Bone adhesive materials: From bench to bedside

Florencio-Silva, 2015, Biology of bone tissue: structure, function, and factors that influence bone cells, BioMed Res. Int., 2015, 10.1155/2015/421746 Taljanovic, 2003, Fracture fixation, Radiographics, 23, 1569, 10.1148/rg.236035159 Sánchez-Fernández, 2019, Bone-adhesive materials: clinical requirements, mechanisms of action, and future perspective, Adv. Mater. Interfac., 6, 10.1002/admi.201802021 Tzagiollari, 2022, Biodegradable and biocompatible adhesives for the effective stabilisation, repair and regeneration of bone, Bioengineering, 9, 10.3390/bioengineering9060250 Farrar, 2012, Bone adhesives for trauma surgery: a review of challenges and developments, Int. J. Adhesion Adhes., 33, 89, 10.1016/j.ijadhadh.2011.11.009 Weber, 1984, Adhesives in orthopedic surgery: a reivew of the literatures and in vitro bonding strengths of bone-bonding agents, Clin. Orthop. Relat. Res., 191, 249, 10.1097/00003086-198412000-00034 Böker, 2019, Current state of bone adhesives-Necessities and hurdles, Materials, 12, 10.3390/ma12233975 Shokri, 2022, Strong and bioactive bioinspired biomaterials, next generation of bone adhesives, Adv. Colloid Interface Sci., 305, 10.1016/j.cis.2022.102706 Zhang, 2022, Functional macromolecular adhesives for bone fracture healing, ACS Appl. Mater. Interfaces, 14 Panagiotopoulou, 2022, Adhesives for treatment of bone fractures: a review of the state-of-the art, Injury, 53, 10.1016/j.injury.2021.02.019 Shah, 2013, Current state and use of biological adhesives in orthopedic surgery, Orthopedics, 36, 945, 10.3928/01477447-20131120-09 Keller, 1985, Fixation of osteochondral fractures- Fibrin sealant tested in dogs, Acta Orthop. Scand., 56, 323, 10.3109/17453678508993025 Meyers, 1964, A fibrin adhesive seal for the repair of osteochondral fracture fragments, Clin. Orthop. Relat. Res., 182, 258 Plaga, 1992, Fixation of osteochondral fractures in rabbit knees a comparison of Kirschner wires, fibrin sealant, and polydioxanone pins, J. Bone Joint Surg., 74, 292, 10.1302/0301-620X.74B2.1544972 Azarpira, 2017, Comparison of healing intra-articular fracture of distal femur using a Kirschner wire and autologous fibrin glue in an animal model, J. Pediatr. Orthop. B, 26, 454, 10.1097/BPB.0000000000000444 Shah, 2002, Fibrin glue fixation of a digital osteochondral fracture: case report and review of the literature, J Hand Surg Am, 27, 464, 10.1053/jhsu.2002.32957 Allende, 2004, Intercondylar distal humerus fractures - surgical treatment and results, Chir. Main, 23, 85, 10.1016/j.main.2004.02.005 Jeong, 2010, Use of fibrin glue for open comminuted nasal bone fractures, J. Craniofac. Surg., 21, 75, 10.1097/SCS.0b013e3181c3ba30 Jo, 2015, Fixation of fractured inferior orbital wall using fibrin glue in inferior blowout fracture surgery, J. Craniofac. Surg., 26 Kim, 2015, Reconstruction of inferior orbital wall fractures using bone fragments, J. Craniofac. Surg., 26, 2412, 10.1097/SCS.0000000000002090 Song, 2014, Fixation of fractured anterior wall of maxillary sinus using fibrin glue in a zygomaticomaxillary complex fracture, J. Craniofac. Surg., 25, 919, 10.1097/SCS.0000000000000663 Kim, 2017, Reduction of the isolated anterior wall of the maxillary sinus fracture with double urinary balloon catheters and fibrin glue, Arch Craniofac Surg, 18, 238, 10.7181/acfs.2017.18.4.238 Arce, 1995, Treatment of radial head fractures using a fibrin adhesive seal: a review of 15 cases, J. Bone Joint Surg., 77, 422, 10.1302/0301-620X.77B3.7744928 Scapinelli, 1990, Treatment of fractures of the humeral capitulum using fibrin sealant, Arch. Orthop. Trauma. Surg., 109, 235, 10.1007/BF00453150 Kaplonyi, 1988, The use of fibrin adhesive in the repair of chondral and osteochondral injuries, Injury, 19, 267, 10.1016/0020-1383(88)90043-5 Visuri, 1989, Fixation of large osteochondral fractures of the patella with fibrin adhesive system, Am. J. Sports Med., 17, 842, 10.1177/036354658901700621 Angermann, 1990, Fibrin fixation of osteochondral talar fracture, Acta Orthop. Scand., 61, 551, 10.3109/17453679008993581 Stafford, 2011, Arthroscopic repair of delaminated acetabular articular cartilage using fibrin adhesive. Results at one to three years, Hip Int., 21, 744, 10.5301/HIP.2011.8843 Chivers, 1997, The strength of adhesive-bonded tissue joints, Int. J. Adhesion Adhes., 17, 127, 10.1016/S0143-7496(96)00041-3 Cohen, 2014, Effect