Bombesin receptor antagonists

Anastasi, 1971, Isolation and structure of bombesin and alytesin, two analogous active peptides from the skin of the European amphibian Bombina and Alytes, Experientia, 27, 166, 10.1007/BF02145873 Anastasi, 1975, Amino acid composition and sequence of litorin, a bombesin-like nonapeptide occurring in methanol extracts of the skin of the Australian leptodactylid frog Litoria aurea, Experientia, 31, 510, 10.1007/BF01932427 Nakajima, 1970, Isolation and structure of a new vasoactive polypeptide, 29, 282 Yasuhara, 1983, Two new frog skin peptides, phyllolitorins, of the bombesin-ranatensin family Phyllomedusa sauvagei, Biomed Res, 4, 407, 10.2220/biomedres.4.407 McDonald, 1979, Characterization of a gastrin releasing peptide from porcine non-antral gastric tissue, FEBS Lett, 122, 45, 10.1016/0014-5793(80)80398-X Minamino, 1983, Neuromedin B: a novel bombesin-like peptide identified in porcine spinal cord, Biochem Biophys Res Commun, 114, 541, 10.1016/0006-291X(83)90814-8 Minamino, 1984, Neuromedin C: a bombesin-like peptide identified in porcine spinal cord, Biochem Biophys Res Commun, 119, 14, 10.1016/0006-291X(84)91611-5 Nagalla, 1992, Gastrin-releasing peptide (GRP) is not mammalian bombesin. Identification and molecular cloning of a true amphibian GRP distinct from amphibian bombesin in Bombina orientalis, J Biol Chem, 267, 6916, 10.1016/S0021-9258(19)50516-6 Falconieri Erspamer, 1988, Parallel bioassay of 27 bombesin-like peptides on 9 smooth muscle preparations. 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Specific receptors, signal transduction, and early events, Am Rev Respir Dis, 142, S11, 10.1164/ajrccm/142.6_Pt_2.S11 Cirillo, 1986, Receptor for bombesin with associated tyrosine kinase activity, Mol Cell Biol, 6, 4641, 10.1128/MCB.6.12.4641 Zachary, 1991, Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells, 88, 4577 Erspamer, 1980, Peptides of the amphibian skin active on the gut. II. Bombesin-like peptides: isolation, structure, and basic functions, 343 Taché, 1982, On the role of bombesin in homeostasis, Trends Neurosci, 5, 431, 10.1016/0166-2236(82)90234-X Walsh, 1983, Bombesin-like peptides, 941 Zachary, 1987, A role for neuropeptides in the control of cell proliferation, Dev Biol, 124, 295, 10.1016/0012-1606(87)90483-0 Lebacq-verheyden, 1991, Bombesin and gastrin-releasing peptide: neuropeptides, secretogogues, and growth factors, 71 Broccardo, 1975, Relative potency of bombesin-like peptides, Br J Pharm, 55, 221, 10.1111/j.1476-5381.1975.tb07631.x Rivier, 1978, Bombesin, bombesin analogues, and related peptides: effects on thermoregulation, Biochemistry, 17, 1766, 10.1021/bi00602a030 Moody, 1982, Pharmacology and neurochemistry of bombesin-like peptides, Peptides, 3, 559, 10.1016/0196-9781(82)90126-7 Cuttitta, 1985, Bombesin-like peptides can function as autocrine growth factors in human small-cell lung cancer, Nature (Lond), 316, 823, 10.1038/316823a0 Sunday, 1988, Gastrin-releasing peptide (mammalian bombesin) gene expression in health and disease, Lab Invest, 59, 5 Moody, 1988, The release of bombesin-like peptides from small cell lung cancer cells, Ann NY Acad Sci, 547, 351, 10.1111/j.1749-6632.1988.tb23902.x Giacchetti, 1990, Characterization, in some human breast