Bone and metal: An orthopaedic perspective on osseointegration of metals

Acta Biomaterialia - Tập 10 Số 10 - Trang 4043-4057 - 2014
Vitali Goriainov1, Richard Cook2, Jeremy M. Latham3, D. Dunlop3, Richard O.C. Oreffo1
1Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute for Developmental Sciences, University of Southampton, MP887, Institute of Development Science Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
2National Centre for Advanced Tribology at Southampton (nCATS), Faculty of Engineering and the Environment, University of Southampton, Highfield, Southampton SO17 1BJ, UK
3Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK

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Tài liệu tham khảo

Global Orthopedic Implants Market Discussed in New Report. Industry Experts; 2011.

NJR. 10th annual report 2013. <http://www.njrcentre.org.uk/njrcentre/Portals/0/Documents/England/Reports/10th_annual_report/NJR 10th Annual Report 2013 B.pdf>. National Joint Registry for England, Wales and Northern Ireland; 2013.

Brånemark, 2001, Osseointegration in skeletal reconstruction and rehabilitation: a review, J Rehabil Res Dev, 38, 175

Linder, 1988, Clinical aspects of osseointegration in joint replacement. A histological study of titanium implants, J Bone Joint Surg Br, 70, 550, 10.1302/0301-620X.70B4.3403596

Iezzi G, Piattelli A, Mangano C, Shibli JA, Vantaggiato G, Frosecchi M, et al. Peri-implant bone tissues around retrieved human implants after time periods longer than 5 years: a retrospective histologic and histomorphometric evaluation of 8 cases. Odontology/the Society of the Nippon Dental University 2012.

Zarb, 1991, Osseointegration – a requiem for the periodontal ligament? – an editorial, Int J Periodontics Restorative Dent, 11, 88

Karrholm, 1997, Radiostereometry of hip prostheses. Review of methodology and clinical results, Clin Orthop Relat Res, 94

Williams, 2008, On the mechanisms of biocompatibility, Biomaterials, 29, 2941, 10.1016/j.biomaterials.2008.04.023

Williams, 1987

Davies, 2003, Understanding peri-implant endosseous healing, J Dent Educ, 67, 932, 10.1002/j.0022-0337.2003.67.8.tb03681.x

Osborn, 1980, Dynamic aspects of the implant-bone interface, 111

Lian, 1995, Development of the osteoblast phenotype: molecular mechanisms mediating osteoblast growth and differentiation, Iowa Orthop J, 15, 118

Binyamin, 2006, Biomaterials: a primer for surgeons, Semin Pediatr Surg, 15, 276, 10.1053/j.sempedsurg.2006.07.007

Niinomi, 2012, Development of new metallic alloys for biomedical applications, Acta Biomater, 8, 3888, 10.1016/j.actbio.2012.06.037

Geetha, 2009, Ti based biomaterials, the ultimate choice for orthopaedic implants – a review, Prog Mater Sci, 54, 397, 10.1016/j.pmatsci.2008.06.004

Long, 1998, Titanium alloys in total joint replacement—a materials science perspective, Biomaterials, 19, 1621, 10.1016/S0142-9612(97)00146-4

Frost, 2004, A 2003 update of bone physiology and Wolff’s Law for clinicians, Angle Orthod, 74, 3

Gardner, 2006, In vivo cyclic axial compression affects bone healing in the mouse tibia, J Orthop Res, 24, 1679, 10.1002/jor.20230

Bozec, 2006, Skeletal tissues as nanomaterials, J Mater Sci – Mater Med, 17, 1043, 10.1007/s10856-006-0442-x

Kaplan, 1994, Form and function of bone, 128

Huiskes, 1992, The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials, Clin Orthop Relat Res, 124

Rubin, 1984, Regulation of bone formation by applied dynamic loads, J Bone Joint Surg Am, 66, 397, 10.2106/00004623-198466030-00012

Robling, 2000, Partitioning a daily mechanical stimulus into discrete loading bouts improves the osteogenic response to loading, J Bone Miner Res, 15, 1596, 10.1359/jbmr.2000.15.8.1596

