Bovine leukemia virus linked to breast cancer but not coinfection with human papillomavirus: Case‐control study of women in Texas

Cancer - Tập 124 Số 7 - Trang 1342-1349 - 2018
Kimberly Baltzell1, Hua Shen2, Savitri Krishnamurthy3, Jennette D. Sison4, Gerard J. Nuovo5, Gertrude Case Buehring2
1Department of Family Health Care Nursing, University of California at San Francisco, San Francisco, California
2School of Public Health, University of California at Berkeley, Berkeley, California
3Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas
4Department of Neurological Surgery, School of Medicine, University of California at San Francisco, San Francisco, California
5Department of Pathology, Ohio State University Comprehensive Cancer Center, Columbus, Ohio

Tóm tắt

BACKGROUNDBovine leukemia virus (BLV) and human papillomavirus (HPV) were previously identified in human breast tissue and have been associated with breast cancer in independent studies. The objective of the current study was to test for the presence of BLV and HPV in the same breast tissue specimens to determine whether the viruses were associated with breast cancer either singly or together.METHODSArchival formalin‐fixed paraffin‐embedded breast tissue sections from 216 women were received from The University of Texas MD Anderson Cancer Center along with patient diagnosis. In situ polymerase chain reaction and/or DNA hybridization methods were used to detect targeted DNA segments of BLV and HPV. Standard statistical methods were used to calculate age‐adjusted odds ratios, attributable risk, and P values for the trend related to the association between presence of a virus and a diagnosis of breast disease.RESULTSWomen diagnosed with breast cancer were significantly more likely to have BLV DNA in their breast tissue compared with women with benign diagnoses and no history of breast cancer. Women with breast pathology classified as premalignant and no history of breast cancer also were found to have an elevated risk of harboring BLV DNA in their breast tissue. HPV status was not associated with malignancy, premalignant breast disease, or the presence of BLV in the breast tissues.CONCLUSIONSThe data from the current study supported previous findings of a significant association between BLV DNA in breast tissue and a diagnosis of breast cancer, but did not demonstrate oncogenic strains of HPV associated with breast cancer or the presence of BLV DNA in breast tissue. The authors believe the findings of the current study contribute to overall knowledge regarding a possible causal role for viruses in human breast cancer. Cancer 2018;124:1342‐9. © 2017 American Cancer Society.

Từ khóa


Tài liệu tham khảo

10.1016/S0140-6736(13)62224-2

10.1007/s10549-011-1921-4

10.1002/ijc.28210

10.3201/eid2005.131298

10.1371/journal.pone.0134304

10.1177/1040638717702183

Gyles C, 2016, Should we be more concerned about bovine leukemia virus?, Can Vet J, 57, 115

10.1016/j.virusres.2016.11.002

10.1002/(SICI)1097-0142(19981015)83:8<1529::AID-CNCR7>3.0.CO;2-V

Nuovo GJ, 1998, Rapid Detection of Infectious Agents

10.1177/104063870501700217

Lee L, 2012, Bovine leukemia virus infection in a juvenile alpaca with multicentric lymphoma, Can Vet J, 53, 283

Maaten MJ, 1975, Replication of bovine leukemia virus in monolayer cell cultures, Bibl Haematol, 43, 360

10.1007/s11626-007-9060-2

10.1126/science.867042

Nuovo G, 2013, Situ Molecular Pathology and Co‐Expression Analyses

10.1186/1742-4690-4-18

10.1111/j.1365-2257.2005.00698.x

10.1007/s11262-005-6907-z

National Center for Biotechnology Information US National Library of Medicine National Institutes of Health.Standard nucleotide BLAST.https://blast.ncbi.nlm.nih.gov/Blast.cgi. Accessed November 15 2017.

10.1177/003591576505800503

10.1093/jnci/91.11.933

10.1002/cncr.26389

Thông tin
Thông tin xuất bản

Cancer

Tập 124 Số 7

1342-1349

Thông tin tác giả