C-Reactive protein during chemotherapy for acute leukemia with special reference to non-infective causes of fever
Tóm tắt
C-reactive protein, CRP, was followed longitudinally in 41 patients being treated for acute leukemia. It was analysed by a rapid (2-h) immunochemical assay in a laser-nephelometer. The, cytostatic treatment given either intravenously or intrathecally did not cause any CRP increase with the exception of 7% of the treatment courses, given to 3 patients, and neither did transfusion reactions. The patients had altogether 117 febrile episodes. During 44 episodes with evidence of bacterial or fungal infection, CRP increased above the reference value (90 mg I−1) The same observation was made during 37 febrile episodes with clinically probable infections. CRP remained within the reference value when fever was caused by virus infections or occurring for unknown reasons.
Tài liệu tham khảo
Dinarillo C A: Interleukin I.Rev Infect Dis 6, 51 (1984).
Gewurtz H, Mold C, Siegel J, Field B: C-reactive protein and the acute phase response.Adv Intern Med 27, 345 (1982).
Kushner I, Broder M L, Karp D: Serum C-reactive protein kinetics after acute myocardial infarction.J Clin Invest 61, 235 (1978).
Pepys M B: C-reactive protein fifty years on.Lancet i, 653 (1981).
Mackie P H, Crockson R A, Stuart J: C-reactive protein for rapid diagnosis of infection in leukemia.J Clin Pathol 32, 1253 (1979).
Rose P E, Johnson S A, Meakin M, Mackie P H, Stuart J: Serial study of C-reactive protein during infection in leukemia.J Clin Pathol 34, 263 (1981).
Starke I D, Deber F C, Donnelly J F, Goldman J M, Galton D A, Pepys M B: Serum C-reactive protein levels in the management of infection in acute leukemia.Eur J Cancer Clin Oncol 20, 319 (1984).
Mancini G, Carbonare A O, Heseman J F: Immunochemical quantitation of antigens by simple radial immunodiffusion.Immunochemistry 2, 235, (1965).
Gale R P, Cline M J: High remission rate in acute myeloid leukemia.Lancet i, 497 (1977).
Esterhay R, Wiernik P H, Grove W, Markus S, Wesley M: Moderate dose methotrexate, vincristine, asparaginase and dexamethasone for treatment of adult acute lymphocytic leukemia.Blood 59, 334 (1983).