Hsieh, 2001, Effects of loading frequency on mechanically induced bone formation, J Bone Miner Res, 16, 918, 10.1359/jbmr.2001.16.5.918

Yang, 2010, Cyclic tensile stretch modulates osteogenic differentiation of adipose-derived stem cells via the BMP-2 pathway, Arch Med Sci, 6, 152, 10.5114/aoms.2010.13886

Weinbaum, 1994, A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses, J Biomech, 27, 339, 10.1016/0021-9290(94)90010-8

Otter, 1992, A comparative analysis of streaming potentials in vivo and in vitro, J Orthop Res, 10, 710, 10.1002/jor.1100100513

Pavalko, 1998, Fluid shear-induced mechanical signaling in MC3T3-E1 osteoblasts requires cytoskeleton-integrin interactions, Am J Physiol, 275, C1591, 10.1152/ajpcell.1998.275.6.C1591

Lorich, 1998, Biochemical pathway mediating the response of bone cells to capacitive coupling, Clin Orthop Relat Res, 246

Abdel-Hady Gepreel, 2013, Biocompatibility of Ti-alloys for long-term implantation, J Mech Behav Biomed Mater, 20, 407, 10.1016/j.jmbbm.2012.11.014

Niinomi, 2008, Metallic biomaterials, J Artif Organs, 11, 105, 10.1007/s10047-008-0422-7

Song, 1999, Theoretical study of the effects of alloying elements on the strength and modulus of β-type bio-titanium alloys, Mater Sci Eng A, 260, 269, 10.1016/S0921-5093(98)00886-7

McGee, 2000, Implant retrieval studies of the wear and loosening of prosthetic joints: a review, Wear, 241, 158, 10.1016/S0043-1648(00)00370-7

Navarro, 2008, Biomaterials in orthopaedics, J R Soc Interface, 5, 1137, 10.1098/rsif.2008.0151

Xie, 2013, Nanocrystalline beta-Ti alloy with high hardness, low Young’s modulus and excellent in vitro biocompatibility for biomedical applications, Mater Sci Eng C Mater Biol Appl, 33, 3530, 10.1016/j.msec.2013.04.044

Estrin, 2009, Accelerated growth of preosteoblastic cells on ultrafine grained titanium, J Biomed Mater Res A, 90, 1239, 10.1002/jbm.a.32174

Estrin, 2011, Accelerated stem cell attachment to ultrafine grained titanium, Acta Biomater, 7, 900, 10.1016/j.actbio.2010.09.033

Duff-Barclay, 1966, Biomechanics. The development of the Stanmore total hip replacement, Proc R Soc Med, 59, 948

Roach, 2005, Interpretation of protein adsorption: surface-induced conformational changes, J Am Chem Soc, 127, 8168, 10.1021/ja042898o

Schwartz, 1994, Underlying mechanisms at the bone-biomaterial interface, J Cell Biochem, 56, 340, 10.1002/jcb.240560310

Dalby, 2007, The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder, Nat Mater, 6, 997, 10.1038/nmat2013

Ronold, 2003, Analysing the optimal value for titanium implant roughness in bone attachment using a tensile test, Biomaterials, 24, 4559, 10.1016/S0142-9612(03)00256-4

Dohan Ehrenfest, 2010, Classification of osseointegrated implant surfaces: materials, chemistry and topography, Trends Biotechnol, 28, 198, 10.1016/j.tibtech.2009.12.003

Anselme, 2000, Osteoblast adhesion on biomaterials, Biomaterials, 21, 667, 10.1016/S0142-9612(99)00242-2

Sinha, 1994, Surface composition of orthopaedic implant metals regulates cell attachment, spreading, and cytoskeletal organization of primary human osteoblasts in vitro, Clin Orthop Relat Res, 258

Jinno, 1998, Osseointegration of surface-blasted implants made of titanium alloy and cobalt-chromium alloy in a rabbit intramedullary model, J Biomed Mater Res, 42, 20, 10.1002/(SICI)1097-4636(199810)42:1<20::AID-JBM4>3.0.CO;2-Q

Tengvall, 1992, Physico-chemical considerations of titanium as a biomaterial, Clin Mater, 9, 115, 10.1016/0267-6605(92)90056-Y

