Body mass index in midlife and late‐life as a risk factor for dementia: a meta‐analysis of prospective studies

Obesity Reviews - Tập 12 Số 5 - 2011
Kaarin J. Anstey1, Nicolas Cherbuin1, Marc M. Budge2, Jennifer L. Young1
1Ageing Research Unit, Centre for Mental Health Research
2Medical School, Australian National University, Canberra, ACT, Australia

Tóm tắt

SummaryThe relationship between body mass index (BMI) (in midlife and late‐life) and dementia was investigated in meta‐analyses of 16 articles reporting on 15 prospective studies. Follow‐ups ranged from 3.2 to 36.0 years. Meta‐analyses were conducted on samples including 25 624 participants evaluated for Alzheimer's disease (AD), 15 435 participants evaluated for vascular dementia (VaD) and 30 470 followed for any type of dementia (Any Dementia). Low BMI in midlife was associated with 1.96 [95% confidence interval (CI): 1.32, 2.92] times the risk of developing AD. The pooled relative risks for AD, VaD and Any Dementia for overweight BMI in midlife compared with normal BMI were 1.35 (95% CI:1.19, 1.54), 1.33 (95% CI: 1.02, 1.75) and 1.26 (95% CI: 1.10, 1.44), respectively. The pooled relative risks of AD and Any Dementia for obese BMI in midlife compared to normal BMI were 2.04 (95% CI: 1.59, 2.62) and 1.64 (95% CI: 1.34, 2.00), respectively. Continuous BMI in late‐life was not associated with dementia. Small numbers of studies included in pooled analyses reduce generalizability of findings, and emphasize the need for publication of additional findings. We conclude that underweight, overweight and obesity in midlife increase dementia risk. Further research evaluating late‐life BMI and dementia is required.

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Tài liệu tham khảo

10.1152/ajpregu.90817.2008

10.1016/j.mcna.2009.02.010

10.1016/j.arr.2010.04.007

10.1136/jnnp.2009.181743

10.1111/j.1532-5415.2007.01458.x

10.1038/oby.2004.189

10.1016/j.plipres.2006.03.001

10.1016/j.bbadis.2008.12.004

10.1016/j.brainres.2008.07.045

10.1136/bmj.38446.466238.E0

10.1111/j.1467-789X.2008.00473.x

10.1093/ageing/afl123

10.1097/01.JGP.0000310778.20870.ae

10.1097/JGP.0b013e3181a2fd07

10.1093/aje/kwm116

WilliamsJW PlassmanBL BurkeJR HolsingerT BenjaminS.Preventing Alzheimer's disease and cognitive decline. Evidence Report/Technical Assessment No. 193. National Institutes of Health: Durham2010.

10.1111/j.1365-2648.2008.04950.x

10.1001/jama.283.15.2008

10.1001/archinte.165.3.321

American Psychiatric Association, 1987, Diagnostic and Statistical Manual of Mental Disorders

10.1212/WNL.34.7.939

10.1212/WNL.43.2.250

10.1093/oxfordjournals.aje.a116237

10.1093/aje/kwi029

10.1093/aje/kwn229

10.1002/sim.1186

10.1002/9780470743386

10.1016/0197-2456(86)90046-2

Higgins JPT, 2005, Cochrane Handbook for Systematic Reviews of Interventions 4.2.5

10.1212/WNL.57.8.1453

10.1212/01.wnl.0000176061.33817.90

10.1001/jama.2009.1146

10.1001/archneurol.2008.582

10.1001/archinte.163.13.1524

10.1097/01.wad.0000213814.43047.86

10.1212/WNL.0b013e3181a60a58

10.1001/archneur.64.3.392

10.1093/gerona/60.5.566

10.1212/01.WNL.0000038910.46217.AA

10.1001/jama.2009.1144

10.2174/156720507780362047

10.1212/WNL.45.6.1161

10.1111/j.1532-5415.2008.01958.x

10.1038/sj.ejcn.1601311

10.1212/WNL.0b013e3181a92c36

10.1159/000096636

10.1093/gerona/gln006

10.1212/01.wnl.0000238082.13860.50

10.1038/ncpneuro1044

10.1016/j.amjopharm.2009.11.001

10.1001/archneur.63.9.1312

10.1007/s12603-009-0249-9

10.1001/archneurol.2009.201

World_Health_Organization, 1997, Obesity: Preventing and Managing the Global Epidemic

10.1136/bmj.333.7568.597

10.1023/A:1025687102375

10.1097/PSY.0b013e3181a6177c

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Obesity Reviews

Tập 12 Số 5

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