of calcium phosphate-based fillers on the structure and bonding strength of novel gelatin-alginate bioadhesives, J. Biomater. Appl., 28, 1366, 10.1177/0885328213509502 Mo, 2019, Characterization and performance of soybean protein modified by tyrosinase, Int. J. Adhesion Adhes., 92, 111, 10.1016/j.ijadhadh.2019.04.013 Cedano Serrano, 2017, Evaluation of a water-resistant and biocompatible adhesive with potential use in bone fractures, J. Adhes. Sci. Technol., 31, 1480, 10.1080/01694243.2016.1263055 Vargas Villanueva, 2019, Bio-adhesion evaluation of a chitosan-based bone bio-adhesive, Int. J. Adhesion Adhes., 92, 80, 10.1016/j.ijadhadh.2019.04.009 Liu, 2020, ZIF-8-modified multifunctional bone-adhesive hydrogels promoting angiogenesis and osteogenesis for bone regeneration, ACS Appl. Mater. Interfaces, 12, 36978, 10.1021/acsami.0c12090 Hoffmann, 2009, Characterisation of a new bioadhesive system based on polysaccharides with the potential to be used as bone glue, J. Mater. Sci. Mater. Med., 20, 2001, 10.1007/s10856-009-3782-5 Tang, 2021, Flexible osteogenic glue as an all-in-one solution to assist fracture fixation and healing, Adv. Funct. Mater., 31, 10.1002/adfm.202102465 Mandarino, 1959, Polyurethane polymer; its use in fractured and diseased bones, Am. J. Surg., 97, 442, 10.1016/0002-9610(59)90011-X Erken, 2020, Effects of ceramic particle size on cell attachment and viability in polyurethane-based bone adhesive composites, J. Compos. Mater., 54, 2013, 10.1177/0021998319884729 Schreader, 2013, A polyurethane-based nanocomposite biocompatible bone adhesive, J. Appl. Polym. Sci., 127, 4974, 10.1002/app.38100 Brandeis, 1993, A new bioadhesive for in vivo bone adhesion, J. Mater. Sci. Mater. Med., 4, 543, 10.1007/BF00125591 Lei, 2019, In vitro and in vivo characterization of a foam-like polyurethane bone adhesive for promoting bone tissue growth, ACS Biomater. Sci. Eng., 5, 5489, 10.1021/acsbiomaterials.9b00918 Fedak, 2011, Enhancing sternal closure using kryptonite bone adhesive: technical report, Surg. Innovat., 18 Fedak, 2011, Adhesive-enhanced sternal closure to improve postoperative functional recovery: a pilot, randomized controlled trial, Ann. Thorac. Surg., 92, 1444, 10.1016/j.athoracsur.2011.05.014 Bayramoglu, 2013, Bone cement-enhanced sternal closure technique in cardiac surgery: effects on sternal union, pain and life quality, J. Cardiothorac. Surg., 8 Spooner, 2017 Guarnieri, 2014, Vertebroplasty using calcium triglyceride bone cement (KryptoniteTM) for vertebral compression fractures: a single-centre preliminary study of outcomes at one-year follow-up, Intervent Neuroradiol., 20, 576, 10.15274/INR-2014-10060 Uzun, 2016, The sealing ability of novel Kryptonite adhesive bone cement as a retrograde filling material, J. Dent. Res. Dent. Clin. Dent. Prospects, 10, 189, 10.15171/joddd.2016.030 Cooper, 2015, Infectious complication following midface reconstruction with calcified triglyceride, Ophthalmic Plast. Reconstr. Surg., 31, 10.1097/IOP.0000000000000193 Kilpikari, 1986, Bonding strength of alkyl-2-cyanoacrylates to bone in vitro, J. Biomed. Mater. Res., 20, 1095, 10.1002/jbm.820200803 Kandalam, 2013, Novel bone adhesives: a comparison of bond strengths in vitro, Int. J. Oral Maxillofac. Surg., 42, 1054, 10.1016/j.ijom.2013.04.005 Cural, 2018, Comparison of mechanical stabilization of the mandibular angulus fracture fixation, with titanium plates and screws, resorbable plates and screws, and bone adhesives, J. Craniofac. Surg., 29, 1780, 10.1097/SCS.0000000000004866 Amarante, 1995, Cyanoacrylate fixation of the craniofacial skeleton, Plast. Reconstr. Surg., 95, 639, 10.1097/00006534-199504000-00004 Sérgio, 2012, The effect of 2-butyl-cyanoacrylate adhesive in osteotomies and bone grafts in rabbits: macroscopic and radiographic characteristics, Rev Bras Ortop (Sao Paulo)., 47, 639 Akif Akcal, 2014, Effect of N-butyl-cyanoacrylate on fracture healing in segmental rat tibia fracture model, J. Orthop. Surg. Res., 9 Dadas, 2007, Treatment of tripod fracture of zygomatic bone by N-2-butyl cyanoacrylate glue fixation, and its effects on the tissues, Eur. Arch. Oto-Rhino-Laryngol., 264, 539, 10.1007/s00405-006-0227-3 Shermak, 1998, Fixation of the cranofacial skeleton with butyl-2-cyanoacrylate and its effects on histotoxicity and healing, Plast. Reconstr. Surg., 102, 309, 10.1097/00006534-199808000-00003 Ahn, 1997, Cranofacial skeletal