji.200839313 Osorio, 2008, DC activated via dectin-1 convert Treg into IL-17 producers, Eur J Immunol, 38, 3274, 10.1002/eji.200838950 Martin, 2009, Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals, Immunity, 31, 321, 10.1016/j.immuni.2009.06.020 Cunha, 2010, Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity, Blood, 10.1182/blood-2010-04-279307 van der Velden, 2010, The incidence of acute graft-versus-host disease increases with Candida colonization depending the dectin-1 gene status, Clin Immunol, 136, 302, 10.1016/j.clim.2010.04.007 Zenaro, 2009, Induction of Th1/Th17 immune response by Mycobacterium tuberculosis: role of dectin-1, Mannose Receptor, and DC-SIGN, J Leukoc Biol, 86, 1393, 10.1189/jlb.0409242 van de Veerdonk, 2010, Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1, J Leukoc Biol, 88, 227, 10.1189/jlb.0809550 Taylor, 2005, Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited in vivo, Eur J Immunol, 35, 2163, 10.1002/eji.200425785 McGreal, 2006, The carbohydrate recognition domain of Dectin-2 is a C-type lectin with specificity for high-mannose, Glycobiology, 16, 422, 10.1093/glycob/cwj077 Sato, 2006, Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor gamma chain to induce innate immune responses, J Biol Chem, 281, 38854, 10.1074/jbc.M606542200 Aragane, 2003, Involvement of dectin-2 in ultraviolet radiation-induced tolerance, J Immunol, 171, 3801, 10.4049/jimmunol.171.7.3801 Barrett, 2009, Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells, J Immunol, 182, 1119, 10.4049/jimmunol.182.2.1119 Suram, 2010, Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans, J Biol Chem, 10.1074/jbc.M110.143800 Saijo, 2010, Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans, Immunity, 32, 681, 10.1016/j.immuni.2010.05.001 Robinson, 2009, Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection, J Exp Med, 206, 2037, 10.1084/jem.20082818 Bi, 2010, CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans, J Biol Chem, 285, 25969, 10.1074/jbc.M110.131300 McKenzie, 2007, Mannose receptor expression and function define a new population of murine dendritic cells, J Immunol, 178, 4975, 10.4049/jimmunol.178.8.4975 Gazi, 2009, Influence of the mannose receptor in host immune responses, Immunobiology, 214, 554, 10.1016/j.imbio.2008.11.004 Zhang, 2005, Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro, J Leukoc Biol, 78, 665, 10.1189/jlb.1204699 Heinsbroek, 2008, Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis, PLoS Pathog, 4, e1000218, 10.1371/journal.ppat.1000218 Lee, 2003, Normal host defense during systemic candidiasis in mannose receptor-deficient mice, Infect Immun, 71, 437, 10.1128/IAI.71.1.437-445.2003 Swain, 2003, Absence of the macrophage mannose receptor in mice does not increase susceptibility to Pneumocystis carinii infection in vivo, Infect Immun, 71, 6213, 10.1128/IAI.71.11.6213-6221.2003 Lee, 2002, Mannose receptor-mediated regulation of serum glycoprotein homeostasis, Science, 295, 1898, 10.1126/science.1069540 Dan, 2008, Role of the mannose receptor in a murine model of Cryptococcus neoformans infection, Infect Immun, 76, 2362, 10.1128/IAI.00095-08 van de Veerdonk, 2009, The macrophage mannose receptor induces IL-17 in response to Candida albicans, Cell Host Microbe, 5, 329, 10.1016/j.chom.2009.02.006 Matsumoto, 1999, A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages, J Immunol, 163, 5039, 10.4049/jimmunol.163.9.5039 Werninghaus, 2009, Adjuvanticity of a synthetic cord factor analogue for subunit Mycobacterium tuberculosis vaccination requires FcRgamma-Syk-Card9-dependent innate immune activation, J Exp Med, 206, 89, 10.1084/jem.20081445 Yamasaki, 2008, Mincle is an ITAM-couples activating receptor that senses damaged cells, Nat Immunol, 9, 1179, 10.1038/ni.1651 Wells, 2008, The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans, J Immunol, 180, 7404, 10.4049/jimmunol.180.11.7404 Yamasaki, 2009, C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia, Proc Natl Acad Sci USA, 106, 1897, 10.1073/pnas.0805177106 Schoenen, 2010, Cutting edge: