Strubin M, Berte C, Mach B: Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain. EMBO J. 1986, 5: 3483-3488.
Roche PA, Cresswell P: Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature. 1990, 345: 615-618. 10.1038/345615a0.
Lindner R: Transient surface delivery of invariant chain-MHC II complexes via endosomes: a quantitative study. Traffic. 2002, 3: 133-146. 10.1034/j.1600-0854.2002.030206.x.
Cella M, Sallusto F, Lanzavecchia A: Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol. 1997, 9: 10-16. 10.1016/S0952-7915(97)80153-7.
Saudrais C, Spehner D, de la Salle H, Bohbot A, Cazenave JP, Goud B, Hanau D, Salamero J: Intracellular pathway for the generation of functional MHC class II peptide complexes in immature human dendritic cells. J Immunol. 1998, 160: 2597-2607.
Dugast M, Toussaint H, Dousset C, Benaroch P: AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class II to endosomes. J Biol Chem. 2005, 280: 19656-19664. 10.1074/jbc.M501357200.
McCormick PJ, Martina JA, Bonifacino JS: Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proc Natl Acad Sci USA. 2005, 102: 7910-7915. 10.1073/pnas.0502206102.
Schutze MP, Peterson PA, Jackson MR: An N-terminal double-arginine motif maintains type II membrane proteins in the endoplasmic reticulum. EMBO J. 1994, 13: 1696-1705.
Stumptner P, Benaroch P: Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81–90) region. EMBO J. 1997, 16: 5807-5818. 10.1038/sj.emboj.7590555.
Romagnoli P, Germain RN: The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy. J Exp Med. 1994, 180: 1107-1113. 10.1084/jem.180.3.1107.
Hsing LC, Rudensky AY: The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol Rev. 2005, 207: 229-241. 10.1111/j.0105-2896.2005.00310.x.
Busch R, Rinderknecht CH, Roh S, Lee AW, Harding JJ, Burster T, Hornell TM, Mellins ED: Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression. Immunol Rev. 2005, 207: 242-260. 10.1111/j.0105-2896.2005.00306.x.
Benaroch P, Yilla M, Raposo G, Ito K, Miwa K, Geuze HJ, Ploegh HL: How MHC class II molecules reach the endocytic pathway. EMBO J. 1995, 14: 37-49.
Koch N, Lauer W, Habicht J, Dobberstein B: Primary structure of thegene for the murineIa antigen-associated invariant chains(Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin. EMBO J. 1987, 6: 1677-1683.
Rudensky AY, Maric M, Eastman S, Shoemaker L, DeRoos PC, Blum JS: Intracellular assembly and transport of endogenous peptide-MHC class II complexes. Immunity. 1994, 1: 585-594. 10.1016/1074-7613(94)90048-5.
Vogt AB, Stern LJ, Amshoff C, Dobberstein B, Hammerling BJ, Kropshofer H: Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR. J Immunol. 1995, 155: 4757-4765.
Ashman JB, Miller JJ: A role for the transmembrane domain in the trimerization of the MHC class II-associated invariant chain. Immunol. 1999, 163: 2704-2712.
Frauwirth K, Shastri N: Mutation of the invariant chain transmembrane region inhibits II degradation, prolongs association with MHC class II, and selectively disrupts antigen presentation. Cell Immunol. 2001, 209: 97-108. 10.1006/cimm.2001.1796.
Dixon AM, Stanley BJ, Matthews EE, Dawson JP, Engelman DM: Invariant chain transmembrane domain trimerization: a step in MHC class II assembly. Biochemistry. 2006, 45: 5228-5234. 10.1021/bi052112e.
Jasanoff A, Wagner G, Wiley DC: Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii. EMBO J. 1998, 17: 6812-6818. 10.1093/emboj/17.23.6812.
Kallinteris NL, Wu S, Lu X, Humphreys RE, von Hofe E, Xu M: Enhanced CD4+ T-cell response in DR4-transgenic mice to a hybrid peptide linking the Ii-Key segment of the invariant chain to the melanoma gp100(48–58) MHC class II epitope. J Immunother. 2005, 28: 352-358. 10.1097/01.cji.0000170362.45456.00.
Zinckgraf JW, Sposato M, Zielinski V, Powell D, Treanor JJ, von Hofe E: Identification of HLA class II H5N1 hemagglutinin epitopes following subvirion influenza A (H5N1) vaccination. Vaccine. 2009, 27: 5393-5401. 10.1016/j.vaccine.2009.06.081.
Xu M, Lu X, Sposato M, Zinckgraf JW, Wu S, von Hofe E: Ii-Key/HPV16 E7 hybrid peptide immunotherapy for HPV16+ cancers. Vaccine. 2009, 27: 4641-4647. 10.1016/j.vaccine.2009.05.054.
Nagata T, Aoshi T, Suzuki M, Uchijima M, Kim YH, Yang Z, Koide Y: Induction of protective immunity to Listeria monocytogenes by immunization with plasmid DNA expressing a helper T-cell epitope that replaces the class II-associated invariant chain peptide of the invariant chain. Infect Immun. 2002, 70: 2676-2680. 10.1128/IAI.70.5.2676-2680.2002.
Gao M, Wang HP, Wang YN, Zhou Y, Wang QL: HCV-NS3 Th1 minigene vaccine based on invariant chain CLIP genetic substitution enhances CD4(+) Th1 cell responses in vivo. Vaccine. 2006, 24: 5491-7. 10.1016/j.vaccine.2006.04.004.
Adams S, Humphreys RE: Invariant chain peptides enhancing or inhibiting the presentation of antigenic peptides by major histocompatibility complex class II molecules. Eur J Immun. 1995, 25: 1693-1702. 10.1002/eji.1830250632.
