Body fat distribution is more predictive of all‐cause mortality than overall adiposity

Diabetes, Obesity and Metabolism - Tập 20 Số 1 - Trang 141-147 - 2018
Sung Woo Lee1,2, Jee Young Son3, Jeong‐Min Kim1, Seung-Sik Hwang4, Jin Suk Han5, Nam Ju Heo6
1Department of Internal Medicine Eulji Medical Center, Eulji University Seoul South Korea
2Department of Internal Medicine Seoul National University Postgraduate School Seoul South Korea
3Department of Radiology, Healthcare System Gangnam Center Seoul National University Hospital Seoul South Korea
4Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, South Korea
5Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea
6Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea

Tóm tắt

AimsThe relationship between directly measured body fat and all‐cause mortality has been rarely studied. The aim of this study was to evaluate the predictive significance of computed tomography (CT)‐measured body fat, including both visceral fat area (VFA) and subcutaneous fat area (SFA), for mortality.MethodsThe study included 36 656 participants who underwent abdominal CT as part of a health check‐up at a single university‐affiliated healthcare center in 2007 to 2015. Of those, 32 593 participants with data regarding vital status as of May 2016 were included in the final analysis. The main factors evaluated were VFA, SFA and visceral‐to‐subcutaneous fat area ratio (VSR), and the primary outcome was all‐cause mortality.ResultsThere were 253 deaths during a mean follow‐up of 5.7 years. Increased SFA was associated with decreased all‐cause mortality, whereas an increased VFA and VSR were related to increased all‐cause mortality. Compared with the predictive power of body mass index (BMI), SFA and VSR showed a larger area under the curve than did BMI. In Kaplan–Meier survival curve analysis, increased SFA and VSR were associated with decreased and increased hazard of all‐cause death, respectively. However, in multivariate Cox proportional hazard regression analysis, only VSR was independently associated with all‐cause mortality. Moreover, this relationship was paralleled by the harmful impact of increased VSR on metabolic profiles.ConclusionIncreased VSR was an independent predictor of all‐cause mortality. This suggests that the location of fat deposits may be more important than the actual amount of body fat.

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Diabetes, Obesity and Metabolism

Tập 20 Số 1

141-147

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