C/EBPζ (CHOP/Gadd153) is a negative regulator of LPS-induced IL-6 expression in B cells

Molecular Immunology - Tập 47 - Trang 390-397 - 2009
Hongwei Gao1, Richard C. Schwartz1
1Department of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824, United States

Tài liệu tham khảo

Adcock, 2001, Cross-talk between pro-inflammatory transcription factors and glucocorticoids, Immunol. Cell Biol., 79, 376, 10.1046/j.1440-1711.2001.01025.x Akira, 1990, A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family, EMBO J., 9, 1897, 10.1002/j.1460-2075.1990.tb08316.x Akira, 1997, NF-IL6 and NF-kappa B in cytokine gene regulation, Adv. Immunol., 65, 1, 10.1016/S0065-2776(08)60740-3 Bartlett, 1992, Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153, J. Biol. Chem., 267, 20465, 10.1016/S0021-9258(19)88725-2 Bauer, 1986, Clonal relationship of the lymphoblastic cell line P388 to the macrophage cell line P388D1 as evidenced by immunoglobulin gene rearrangements and expression of cell surface antigens, J. Immunol., 136, 4695, 10.4049/jimmunol.136.12.4695 Bretz, 1994, C/EBP-related protein 2 confers lipopolysaccharide-inducible expression of interleukin 6 and monocyte chemoattractant protein 1 to a lymphoblastic cell line, Proc. Natl. Acad. Sci. U.S.A., 91, 7306, 10.1073/pnas.91.15.7306 Bruhat, 1997, Amino acid limitation induces expression of chop, a CCAAT/enhancer binding protein related gene at both transcriptional and post-transcriptional levels, J. Biol. Chem., 272, 17588, 10.1074/jbc.272.28.17588 Carlson, 1993, Regulation of the C/EBP-related gene, gadd153, by glucose deprivation, Mol. Cell. Biol., 13, 4736, 10.1128/MCB.13.8.4736 Chen, 1992, Activation of the growth arrest and DNA damage-inducible gene gadd153 by nephrotoxic cysteine conjugates and dithiothreitol, J. Biol. Chem., 267, 8207, 10.1016/S0021-9258(18)42428-3 Choi, 1992, Cell growth inhibition by prostaglandin A2 results in elevated expression of gadd153 mRNA, Exp. Cell Res., 199, 85, 10.1016/0014-4827(92)90464-J De Bosscher, 2000, Glucocorticoids repress NF-κB-driven genes by disturbing the interaction of p65 with the basal transcription machinery, irrespective of coactivator levels in the cell, Proc. Natl. Acad. Sci. U.S.A., 97, 3919, 10.1073/pnas.97.8.3919 Fornace, 1989, DNA damage-inducible transcripts in mammalian cells, Proc. Natl. Acad. Sci. U.S.A., 85, 8800, 10.1073/pnas.85.23.8800 Fort, 1985, Various rat adult tissues express only one major mRNA species from the Glyceraldehyde-3-phosphate-dehydrogenase multigenic family, Nucleic Acids Res., 13, 1431, 10.1093/nar/13.5.1431 Gao, 2002, C/EBPγ has a stimulatory role on the IL-6 and IL-8 promoters, J. Biol. Chem., 277, 38827, 10.1074/jbc.M206224200 Galien, 1997, Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-κB site, Nucleic Acids Res., 25, 2424, 10.1093/nar/25.12.2424 Gutman, 1981, Immunoglobulin production by murine B-lymphoma cells, Clin. Immunol. Immunopathol., 18, 230, 10.1016/0090-1229(81)90029-5 Halleck, 1997, The molecular response to reductive stress in LLC-PK1 renal epithelial cells: coordinate transcriptional regulation of gadd153 and grp78 genes by thiols, Cell Stress Chaperones, 2, 31, 10.1379/1466-1268(1997)002<0031:TMRTRS>2.3.CO;2 Hobbs, 1991, Interleukin-6 production by murine B cells and B cell lines, Cell. Immunol., 132, 442, 10.1016/0008-8749(91)90041-9 Hu, 1998, Redundancy of C/EBPα, -β and -δ in supporting the lipopolysaccharide-induced transcription of IL-6 and monocyte chemoattractant protein-1, J. Immunol., 160, 2334, 10.4049/jimmunol.160.5.2334 Hu, 2000, The C/EBP bZIP domain can mediate lipopolysaccharide induction of the proinflammatory cytokines interleukin-6 and monocyte chemoattractant protein-1, J. Biol. Chem., 275, 16373, 10.1074/jbc.M910269199 Karin, 1998, New twists in gene regulation by glucocorticoid receptor: is DNA binding dispensable?, Cell, 93, 487, 10.1016/S0092-8674(00)81177-0 Kinoshita, 1992, A member of the C/EBP family, NF-IL6β forms a heterodimer and transcriptionally synergizes with NF-IL6, Proc. Natl. Acad. Sci. U.S.A., 89, 1473, 10.1073/pnas.89.4.1473 