cancer cell lines, of gastrin-releasing peptide-like receptors which are absent in normal breast epithelial cells, Int J Cancer, 46, 293, 10.1002/ijc.2910460226 Pagani, 1991, Expression of the gastrin-releasing peptide gene in carcinomas of the breast, Int J Cancer, 47, 371, 10.1002/ijc.2910470310 Narayan, 1990, Specific binding and growth effects of bombesin-related peptides on mouse colon cancer cells in vitro, Cancer Res, 50, 6772 Frucht, 1992, Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells, Cancer Res, 52, 1114 Avis, 1988, The role of gastrin releasing peptide in a pancreatic tumor cell line (Capan), 29, 54 Hajri, 1992, Gastrin-releasing-peptide stimulates growth of a pancreatic acinar cell carcinoma in vitro and in vivo, Regul Pept, 40, 165, 10.1016/0167-0115(92)90247-R Hajri, 1992, Expression of GRP receptors in normal and cancerous pancreatic cells, Regul Pept, 40, 165 Bologna, 1989, Bombesin stimulates growth of human prostatic cancer cells in vitro, Cancer, 63, 1714, 10.1002/1097-0142(19900501)63:9<1714::AID-CNCR2820630912>3.0.CO;2-H Coy, 1990, Developing receptor antagonists of neuropeptides: the bombesin/GRP and substance P systems, 376 Jensen, 1991, Progress in the development of potent bombesin receptor antagonists, Trends Pharmacol Sci, 12, 13, 10.1016/0165-6147(91)90483-9 Houben, 1991, Bombesin receptor antagonists and their use in the evaluation of paracrine and autocrine intercellular communication, Front Horm Res, 19, 176, 10.1159/000419648 Coy, 1992, Systematic development of bombesin/gastrin-releasing peptide antagonists, J Natl Cancer Inst Monogr, 13, 133 Jensen, 1984, A synthetic peptide is a bombesin receptor antagonist, Nature (Lond), 309, 61, 10.1038/309061a0 Woll, 1990, A neuropeptide antagonist that inhibits the growth of small cell lung cancer in vitro, Cancer Res, 50, 3968 Sethi, 1991, Galanin stimulates Ca2+ mobilization, inositol phosphate accumulation, and clonal growth in small cell lung cancer cells, Cancer Res, 51, 1674 Sethi, 1992, Growth of small cell lung cancer cells: stimulation by multiple neuropeptides and inhibition by broad spectrum antagonists in vitro and in vivo, Cancer Res (Suppl), 52, 2737s Takuwa, 1990, Stimulation of calcium mobilization but not proliferation by bombesin and tachykinin neuropeptides in human small cell lung cancer cells, Cancer Res, 50, 240 Bunn, 1992, Effects of neuropeptides on human lung and breast cancer cells, J Natl Cancer Inst Monogr, 13, 145 Fabregat, 1990, [D-Arg1,D-Phe5,D-Trp7,9,Leu11] substance P, a neuropeptide antagonist, blocks binding, Ca2+-mobilizing, and mitogenic effects of endothelin and vasoactive intestinal contractor in mouse 3T3 cells, J Cell Physiol, 145, 88, 10.1002/jcp.1041450113 Tan-No, 1993, Spantide-induced antinociception in the opioid mechanism, Regul Pept, 46, 343, 10.1016/0167-0115(93)90080-R Bitar, 1991, Effect of substance P/bombesin antagonists on the release of growth hormone by GHRP and GHRH, Biochem Biophys Res Commun, 180, 156, 10.1016/S0006-291X(05)81269-0 Iwatsuki, 1992, Effects of gastrin releasing peptide (GRP) on pancreatic exocrine secretion in anaesthetized dogs, Asia Pac J Pharmacol, 7, 129 Patel, 1991, Modulation of inositol lipid hydrolysis in human breast cancer by two classes of bombesin antagonists, J Mol Endocrinol, 6, 71, 10.1677/jme.0.0060071 von Schrenck, 1990, Potent bombesin receptor antagonists distinguish receptor subtypes, Am J Physiol, 259, G468 Coy, 1988, Progress in the development of competitive bombesin antagonists, Ann NY Acad Sci, 547, 150, 10.1111/j.1749-6632.1988.tb23883.x Rusconi, 1991, Bombesin receptor antagonists. 