C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation

Cell - Tập 107 Số 1 - Trang 43-54 - 2001
Andrew Epstein1, Jonathan Gleadle1, Luke A. McNeill2, Kirsty S. Hewitson2, John P. O’Rourke1, David R. Mole1, Mridul Mukherji2, Eric Metzen1, Michael Wilson1, Anu Dhanda2, Ya‐Min Tian1, Norma Masson1, Donald L. Hamilton1, Panu Jaakkola1, Robert Barstead3, Jonathan Hodgkin4, Patrick H. Maxwell1, Christopher W. Pugh1, Christopher J. Schofield2, Peter J. Ratcliffe1
1The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
2The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, South Parks Road, Oxford OX1 3QY, United Kingdom
3Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK USA 73104
4Genetics Unit, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, United Kingdom

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Tài liệu tham khảo

Barton, 1993, Alscript, Prot. Eng., 6, 37, 10.1093/protein/6.1.37

Berra, 2001, HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1α degradation, FEBS Lett., 491, 85, 10.1016/S0014-5793(01)02159-7

Cockman, 2000, Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein, J. Biol. Chem., 275, 25733, 10.1074/jbc.M002740200

Darby, 1999, Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa, Proc. Natl. Acad. Sci. USA, 96, 15202, 10.1073/pnas.96.26.15202

Dupuy, 2000, Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2, Genomics, 69, 348, 10.1006/geno.2000.6343

Hegg, 1997, The 2-His-1-carboxylate facial triad—an emerging structural motif in mononuclear non-heme iron (II) enzymes, Eur. J. Biochem., 250, 625, 10.1111/j.1432-1033.1997.t01-1-00625.x

Huang, 1998, Regulation of hypoxia-inducible factor 1α is mediated by an oxygen-dependent domain via the ubiquitin-proteasome pathway, Proc. Natl. Acad. Sci. USA, 95, 7987, 10.1073/pnas.95.14.7987

Huang, 1999, Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide, J. Biol. Chem., 274, 9038, 10.1074/jbc.274.13.9038

Ivan, 2001, HIFα targeted for VHL-mediated destruction by proline hydroxylation, Science, 292, 464, 10.1126/science.1059817

Jaakkola, 2001, Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation, Science, 292, 468, 10.1126/science.1059796

Jiang, 1996, Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension, Am. J. Phys., 271, C1172, 10.1152/ajpcell.1996.271.4.C1172

Jiang, 2001, The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia, Proc. Natl. Acad. Sci. USA, 98, 7916, 10.1073/pnas.141234698

Kamura, 2000, Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex, Proc. Natl. Acad. Sci. USA, 97, 10430, 10.1073/pnas.190332597

Kivirikko, 1998, Prolyl 4-hydroxylases and their protein disulfide isomerase subunit, Matrix Biol., 16, 357, 10.1016/S0945-053X(98)90009-9

Lipscomb, 2001, SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons, J. Biol. Chem., 276, 5085, 10.1074/jbc.M008407200

Lloyd, 1999, Studies on the active site of deacetoxycephalosporin C synthase, J. Mol. Biol., 287, 943, 10.1006/jmbi.1999.2594

Madden, 1996, Induction of cell growth regulatory genes by p53, Cancer Res., 56, 5384

Masson, 2001, Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation, EMBO J., 20, 5197, 10.1093/emboj/20.18.5197

Maxwell, 1999, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis, Nature, 399, 271, 10.1038/20459

Maxwell, 2001, Activation of the HIF pathway in cancer, Curr. Opin. Genet. Dev., 11, 293, 10.1016/S0959-437X(00)00193-3

Mukherji, 2001, Chemical co-substrate rescue of phytanoyl-CoA 2-hydroxylase mutants causing Refsum's Disease, Chem. Comm., 11, 972, 10.1039/b101039p

O'Rourke, 1999, Oxygen-regulated and transactivating domains in endothelial PAS protein 1, J. Biol. Chem., 274, 2060, 10.1074/jbc.274.4.2060

Ohh, 2000, Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein, Nat. Cell Biol., 2, 423, 10.1038/35017054

Palmer, 2000, Normoxic stabilization of hypoxia-inducible factor-1 expression and activity, Mol. Pharmacol., 58, 1197, 10.1124/mol.58.6.1197

Salceda, 1997, Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions, J. Biol. Chem., 272, 22642, 10.1074/jbc.272.36.22642

Schofield, 1999, Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes, Curr. Opin. Struct. Biol., 9, 722, 10.1016/S0959-440X(99)00036-6

Semenza, 1999, Perspectives on oxygen sensing, Cell, 98, 281, 10.1016/S0092-8674(00)81957-1

Semenza, 2000, HIF-1 and human disease, Genes Dev., 14, 1983

Semenza, 2000, HIF-1, J. Appl. Physiol., 88, 1474, 10.1152/jappl.2000.88.4.1474

Sutter, 2000, Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations, Proc. Natl. Acad. Sci. USA, 97, 4748, 10.1073/pnas.080072497

Tanimoto, 2000, Mechanism of regulation of the hypoxia-inducible factor-1α by the von Hippel-Lindau tumor suppressor protein, EMBO J., 19, 4298, 10.1093/emboj/19.16.4298

Trent, 1983, Egg-laying defective mutants of the nematode Caenorhabditis elegans, Genetics, 104, 619, 10.1093/genetics/104.4.619

Wang, 1995, Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension, Proc. Natl. Acad. Sci. USA, 92, 5510, 10.1073/pnas.92.12.5510

Wax, 1994, Identification of a novel growth factor-responsive gene in vascular smooth muscle cells, J. Biol. Chem., 269, 13041, 10.1016/S0021-9258(18)99981-3

Wenger, 2000, Mammalian oxygen sensing, signalling and gene regulation, J. Exp. Biol., 203, 1253, 10.1242/jeb.203.8.1253

Woodward, 2000, Comparative sequence analysis of the VHL tumour suppressor gene, Genomics, 65, 253, 10.1006/geno.2000.6144

Wu, 1999, Mechanism-based inactivation of the human prolyl-4-hydroxylase by 5-oxaproline-containing peptides, J. Am. Chem. Soc., 121, 587, 10.1021/ja981193h

Zhang, 2000, Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase, Nat. Struct. Biol., 7, 127, 10.1038/72398

Zhou, 1998, Substrate binding to the alpha-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2, J. Am. Chem. Soc., 120, 13539, 10.1021/ja983534x

Zhu, 2001, How do cells sense oxygen?, Science, 292, 449, 10.1126/science.1060849