Lee, 2012, Surface characteristics of thermally treated titanium surfaces, J Periodontal Implant Sci, 42, 81, 10.5051/jpis.2012.42.3.81

Feng, 2002, Characterization of surface oxide films on titanium and bioactivity, J Mater Sci – Mater Med, 13, 457, 10.1023/A:1014737831371

Li, 1994, The role of hydrated silica, titania, and alumina in inducing apatite on implants, J Biomed Mater Res, 28, 7, 10.1002/jbm.820280103

Ellingsen, 1991, A study on the mechanism of protein adsorption to TiO2, Biomaterials, 12, 593, 10.1016/0142-9612(91)90057-H

Bucci-Sabattini, 2010, Effect of titanium implant surface nanoroughness and calcium phosphate low impregnation on bone cell activity in vitro, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 109, 217, 10.1016/j.tripleo.2009.09.007

Coelho, 2009, Early healing of nanothickness bioceramic coatings on dental implants. An experimental study in dogs, J Biomed Mater Res B Appl Biomater, 88, 387, 10.1002/jbm.b.31090

Mendes, 2009, Discrete calcium phosphate nanocrystalline deposition enhances osteoconduction on titanium-based implant surfaces, J Biomed Mater Res A, 90, 577, 10.1002/jbm.a.32126

Junker, 2009, Effects of implant surface coatings and composition on bone integration: a systematic review, Clin Oral Implant Res, 20, 185, 10.1111/j.1600-0501.2009.01777.x

de Jonge, 2008, Organic-inorganic surface modifications for titanium implant surfaces, Pharm Res, 25, 2357, 10.1007/s11095-008-9617-0

Baas, 2008, Adjuvant therapies of bone graft around non-cemented experimental orthopedic implants stereological methods and experiments in dogs, Acta Orthop Suppl, 79, 1, 10.1080/17453690610046567

Sul, 2003, The significance of the surface properties of oxidized titanium to the bone response: special emphasis on potential biochemical bonding of oxidized titanium implant, Biomaterials, 24, 3893, 10.1016/S0142-9612(03)00261-8

Sul, 2009, The roles of surface chemistry and topography in the strength and rate of osseointegration of titanium implants in bone, J Biomed Mater Res A, 89, 942, 10.1002/jbm.a.32041

Park, 2010, Enhanced osteoblast response to hydrophilic strontium and/or phosphate ions-incorporated titanium oxide surfaces, Clin Oral Implant Res, 21, 398, 10.1111/j.1600-0501.2009.01863.x

Lamolle, 2009, The effect of hydrofluoric acid treatment of titanium surface on nanostructural and chemical changes and the growth of MC3T3-E1 cells, Biomaterials, 30, 736, 10.1016/j.biomaterials.2008.10.052

Monjo, 2008, In vivo expression of osteogenic markers and bone mineral density at the surface of fluoride-modified titanium implants, Biomaterials, 29, 3771, 10.1016/j.biomaterials.2008.06.001

Ellingsen, 1995, Pre-treatment of titanium implants with fluoride improves their retention in bone, J Mater Sci - Mater Med, 6, 749, 10.1007/BF00134312

Kajiwara, 2005, The bisphosphonate pamidronate on the surface of titanium stimulates bone formation around tibial implants in rats, Biomaterials, 26, 581, 10.1016/j.biomaterials.2004.02.072

Prieto-Alhambra, 2011, Association between bisphosphonate use and implant survival after primary total arthroplasty of the knee or hip: population based retrospective cohort study, BMJ, 343, d7222, 10.1136/bmj.d7222

Suratwala, 2008, Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite, J Bone Joint Surg Am, 90, 2189, 10.2106/JBJS.G.00409

Cross, 2012, A rare case of a bisphosphonate-induced peri-prosthetic femoral fracture, J Bone Joint Surg Br, 94, 994, 10.1302/0301-620X.94B7.28778

Pierschbacher, 1984, Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature, 309, 30, 10.1038/309030a0

Morra, 2006, Biochemical modification of titanium surfaces: peptides and ECM proteins, Eur Cell Mater, 12, 1, 10.22203/eCM.v012a01