fixation using biodegradable plates and cyanoacrylate glue, Plast. Reconstr. Surg., 99, 1508, 10.1097/00006534-199705010-00005 Shermak, 1998, Butyl-2-cyanoacrylate fixation of mandibular osteotomies, Plast. Reconstr. Surg., 102, 319, 10.1097/00006534-199808000-00004 Bas, 2012, Screw fixation is superior to N-butyl-2-cyanoacrylate in onlay grafting procedure: a histomorphologic study, Int. J. Oral Maxillofac. Surg., 41, 537, 10.1016/j.ijom.2011.10.025 Gosain, 1998, Biomechanical evaluation of titanium, biodegradable plate and screw, and cyanoacrylate glue fixation systems in craniofacial surgery, Plast. Reconstr. Surg., 101, 582, 10.1097/00006534-199803000-00004 Mehta, 1997, Osteosynthesis of mandibular fractures with N-Butyl cyanoacrylate: a pilot study, J. Oral Maxillofac. Surg., 45, 393, 10.1016/0278-2391(87)90006-1 Yilmaz, 2005, Fixation of a talar osteochondral fracture with cyanoacrylate glue, Arthrosc. J. Arthrosc. Relat. Surg., 21, 10.1016/j.arthro.2005.05.029 Sultan, 2018, Efficacy and safety of using N-butyl cyanoacrylate in cranial fixation following trauma and other pathologies, Turk Neurosurg, 28, 416 Kim, 1997, Use of cyanoacrylate in facial bone fractures, J. Craniofac. Surg., 8, 229, 10.1097/00001665-199705000-00017 Foresta, 2015, Use of N-butyl-2-cyanoacrylate (Glubran2®) in fractures of orbital-maxillo-zygomatic complex, J Maxillofac Oral Surg, 14, 761, 10.1007/s12663-015-0751-z Esteves, 2014, Utilization of ethyl cyanoacrylate and 2-octyl cyanoacrylate adhesives for autogenous bone graft fixation: histomorphometric study in rats, J. Oral Implantol., 40, 411, 10.1563/AAID-JOI-D-12-00063 Gomez, 2021, 2-Octyl cyanoacrylate (Dermabond®) inhibits bridging bone formation of articular fractures in a rat model, Cureus, 13 Vieira, 2016, Bond strength evaluation of cyanoacrylate-based adhesives and screws for bone fixation, Oral Maxillofac. Surg., 20, 157, 10.1007/s10006-015-0541-2 Vainio’, 1979, Experimental fixation of bone cement and composite resins to bone, Arch. Orthop. Trauma Surg., 94, 191, 10.1007/BF00618445 Heiss, 2005, The tissue response to an alkylene bis(dilactoyl)-methacrylate bone adhesive, Biomaterials, 26, 1389, 10.1016/j.biomaterials.2004.04.048 Heiss, 2010, Bond strength of an alkylene bis(dilactoyl)-methacrylate bone adhesive: a biomechanical evaluation in sheep, J. Biomater. Sci. Polym. Ed., 21, 1345, 10.1163/092050609X12517190417759 Grossterlinden, 2006, Deleterious tissue reaction to an alkylene bis(dilactoyl)-methacrylate bone adhesive in long-term follow up after screw augmentation in an ovine model, Biomaterials, 27, 3379, 10.1016/j.biomaterials.2006.01.051 Ishihara, 1992, Adhesive bone cement containing hydroxyapatite particle as bone compatible filler, J. Biomed. Mater. Res., 26, 937, 10.1002/jbm.820260708 Bauer, 2009, Biodegradable β-tri-calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model, J. Biomed. Mater. Res. B Appl. Biomater., 90 B, 767, 10.1002/jbm.b.31346 Shahbazi, 2016, In vitro study of a new biodegradable nanocomposite based on polypropylene fumarate as bone glue, Mater. Sci. Eng. C, 69, 1201, 10.1016/j.msec.2016.08.035 Ishihara, 1989, Adhesive bone cement both to bone and metals: 4-META in MMA initiated with tri-n-butyl borane, J. Biomed. Mater. Res., 23, 1475, 10.1002/jbm.820231209 Lee, 1997, Examination of hydroxyapatite filled 4-META/MMA-TBB adhesive bone cement in in vitro and in vivo environment, Inc. J Biomed Mater Res (Appl Biomater)., 38, 11, 10.1002/(SICI)1097-4636(199721)38:1<11::AID-JBM2>3.0.CO;2-K Sakai, 2000, In vivo evaluation of the bond strength of adhesive 4-META/MMA-TBB bone cement under weight-bearing conditions, J. Biomed. Mater. Res., 52, 128, 10.1002/1097-4636(200010)52:1<128::AID-JBM16>3.0.CO;2-L Maurer, 2004, Comparison of the bond strength of selected adhesive dental systems to cortical bone under in vitro conditions, Int. J. Oral Maxillofac. Surg., 33, 377, 10.1016/j.ijom.2003.10.020 Ortiz Ruiz, 2010, A new use for self-etching resin adhesives: cementing bone fragments, J. Dent., 38, 750 Sánchez-Fernández, 2021, Bone-adhesive hydrogels based on dual crosslinked poly(2-oxazoline)s, Macromol. Biosci., 21, 10.1002/mabi.202100257 Wistlich, 2017, A bone glue with sustained adhesion under wet conditions, Adv Healthc Mater, 6, 10.1002/adhm.201600902 Wang, 2007, Co-polypeptides of 3,4-dihydroxyphenylalanine and l-lysine to mimic marine adhesive protein, Biomaterials, 