2. Analogues based on substance P antagonists, Farmaco, 46, 725 Cowan, 1985, Effects of bombesin on behavior, Life Sci, 37, 135, 10.1016/0024-3205(85)90416-3 Jensen, 1986, (D-Phe12,Leu14)-bombesin: a new class of bombesin receptor antagonist, Can J Physiol Pharmacol, 64, 175 Flynn, 1993, Fourth ventricular injection of selective bombesin receptor antagonists facilitates feeding in rats, Am J Physiol, 264, R218 Mukai, 1990, Antagonism by GRP(18–27) and substance P analogues on insulin release stimulated by GRP(18–27), Peptides, 11, 173, 10.1016/0196-9781(90)90127-Q de Castiglione, 1990, Bombesin receptor antagonists. 1. Analogues with deleted, inverted or substituted amino acid residues, Farmaco, 45, 1251 Mukai, 1989, [Ala6]gastrin-releasing peptide-10: an analogue with dissociated biological activities, Am J Physiol, 257, E235 Mrozinski, 1993, Sidechain restricted analogues. A new class of bombesin receptor antagonists, Gastroenterology, 104, A323 Edwards, 1992, Amide bond substitutions and conformational constraints applied to bombesin antagonists, 52 Spanarkel, 1983, Cholecytokinin-27-32-amide. A member of a new class of cholecystokinin receptor antagonists, J Biol Chem, 258, 6746, 10.1016/S0021-9258(18)32283-X Martinez, 1984, Synthesis and biological activity of new peptide segments of gastrin exhibiting gastrin antagonist property, J Med Chem, 27, 1597, 10.1021/jm00378a012 Martinez, 1986, Phenylethylamide derivatives of the C-terminal tetrapeptide of gastrin, Int J Peptide Protein Res, 28, 529, 10.1111/j.1399-3011.1986.tb03288.x Martinez, 1986, Phenethyl ester derivative analogues of the C-terminal tetrapeptide of gastrin as potent gastrin antagonists, J Med Chem, 29, 2201, 10.1021/jm00161a012 Wang, 1990, Desmethionine alkylamide bombesin analogues: a new class of bombesin receptor antagonists with potent antisecretory activity in pancreatic acini and antimitotic activity in Swiss 3T3 cells, Biochemistry, 29, 616, 10.1021/bi00455a004 Wang, 1990, Des-Met carboxyl terminal modified analogues of bombesin function as potent bombesin receptor antagonists, partial agonists, or agonists, J Biol Chem, 265, 15695, 10.1016/S0021-9258(18)55454-5 Narayan, 1992, A potent bombesin receptor antagonist inhibits bombesin-stimulated growth of mouse colon cancer cells in vitro: absence of autocrine effects, Cell Growth Differentiation, 3, 111 Belvisi, 1991, Bombesin-induced bronchoconstriction in the guinea pig: mode of action, J Pharmacol Exp Ther, 258, 36 Alptekin, 1991, Comparison of prolonged in vivo inhibitory activity of several potent bombesin (BN) antagonists on BN-stimulated amylase secretion in the rat, Peptides, 12, 749, 10.1016/0196-9781(91)90128-C Buchan, 1990, Inhibition of bombesinstimulated gastrin release from isolated human G cells by bombesin analogs, Pharmacol, 41, 237, 10.1159/000138725 Singh, 1992, A novel bombesin receptor antagonist (2258U89) potently inhibits bombesin