Riley, 1996, Bone morphogenetic protein-2: biology and applications, Clin Orthop Relat Res, 39, 10.1097/00003086-199603000-00006

Ramazanoglu, 2013, Bone response to biomimetic implants delivering BMP-2 and VEGF: an immunohistochemical study, J Craniomaxillofac Surg, 41, 826, 10.1016/j.jcms.2013.01.037

Schliephake, 2005, Functionalization of dental implant surfaces using adhesion molecules, J Biomed Mater Res B Appl Biomater, 73, 88, 10.1002/jbm.b.30183

Liu, 2007, The influence of BMP-2 and its mode of delivery on the osteoconductivity of implant surfaces during the early phase of osseointegration, Biomaterials, 28, 2677, 10.1016/j.biomaterials.2007.02.003

Itoh, 2001, Bone morphogenetic protein 2 stimulates osteoclast differentiation and survival supported by receptor activator of nuclear factor-kappaB ligand, Endocrinology, 142, 3656, 10.1210/endo.142.8.8300

Poynton, 2002, Safety profile for the clinical use of bone morphogenetic proteins in the spine, Spine, 27, S40, 10.1097/00007632-200208151-00010

Zhao, 2006, Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2, Adv Biol Chem, 281, 23246, 10.1074/jbc.M511039200

Xiao, 1997, Immobilization of the cell-adhesive peptide Arg-Gly-Asp-Cys (RGDC) on titanium surfaces by covalent chemical attachment, J Mater Sci - Mater Med, 8, 867, 10.1023/A:1018501804943

De Giglio, 2000, Synthesis, analytical characterization, and osteoblast adhesion properties on RGD-grafted polypyrrole coatings on titanium substrates, J Biomater Sci Polym Ed, 11, 1073, 10.1163/156856200743580

Rezania, 2000, The effect of peptide surface density on mineralization of a matrix deposited by osteogenic cells, J Biomed Mater Res, 52, 595, 10.1002/1097-4636(20001215)52:4<595::AID-JBM3>3.0.CO;2-3

Zreiqat, 2003, Differentiation of human bone-derived cells grown on GRGDSP-peptide bound titanium surfaces, J Biomed Mater Res A, 64, 105, 10.1002/jbm.a.10376

Kroese-Deutman, 2005, Influence of RGD-loaded titanium implants on bone formation in vivo, Tissue Eng, 11, 1867, 10.1089/ten.2005.11.1867

Elmengaard, 2005, In vivo effects of RGD-coated titanium implants inserted in two bone-gap models, J Biomed Mater Res A, 75, 249, 10.1002/jbm.a.30301

LeBaron, 2000, Extracellular matrix cell adhesion peptides: functional applications in orthopedic materials, Tissue Eng, 6, 85, 10.1089/107632700320720

Muller, 2006, Influence of surface pretreatment of titanium- and cobalt-based biomaterials on covalent immobilization of fibrillar collagen, Biomaterials, 27, 4059, 10.1016/j.biomaterials.2006.03.019

van den Dolder, 2003, Effect of fibronectin- and collagen I-coated titanium fiber mesh on proliferation and differentiation of osteogenic cells, Tissue Eng, 9, 505, 10.1089/107632703322066688

Schliephake, 2009, Effect of modifications of dual acid-etched implant surfaces on peri-implant bone formation. Part I: organic coatings, Clin Oral Implant Res, 20, 31, 10.1111/j.1600-0501.2008.01603.x

Hickok, 2012, Immobilized antibiotics to prevent orthopaedic implant infections, Adv Drug Deliv Rev, 64, 1165, 10.1016/j.addr.2012.03.015

Cadosch, 2009, Metal is not inert: role of metal ions released by biocorrosion in aseptic loosening—current concepts, J Biomed Mater Res A, 91, 1252, 10.1002/jbm.a.32625

Schalock, 2012, Hypersensitivity reactions to metallic implants—diagnostic algorithm and suggested patch test series for clinical use, Contact Dermat, 66, 4, 10.1111/j.1600-0536.2011.01971.x

Shaw, 2006, What is corrosion?, Electrochem Soc Interface, 15, 24, 10.1149/2.F06061IF

Urish KL, Anderson PA, Mihalko WMtABEC. The Challenge of Corrosion in Orthopaedic Implants. AAOS Now 2013.

