Body Fat and Fat‐Free Mass and All‐Cause Mortality

Wiley - Tập 12 Số 7 - Trang 1042-1049 - 2004
Janne Bigaard1, Kirsten Frederiksen1, Anne Tjønneland1, Birthe Lykke Thomsen1, Kim Overvad2, Berit L. Heitmann3, Grith Lykke Sørensen3
1Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark
2Department of Clinical Epidemiology, Aalborg Hospital and Aarhus University Hospital, Aalborg, Denmark.
3Danish Epidemiology Science Centre and Research Unit for Dietary Studies at the Institute of Preventive Medicine, Copenhagen University Hospital, Denmark

Tóm tắt

AbstractObjective: To investigate whether the association between BMI and all‐cause mortality could be disentangled into opposite effects of body fat and fat‐free mass (FFM).Research Methods and Procedures: All‐cause mortality was studied in the Danish follow‐up study “Diet, Cancer and Health” with 27, 178 men and 29, 875 women 50 to 64 years old recruited from 1993 to 1997. By the end of year 2001, the median follow‐up was 5.8 years, and 1851 had died. Body composition was assessed by bioelectrical impedance. Cox regression models were used to estimate the relationships among body fat mass index (body fat mass divided by height squared), FFM index (FFM divided by height squared), and mortality. All analyses were adjusted for smoking habits.Results: Men and women showed similar associations. J‐shaped associations were found between body fat mass index and mortality adjusted for FFM and smoking. The mortality rate ratios in the upper part of body fat mass were 1.12 per kg/m2 (95% confidence interval: 1.07, 1.18) in men and 1.06 per kg/m2 (95% confidence interval: 1.02, 1.10) in women. Reversed J‐shaped associations were found between FFM index and mortality with a tendency to level off for high values of FFM.Discussion: Our findings suggest that BMI represents joint but opposite associations of body fat and FFM with mortality. Both high body fat and low FFM are independent predictors of all‐cause mortality.

Từ khóa


Tài liệu tham khảo

Troiano R. P., 1996, The relationship between body weight and mortality: a quantitative analysis of combined information from existing studies, Int J Obes Relat Metab Disord., 20, 63

Solomon C. G., 1997, Obesity and mortality: a review of the epidemiologic data, Am J Clin Nutr., 66, 1044, 10.1093/ajcn/66.4.1044S

10.1093/ije/27.5.824

10.1056/NEJM199910073411501

10.1093/oxfordjournals.aje.a009942

10.1093/aje/152.3.264

10.1001/archinte.160.14.2117

10.1016/S0895-4356(01)00356-0

10.1038/oby.2002.50

10.1097/00001648-199805000-00007

10.1038/sj.ijo.0800623

10.1056/NEJM199509143331101

10.1001/jama.1987.03390030083026

10.1002/j.1550-8528.1999.tb00417.x

10.1093/oxfordjournals.aje.a009961

10.1002/j.1550-8528.1995.tb00124.x

10.1038/sj.ijo.0801082

10.1038/sj.ijo.0801925

10.1016/S1047-2797(02)00417-9

10.1093/ajcn/75.6.1107

10.1093/ajcn/52.6.953

Tjønneland A., 2000, Diet, cancer and health: a population study and establishment of a biological bank in Denmark, Ugeskr Laeger, 162, 350

Heitmann BL., 1990, Prediction of body water and fat in adult Danes from measurement of electrical impedance: a validation study, Int J Obes Relat Metab Disord., 14, 789

Andersen T. F., 1999, The Danish National Hospital Register: a valuable source of data for modern health sciences, Dan Med Bull., 46, 263

10.1093/oxfordjournals.aje.a009034

10.1097/00001648-199507000-00005

World Health Organization, 2000, Obesity: Preventing and Managing the Global Epidemic. Technical Report Series 894

10.1038/oby.2003.123

10.1093/aje/153.10.946

10.1093/oxfordjournals.aje.a009334

10.1093/ajcn/51.1.3

Baumgartner RN., 1993, Body composition in elderly persons: a critical review of needs and methods, Prog Food Nutr Sci., 17, 223

10.1080/02701367.1999.10608031

10.2105/AJPH.85.5.726

Roubenoff R., 1996, Applications of bioelectrical impedance analysis for body composition to epidemiologic studies, Am J Clin Nutr., 64, 459, 10.1093/ajcn/64.3.459S

Guo S. S., 1996, Use of statistical methods to estimate body composition, Am J Clin Nutr., 64, 428, 10.1093/ajcn/64.3.428S

10.1093/ajcn/66.1.8

Thông tin
Thông tin xuất bản

Wiley

Tập 12 Số 7

1042-1049

Thông tin tác giả