evoked release of gastrointestinal hormones from rats and dogs, in vitro and in vivo, Regul Pept, 40, 75, 10.1016/0167-0115(92)90085-9 Staley, 1991, [Des-Met14] bombesin analogues function as small cell lung cancer bombesin receptor antagonists, Peptides, 12, 145, 10.1016/0196-9781(91)90181-N Weigert, 1993, Effect of bombesin antagonist D-Phe6-BN(6–13)OMe on vagally induced gastrin release from perfused rat stomach, Life Sci, 52, 725, 10.1016/0024-3205(93)90234-T Varga, 1992, Effect of potent bombesin receptor antagonist on release of gut hormones in rats, Regul Pept, 40, 267, 10.1016/0167-0115(92)90452-Z Varga, 1991, Effects of potent bombesin antagonist on exocrine pancreatic secretion in rats, Peptides, 12, 493, 10.1016/0196-9781(91)90090-C Maggi, 1992, Effect of [D-Phe6]bombesin (6–13)methylester, a bombesin receptor antagonist, towards bombesin-induced contractions in the guinea-pig and rat isolated urinary bladder, J Auton Pharmacol, 12, 215, 10.1111/j.1474-8673.1992.tb00335.x Lach, 1993, Contractile effect of bombesin on guinea pig lung in vitro: involvement of gastrin-releasing peptide-preferring receptors, Lung Cell Mol Physiol, 264, L80, 10.1152/ajplung.1993.264.1.L80 Mantey, 1993, Characterization of bombesin receptors using a novel, potent, radiolabeled antagonist that distinguishes bombesin receptor subtypes, Mol Pharmacol, 43, 762 Coy, 1992, Development of a potent bombesin receptor antagonist with prolonged in vivo inhibitory activity on bombesin-stimulated amylase and protein release in the rat, Peptides, 13, 775, 10.1016/0196-9781(92)90186-7 Ladenheim, 1993, Bombesin receptor antagonists differentiate receptor subtypes in rat brain, Eur J Pharmacol, 235, 121, 10.1016/0014-2999(93)90830-B Guard, 1993, Structure-activity requirements of bombesin for gastrin-releasing peptide- and neuromedin B-preferring bombesin receptors in rat brain, Eur J Pharmacol, 240, 177, 10.1016/0014-2999(93)90896-P Bitar, 1992, Identification and initial characterization of a putative neuromedin B-type receptor from rat urinary bladder membranes, Eur J Pharmacol, 219, 117, 10.1016/0014-2999(92)90588-U Davis, 1992, Metabolic stability and tumor inhibition of bombesin/GRP receptor antagonists, Peptides, 13, 401, 10.1016/0196-9781(92)90128-P Staley, 1993, Solubilization and purification of bombesin/gastrin releasing peptide receptors from human cell lines, J Mol Neurosci, 4, 29, 10.1007/BF02736688 Feldman, 1990, Purification and characterization of the bombesin/gastrin releasing peptide receptor from Swiss 3T3 cells, J Biol Chem, 265, 17364, 10.1016/S0021-9258(17)44911-8 Kim, 1990, C-terminal modified bombesin and litorin analogs with potent in vitro and in vivo antiproliferative activity, 182 Thomas, 1992, Antitumoral activity of bombesin analogues on small cell lung cancer xenografts: relationship with bombesin receptor expression, Cancer Res, 52, 4872 Heimbrook, 1989, Elucidation of a novel gastrin releasing peptide antagonist by minimal ligand analysis, 295 Märki, 1981, Bombesin analogs: effects on thermoregulation and glucose metabolism, Peptides, 2, 169, 10.1016/0196-9781(81)90027-9 Taché, 1980, Gastrin releasing peptide (GRP): central nervous system (CNS) action to inhibit gastric secretion in rats, Regul Pept, 1, S112, 10.1016/0167-0115(80)90242-6 Heimbrook, 1989, Carboxyl-terminal modification of a gastrin releasing peptide derivative generates potent antagonists, J Biol Chem, 264, 11258, 10.1016/S0021-9258(18)60457-0 Coy, 1988, Probing peptide backbone function in bombesin. A reduced peptide bond analogue with potent and specific receptor antagonist activity, J Biol Chem, 263, 5056, 10.1016/S0021-9258(18)60678-7 de Castiglione, 1991, Bombesin receptor antagonists. 