Hallab, 2005, Effects of soluble metals on human peri-implant cells, J Biomed Mater Res A, 74, 124, 10.1002/jbm.a.30345

Yan, 2006, Biotribocorrosion—an appraisal of the time dependence of wear and corrosion interactions: I. the role of corrosion, J Phys D Appl Phys, 39, 3200, 10.1088/0022-3727/39/15/S10

Yan, 2013, In-situ electrochemical study of interaction of tribology and corrosion in artificial hip prosthesis simulators, J Mech Behav Biomed Mater, 18, 191, 10.1016/j.jmbbm.2012.08.009

Jacobs, 1998, Metal release in patients who have had a primary total hip arthroplasty. A prospective, controlled, longitudinal study, J Bone Joint Surg Am, 80, 1447, 10.2106/00004623-199810000-00006

Gilbert, 1993, In vivo corrosion of modular hip prosthesis components in mixed and similar metal combinations. The effect of crevice, stress, motion, and alloy coupling, J Biomed Mater Res, 27, 1533, 10.1002/jbm.820271210

Lombardi, 2012, The Hip Society: algorithmic approach to diagnosis and management of metal-on-metal arthroplasty, J Bone Joint Surg Br, 94, 14, 10.1302/0301-620X.94B11.30680

Langton, 2012, Taper junction failure in large-diameter metal-on-metal bearings, Bone Joint Res, 1, 56, 10.1302/2046-3758.14.2000047

Langton, 2013, Metal debris release from taper junctions appears to have a greater clinical impact than debris released from metal on metal bearing surfaces, Bone Joint J, 95-B, 28

Stohs, 1995, Oxidative mechanisms in the toxicity of metal ions, Free Radical Biol Med, 18, 321, 10.1016/0891-5849(94)00159-H

Domingo, 2002, Vanadium and tungsten derivatives as antidiabetic agents, Biol Trace Elem Res, 88, 97, 10.1385/BTER:88:2:097

Kumar, 2009, Aluminium neurotoxicity: neurobehavioural and oxidative aspects, Arch Toxicol, 83, 965, 10.1007/s00204-009-0455-6

Yang, 1994, Competitive binding of chromium, cobalt and nickel to serum proteins, Biomaterials, 15, 262, 10.1016/0142-9612(94)90049-3

Merritt, 1996, Immune response to synthetic materials. Sensitization of patients receiving orthopaedic implants, Clin Orthop Relat Res, 71, 10.1097/00003086-199605000-00009

Basketter, 2003, Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium, Contact Dermat, 49, 1, 10.1111/j.0105-1873.2003.00149.x

Thyssen, 2011, Nickel and cobalt allergy before and after nickel regulation—evaluation of a public health intervention, Contact Dermat, 65, 1, 10.1111/j.1600-0536.2011.01957.x

Athavale, 2007, Occupational dermatitis related to chromium and cobalt: experience of dermatologists (EPIDERM) and occupational physicians (OPRA) in the U.K. over an 11-year period (1993–2004), Br J Dermatol, 157, 518, 10.1111/j.1365-2133.2007.08030.x

Wagner, 2012, Metal-on-metal joint bearings and hematopoietic malignancy, Acta Orthop, 83, 553, 10.3109/17453674.2012.747055

Sabbioni, 1993, The intensity of vanadium(V)-induced cytotoxicity and morphological transformation in BALB/3T3 cells is dependent on glutathione-mediated bioreduction to vanadium(IV), Carcinogenesis, 14, 2565, 10.1093/carcin/14.12.2565

Okazaki, 1998, Corrosion resistance, mechanical properties, corrosion fatigue strength and cytocompatibility of new Ti alloys without Al and V, Biomaterials, 19, 1197, 10.1016/S0142-9612(97)00235-4

Fanti, 1992, Dose-dependent effects of aluminum on osteocalcin synthesis in osteoblast-like ROS 17/2 cells in culture, Am J Physiol, 263, E1113

