Bone morphogenetic protein 7: a novel treatment for chronic renal and bone disease

Remuzzi, 2002, Chronic renal diseases: renoprotective benefits of renin-angiotensin system inhibition., Ann Intern Med, 136, 604, 10.7326/0003-4819-136-8-200204160-00010

Vukicevic, 1998, Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat., J Clin Invest, 102, 202, 10.1172/JCI2237

Gould, 2002, BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells., Kidney Int, 61, 51, 10.1046/j.1523-1755.2002.00103.x

Hruska, 2000, Osteogenic protein-1 prevents renal fibrogenesis associated with ureteral obstruction., Am J Physiol (Renal), 279, F130, 10.1152/ajprenal.2000.279.1.F130

Zeisberg, 2003, BMP-7 counteracts TGF1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury., Nat Med, 9, 964, 10.1038/nm888

Wang, 2003, Bone morphogenetic protein-7 (BMP-7), a novel therapy for diabetic nephropathy., Kidney Int, 63, 2037, 10.1046/j.1523-1755.2003.00035.x

Zeisberg, 2003, Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models., Am J Physiol (Renal), 285, F1060, 10.1152/ajprenal.00191.2002

Vukicevic, 1996, Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7)., Proc Natl Acad Sci U S A, 93, 9021, 10.1073/pnas.93.17.9021

Dudley, 1995, A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye., Genes Dev, 9, 2795, 10.1101/gad.9.22.2795

Luo, 1995, BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning., Genes Dev, 9, 2808, 10.1101/gad.9.22.2808

Lund, 2002, Bone morphogenetic protein-7: an anti-fibrotic morphogenetic protein with therapeutic importance in renal disease., Curr Opin Nephrol Hypertens, 11, 31, 10.1097/00041552-200201000-00005

Simon, 1999, Expression of bone morphogenetic protein-7 mRNA in normal and ischemic adult rat kidney., Am J Physiol, 276, F382

Kopp, 2002, BMP-7 and the proximal tubule., Kidney Int, 61, 351, 10.1046/j.1523-1755.2002.00126.x

Morrissey, 2002, Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function., J Am Soc Nephrol, 13, S14, 10.1681/ASN.V13suppl_1s14

Thiery, 2002, Epithelial-mesenchymal transitions in tumour progression., Nat Rev Cancer, 2, 442, 10.1038/nrc822

Liu, 2004, Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention., J Am Soc Nephrol, 15, 1, 10.1097/01.ASN.0000106015.29070.E7

Wang, 2003, BMP7 antagonizes TGF-beta-dependent fibrogenesis in mesangial cells., Am J Physiol (Renal), 284, F1006, 10.1152/ajprenal.00382.2002

Reeves, 2000, Transforming growth factor beta contributes to progressive diabetic nephropathy., Proc Natl Acad Sci U S A, 97, 7667, 10.1073/pnas.97.14.7667

Ziyadeh, 2004, Mediators of diabetic renal disease: the case for TGF- as the major mediator., J Am Soc Nephrol, 15, S55, 10.1097/01.ASN.0000093460.24823.5B

Wang, 2001, Loss of tubular bone morphogenetic protein-7 in diabetic nephropathy., J Am Soc Nephrol, 12, 2392, 10.1681/ASN.V12112392

Sato, 2003, Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction., J Clin Invest, 112, 1486, 10.1172/JCI200319270

Comijn, 2001, The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion., Mol Cell, 7, 1267, 10.1016/S1097-2765(01)00260-X

Postigo, 2003, Opposing functions of ZEB proteins in the regulation of the TGF/BMP signaling pathway., EMBO J, 22, 2443, 10.1093/emboj/cdg225

Hua, 1998, Synergistic cooperation of TFE3 and Smad proteins in TGF-beta-induced transcription of the plasminogen activator inhibitor-1 gene., Genes Dev, 12, 3084, 10.1101/gad.12.19.3084