3. Irreversible alkylating analogues: melphalan derivatives, Farmaco, 46, 743 Stephens, 1991, N-Acetyl-GRP(20–26)-O-CH3 reverses intracisternal bombesin-induced inhibition of gastric acid secretion in rats, Peptides, 12, 665, 10.1016/0196-9781(91)90116-7 Rouissi, 1991, Characterization of bombesin receptors in peripheral contractile organs, Br J Pharmacol, 103, 1141, 10.1111/j.1476-5381.1991.tb12314.x Karlsson, 1990, Peptide receptor antagonists in the study of insulin and glucagon secretion in mice, Eur J Pharmacol, 191, 457, 10.1016/0014-2999(90)94180-6 Heimbrook, 1991, Gastrin releasing peptide antagonists with improved potency and stability, J Med Chem, 34, 2102, 10.1021/jm00111a027 Heimbrook, 1990, High-density functional gastrin releasing peptide receptors on primate cells, J Natl Cancer Inst, 82, 402, 10.1093/jnci/82.5.402 Heimbrook, 1990, Design and evaluation of novel gastrin-releasing peptide antagonists for the treatment of small cell lung cancer, 56 Houben, 1991, Effect of the bombesin receptor blockers [Leu13,ψCH2NH-Leu14]bombesin and N-pivaloyl GRP(20–25) alkylamide (L 686,095-001C002) on basal and neuromedin C-stimulated PRL and GH release in pituitary cell aggregates, Peptides, 12, 371, 10.1016/0196-9781(91)90028-N Camble, 1989, N-IsobutyrylHisTrpAlaValD-AlaHisLeuNHMe (ICI 216140) a potent in vivo antagonist of bombesin/gastrin releasing peptide (BN/GRP) derived from the C-terminal sequence lacking the final methionine residue, Life Sci, 45, 1521, 10.1016/0024-3205(89)90417-7 Campbell, 1991, Hormonal control of avian pancreas by gastrin-releasing peptide from the proventriculus, Am J Physiol, 261, G16 Cowan, 1990, Pharmacological profile of ICI 216140, a novel bombesin antagonist, Eur J Pharmacol, 183, 235, 10.1016/0014-2999(90)93078-5 Ryan, 1993, Two bombesin analogues discriminate between neuromedin B- and bombesin-induced calcium flux in a lung cancer cell line, Peptides, 14, 1231, 10.1016/0196-9781(93)90181-F Best, 1990, Antagonists of bombesin/gastrin releasing peptide based on [D-Ala24] GRP(20–26)-hep-tapeptide. 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Prediction of membrane interactions of gastrin-releasing peptide, neuromedin B, and neuromedin C, Biochemistry, 26, 6316, 10.1021/bi00394a004 Di Bello, 1991, Conformational studies on bombesin antagonists: CD and NMR characterization of [Thr6,Leu13ψ(CH2NH)Met14]bombesin(6–14), Biopolymers, 31, 1397, 10.1002/bip.360311206 Malikayil, 1992, Micelle-bound conformations of a bombesin/gastrin releasing peptide receptor agonist and an antagonist by two-dimensional NMR and restrained molecular dynamics, Biochemistry, 31, 7043, 10.1021/bi00146a004 Coy, 1991, Covalently cyclized agonist and antagonist analogues of bombesin and related peptides, J Biol Chem, 266, 16441, 10.1016/S0021-9258(18)55319-9 Kull, 