28, 3456, 10.1016/j.biomaterials.2007.04.009 Lu, 2017, Mussel-inspired thermoresponsive polypeptide-pluronic copolymers for versatile surgical adhesives and hemostasis, ACS Appl. Mater. Interfaces, 9, 16756, 10.1021/acsami.6b16575 Lu, 2017, Versatile surgical adhesive and hemostatic Mmterials: synthesis, properties, and application of thermoresponsive polypeptides, Chem. Mater., 29, 5493, 10.1021/acs.chemmater.7b00255 Lu, 2018, All-in-one hyperbranched polypeptides for surgical adhesives and interventional embolization of tumors, J. Mater. Chem. B, 6, 7511, 10.1039/C8TB01015C Lu, 2019, Biomimetic chitosan-graft-polypeptides for improved adhesion in tissue and metal, Carbohydr. Polym., 215, 20, 10.1016/j.carbpol.2019.03.065 Xie, 2015, Development of injectable citrate-based bioadhesive bone implants, J. Mater. Chem. B, 3, 387, 10.1039/C4TB01498G Puertas-Bartolomé, 2018, Biocompatible and bioadhesive low molecular weight polymers containing long-arm catechol-functionalized methacrylate, Eur. Polym. J., 98, 47, 10.1016/j.eurpolymj.2017.11.011 Yan, 2018, Preparation of mussel-inspired injectable hydrogels based on dual-functionalized alginate with improved adhesive, self-healing, and mechanical properties, J. Mater. Chem. B, 6, 6377, 10.1039/C8TB01928B Cui, 2019, Water-triggered hyperbranched polymer universal adhesives: from strong underwater adhesion to rapid sealing hemostasis, Adv. Mater., 31, 10.1002/adma.201905761 Shao, 2009, A water-borne adhesive modeled after the sandcastle glue of P. californica, Macromol. Biosci., 9, 464, 10.1002/mabi.200800252 Shao, 2010, Biomimetic underwater adhesives with environmentally triggered setting mechanisms, Adv. Mater., 22, 729, 10.1002/adma.200902380 Winslow, 2010, Biocompatibility of adhesive complex coacervates modeled after the sandcastle glue of Phragmatopoma californica for craniofacial reconstruction, Biomaterials, 31, 9373, 10.1016/j.biomaterials.2010.07.078 Bhagat, 2016, Caddisfly inspired phosphorylated poly(ester urea)-based degradable bone Adhesives, Biomacromolecules, 17, 3016, 10.1021/acs.biomac.6b00875 Yamamoto, 1992, Polypeptide models of the arthropodin protein of the barnacle Balanus balanoides, Mar. Chem., 37, 131, 10.1016/0304-4203(92)90061-E Kirillova, 2018, Bioinspired mineral-organic bioresorbable bone adhesive, Adv Healthc Mater, 7 Cochran, 2020, Immediate dental implant stabilization in a canine model using a novel mineral-organic adhesive: 4-month results, Int. J. Oral Maxillofac. Implants, 35, 39, 10.11607/jomi.7891 Foley, 2021, Cranial flap fixation in sheep using a resorbable bone adhesive, J. Neurosurg., 134, 621, 10.3171/2019.11.JNS192806 Pujari-Palmer, 2018, A novel class of injectable bioceramics that glue tissues and biomaterials, Materials, 11, 10.3390/ma11122492 Procter, 2019, A biomechanical test model for evaluating osseous and osteochondral tissue adhesives, BMC Biomed Eng, 1, 10.1186/s42490-019-0011-2 Hulsart-Billström, 2020, In vivo safety assessment of a bio-inspired bone adhesive, J. Mater. Sci. Mater. Med., 31, 10.1007/s10856-020-6362-3 Brückner, 2019, Magnesium phosphate cement as mineral bone adhesive, Materials, 12, 3819, 10.3390/ma12233819 Gulotta, 2008, Augmentation of tendon-to-bone healing with a magnesium-based bone adhesive, Am. J. Sports Med., 36, 1290, 10.1177/0363546508314396 Waselau, 2007, Effects of a magnesium adhesive cement on bone stability and healing following a metatarsal osteotomy in horses, Am. J. Vet. Res., 68, 370, 10.2460/ajvr.68.4.370 Hirvinen, 2009, Influence of bone cements on bone-screw interfaces in the third metacarpal and third metatarsal bones of horses, Am. J. Vet. Res., 70, 964, 10.2460/ajvr.70.8.964 Sehlke, 2013, The use of a magnesium-based bone cement to secure immediate dental implants, Int. J. Oral Maxillofac. Implants, 28, 10.11607/jomi.te16 Schendel, 2009, Magnesium-based bone cement and bone void filler: preliminary experimental studies, J. Craniofac. Surg., 20, 461, 10.1097/SCS.0b013e31819b9819 Thomopoulos, 2009, Use of a magnesium-based bone adhesive for flexor tendon-to-bone healing, J. Hand Surg., 34, 1066 Khader, 2017, An injectable glass polyalkenoate cement engineered for fracture fixation and stabilization, J. Funct. Biomater., 8 Mehrvar, 2019, Novel adhesives for sternal fixation and stabilization: a biomechanical analysis, Clin. BioMech., 62, 66, 10.1016/j.clinbiomech.2019.01.007 Mehrvar, 2019, Novel adhesives