Thompson, 1995, Effects of sublethal metal-ion concentrations on osteogenic cells derived from bone-marrow stromal cells, J Appl Biomater, 6, 249, 10.1002/jab.770060406

Kumazawa, 2002, Effects of Ti ions and particles on neutrophil function and morphology, Biomaterials, 23, 3757, 10.1016/S0142-9612(02)00115-1

Campbell, 2010, Histological features of pseudotumor-like tissues from metal-on-metal hips, Clin Orthop Relat Res, 468, 2321, 10.1007/s11999-010-1372-y

Sabokbar, 1997, Human arthroplasty derived macrophages differentiate into osteoclastic bone resorbing cells, Ann Rheum Dis, 56, 414, 10.1136/ard.56.7.414

Cadosch, 2010, Biocorrosion and uptake of titanium by human osteoclasts, J Biomed Mater Res A, 95, 1004, 10.1002/jbm.a.32914

Mostardi, 2010, A comparison of the effects of prosthetic and commercially pure metals on retrieved human fibroblasts: the role of surface elemental composition, Acta Biomater, 6, 702, 10.1016/j.actbio.2009.07.006

Willert, 2005, Metal-on-metal bearings and hypersensitivity in patients with artificial hip joints. A clinical and histomorphological study, J Bone Joint Surg Am, 87, 28, 10.2106/JBJS.A.02039pp

Vanos, 2013, In vitro macrophage response to nanometer-size chromium oxide particles, J Biomed Mater Res B Appl Biomater

Doorn, 1996, Tissue reaction to metal on metal total hip prostheses, Clin Orthop Relat Res, S187, 10.1097/00003086-199608001-00017

Pandit, 2008, Pseudotumours associated with metal-on-metal hip resurfacings, J Bone Joint Surg Br, 90, 847, 10.1302/0301-620X.90B7.20213

Greenfield, 2002, The role of osteoclast differentiation in aseptic loosening, J Orthop Res, 20, 1, 10.1016/S0736-0266(01)00070-5

Smith, 2012, Failure rates of stemmed metal-on-metal hip replacements: analysis of data from the National Joint Registry of England and Wales, Lancet, 379, 1199, 10.1016/S0140-6736(12)60353-5

Bacakova, 2011, Modulation of cell adhesion, proliferation and differentiation on materials designed for body implants, Biotechnol Adv, 29, 739, 10.1016/j.biotechadv.2011.06.004

Filova, 2009, Regionally-selective cell colonization of micropatterned surfaces prepared by plasma polymerization of acrylic acid and 1,7-octadiene, Physiol Res, 58, 669, 10.33549/physiolres.931529

Aita, 2009, The effect of ultraviolet functionalization of titanium on integration with bone, Biomaterials, 30, 1015, 10.1016/j.biomaterials.2008.11.004

Zhao, 2005, High surface energy enhances cell response to titanium substrate microstructure, J Biomed Mater Res A, 74, 49, 10.1002/jbm.a.30320

Park, 2012, The responses to surface wettability gradients induced by chitosan nanofilms on microtextured titanium mediated by specific integrin receptors, Biomaterials, 33, 7386, 10.1016/j.biomaterials.2012.06.066

Buser, 2004, Enhanced bone apposition to a chemically modified SLA titanium surface, J Dent Res, 83, 529, 10.1177/154405910408300704

Hori, 2009, Age-dependent degradation of the protein adsorption capacity of titanium, J Dent Res, 88, 663, 10.1177/0022034509339567

Keselowsky, 2003, Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion, J Biomed Mater Res A, 66, 247, 10.1002/jbm.a.10537

Iuliano, 1993, Effect of the conformation and orientation of adsorbed fibronectin on endothelial cell spreading and the strength of adhesion, J Biomed Mater Res, 27, 1103, 10.1002/jbm.820270816

Kennedy, 2006, Combinatorial screen of the effect of surface energy on fibronectin-mediated osteoblast adhesion, spreading and proliferation, Biomaterials, 27, 3817, 10.1016/j.biomaterials.2006.02.044

