Chondroadherin xương thúc đẩy sự bám dính của tế bào tạo xương lên bề mặt rắn và thể hiện ái lực với collagen

Calcified Tissue International - Tập 59 - Trang 163-167 - 1996
M. Mizuno1, R. Fujisawa1, Y. Kuboki1
1Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo Japan

Tóm tắt

Chondroadherin, được báo cáo là được tổng hợp bởi các tế bào sụn và thúc đẩy sự bám dính của chúng, đã được tinh chế từ xương bò. Đây là một thành phần nhỏ trong ma trận hữu cơ của xương và có mặt trong chiết xuất guanidine 4 M từ xương đã khử khoáng. Chondroadherin thúc đẩy sự bám dính của các tế bào tạo xương lên các bề mặt rắn và liên kết với collagen. Sự liên kết của chondroadherin với collagen cao hơn đáng kể so với osteonectin hoặc decorin. Những phát hiện này cho thấy chondroadherin có thể đóng vai trò quan trọng trong việc duy trì các tế bào xương trên các ma trận collagen của xương.

Từ khóa

#Chondroadherin #tế bào tạo xương #liên kết collagen #ma trận hữu cơ xương

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