for distal radius fixation: a biomechanical analysis, J. Mech. Behav. Biomed. Mater., 89, 99, 10.1016/j.jmbbm.2018.09.011 Zalzal, 2018, Percutaneous upper extremity fracture fixation using a novel glass-based adhesive, J. Orthop., 15, 67 Khader, 2018, The effect of Mg2+ incorporation into the glass phase of zinc-based glass polyalkenoate cements, J. Non-Cryst. Solids, 483, 106, 10.1016/j.jnoncrysol.2018.01.007 Cronkite, 1944, Use of thrombin and fibrinogen in skin grafting: preliminary report, J. Am. Med. Assoc., 124, 976 Thoms, 2009, The role of fibrin sealants in orthopaedic surgery, J. Am. Acad. Orthop. Surg., 17, 727, 10.5435/00124635-200912000-00001 Donkerwolcke, 1998, Tissues and bone adhesives-Historical aspects, Biomaterials, 19, 1461, 10.1016/S0142-9612(98)00059-3 Heiss, 2006, Bone adhesives in trauma and orthopedic surgery, Eur. J. Trauma, 32, 141, 10.1007/s00068-006-6040-2 Spotnitz, 2014, Fibrin sealant: the only approved hemostat, sealant, and adhesive—a laboratory and clinical perspective, ISRN Surg, 1, 10.1155/2014/203943 Bhagat, 2017, Degradable adhesives for surgery and tissue engineering, Biomacromolecules, 18, 3009, 10.1021/acs.biomac.7b00969 Schlag, 1968, Fibrin sealant in orthopedic surgery, Clin. Orthop. Relat. Res., 227, 269 Sierra, 1992, A method to determine shear adhesive strength of fibrin sealants, J. Appl. Biomater., 3, 147, 10.1002/jab.770030210 Arbes, 1981, First clinical experience with heterologous aancellous bone grafting combined with the fibrin adhesive system (FAS), Arch. Orthop. Trauma. Surg., 98, 183, 10.1007/BF00632975 Giebel, 1981, Klebungen am skelettsystem: klebstoffe, 50 jahre hilfsstoffe für den chirurgen. Teil 1, Biomed. Tech., 26, 35, 10.1515/bmte.1981.26.3.35 Iranmanesh, 2021, Bioprinting of three-dimensional scaffold based on alginate-gelatin as soft and hard tissue regeneration, J. Mater. Res. Technol., 14, 2853, 10.1016/j.jmrt.2021.08.069 Cheng, 2021, A multilayer biomimetic chitosan-gelatin-fluorohydroxyapatite cartilage scaffold using for regenerative medicine application, J. Mater. Res. Technol., 14, 1761, 10.1016/j.jmrt.2021.07.052 Zare-Harofteh, 2016, The effective role of akermanite on the apatite-forming ability of gelatin scaffold as a bone graft substitute, Ceram. Int., 42, 17781, 10.1016/j.ceramint.2016.08.106 Walker, 1997, Fate of gelatin-resorcinol-formaldehyde/glutaraldehyde adhesive on femoral vessel morphology, J. Surg. Res., 71, 73, 10.1006/jsre.1997.5128 Albes, 1993, Biophysical properties of the gelatin-resorcinformaldehyde/glutaraldehyde adhesive, Ann. Thorac. Surg., 56, 910, 10.1016/0003-4975(93)90354-K Graham, 2005, Characterization of a protein-based adhesive elastomer secreted by the Australian frog Notaden bennetti, Biomacromolecules, 6, 3300, 10.1021/bm050335e Graham, 2010, Biocompatibility and modification of the protein-based adhesive secreted by the Australian frog Notaden bennetti, J. Biomed. Mater. Res., 93, 429, 10.1002/jbm.a.32559 Szomor, 2008, Meniscal repair with a new biological glue: an ex vivo study, Tech. Knee Surg., 7, 261, 10.1097/BTK.0b013e31818f8e7f Millar, 2009, Frog glue enhances rotator cuff repair in a laboratory cadaveric model, J. Shoulder Elbow Surg., 18, 639, 10.1016/j.jse.2008.12.007 Sidle, 2008, Determination of shear strength of periosteum attached to bone with BioGlue surgical adhesive, Arch. Facial Plast. Surg., 10, 316, 10.1001/archfaci.10.5.316 Bouten, 2014, The chemistry of tissue adhesive materials, Prog. Polym. Sci., 39, 1375, 10.1016/j.progpolymsci.2014.02.001 Zaokari, 2020, Biomaterials for adhesion in orthopedic applications: a review, Engineered Regeneration, 1, 51, 10.1016/j.engreg.2020.07.002 Katz, 1993, Biomedical adhesive compositions, US5266608 Ferreira, 2007, Modification of the biopolymer castor oil with free isocyanate groups to be applied as bioadhesive, Int. J. Biol. Macromol., 40, 144, 10.1016/j.ijbiomac.2006.06.023 Fedak, 2010, Kryptonite bone cement prevents pathologic sternal displacement, Ann. Thorac. Surg., 90, 979, 10.1016/j.athoracsur.2010.05.009 Doumit, 2014, The expansile properties of Kryptonite relating to cranioplasty, J. Craniofac. Surg., 25, 880, 10.1097/SCS.0000000000000508 Ball, 2018, Examples of dramatic failures and their effectiveness in modern surgical disciplines: can we learn from our mistakes?, J Comp Eff Res, 7, 709, 10.2217/cer-2017-0090 García Cerdá, 2015, Use of cyanoacrylate adhesives in