Mincle is essential for recognition and adjuvanticity of the mycobacterial cord factor and its synthetic analog trehalose-dibehenate, J Immunol, 184, 2756, 10.4049/jimmunol.0904013 Ishikawa, 2009, Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle, J Exp Med, 206, 2879, 10.1084/jem.20091750 Hunter, 2006, Multiple roles of cord factor in the pathogenesis of primary, secondary, and cavitary tuberculosis, including a revised description of the pathology of secondary disease, Ann Clin Lab Sci, 36, 371 Krutzik, 2005, TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells, Nat Med, 11, 653, 10.1038/nm1246 Lai, 2006, Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles, Am J Pathol, 169, 200, 10.2353/ajpath.2006.051191 Tailleux, 2005, DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis, PLoS Med, 2, e381, 10.1371/journal.pmed.0020381 Koppel, 2005, Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation, Cell Microbiol, 7, 157, 10.1111/j.1462-5822.2004.00480.x Powlesland, 2006, Widely divergent biochemical properties of the complete set of mouse DC-SIGN-related proteins, J Biol Chem, 281, 20440, 10.1074/jbc.M601925200 Mansour, 2006, Cryptococcus neoformans glycoantigens are captured by multiple lectin receptors and presented by dendritic cells, J Immunol, 176, 3053, 10.4049/jimmunol.176.5.3053 Serrano-Gomez, 2004, Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin mediates binding and internalization of Aspergillus fumigatus conidia by dendritic cells and macrophages, J Immunol, 173, 5635, 10.4049/jimmunol.173.9.5635 Cambi, 2008, Dendritic cell interaction with Candida albicans critically depends on N-linked mannan, J Biol Chem, 283, 20590, 10.1074/jbc.M709334200 Gringhuis, 2007, C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-kappaB, Immunity, 26, 605, 10.1016/j.immuni.2007.03.012 Gringhuis, 2009, Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori, Nat Immunol, 10, 1081, 10.1038/ni.1778 Colonna, 2000, Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells, Eur J Immunol, 30, 697, 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M Sobanov, 2001, A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex, Eur J Immunol, 31, 3493, 10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9 Thebault, 2009, The C-type lectin-like receptor CLEC-1, expressed by myeloid cells and endothelial cells, is up-regulated by immunoregulatory mediators and moderates T cell activation, J Immunol, 183, 3099, 10.4049/jimmunol.0803767 Lanier, 1994, Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes, J Immunol, 153, 2417, 10.4049/jimmunol.153.6.2417 Exley, 1998, CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains, J Exp Med, 188, 867, 10.1084/jem.188.5.867 Poggi, 1997, Expression and function of NKRP1A molecule on human monocytes and dendritic cells, Eur J Immunol, 27, 2965, 10.1002/eji.1830271132 Bezouska, 1994, Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity, Nature, 372, 150, 10.1038/372150a0 Rosen, 2005, Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor, J Immunol, 175, 7796, 10.4049/jimmunol.175.12.7796 Huarte, 2008, PILAR is a novel modulator of human T-cell expansion, Blood, 112, 1259, 10.1182/blood-2007-12-130773 Poggi, 1996, Expression of human NKRP1A by CD34+ immature thymocytes: NKRP1A-mediated regulation of proliferation and cytolytic activity, Eur J Immunol, 26, 1266, 10.1002/eji.1830260613 Poggi, 1997, NKRP1A molecule is involved in transendothelial migration of CD4+ human T lymphocytes, Immunol Lett, 57, 121, 10.1016/S0165-2478(97)00050-3 Rosen, 2008, Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells, J Immunol, 180, 6508, 10.4049/jimmunol.180.10.6508 Pozo, 2006, CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase, J Immunol, 176, 2397, 10.4049/jimmunol.176.4.2397 Takahashi, 2006, Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities, J Immunol, 176, 211, 10.4049/jimmunol.176.1.211 Cosmi, 2008, Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor, J Exp Med, 205, 1903, 10.1084/jem.20080397 Billerbeck, 2010, Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties, Proc