1992, Conveyance of partial agonism/antagonism to bombesin/gastrin-releasing peptide analogues on Swiss 3T3 cells by a carboxyl-terminal leucine insertion, J Biol Chem, 267, 21 132, 10.1016/S0021-9258(19)36807-3 Woll, 1988, [Leu13-ψ(CH2NH)Leu14]bombesin is a specific bombesin receptor antagonist in Swiss 3T3 cells, Biochem Biophys Res Commun, 155, 359, 10.1016/S0006-291X(88)81093-3 Saari, 1989, A gastrin-releasing peptide antagonist containing a ψ(CH2O) amide bond surrogate, Biochem Biophys Res Commun, 165, 114, 10.1016/0006-291X(89)91041-3 Woll, 1988, Two classes of antagonist interact with receptors for the mitogenic neuropeptides bombesin, bradykinin, and vasopressin, Growth Factors, 1, 75, 10.3109/08977198809000249 Millar, 1990, Arachidonic acid release by bombesin. A novel postreceptor target for heterologous mitogenic desensitization, J Biol Chem, 265, 19973, 10.1016/S0021-9258(17)45470-6 Erusalimsky, 1988, Bombesin, diacylglycerols, and phorbol esters rapidly stimulate the phosphorylation of an Mr = 80 000 protein kinase C substrate in permeabilizes 3T3 cells. Effect of guanine nucleotides, J Biol Chem, 263, 19188, 10.1016/S0021-9258(18)37408-8 Brooks, 1992, The expression of 80 K/MARCKs, a major substrate of protein kinase C (PKC), is down-regulated through both PKC-dependent and -independent pathways. Effect of bombesin, platelet-derived growth factor, and cAMP, J Biol Chem, 267, 14212, 10.1016/S0021-9258(19)49699-3 Millar, 1990, Chronic desensitization to bombesin by progressive down-regulation of bombesin receptors in Swiss 3T3 cells. Distinction from acute desensitization, J Biol Chem, 265, 12052, 10.1016/S0021-9258(19)38506-0 Trepel, 1988, A novel bombesin receptor antagonist inhibits autocrine signals in a small cell lung carcinoma cell line, Biochem Biophys Res Commun, 156, 1383, 10.1016/S0006-291X(88)80785-X Mahamoud, 1989, Small cell lung cancer bombesin receptors are antagonized by reduced peptide bond analogues, Life Sci, 44, 367, 10.1016/0024-3205(89)90231-2 Mahmoud, 1991, [Psi13,14] bombesin analogues inhibit growth of small cell lung cancer in vitro and in vivo, Cancer Res, 51, 1798 Sausville, 1990, Inhibitors of bombesinstimulated intracellular signals: interruption of an autocrine pathway as a therapeutic strategy in small cell lung carcinoma, 193 Ciomei, 1993, In vitro and in vivo activity of alkylating bombesin receptor antagonists on small cell lung carcinoma, Anticancer Res, 13, 75 Severi, 1989, Pharmacological characterization of [Leu-13-ψ-CH2NH-Leu14]-bombesin as a specific bombesin receptor antagonist on isolated smooth muscle cells, J Pharmacol Exp Ther, 251, 713 Hoist, 1990, Identification of the neurotransmitter/neuromodulator functions of the neuropeptide gastrin-releasing peptide in the porcine antrum, using the antagonist (Leu13-ψ-CH2NH-Leu14)-bombesin, Scand J Gastroenterol, 25, 89, 10.3109/00365529008999214 Rossowski, 1989, Effects of a novel antagonist analogue on bombesin-stimulated gastric acid secretion and growth hormone release in the pentobarbital-anesthetized rat, Scand J Gastroenterol, 24, 121, 10.3109/00365528909092249 Schubert, 1991, Regulation of acid secretion by bombesin/GRP neurons of the gastric fundus, Am J Physiol, 260, G156 Schubert, 1992, Peptone stimulates gastrin