Park, 2012, Use of polyelectrolyte thin films to modulate osteoblast response to microstructured titanium surfaces, Biomaterials, 33, 5267, 10.1016/j.biomaterials.2012.03.074

Sommerfeld, 2012, Protein adsorption on nano-scaled, rippled TiO2 and Si surfaces, Biointerphases, 7, 55, 10.1007/s13758-012-0055-5

Yan, 2008, Reversible UV-light-induced ultrahydrophobic-to-ultrahydrophilic transition in an alpha-Fe2O3 nanoflakes film, Langmuir, 24, 10569, 10.1021/la801900r

Suzuki, 2009, Ultraviolet treatment overcomes time-related degrading bioactivity of titanium, Tissue Eng Part A, 15, 3679, 10.1089/ten.tea.2008.0568

Funato, 2013, Success rate, healing time, and implant stability of photofunctionalized dental implants, Int J Oral Maxillofac Implants, 28, 1261, 10.11607/jomi.3263

Weiss, 1952, Shape and movement of mesenchyme cells as functions of the physical structure of the medium: contributions to a quantitative morphology, Proc. Natl. Acad. Sci. U.S.A., 38, 264, 10.1073/pnas.38.3.264

Wennerberg, 2009, Effects of titanium surface topography on bone integration: a systematic review, Clin Oral Implant Res, 20, 172, 10.1111/j.1600-0501.2009.01775.x

Logan, 2013, The control of mesenchymal stromal cell osteogenic differentiation through modified surfaces, Stem Cells Int, 2013, 361637, 10.1155/2013/361637

Oh, 2009, Stem cell fate dictated solely by altered nanotube dimension, Proc. Natl. Acad. Sci. U.S.A., 106, 2130, 10.1073/pnas.0813200106

Ellingsen, 2000, Surface configurations of dental implants, Periodontology, 1998, 36

Wennerberg, 2000, Suggested guidelines for the topographic evaluation of implant surfaces, Int J Oral Maxillofac Implants, 15, 331

Wennerberg, 2004, Titanium release from implants prepared with different surface roughness—an in vitro and in vivo study, Clin Oral Implant Res, 15, 505, 10.1111/j.1600-0501.2004.01053.x

McBeath, 2004, Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment, Dev Cell, 6, 483, 10.1016/S1534-5807(04)00075-9

Bobyn, 1980, The optimum pore size for the fixation of porous-surfaced metal implants by the ingrowth of bone, Clin Orthop Relat Res, 263

Lohmann, 2000, Maturation state determines the response of osteogenic cells to surface roughness and 1,25-dihydroxyvitamin D3, J Bone Miner Res, 15, 1169, 10.1359/jbmr.2000.15.6.1169

Kim, 2005, Varying Ti-6Al-4V surface roughness induces different early morphologic and molecular responses in MG63 osteoblast-like cells, J Biomed Mater Res A, 74, 366, 10.1002/jbm.a.30327

Burridge, 1996, Focal adhesions, contractility, and signaling, Annu Rev Cell Dev Biol, 12, 463, 10.1146/annurev.cellbio.12.1.463

Wang, 2006, Integrin beta1 silencing in osteoblasts alters substrate-dependent responses to 1,25-dihydroxy vitamin D3, Biomaterials, 27, 3716, 10.1016/j.biomaterials.2006.02.022

Boyan, 1998, Titanium surface roughness alters responsiveness of MG63 osteoblast-like cells to 1 alpha,25-(OH)2D3, J Biomed Mater Res, 39, 77, 10.1002/(SICI)1097-4636(199801)39:1<77::AID-JBM10>3.0.CO;2-L

Deligianni, 2001, Effect of surface roughness of the titanium alloy Ti-6Al-4V on human bone marrow cell response and on protein adsorption, Biomaterials, 22, 1241, 10.1016/S0142-9612(00)00274-X

Ogawa, 2000, Biomechanical evaluation of osseous implants having different surface topographies in rats, J Dent Res, 79, 1857, 10.1177/00220345000790110701

Biggs, 2009, Interactions with nanoscale topography: adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage, J Biomed Mater Res A, 91, 195, 10.1002/jbm.a.32196