Zawaideh, 2003, BMP-7 inhibits high glucose induced renal glomerular mesangial cell phenotype abstract., J Am Soc Nephrol, 14, 62A

Wang, 2003, BMP7 opposes TGF-dependent fibrogenesis in mesangial cells through Smad5 and Smad6 abstract., J Am Soc Nephrol, 14, 590A

Benchabane, 2003, GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations., Mol Cell Biol, 23, 6646, 10.1128/MCB.23.18.6646-6661.2003

Imamura, 1997, Smad6 inhibits signalling by the TGF-b superfamily., Nature, 389, 622, 10.1038/39355

Nakao, 1997, Identification of Smad7, a TGF--inducible antagonist of TGF- signalling., Nature, 389, 631, 10.1038/39369

Li, 2002, Smad7 inhibits fibrotic effect of TGF- on renal tubular epithelial cells by blocking Smad2 activation., J Am Soc Nephrol, 13, 1464, 10.1097/01.ASN.0000014252.37680.E4

Lan, 2003, Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model., J Am Soc Nephrol, 14, 1535, 10.1097/01.ASN.0000067632.04658.B8

Lee, 2003, Bone morphogenetic protein-7 inhibits constitutive and interleukin-1 beta-induced monocyte chemoattractant protein-1 expression in human mesangial cells: role for JNK/AP-1 pathway., J Immunol, 170, 2557, 10.4049/jimmunol.170.5.2557

Hu, 2004, p38MAPK acts in the BMP-7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1., J Biol Chem, 279, 12051, 10.1074/jbc.M310526200

Bellusci, 1996, Evidence from normal expression and targeted misexpression that bone morphogenetic protein (BMP-4) plays a role in mouse embryonic lung morphogenesis., Development, 122, 1693, 10.1242/dev.122.6.1693

Lund, 2004, Successful treatment of an adynamic bone disorder with bone morphogenetic protein-7 in a renal ablation model., J Am Soc Nephrol, 15, 359, 10.1097/01.ASN.0000109671.99498.08

Ibels, 1979, Arterial calcification and pathology in uremic patients undergoing dialysis., Am J Med, 66, 790, 10.1016/0002-9343(79)91118-5

Raggi, 2002, Cardiac calcification in adult hemodialysis patients: a link between end-stage renal disease and cardiovascular disease?, J Am Coll Cardiol, 39, 695, 10.1016/S0735-1097(01)01781-8

Goodman, 2000, Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis., N Engl J Med, 342, 1478, 10.1056/NEJM200005183422003

Doherty, 2004, Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads., Proc Natl Acad Sci U S A, 100, 11201, 10.1073/pnas.1932554100

Jono, 2000, Phosphate regulation of vascular smooth muscle cell calcification., Circ Res, 87, e10, 10.1161/01.RES.87.7.e10

Tintut, 1998, cAMP stimulates osteoblast-like differentiation of calcifying vascular cells., J Biol Chem, 273, 7547, 10.1074/jbc.273.13.7547

Luo, 1997, Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein., Nature, 386, 78, 10.1038/386078a0

Bucay, 1998, Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification., Genes Dev, 12, 1260, 10.1101/gad.12.9.1260

Davies, 2003, BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure., J Am Soc Nephrol, 14, 1559, 10.1097/01.ASN.0000068404.57780.DD

Binkert, 1999, Regulation of osteogenesis by Fetuin., J Biol Chem, 274, 28514, 10.1074/jbc.274.40.28514

Price, 2002, Discovery of a high molecular weight complex of calcium, phosphate, fetuin, and matrix Gla protein in the serum of etidronate-treated rats., J Biol Chem, 277, 3926, 10.1074/jbc.M106366200

Price, 2003, The inhibition of calcium phosphate precipitation by fetuin is accompanied by the formation of a fetuin-mineral complex., J Biol Chem, 278, 22144, 10.1074/jbc.M300744200