Bullying in clinical high risk for psychosis participants from the NAPLS-3 cohort

Social psychiatry - Tập 57 - Trang 1379-1388 - 2022
Amy Braun1, Lu Liu1, Carrie E. Bearden2, Kristin S. Cadenhead3, Barbara A. Cornblatt4, Matcheri Keshavan5, Daniel H. Mathalon6, Thomas H. McGlashan7, Diana O. Perkins8, Larry J. Seidman5, William Stone5, Ming T. Tsuang3,9, Elaine F. Walker10, Scott W. Woods7, Tyrone D. Cannon11, Jean Addington1
1Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Canada
2Departments of Psychiatry and Biobehavioral Sciences and Psychology, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, USA
3Department of Psychiatry, UCSD, San Diego, USA
4Department of Psychiatry, Zucker Hillside Hospital, Long Island, USA
5Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, USA
6Department of Psychiatry, UCSF, and SFVA Medical Center, San Francisco, USA
7Department of Psychiatry, Yale University, New Haven, USA
8Department of Psychiatry, University of North Carolina, Chapel Hill, USA
9Institute of Genomic Medicine, University of California, La Jolla, USA
10Departments of Psychology and Psychiatry, Emory University, Atlanta, USA
11Department of Psychology, Yale University, New Haven, USA

Tóm tắt

Bullying is associated with a heightened risk for poor outcomes, including psychosis. This study aimed to replicate previous findings on bullying prevalence in clinical high-risk (CHR) individuals, to assess the longitudinal course of clinical and functional variables between bullied and non-bullied CHR and the association of bullying with premorbid functioning, clinical outcome, transition to psychosis and risk of violence. The sample consisted of 691 CHR participants and 96 healthy controls. Participants reported whether they had experienced bullying and how long it had lasted. Assessments included DSM-5 diagnoses, attenuated psychotic symptoms, negative symptoms, social and role functioning, depression, stress, premorbid functioning, and risk of violence. The bullied and non-bullied CHR groups were compared at baseline and further longitudinally on clinical and functioning variables and transition to psychosis. Bullying was more prevalent among CHR individuals than healthy controls. Bullied CHR had a higher prevalence of PTSD and more severe depression and stress at baseline than non-bullied CHR. There was no impact of bullying on clinical and functional variables over time. Bullying was not related to final clinical status or transition to psychosis. However, bullied participants had poorer premorbid functioning and a greater risk of violence. While bullying may not impact the likelihood of CHR individuals to transition to psychosis, it may be a risk factor for development of the at-risk state and may be related to a greater risk of violence. Future studies should consider bullying perpetration among CHR individuals.

Tài liệu tham khảo

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