Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

McMahon, S. B. & Bennett, D. L. H. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 105–128 (Harcourt, London, 1999).

Bevan, S. in Textbook of Pain (eds Wall, P. D. & Melzack, R.) 85–103 (Harcourt, London, 1999).

Ganju, P., O'Bryan, J. P., Der, C., Winter, J. & James, I. F. Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells. Eur. J. Neurosci. 10, 1995–2008 (1998).

Burgess, G. M., Mullaney, I., McNeill, M., Dunn, P. M. & Rang, H. P. Second messengers involved in the mechanism of action of bradykinin in sensory neurons in culture. J. Neurosci. 9, 3314–3325 (1989).

Woolf, C. J. & Salter, M. W. Neuronal plasticity: increasing the gain in pain. Science 288, 1765–1769 (2000).

Shu, X. Q. & Mendell, L. M. Neurotrophins and hyperalgesia. Proc. Natl Acad. Sci. USA 96, 7693–7696 (1999).

Nicholas, R. S., Winter, J., Wren, P., Bergmann, R. & Woolf, C. J. Peripheral inflammation increases the capsaicin sensitivity of dorsal root ganglion neurons in a nerve growth factor-dependent manner. Neuroscience 91, 1425–1433 (1999).

Koltzenburg, M., Bennett, D. L., Shelton, D. L. & McMahon, S. B. Neutralization of endogenous NGF prevents the sensitization of nociceptors supplying inflamed skin. Eur. J. Neurosci. 11, 1698–1704 (1999).

Woolf, C. J. Phenotypic modification of primary sensory neurons: the role of nerve growth factor in the production of persistent pain. Phil. Trans. R. Soc. Lond. B 351, 441–448 (1996).

Koltzenburg, M. The changing sensitivity in the life of the nociceptor. Pain 6 (Suppl.), S93–S102 (1999).

Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816–824 (1997).

Tominaga, M. et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531–543 (1998).

Caterina, M. J. et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306–313 (2000).

Davis, J. B. et al. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405, 183–187 (2000).

Jordt, S. E., Tominaga, M. & Julius, D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc. Natl Acad. Sci. USA 97, 8134–8139 (2000).

Harteneck, C., Plant, T. D. & Schultz, G. From worm to man: three subfamilies of TRP channels. Trends Neurosci. 23, 159–166 (2000).

Shu, X. & Mendell, L. M. Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. Neurosci. Lett. 274, 159–162 (1999).

Bergmann, I., Reiter, R., Toyka, K. V. & Koltzenburg, M. Nerve growth factor evokes hyperalgesia in mice lacking the low-affinity neurotrophin receptor p75. Neurosci. Lett. 255, 87–90 (1998).

Stephens, R. M. et al. Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses. Neuron 12, 691–705 (1994).

Cesare, P., Dekker, L. V., Sardini, A., Parker, P. J. & McNaughton, P. A. Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. Neuron 23, 617–624 (1999).

Premkumar, L. S. & Ahern, G. P. Induction of vanilloid receptor channel activity by protein kinase C. Nature 408, 985–990 (2000).

Womack, K. B. et al. Do phosphatidylinositides modulate vertebrate phototransduction? J. Neurosci. 20, 2792–2799 (2000).

Huang, C. L., Feng, S. & Hilgemann, D. W. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ. Nature 391, 803–806 (1998).

Zhang, H., He, C., Yan, X., Mirshahi, T. & Logothetis, D. E. Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biol. 1, 183–188 (1999).

Li, H. S., Xu, X. Z. & Montell, C. Activation of a TRPC3-dependent cation current through the neurotrophin BDNF. Neuron 24, 261–273 (1999).

Estacion, M., Sinkins, W. G. & Schilling, W. P. Regulation of Drosophila transient receptor potential-like (TrpL) channels by phospholipase C-dependent mechanisms. J. Physiol. 530, 1–19 (2001).

Zygmunt, P. M. et al. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400, 452–457 (1999).

Hofmann, T. et al. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397, 259–263 (1999).

Chevesich, J., Kreuz, A. J. & Montell, C. Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex. Neuron 18, 95–105 (1997).

Scott, K. & Zuker, C. S. Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses. Nature 395, 805–808 (1998).