general surgery, Surg. Today, 45, 939, 10.1007/s00595-014-1056-4 Mehdizadeh, 2013, Design strategies and applications of tissue bioadhesives, Macromol. Biosci., 13, 271, 10.1002/mabi.201200332 Sohn, 2016, Comparison of 2-ethyl-cyanoacrylate and 2-butyl-cyano acrylate for use on the calvaria of CD1 mice, J Am Assoc Lab Anim Sci, 55, 199 Caldeira, 2011, Histomorphometric analysis of the repair process of autogenous bone grafts fixed at rat calvaria with cyanoacrylate, J. Appl. Oral Sci., 19, 529, 10.1590/S1678-77572011000500016 Hunter, 1976, Cyanoacrylate tissue adhesive in osseous repair, Br. J. Oral Surg., 14, 80, 10.1016/0007-117X(76)90098-6 Singer, 2004, A review of the literature on octylcyanoacrylate tissue adhesive, Am. J. Surg., 187, 238, 10.1016/j.amjsurg.2003.11.017 Papatheofanis, 1989, Cytotoxicity of alkyl-2-cyanoacrylate adhesives, J. Biomed. Mater. Res., 23, 661, 10.1002/jbm.820230609 Benthien, 2004, Investigating the effects of bone cement, cyanoacrylate glue and marine mussel adhesive protein from Mytilus edulis on human osteoblasts and fibroblasts in vitro, Ann. Anat., 186, 561, 10.1016/S0940-9602(04)80108-0 Ekelund, 1991, Tissue adhesives inhibit experimental new bone formation, Int. Orthop., 15, 331, 10.1007/BF00186872 Montanaro, 2001, Cytotoxicity, blood compatibility and antimicrobial activity of two cyanoacrylate glues for surgical use, Biomaterials, 22, 59, 10.1016/S0142-9612(00)00163-0 Kusleika, 1983, Mechanical strength of poly(methyl methacrylate) cement-human bone interfaces, J. Biomed. Mater. Res., 17, 441, 10.1002/jbm.820170305 Yousefi, 2019, A review of calcium phosphate cements and acrylic bone cements as injectable materials for bone repair and implant fixation, J. Appl. Biomater. Funct. Mater., 17 Cervantes-Uc, 2015, Bone cements: formulation, modification, and characterization, 1053 O'Dowd-Booth, 2011, Bone cement: perioperative issues, orthopaedic applications and future developments, J. Perioperat. Pract., 21, 304, 10.1177/175045891102100902 Sallent, 2020, The few who made it: commercially and clinically successful innovative bone grafts, Front. Bioeng. Biotechnol., 8, 10.3389/fbioe.2020.00952 Erli, 2003, Surface pretreatments for medical application of adhesion, Biomed. Eng. Online, 2, 10.1186/1475-925X-2-15 Ho, 2006, Synthesis, polymerisation and degradation of poly(lactide-co-propylene glycol) dimethacrylate adhesives, Eur. Polym. J., 42, 1775, 10.1016/j.eurpolymj.2006.03.018 Young, 2009, Chemical characterization of a degradable polymeric bone adhesive containing hydrolysable fillers and interpretation of anomalous mechanical properties, Acta Biomater., 5, 2072, 10.1016/j.actbio.2009.02.022 Gellynck, 2011, Cell attachment and response to photocured, degradable bone adhesives containing tricalcium phosphate and purmorphamine, Acta Biomater., 7, 2672, 10.1016/j.actbio.2011.02.033 Abou Neel, 2010, Chemical, modulus and cell attachment studies of reactive calcium phosphate filler-containing fast photo-curing, surface-degrading, polymeric bone adhesives, Acta Biomater., 6, 2695, 10.1016/j.actbio.2010.01.012 Neel, 2012, Viscoelastic and biological performance of low-modulus, reactive calcium phosphate-filled, degradable, polymeric bone adhesives, Acta Biomater., 8, 313, 10.1016/j.actbio.2011.08.008 Ignatius, 2001, A new bioresorbable polymer for screw augmentation in the osteosynthesis of osteoporotic cancellous bone: a biomechanical evaluation, J. Biomed. Mater. Res., 58, 254, 10.1002/1097-4636(2001)58:3<254::AID-JBM1014>3.0.CO;2-A Morita, 1998, Performance of adhesive bone cement containing hydroxyapatite particles, Biomaterials, 19, 1601, 10.1016/S0142-9612(97)00120-8 Moszner, 2005, Chemical aspects of self-etching enamel-dentin adhesives: a systematic review, Dent. Mater., 21, 895, 10.1016/j.dental.2005.05.001 Park, 2017, Advances in medical adhesives inspired by aquatic organisms' adhesion, Biomater. Res., 21, 10.1186/s40824-017-0101-y Rathi, 2019, Protein-based bioadhesives and bioglues, Polym. Adv. Technol., 30, 217, 10.1002/pat.4465 Bré, 2013, Taking tissue adhesives to the future: from traditional synthetic to new biomimetic approaches, Biomater. Sci., 1, 239, 10.1039/C2BM00121G Hofman, 2018, Bioinspired underwater adhesives by using the supramolecular toolbox, Adv. Mater., 30, 10.1002/adma.201704640 Sun, 2020, Fabrication and mechanical properties of engineered protein-based adhesives and fibers, Adv. Mater., 