Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

Molecular Metabolism - Tập 5 Số 7 - Trang 538-551 - 2016
Phillip J. White1, Amanda L. Lapworth2, Jie An1, Liping Wang1, Robert W. McGarrah1, Robert D. Stevens1, Olga Ilkayeva1, Tabitha George1, Michael J. Muehlbauer1, James R. Bain1, Jeff K. Trimmer2, M. Julia Brosnan2, Timothy P. Rolph2, Christopher B. Newgard1
1Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Departments of Pharmacology & Cancer Biology and Medicine, Duke University Medical Center, Durham, NC, 27701, USA
2CV and Metabolic Diseases Research Unit, Pfizer, Cambridge, MA, USA

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Felig, 1969, Plasma amino acid levels and insulin secretion in obesity, The New England Journal of Medicine, 281, 811, 10.1056/NEJM196910092811503

Newgard, 2009, A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance, Cell Metabolism, 9, 311, 10.1016/j.cmet.2009.02.002

Huffman, 2009, Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women, Diabetes Care, 32, 1678, 10.2337/dc08-2075

Tai, 2010, Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men, Diabetologia, 53, 757, 10.1007/s00125-009-1637-8

Wang, 2011, Metabolite profiles and the risk of developing diabetes, Nature Medicine, 17, 448, 10.1038/nm.2307

Shah, 2010, Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events, Circulation. Cardiovascular Genetics, 3, 207, 10.1161/CIRCGENETICS.109.852814

Laferrère, 2011, Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss, Science Translational Medicine, 3, 10.1126/scitranslmed.3002043

Shah, 2012, Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss, Diabetologia, 55, 321, 10.1007/s00125-011-2356-5

Newgard, 2012, Interplay between lipids and branched-chain amino acids in development of insulin resistance, Cell Metabolism, 15, 606, 10.1016/j.cmet.2012.01.024

Ridaura, 2013, Gut microbiota from twins discordant for obesity modulate metabolism in mice, Science (New York, N.Y.), 341, 1241214, 10.1126/science.1241214

She, 2007, Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism, American Journal of Physiology. Endocrinology and Metabolism, 293, E1552, 10.1152/ajpendo.00134.2007

Lian, 2015, Impaired adiponectin signaling contributes to disturbed catabolism of branched-chain amino acids in diabetic mice, Diabetes, 64, 49, 10.2337/db14-0312

Shin, 2014, Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism, Cell Metabolism, 10.1016/j.cmet.2014.09.003

Herman, 2010, Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels, The Journal of Biological Chemistry, 285, 11348, 10.1074/jbc.M109.075184

Hsiao, 2011, Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats, American Journal of Physiology. Endocrinology and Metabolism, 300, E164, 10.1152/ajpendo.00219.2010

Lynch, 2014, Branched-chain amino acids in metabolic signalling and insulin resistance, Nature Reviews Endocrinology, 10, 723, 10.1038/nrendo.2014.171

Krebs, 2002, Mechanism of amino acid-induced skeletal muscle insulin resistance in humans, Diabetes, 51, 599, 10.2337/diabetes.51.3.599

Krebs, 2003, Direct and indirect effects of amino acids on hepatic glucose metabolism in humans, Diabetologia, 46, 917, 10.1007/s00125-003-1129-1

Tremblay, 2005, Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability, Diabetes, 54, 2674, 10.2337/diabetes.54.9.2674

Nairizi, 2009, Leucine supplementation of drinking water does not alter susceptibility to diet-induced obesity in mice, The Journal of Nutrition, 139, 715, 10.3945/jn.108.100081

Macotela, 2011, Dietary leucine–an environmental modifier of insulin resistance acting on multiple levels of metabolism, PloS One, 6, e21187, 10.1371/journal.pone.0021187

Guo, 2010, Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus, Nutrition & Metabolism, 7, 57, 10.1186/1743-7075-7-57

She, 2013, Leucine and protein metabolism in obese Zucker rats, PloS One, 8, e59443, 10.1371/journal.pone.0059443

James, 1985, Heterogeneity of insulin action in individual muscles in vivo: euglycemic clamp studies in rats, The American Journal of Physiology, 248, E567

Ferrara, 2008, Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling, PLoS Genetics, 4, e1000034, 10.1371/journal.pgen.1000034

Ronnebaum, 2006, A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion, The Journal of Biological Chemistry, 281, 30593, 10.1074/jbc.M511908200

An, 2004, Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance, Nature Medicine, 10, 268, 10.1038/nm995

Olson, 2013, Quantification of branched-chain keto acids in tissue by ultra fast liquid chromatography-mass spectrometry, Analytical Biochemistry, 439, 116, 10.1016/j.ab.2013.05.002

Glynn, 2015, Impact of combined resistance and aerobic exercise training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans, Diabetologia, 58, 2324, 10.1007/s00125-015-3705-6

Thalacker-Mercer, 2014, BMI, RQ, diabetes, and sex affect the relationships between amino acids and clamp measures of insulin action in humans, Diabetes, 63, 791, 10.2337/db13-0396

Terrettaz, 1986, Severe hepatic and peripheral insulin resistance as evidenced by euglycemic clamps in genetically obese fa/fa rats, Endocrinology, 118, 674, 10.1210/endo-118-2-674

Koves, 2008, Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance, Cell Metabolism, 7, 45, 10.1016/j.cmet.2007.10.013

Muoio, 2012, Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility, Cell Metabolism, 15, 764, 10.1016/j.cmet.2012.04.005

Jang, 2016, A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance, Nature Medicine, 10.1038/nm.4057

Sunny, 2015, Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver disease, American Journal of Physiology. Endocrinology and Metabolism, 309, E311, 10.1152/ajpendo.00161.2015

Davies, 2016, The acetyl group buffering action of carnitine acetyltransferase offsets macronutrient-induced lysine acetylation of mitochondrial proteins, Cell Reports, 14, 243, 10.1016/j.celrep.2015.12.030

Coen, 2012, Role of intramyocelluar lipids in human health, Trends in Endocrinology and Metabolism: TEM, 23, 391, 10.1016/j.tem.2012.05.009

Fernstrom, 2013, Large neutral amino acids: dietary effects on brain neurochemistry and function, Amino Acids, 45, 419, 10.1007/s00726-012-1330-y

van Hove, 1995, 3-Hydroxyisovalerylcarnitine in 3-methylcrotonyl-CoA carboxylase deficiency, Journal of Inherited Metabolic Disease, 18, 592, 10.1007/BF02436004

Horvath, 2010, Quantitative measurement of plasma 3-hydroxyisovaleryl carnitine by LC-MS/MS as a novel biomarker of biotin status in humans, Analytical Chemistry, 82, 4140, 10.1021/ac1003213

Cota, 2006, Hypothalamic mTOR signaling regulates food intake, Science (New York, N.Y.), 312, 927, 10.1126/science.1124147

Green, 2016, Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis, Nature Chemical Biology, 12, 15, 10.1038/nchembio.1961