secretion from the stomach by activating bombesin/GRP and cholinergic neurons, Am J Physiol, 262, G685 Cuber, 1990, Blockade of bombesin receptors with [Leu14-ψ(CH2NH)-Leu13]bombesin fails to suppress nutrient-induced CCK release from rat duodenojejunum, Peptides, 11, 255, 10.1016/0196-9781(90)90078-J Campos, 1989, Inhibition of bombesin-stimulated gastrin release from isolated canine G cells by bombesin antagonists, Can J Pharmacol, 67, 1520, 10.1139/y89-245 Tang, 1993, Stimulatory effects of bombesin-like peptides on suprachiasmatic neurons in brain slices, Brain Res, 614, 125, 10.1016/0006-8993(93)91025-N Houben, 1990, Stimulation of growth hormone release and prolactin release from rat pituitary cell aggregates by bombesin- and ranatensin-like peptides is potentiated by estradiol, 5α-dihydrotestosterone, and dexamethasone, Endocrinology, 126, 2257, 10.1210/endo-126-5-2257 Feldman, 1993, Peptides stimulate phospho-inositide hydrolysis in human retinal pigment epithelium, Invest Ophthalmol Visual Sci, 34, 431 Merali, 1993, Blockade of brain bombesin/GRP receptors increases food intake in satiated rats, Am J Physiol, 264, R1031 Motamedi, 1993, Bombesin-induced anorexia requires central bombesin receptor activation: independence from interaction with central catecholaminergic systems, Psychopharmacol, 110, 193, 10.1007/BF02246972 Bado, 1992, Possible mediation by luminal somatostatin of bombesin-induced satiety in the cat, Am J Physiol, 263, R84 Babcock, 1992, Bombesin-induced hypothermia: a dose-response and receptor antagonist study, Pharmacol Biochem Behav, 43, 957, 10.1016/0091-3057(92)90432-F Cowan, 1988, Studies in vivo with Leu13-ψ[CH2NH]-Leu14-bombesin, a proposed competitive antagonist of bombesin, FASEB J, 2, A784 Dickinson, 1988, Partial agonist activity of the bombesin-receptor antagonist [Leu14-ψ-CH2-NH-Leu13]-bombesin in frog peptic cells, Biochem Biophys Res Commun, 157, 1154, 10.1016/S0006-291X(88)80994-X Coy, 1989, Short-chain pseudo-peptide bombesin receptor antagonists with enhanced binding affinities for pancreatic acinar and Swiss 3T3 cells display strong antimitotic activity, J Biol Chem, 264, 14691, 10.1016/S0021-9258(18)63753-6 Wisner, 1990, [D-Ala1,Leu9-ψ-CH2NH/(ψ-CH2NH)-Leu10]neuromedin C antagonizes neuromedin C-stimulated amylase release by acini isolated from the rat pancreas, Pancreas, 5, 408, 10.1097/00006676-199007000-00006 Coy, 1990, Short chain bombesin pseudopeptides with potent bombesin receptor antagonist activity in rat and guinea pig pancreatic acinar cells, Eur J Pharmacol, 190, 31, 10.1016/0014-2999(90)94109-B Piggins, 1993, Effects of neonatal blockade of bombesin (BN) receptors with [D-Phe6,ψLeu13-Cpa14]BN(6–14) on adult behavior and sensitivity to BN, Peptides, 14, 845, 10.1016/0196-9781(93)90123-X Laferrère, 1992, Effects of bombesin, of a new bombesin agonist (BIM 187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin, Eur J Pharmacol, 215, 23, 10.1016/0014-2999(92)90603-2 Radulovic, 1991, Biological effects and receptor binding affinities of new pseudononapeptide bombesin/GRP receptor antagonists with N-terminal D-Trp or D-Tpi, Int J Pept Protein Res, 38, 593, 10.1111/j.1399-3011.1991.tb01545.x Cai, 1992, Pseudononapeptide 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