Sjostrom, 2009, Fabrication of pillar-like titania nanostructures on titanium and their interactions with human skeletal stem cells, Acta Biomater, 5, 1433, 10.1016/j.actbio.2009.01.007

McNamara, 2011, Skeletal stem cell physiology on functionally distinct titania nanotopographies, Biomaterials, 32, 7403, 10.1016/j.biomaterials.2011.06.063

Dalby, 2008, Genomic expression of mesenchymal stem cells to altered nanoscale topographies, J R Soc Interface, 5, 1055, 10.1098/rsif.2008.0016

Zaidel-Bar, 2003, Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells, J Cell Sci, 116, 4605, 10.1242/jcs.00792

Biggs, 2008, Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330nm deep microgrooves, J R Soc Interface, 5, 1231, 10.1098/rsif.2008.0035

Lavenus, 2012, Cell differentiation and osseointegration influenced by nanoscale anodized titanium surfaces, Nanomedicine (Lond), 7, 967, 10.2217/nnm.11.181

Zhang, 2012, Biofunctionalization of a titanium surface with a nano-sawtooth structure regulates the behavior of rat bone marrow mesenchymal stem cells, Int J Nanomed, 7, 4459

Dalby, 2004, Investigating the limits of filopodial sensing: a brief report using SEM to image the interaction between 10 nm high nano-topography and fibroblast filopodia, Cell Biol Int, 28, 229, 10.1016/j.cellbi.2003.12.004

Dalby, 2006, Osteoprogenitor response to semi-ordered and random nanotopographies, Biomaterials, 27, 2980, 10.1016/j.biomaterials.2006.01.010

McMurray, 2011, Nanoscale surfaces for the long-term maintenance of mesenchymal stem cell phenotype and multipotency, Nat Mater, 10, 637, 10.1038/nmat3058

Park, 2001, Platelet interactions with titanium: modulation of platelet activity by surface topography, Biomaterials, 22, 2671, 10.1016/S0142-9612(01)00009-6

Kuboki, 1998, BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis, J Biomed Mater Res, 39, 190, 10.1002/(SICI)1097-4636(199802)39:2<190::AID-JBM4>3.0.CO;2-K

Black, 1994, Biological performance of tantalum, Clin Mater, 16, 167, 10.1016/0267-6605(94)90113-9

Miyaza, 2002, Mechanism of bonelike apatite formation on bioactive tantalum metal in a simulated body fluid, Biomaterials, 23, 827, 10.1016/S0142-9612(01)00188-0

Cohen, 2002, A porous tantalum trabecular metal: basic science, Am J Orthop (Belle Mead NJ), 31, 216

Bobyn, 1999, Characteristics of bone ingrowth and interface mechanics of a new porous tantalum biomaterial, J Bone Joint Surg Br, 81, 907, 10.1302/0301-620X.81B5.9283

Goriainov, 2014, Do the cup surface properties influence the initial stability?, J Arthroplasty, 29, 757, 10.1016/j.arth.2013.07.007

Gruen, 2005, Radiographic evaluation of a monoblock acetabular component: a multicenter study with 2- to 5-year results, J Arthroplasty, 20, 369, 10.1016/j.arth.2004.12.049

Unger, 2005, Evaluation of a porous tantalum uncemented acetabular cup in revision total hip arthroplasty: clinical and radiological results of 60 hips, J Arthroplasty, 20, 1002, 10.1016/j.arth.2005.01.023

Kwon, 2012, Evidence-based understanding of management perils for metal-on-metal hip arthroplasty patients, J Arthroplasty, 27, 20, 10.1016/j.arth.2012.03.029

Jacobs, 2004, Three- to six-year results with the Ultima metal-on-metal hip articulation for primary total hip arthroplasty, J Arthroplasty, 19, 48, 10.1016/j.arth.2004.06.021

Metal on Metal Hips. British Orthopaedic Association 2013.

De Maeztu, 2008, Improvement of osseointegration of titanium dental implant surfaces modified with CO ions: a comparative histomorphometric study in beagle dogs, Int J Oral Maxillofac Surg, 37, 441, 10.1016/j.ijom.2008.01.010