Xu M, Lis J, Gulfo JV: MHC class II allosteric site drugs: New immunotherapeutics for malignant, infectious and autoimmune disease. Scan J Immunol. 2001, 54: 39-44. 10.1046/j.1365-3083.2001.00964.x.
Sotiriadou NN, Kallinteris NL, Gritzapis AD, Voutsas IF, Papamichail M, von Hofe E, Humphreys RE, Pavlis T, Perez SA, Baxevanis CN: Ii-Key/HER-2/neu(776–790) hybrid peptides induce more effective immunological responses over the native peptide in lymphocyte cultures from patients with HER-2/neu + tumors. Cancer Immunol Immunother. 2007, 56: 601-613. 10.1007/s00262-006-0213-z.
Humphreys RE, Adams S, Koldzic G: Increasing the potentcy of MHC class II-presented epitopes by linking to Ii-Key peptide. Vaccine. 2000, 18: 2693-2697. 10.1016/S0264-410X(00)00067-0.
Gillogly ME, Kallinteris NL, Xu M, Gulfo JV, Humphreys RE, Murray JL: Ii-Key/HER-2/neu MHC class-II antigenic epitope vaccine peptide for breast cancer. Cancer Immunol Immunother. 2004, 53: 490-496. 10.1007/s00262-003-0463-y.
Rhyner C, Kündig T, Akdis CA, Crameri R: Targeting the MHC II presentation pathway in allergy vaccine development. Biochem Soc Trans. 2007, 35: 833-834. 10.1042/BST0350833.
Gjertsson I, Laurie KL, Devitt J, Howe SJ, Thrasher AJ, Holmdahl R, Gustafsson K: Tolerance induction using lentiviral gene delivery delays onset and severity of collagen II arthritis. Mol Ther. 2009, 17: 632-640. 10.1038/mt.2009.299.
Dong L, Yu W, Xu F, Liu G: Cloning and identifying of mouse invariant chain gene and its identification in prokaryotic cells. J Anhui Agri Sci. 2007, 35: 7856-7857. Chines
Xu F, Wu S, Yu W: Establishment of P815 cell line stably expressing Newcastle disease virus-F gene (NDV-F). J Agri Biotech. 2009, 17: 567-570. Chines
Sadegh-Nasseri S, Germain RN: A role for peptide in determining MHC class II structure. Nature. 1991, 353: 167-170. 10.1038/353167a0.
Sadegh-Nasseri S, Stern LJ, Wiley DC, Germain RN: MHC class II function preserved by lowaffinity peptide interactions preceding stable binding. Nature. 1994, 370: 647-650. 10.1038/370647a0.
Sato AK, Zarutskie JA, Rushe MM, Lomakin A, Natarajan SK, Adegh-Nasseri SS: Determinants of the peptide-induced conformational change in the human class II major histocompatibility complex protein HLA-DR1. J Biol Chem. 2000, 275: 2165-2173. 10.1074/jbc.275.3.2165.
Carven GJ, Stern LJ: Probing the ligand-induced conformational change in HLA-DR1 by selective chemical modification and mass spectrometric mapping. Biochemistry. 2005, 44: 13625-13637. 10.1021/bi050972p.
Dornmair K, Rothenhausler B, McConnell HM: Structural intermediates in the reactions of antigenic peptides with MHC molecules. Cold Spring Harb Symp Quant Biol. 1989, 54: 409-416. 10.1101/SQB.1989.054.01.050.
Witt SN, McConnell HM: Formation and dissociation of short-lived class II MHC-peptide complexes. Biochemistry. 1994, 33: 1861-1868. 10.1021/bi00173a032.
Schmitt L, Boniface JJ, Davis MM, McConnell HM: Conformational isomers of a class II MHCpeptide complex in solution. J Mol Biol. 1999, 286: 207-218. 10.1006/jmbi.1998.2463.
Natarajan SK, Assadi M, Sadegh-Nasser S: Stable peptide binding to MHC class II molecule is rapid and is determined by a receptive conformation shaped by prior association with low affinity peptides. J Immunol. 1999, 162: 4030-4036.
Rabinowitz JD, Vrljic M, Kasson PM, Liang MN, Busch R, Boniface JJ: Formation of a highly peptide-receptive state of class II MHC. Immunity. 1998, 9: 699-709. 10.1016/S1074-7613(00)80667-6.
Germain RN, Hendrix LR: MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding. Nature. 1991, 353: 134-139. 10.1038/353134a0.
Natarajan SK, Assadi M, Sadegh-Nasseri S: Stable peptide binding to MHC class II molecule is rapid and is determined by a receptive conformation shaped by prior association with low affinity peptides. J Immunol. 1999, 162: 4030-4036.
Huby RD, Dearman RJ, Kimber I: Intracellular phosphotyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. J Biol Chem. 1999, 274: 22591-22596. 10.1074/jbc.274.32.22591.
Karacsonyi C, Knorr R, Fulbier A, Lindner R: Association of major histocompatibility complex II with cholesterol- and sphingolipid-rich membranes precedes peptide loading. J Biol Chem. 2004, 279: 34818-34826. 10.1074/jbc.M404608200.
Anderson HA, Hiltbold EM, Roche PA: Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat Immunol. 2000, 1: 156-162. 10.1038/77842.
Hiltbold EM, Poloso NJ, Roche PA: MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse. J Immunol. 2003, 170: 1329-1338.
Pond L, Watts C: Functional early endosomes are required for maturation of major histocompatibility complex class II molecules in human B lymphoblastoid cells. J Biol Chem. 1999, 274: 18049-18054. 10.1074/jbc.274.25.18049.
Brachet V, Pehau-Arnaudet G, Desaymard C, Raposo G, Amigorena S: Early endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments. Mol Biol Cell. 1999, 10: 2891-2904.