Bupropion Overdose: Significant Toxicity in Pediatrics

Shepherd, 2005, Adverse effects associated with extra doses of bupropion, Pharmacotherapy, 25, 1378, 10.1592/phco.2005.25.10.1378 Edgemont Pharmaceuticals, 2016 GlaxoSmithKline, 2016 Valeant Pharmaceuticals International, 2014 Orexigen Therapeutics, 2014 GlaxoSmithKline, 2016 Kantor, 2015, Trends in prescription drug use among adults in the United States from 1999-2012, JAMA, 314, 1818, 10.1001/jama.2015.13766 Centers for Disease Control and Prevention Lee, 2012, Off-label prescribing patterns of antidepressants in children and adolescents, Pharmacoepidemiol Drug Saf, 21, 137, 10.1002/pds.2145 Lovegrove, 2015, Trends in emergency department visits for unsupervised pediatric medication exposures, 2004-2013, Pediatrics, 135, e821, 10.1542/peds.2015-2092 Even, 2014, Poisonings requiring admission to the pediatric intensive care unit: a 5-year review, Clin Toxicol, 52, 519, 10.3109/15563650.2014.909601 Mowry, 2015, 2014 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 32nd annual report, Clin Toxicol, 53, 962, 10.3109/15563650.2015.1102927 Mowry, 2016, 2015 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 33rd annual report, Clin Toxicol, 54, 924, 10.1080/15563650.2016.1245421 Mowry, 2014, 2013 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 31st annual report, Clin Toxicol, 52, 1032, 10.3109/15563650.2014.987397 Dwoskin, 2006, Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent, CNS Drug Rev, 12, 178, 10.1111/j.1527-3458.2006.00178.x Johnston, 1991, A 102-center prospective study of seizure in association with bupropion, J Clin Psychiatry, 52, 450 Dunner, 1998, A prospective safety surveillance study for bupropion sustained-release in the treatment of depression, J Clin Psychiatry, 59, 366, 10.4088/JCP.v59n0705 Pesola, 2002, Bupropion seizure proportion among new-onset generalized seizures and drug related seizures presenting to an emergency department, J Emerg Med, 22, 235, 10.1016/S0736-4679(01)00474-7 Beuhler, 2010, The outcome of unintentional pediatric bupropion ingestions: a NPDS database review, J Med Toxicol, 6, 4, 10.1007/s13181-010-0027-4 Spiller, 2010, Unintentional ingestion of bupropion in children, J Emerg Med, 38, 332, 10.1016/j.jemermed.2007.11.081 Belson, 2002, Bupropion exposures: clinical manifestations and medical outcome, J Emerg Med, 23, 223, 10.1016/S0736-4679(02)00522-X Thundiyil, 2007, Evolving epidemiology of drug-induced seizures reported to a poison control center system, J Med Toxicol, 3, 15, 10.1007/BF03161033 Shepherd, 2004, Intentional bupropion overdoses, J Emerg Med, 27, 147, 10.1016/j.jemermed.2004.02.017 Starr, 2009, Incidence and onset of delayed seizures after overdoses of extended-release bupropion, Am J Emerg Med, 27, 911, 10.1016/j.ajem.2008.07.004 Casey, 2011, Frequency of false positive amphetamine screens due to bupropion using the Syva EMIT II immunoassay, J Med Toxicol, 7, 105, 10.1007/s13181-010-0131-5 Reidy, 2011, Crossreactivity of bupropion metabolite with enzyme-linked immunosorbent assays designed to detect amphetamine in urine, Ther Drug Monit, 33, 366, 10.1097/FTD.0b013e3182126d08 Vidal, 2007, Bupropion interference with immunoassays for amphetamines and LSD, Ther Drug Monit, 29, 373, 10.1097/FTD.0b013e318040adc3 Thanacoody, 2015, Position paper update: whole bowel irrigation for gastrointestinal decontamination of overdose patients, Clin Toxicol, 53, 5, 10.3109/15563650.2014.989326 Chen, 2016, Treatment of drug-induced seizures, Br J Clin Pharmacol, 81, 412, 10.1111/bcp.12720 Shah, 2010, Should phenytoin or barbiturates be used as second-line anticonvulsant therapy for toxicological seizures?, Clin Toxicol, 48, 800, 10.3109/15563650.2010.521506 Caillier, 2012, QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profile, Fundam Clin Pharmacol, 26, 599, 10.1111/j.1472-8206.2011.00953.x Gosselin, 2016, Evidence-based recommendations on the use of intravenous lipid emulsion therapy in poisoning, Clin Toxicol, 54, 899, 10.1080/15563650.2016.1214275 Shenoi, 2011, Refractory hypotension from massive bupropion overdose successfully treated with extracorporeal membrane oxygenation, Pediatr Emerg Care, 27, 43, 10.1097/PEC.0b013e3182045f76 Heise, 2016, Two cases of refractory cardiogenic shock secondary to bupropion successfully treated with veno-arterial extracorporeal membrane oxygenation, J Med Toxicol, 12, 301, 10.1007/s13181-016-0539-7