Boronated derivatives of protohemin IX with L-amino acids as potential anticancer agents

Moscow University Chemistry Bulletin - Tập 62 Số 5 - Trang 238-242 - 2007
Savchenko, A. N.1, Ol’shevskaya, V. A.1, Kalinin, V. N.1, Shtil, A. A.1,2
1Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia
2Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia

Tóm tắt

New water-soluble conjugates of protohemin IX with an anionic 1-carba-closo-dodecaborate polyhedron and L-amino acids have been synthesized. In these compounds, the amino acid residues are bound to the porphyrin ring through the amide or ester bond. The new water-soluble amino acid derivatives of boronated protohemin IX show high antitumor activity for human tumor cell lines.

Tài liệu tham khảo

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