32 Yang, 2014, Aquatic proteins with repetitive motifs provide insights to bioengineering of novel biomaterials, Biotechnol. J., 9, 1493, 10.1002/biot.201400070 Pandey, 2020, Mussel-inspired bioadhesives in halthcare: design parameters, current trends, and future perspectives, Biomater. Sci., 8, 1240, 10.1039/C9BM01848D Lee, 2011, Mussel-inspired adhesives and coatings, Annu. Rev. Mater. Res., 41, 99, 10.1146/annurev-matsci-062910-100429 Silverman, 2007, Understanding marine mussel adhesion, Mar. Biotechnol., 9, 661, 10.1007/s10126-007-9053-x Guo, 2020, Recent progress in synthesis and application of mussel-inspired adhesives, Nanoscale, 12, 1307, 10.1039/C9NR09780E Kord Forooshani, 2017, Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein, J. Polym. Sci. Polym. Chem., 55, 9, 10.1002/pola.28368 Krtička, 2021, Ex-vivo biomechanical testing of pig femur diaphysis B type fracture fixed by novel biodegradable bone glue, J. Mech. Behav. Biomed. Mater., 115, 10.1016/j.jmbbm.2020.104249 Zhang, 2014, A biomimetic hyperbranched poly(amino ester)-based nanocomposite as a tunable bone adhesive for sternal closure, J. Mater. Chem. B, 2, 4067, 10.1039/c4tb00155a Axel Nordberg, 2014, Fiber reinforced adhesive patch (FRAP): a new technology for minimal invasive treatments of bone fractures, J. Trauma Treat., s2 Granskog, 2018, High-performance thiol–ene composites unveil a new era of adhesives suited for bone repair, Adv. Funct. Mater., 28 Nordberg, 2010, Highly adhesive phenolic compounds as interfacial primers for bone fracture fixations, ACS Appl. Mater. Interfaces, 2, 654, 10.1021/am100002s Olofsson, 2016, Activated dopamine derivatives as primers for adhesive-patch fixation of bone fractures, RSC Adv., 6, 26398, 10.1039/C5RA23142F Hed, 2013, Multipurpose heterofunctional dendritic scaffolds as crosslinkers towards functional soft hydrogels and implant adhesives in bone fracture applications, J. Mater. Chem. B, 1, 6015, 10.1039/c3tb21061h Jensen, 1988, The bioadhesive of Phragmatopoma californica tubes: a silk-like cement containing l-DOPA, J. Comp. Physiol. B, 158, 317, 10.1007/BF00695330 Stewart, 2017, The role of coacervation and phase transitions in the sandcastle worm adhesive aystem, Adv. Colloid Interface Sci., 239, 88, 10.1016/j.cis.2016.06.008 Stewart, 2011, Complex coacervates as a foundation for synthetic underwater adhesives, Adv. Colloid Interface Sci., 167, 85, 10.1016/j.cis.2010.10.009 Basiri, 2018, Developing new synthetic biomimetic nanocomposite adhesives: synthesis and evaluation of bond strength and solubilization, React. Funct. Polym., 127, 85, 10.1016/j.reactfunctpolym.2018.04.004 Addison, 2013, β-sheet nanocrystalline domains formed from phosphorylated serine-rich motifs in caddisfly larval silk: a solid state NMR and XRD study, Biomacromolecules, 14, 1140, 10.1021/bm400019d Liang, 2019, Biochemistry of barnacle adhesion: an updated review, Front. Mar. Sci., 6, 10.3389/fmars.2019.00565 Yamamoto, 1989, Synthesis and adhesive studies of barnacle model proteins, Mar. Chem., 26, 331, 10.1016/0304-4203(89)90038-8 Ambard, 2006, Calcium phosphate cement: review of mechanical and biological properties, J. Prosthodont., 15, 321, 10.1111/j.1532-849X.2006.00129.x Schmit, 1999, Reconstruction of bone using calcium phosphate bone cements: a critical review, J. Oral Maxillofac. Surg., 57, 122 Basirun, 2018, Overview of hydroxyapatite–graphene nanoplatelets composite as bone graft substitute: mechanical behavior and in-vitro biofunctionality, Crit. Rev. Solid State Mater. Sci., 43, 177, 10.1080/10408436.2017.1333951 Rad, 2022, Fabrication of elastin additive on polymethyl methacrylate and hydroxyapatite-based bioactive bone cement, Mater. Chem. Phys., 280, 10.1016/j.matchemphys.2022.125783 Li, 2021, Experimental measurement and simulation of mechanical strength and biological behavior of porous bony scaffold coated with alginate-hydroxyapatite for femoral applications, Compos. Sci. Technol., 214 de Lacerda Schickert, 2020, Tough and injectable fiber reinforced calcium phosphate cement as an alternative to polymethylmethacrylate cement for vertebral augmentation: a biomechanical study, Biomater. Sci., 8, 4239, 10.1039/D0BM00413H Grover, 2006, Adhesion of a novel calcium phosphate cement to cortical bone and several common biomaterials, Key Eng. Mater., 309–311, 849, 10.4028/www.scientific.net/KEM.309-311.849 Zhong, 2021, Preparation