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Landschulz, 1988, Isolation of a recombinant copy of the gene encoding C/EBP, Genes Dev., 2, 786, 10.1101/gad.2.7.786 Lee, 1998, Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes, Eur. J. Immunol., 28, 4188, 10.1002/(SICI)1521-4141(199812)28:12<4188::AID-IMMU4188>3.0.CO;2-B Lekstrom-Himes, 1998, Biological role of the CCAAT/enhancer-binding protein family of transcription factors, J. Biol. Chem., 27, 28545, 10.1074/jbc.273.44.28545 Luethy, 1990, Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA, J. Biol. Chem., 265, 16521, 10.1016/S0021-9258(17)46254-5 MacFarlane, 1998, Antagonism of immunostimulatory CpG-oligodeoxynucleotides by quinacrine, chloroquine, and structurally related compounds, J. Immunol., 160, 1122, 10.4049/jimmunol.160.3.1122 Mann, 1983, Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus, Cell, 33, 153, 10.1016/0092-8674(83)90344-6 Marten, 1994, Effect of amino acid limitation on the expression of 19 genes in rat hepatoma cells, FASEB J., 8, 538, 10.1096/fasebj.8.8.8181673 Matsuaka, 1993, Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8, Proc. Natl. Acad. Sci. U.S.A., 90, 10193, 10.1073/pnas.90.21.10193 Muller, 1991, BCR first exon sequences specifically activate the BCR/ABL tyrosine kinase oncogene of Philadelphia chromosome-positive human leukemias, Mol. Cell. Biol., 11, 1785, 10.1128/MCB.11.4.1785 Nordeen, 1988, Luciferase reporter gene vectors for analysis of promoters and enhancers, BioTechniques, 6, 454 O’Neil, 1990, Design of DNA-binding peptides based on the leucine zipper motif, Science, 249, 774, 10.1126/science.2389143 Park, 1992, Isolation, characterization and chromosomal localization of the human GADD153 gene, Gene, 116, 259, 10.1016/0378-1119(92)90523-R Parkin, 2002, Regulation of C/EBP activator proteins by heterodimerization with C/EBPγ (Ig/EBP), J. Biol. Chem., 277, 23563, 10.1074/jbc.M202184200 Pear, 1993, Production of high-titer helper-free retroviruses by transient transfection, Proc. Natl. Acad. Sci. U.S.A., 90, 8392, 10.1073/pnas.90.18.8392 Poli, 1998, The role of C/EBP isoforms in the control of inflammatory and native immunity functions, J. Biol. Chem., 273, 29279, 10.1074/jbc.273.45.29279 Price, 1992, Gadd 45 and Gadd 153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of glucose-regulated proteins, Cancer Res., 52, 3814 Ray, 1990, On the mechanism for efficient repression of the interleukin-6 promoter by glucocorticoids: enhancer, TATA box, and RNA start site (Inr motif) occlusion, Mol. Cell. Biol., 10, 5736, 10.1128/MCB.10.11.5736 Ron, 1992, CHOP, a novel developmentally regulated nuclear protein that dimerized with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription, Genes Dev., 6, 439, 10.1101/gad.6.3.439 Schuman, 1990, Evidence of changes in protease sensitivity and subunit exchange rate on DNA-binding by C/EBP, Science, 249, 771, 10.1126/science.2202050 Sok, 1999, CHOP-dependent stress-inducible expression of a novel form of carbonic anhydrase VI, Mol. Cell. Biol., 19, 495, 10.1128/MCB.19.1.495 Stein, 1995, Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ, Mol. Cell. Biol., 15, 4971, 10.1128/MCB.15.9.4971 Sylvester, 1994, Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression, J. Biol. Chem., 269, 20119, 10.1016/S0021-9258(17)32135-X Tanabe, 1988, Genomic structure of the murine IL-6 gene, J. Immunol., 141, 3875, 10.4049/jimmunol.141.11.3875 Venkataraman, 1999, Bacterial lipopolysaccharide induced B cell activation is mediated via a phosphatidylinositol 3-kinase dependent signaling pathway, Immunol. Lett., 69, 233, 10.1016/S0165-2478(99)00068-1 Wang, 1998, Identification of novel stress-induced genes downstream of chop, EMBO J., 17, 3619, 10.1093/emboj/17.13.3619 Williams, 1991, A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro, Genes Dev., 5, 1553, 10.1101/gad.5.9.1553 Williams, 1998, C/EBPɛ is a myeloid-specific activator of cytokine, chemokine and macrophage-colony stimulating factor receptor genes, J. Biol. Chem., 273, 13493, 10.1074/jbc.273.22.13493