Brèves

Evans JM, Donnelly LA, Emslie-Smith AM, et al (2005) Metformin and reduced risk of cancer in diabetic patients. BMJ 330(7503):1304–1305 Ben Sahra I, Laurent K, Loubat A, et al (2008) The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 27(25):3576–3586 Zakikhani M, Dowling R, Fantus IG, et al (2006) Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 66(21):10269–10273 Buzzai M, Jones RG, Amaravadi RK, et al (2008) Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 67(14):6745–6752 Rocchini AP (2002) Childhood obesity and a diabetes epidemic. N Engl J Med 346:854–855 McMillen IC, Robinson JS (2005) Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 85:571–633 Plagemann A (2006) Perinatal nutrition and hormone-dependent programming of food intake. Horm Res 65(Suppl 3):83–89 Taylor PD, Poston L (2007) Developmental programming of obesity in mammals. Exp Physiol 92:287–298 Beck B, Kozak R, Moar KM, Mercer JG (2006) Hypothalamic orexigenic peptides are overexpressed in young Long-Evans rats after early life exposure to fat-rich diets. Biochem Biophys Res Com 342:452–458 López M, Seoane LM, Tovar S, et al (2005) A possible role of neuropeptide Y, agouti-related protein and leptin receptor isoforms in hypothalamic programming by perinatal feeding in the rat. Diabetologia 1:140–148 Plagemann A, Harder T, Rake A, et al (1999) Observations on the orexigenic hypothalamic neuropeptide Y-system in neonatally overfed weanling rats. J Neuroendocrinol 7: 541–546 Chang GQ, Gaysinskaya V, Karatayev O, Leibowitz SF (2008) Maternal high-fat diet and fetal programming: increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity. J Neurosci 28:12107–12119 Kokoeva MV, Yin H, Flier JS (2007) Evidence for constitutive neural cell proliferation in the adult murine hypothalamus. J Comp Neurol 505:209–220 Bauer S, Hay M, Amilhon B, et al (2005) In vivo neurogenesis in the dorsal vagal complex of the adult rat brainstem. Neuroscience 130:75–90 Ye J, Gao Z, Yin J, He Q (2007) Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 293(4):E1118–E1128 Pasarica M, Sereda OR, Redman LM, et al (2008) Reduced adipose tissue oxygenation in human obesity — evidence for rarefaction, macrophage chemotaxis and inflammation without an angiogenic response. Diabetes [Epub ahead of print] Wang B, Wood IS, Trayhurn P (2007) Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch 455(3):479–492 Regazzetti C, Peraldi P, Grémeaux T, et al (2009) Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes 58(1):95–103 Comment in: Kyle D. Copps and Morris F. White. (2009) Breathing room: the (Un) natural history of adipose microhypoxia and insulin resistance. Diabetes 58:26–27 Osika W, Montgomery SM (2008) Physical control and coordination in childhood study and adult obesity: longitudinal birth cohort BMJ 337; a699