and characterization of calcium phosphate cement with enhanced tissue adhesion for bone defect repair, Ceram. Int., 47, 1712, 10.1016/j.ceramint.2020.08.288 Jang, 2018, Improvement of physical properties of calcium phosphate cement by elastin-like polypeptide supplementation, Sci. Rep., 8 Wu, 2012, Premixed, injectable PLA-modified calcium deficient apatite biocement (cd-AB) with washout resistance, Colloids Surf. B Biointerfaces, 92, 113, 10.1016/j.colsurfb.2011.11.037 Chew, 2011, Reinforcement of calcium phosphate cement with multi-walled carbon nanotubes and bovine serum albumin for injectable bone substitute applications, J. Mech. Behav. Biomed. Mater., 4, 331, 10.1016/j.jmbbm.2010.10.013 Norton, 2020, Bone glue - the final frontier for fracture repair and implantable device stabilization, Int. J. Adhesion Adhes., 102, 10.1016/j.ijadhadh.2020.102647 Kesseli, 2020, Identification of a calcium phosphoserine coordination network in an adhesive organo-apatitic bone cement system, Acta Biomater., 105, 280, 10.1016/j.actbio.2020.01.007 Kirillova, 2021, Reinforcement and fatigue of a bioinspired mineral–organic bioresorbable bone adhesive, Adv Healthc Mater, 10, 10.1002/adhm.202001058 Geddes, 2020, Biomechanical testing of a calcium phosphate-phosphoserine–based mineral-organic adhesive for non-invasive fracture repair of mandibular fractures in dogs, Front. Vet. Sci., 7, 10.3389/fvets.2020.00059 Mathew, 2020, Solid-state NMR rationalizes the bone-adhesive properties of serine- and phosphoserine-bearing calcium phosphate cements by unveiling their organic/inorganic interface, J. Phys. Chem. C, 124, 21512, 10.1021/acs.jpcc.0c06224 Spicer, 2020, Synthesis of phospho-amino acid analogues as tissue adhesive cement additives, ACS Cent. Sci., 6, 226, 10.1021/acscentsci.9b01149 Wu, 2020, The effect of two types of resorbable augmentation materials – a cement and an adhesive – on the screw pullout resistance in human trabecular bone, J. Mech. Behav. Biomed. Mater., 110, 10.1016/j.jmbbm.2020.103897 Qin, 2021, Coating the magnesium implants with reinforced nanocomposite nanoparticles for use in orthopedic applications, Colloids Surf. A Physicochem. Eng. Asp., 621, 10.1016/j.colsurfa.2021.126581 Angili, 2023, Fabrication and finite element simulation of antibacterial 3D printed Poly L-lactic acid scaffolds coated with alginate/magnesium oxide for bone tissue regeneration, Int. J. Biol. Macromol., 224, 1152, 10.1016/j.ijbiomac.2022.10.200 Nabiyouni, 2018, Magnesium-based bioceramics in orthopedic applications, Acta Biomater., 66, 23, 10.1016/j.actbio.2017.11.033 Mestres, 2013, Antimicrobial properties and dentin bonding strength of magnesium phosphate cements, Acta Biomater., 9, 8384, 10.1016/j.actbio.2013.05.032 Yu, 2010, Evaluation of inherent toxicology and biocompatibility of magnesium phosphate bone cement, Colloids Surf. B Biointerfaces, 76, 496, 10.1016/j.colsurfb.2009.12.010 Wu, 2008, Self-setting bioactive calcium-magnesium phosphate cement with high strength and degradability for bone regeneration, Acta Biomater., 4, 1873, 10.1016/j.actbio.2008.06.020 Nicholson, 1998, Adhesive dental materials - a review, Int. J. Adhesion Adhes., 18, 229, 10.1016/S0143-7496(98)00027-X Nicholson, 1998, Chemistry of glass-ionomer cements: a review, Biomaterials, 19, 485, 10.1016/S0142-9612(97)00128-2 Lucksanasombool, 2002, Effects of glass ionomer cements on bone tissue, J. Mater. Sci. Mater. Med., 13, 203, 10.1023/A:1013890331714 Zhang, 2022, Functional macromolecular adhesives for bone fracture healing, ACS Appl. Mater. Interfaces, 14 Albrektsson, 2001, Osteoinduction, osteoconduction and osseointegration, Eur. Spine J., 10, S96, 10.1007/s005860100282 Morgan, 2014, Overview of skeletal repair (fracture healing and its assessment), Methods Mol. Biol., 1130, 13, 10.1007/978-1-62703-989-5_2 Bou-Francis, 2017, Standardized methodology for in vitro assessment of bone-to-bone adhesion strength, Int. J. Adhesion Adhes., 77, 96, 10.1016/j.ijadhadh.2017.03.014 van Erk, 2021, A systematic review and meta-analyses on animal models used in bone adhesive research, J. Orthop. Res. Ge, 2020, Recent advances in tissue adhesives for clinical medicine, Polymers, 12, 10.3390/polym12040939 Bojan, 2022, A new bone adhesive candidate- does it work in human bone? An ex-vivo preclinical evaluation in fresh human osteoporotic femoral head bone, Injury, 53, 1858, 10.1016/j.injury.2022.04.007