Brain Monoamine Oxidase A Activity Predicts Trait Aggression

Journal of Neuroscience - Tập 28 Số 19 - Trang 5099-5104 - 2008
Nelly Alia‐Klein1, Rita Z. Goldstein1, A. Kriplani1, Jean Logan1, Dardo Tomasi1, Benjamin Williams2, Frank Telang3, Elena Shumay1, Anat Biegon1, Ian Craig2, Fritz A. Henn1, Gene‐Jack Wang1,4, Nora D. Volkow3, Joanna S. Fowler1,4
1Medical Department, Brookhaven National Laboratory, Upton, New York, 11973
2King's College, London WC2R 2LS, United Kingdom
3National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892
4Mount Sinai School of Medicine, New York, New York 10029, and

Tóm tắt

The genetic deletion of monoamine oxidase A (MAO A), an enzyme that breaks down the monoamine neurotransmitters norepinephrine, serotonin, and dopamine, produces aggressive phenotypes across species. Therefore, a common polymorphism in the MAO A gene (MAOA, Mendelian Inheritance in Men database number 309850, referred to as high or low based on transcription in non-neuronal cells) has been investigated in a number of externalizing behavioral and clinical phenotypes. These studies provide evidence linking the low MAOA genotype and violent behavior but only through interaction with severe environmental stressors during childhood. Here, we hypothesized that in healthy adult males the gene product of MAO A in the brain, rather than the gene per se, would be associated with regulating the concentration of brain amines involved in trait aggression. Brain MAO A activity was measuredin vivoin healthy nonsmoking men with positron emission tomography using a radioligand specific for MAO A (clorgyline labeled with carbon 11). Trait aggression was measured with the multidimensional personality questionnaire (MPQ). Here we report for the first time that brain MAO A correlates inversely with the MPQ trait measure of aggression (but not with other personality traits) such that the lower the MAO A activity in cortical and subcortical brain regions, the higher the self-reported aggression (in both MAOA genotype groups) contributing to more than one-third of the variability. Because trait aggression is a measure used to predict antisocial behavior, these results underscore the relevance of MAO A as a neurochemical substrate of aberrant aggression.

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Tài liệu tham khảo

10.1016/0969-8051(95)00042-V

Alia-Klein N Kriplani A Pradhan K Yemin Ma J Logan J Williams B Craig IW Telang F Tomasi D Goldstein RZ Wang GJ Vokow ND Fowler JS (2008) The MAO A genotype does not modulate resting brain metabolism in adults. Psychiatry Res Neuroimaging, in press.

10.1007/s00439-001-0652-8

Baumgarten, 2004, Serotonin neurotoxins-past and present, Neurotox Res, 6, 589, 10.1007/BF03033455

10.1001/archpsyc.1961.01710120031004

10.1126/science.8211186

10.1016/j.tins.2007.12.006

10.1002/syn.890100209

10.1126/science.7792602

10.1126/science.1072290

10.1037/0022-3514.66.1.93

10.1002/bies.20538

10.1136/pmj.78.918.233

10.1109/10.486290

10.1073/pnas.93.24.14065

10.1046/j.1471-4159.2001.00649.x

10.1007/s11307-005-0016-1

10.1016/j.biopsych.2006.08.038

10.1016/S0140-6736(00)05064-9

10.1002/ajp.20369

10.1038/sj.mp.4001851

Logan, 2002, Strategy for the formation of parametric images under conditions of low injected radioactivity applied to PET studies with the irreversible monoamine oxidase A tracers [11C]clorgyline and deuterium-substituted [11C]clorgyline, J Cereb Blood Flow Metab, 22, 1367, 10.1097/01.WCB.0000040947.67415.e1

10.1001/archpsyc.61.8.836

10.1016/S0006-3223(02)01418-X

10.1001/archpsyc.63.11.1209

10.1038/nrn1993

10.1073/pnas.0511311103

10.1016/S0006-3223(97)00340-5

10.1017/S0954579402001104

10.1038/nrn2174

10.1016/j.biopsych.2004.10.012

10.1007/s00259-003-1389-5

10.1007/s004390050816

10.1016/S0161-813X(03)00112-8

10.1086/302562

Stevens J (1992) Applied multivariate statistics for the social sciences (Erlbaum, Hillsdale, NJ), Ed 2.

Tellegen A Waller NG (1997) in Personality measures: development and evaluation, Exploring personality through test construction: development of the multidimensional personality questionnaire, eds Briggs SR Cheek JM (JAI, Greenwich, CT).

10.1037/0022-3514.54.6.1031

10.1016/0006-8993(93)91664-E

10.1038/npp.1994.42

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Journal of Neuroscience

Tập 28 Số 19

5099-5104

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