Atsuo Goto1, Toshio Ikeda1, Louis Tobian1, Junichi Iwai1, Mary Ann Johnson1
1Hypertension Section, Department of Medicine, University of Minnesota School of Medicine, and Brookhaven National Laboratory, Upton, NY, U.S.A.
Tóm tắt
1. The rise in blood pressure in Dahl salt-sensitive rats that received intracerebroventricular 6-hydroxydopamine was almost half that of the control rats throughout 20 weeks of high (8%) NaCl feeding.
2. The rise in bood pressure in Dahl salt-sensitive rats with bilateral complete electrolytic lesions of the paraventricular nuclei was almost half that of the control rats during 12 weeks of high (8%) NaCl feeding.
3. The bilateral complete electrolytic lesions of the suprachiasmatic nuclei enhanced the development of NaCl hypertension in Dahl salt-sensitive rats.
4. These results show that NaCl-induced hypertension in Dahl salt-sensitive rats requires the integrity of the central nervous system catecholaminergic neurones and the paraventricular nuclei for its full expression.
