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Sống sót sau ung thư vú và rối loạn tình dục: Một nghiên cứu dựa trên quần thể
Tóm tắt
Ung thư vú là loại ung thư không phải da phổ biến nhất ở phụ nữ và số lượng người sống sót sau ung thư vú ngày càng tăng. Mặc dù tiên lượng đối với ung thư vú tiếp tục cải thiện, tỷ lệ rối loạn chức năng tình dục và các nguy cơ liên quan đến các phương pháp điều trị ung thư chưa được xác định rõ trong các nghiên cứu dựa trên quần thể. Chúng tôi đã xác định một nhóm 19,709 người sống sót sau ung thư vú được chẩn đoán từ năm 1997 đến 2017 thông qua Đăng ký Ung thư Utah, và 93,389 phụ nữ không bị ung thư được ghép cặp theo tuổi và tiểu bang sinh ra từ Cơ sở Dữ liệu Dân số Utah. Các chẩn đoán rối loạn chức năng tình dục được xác định thông qua các mã ICD-9 và ICD-10 từ hồ sơ y tế điện tử và dữ liệu từ các cơ sở chăm sóc sức khỏe trên toàn tiểu bang. Mô hình nguy cơ tỷ lệ Cox đã được sử dụng để ước lượng tỷ lệ nguy cơ cho rối loạn chức năng tình dục. Những người sống sót sau ung thư vú có nguy cơ cao hơn bị chẩn đoán rối loạn chức năng tình dục (9.1% so với 6.9%, HR 1.60, 95% CI 1.51–1.70) so với quần thể chung. Nguy cơ này tăng 2.05 lần trong vòng 1 đến 5 năm sau chẩn đoán ung thư (95% CI 1.89–2.22) và 3.05 lần ở những cá nhân được chẩn đoán ung thư ở độ tuổi <50 (95% CI 2.65–3.51). Các phương pháp điều trị ung thư bao gồm liệu pháp nội tiết, hóa trị và xạ trị có liên quan đến nguy cơ tăng cao về rối loạn chức năng tình dục trong số những người sống sót sau ung thư vú. Nguy cơ rối loạn chức năng tình dục ở những người sống sót sau ung thư vú cao hơn so với quần thể chung, nhưng có thể bị chẩn đoán thiếu trong môi trường lâm sàng. Các chuyên gia chăm sóc sức khỏe nên được khuyến khích để giải quyết vấn đề sức khỏe tình dục sớm trong quá trình điều trị ung thư vú và thường xuyên sàng lọc bệnh nhân cho các triệu chứng rối loạn chức năng tình dục.
Từ khóa
#ung thư vú #sống sót #rối loạn chức năng tình dục #nghiên cứu cộng đồng #sức khỏe tình dụcTài liệu tham khảo
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