Natl Acad Sci USA, 107, 3006, 10.1073/pnas.0914839107 Kleinschek, 2009, Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation, J Exp Med, 206, 525, 10.1084/jem.20081712 Maggi, 2010, CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC, Eur J Immunol, 10.1002/eji.200940257 Annunziato, 2009, Do studies in humans better depict Th17 cells?, Blood, 114, 2213, 10.1182/blood-2009-03-209189 Romani, 2004, Immunity to fungal infections, Nat Rev Immunol, 4, 1, 10.1038/nri1255 Huang, 2004, Requirement of interleukin-17A for systemic anti-Candida albicans host defense in mice, J Infect Dis, 190, 624, 10.1086/422329 Acosta-Rodriguez, 2007, Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells, Nat Immunol, 8, 639, 10.1038/ni1467 Puel, 2010, Inborn errors of mucocutaneous immunity to Candida albicans in humans: a role for IL-17 cytokines?, Curr Opin Immunol, 22, 467, 10.1016/j.coi.2010.06.009 de Beaucoudrey, 2008, Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells, J Exp Med, 205, 1543, 10.1084/jem.20080321 Grimbacher, 1999, Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder, N Engl J Med, 340, 692, 10.1056/NEJM199903043400904 Minegishi, 2007, Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome, Nature, 448, 1058, 10.1038/nature06096 Holland, 2007, STAT3 mutations in the hyper-IgE syndrome, N Engl J Med, 357, 1608, 10.1056/NEJMoa073687 Zhu, 2010, Differentiation of effector CD4 T cell populations (*), Annu Rev Immunol, 28, 445, 10.1146/annurev-immunol-030409-101212 Ma, 2008, Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3, J Exp Med, 205, 1551, 10.1084/jem.20080218 Milner, 2008, Impaired T(H)17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome, Nature, 452, 773, 10.1038/nature06764 Husebye, 2010, Autoimmune polyendocrine syndromes: clues to type 1 diabetes pathogenesis, Immunity, 32, 479, 10.1016/j.immuni.2010.03.016 consortium, 1997, An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains, Nat Genet, 17, 399, 10.1038/ng1297-399 Nagamine, 1997, Positional cloning of the APECED gene, Nat Genet, 17, 393, 10.1038/ng1297-393 Kisand, 2010, Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines, J Exp Med, 207, 299, 10.1084/jem.20091669 Puel, 2010, Autoantibodies against IL-17A, IL-17F, and IL-22 in patients with chronic mucocutaneous candidiasis and autoimmune polyendocrine syndrome type I, J Exp Med, 207, 291, 10.1084/jem.20091983 Gross, 2006, Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity, Nature, 442, 651, 10.1038/nature04926 Dorhoi, 2010, The adaptor molecule CARD9 is essential for tuberculosis control, J Exp Med, 207, 777, 10.1084/jem.20090067 Hsu, 2007, The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens, Nat Immunol, 8, 198, 10.1038/ni1426 Glocker, 2009, A homozygous CARD9 mutation in a family with susceptibility to fungal infections, N Engl J Med, 361, 1727, 10.1056/NEJMoa0810719 Saijo, 2007, Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans, Nat Immunol, 8, 39, 10.1038/ni1425 Conti, 2009, Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis, J Exp Med, 206, 299, 10.1084/jem.20081463 Rudner, 2007, Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection, Infect Immun, 75, 3055, 10.1128/IAI.01329-06 Kleinschek, 2006, IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12, J Immunol, 176, 1098, 10.4049/jimmunol.176.2.1098 Zelante, 2007, IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance, Eur J Immunol, 37, 2695, 10.1002/eji.200737409 Lin, 2009, Th1-Th17 cells mediate protective adaptive immunity against Staphylococcus aureus and Candida albicans infection in mice, PLoS Pathog, 5, e1000703, 10.1371/journal.ppat.1000703 De Luca, 2010, IL-22 defines a novel immune pathway of antifungal resistance, Mucosal Immunol, 3, 361, 10.1038/mi.2010.22 Cheng, 2010, Candida albicans dampens host defense by downregulating IL-17 production, J Immunol, 185, 2450, 10.4049/jimmunol.1000756 Netea, 2010, Variable recognition of Candida albicans strains by TLR4 and lectin recognition receptors, Med Mycol, 48, 897, 10.3109/13693781003621575