Blockade of integrin β3–FAK signaling pathway activated by osteopontin inhibits neointimal formation after balloon injury

Giachelli, 1993, Osteopontin expression is elevated during neointima formation in rat arteries and in human atherosclerotic plaques, J Clin Invest, 92, 1686, 10.1172/JCI116755 Liaw, 1997, Neutralizing antibodies directed against osteopontin inhibit rat carotid neointimal thickening after endothelial denudation, Arterioscler Thromb Vasc Biol, 17, 188, 10.1161/01.ATV.17.1.188 Isoda, 2002, Osteopontin plays an important role in the development of medial thickening and neointimal formation, Circ Res, 91, 77, 10.1161/01.RES.0000025268.10302.0C Butler, 1989, The nature and significance of osteopontin, Connec Tissue Res, 23, 123, 10.3109/03008208909002412 Wen, 2002, Comparison of gene expression patterns and migration capability at quiescent and proliferating vascular smooth muscle cells stimulated by cytokines, Life Sci, 70, 799, 10.1016/S0024-3205(01)01446-1 Liaw, 1995, The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins: role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro, J Clin Invest, 95, 713, 10.1172/JCI117718 Bendeck, 2000, Smooth muscle cell matrix metalloproteinase production is stimulated via avb3 integrin, Arterioscler Thromb Vasc Biol, 20, 1467, 10.1161/01.ATV.20.6.1467 Bendeck, 2001, The beta3 integrin antagonist m7E3 reduces matrix metalloproteinase activity and smooth muscle cell migration, J Vasc Res, 38, 590, 10.1159/000051095 Sieg, 1999, Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration, J Cell Sci, 112, 2677, 10.1242/jcs.112.16.2677 Tamarat, 2002, Angiotensin II angiogenic effect in vivo involves vascular endothelial growth factor- and inflammation-related pathways, Lab Invest, 82, 747, 10.1097/01.LAB.0000017372.76297.EB Schlaepfer, 1997, Fibronectin-stimulated signaling from a focal adhesion kinase-c–Src complex: involvement of Grb2, p130 cas, and NCK adaptor proteins, Mol Cell Biol, 17, 1702, 10.1128/MCB.17.3.1702 Schlaepfer, 1994, Integrin-mediated signal transduction linked to ras-pathway by GRB2 binding to focal adhesion kinase, Nature, 372, 786, 10.1038/372786a0 Li, 2006, FAK and ILK regulate adhesion and migration of vascular smooth muscle cells induced by osteopontin, Chin J Biochem Mol Biol, 22, 477 Liu, 2005, Blockade of nuclear factor of activated T cells activation signaling suppresses balloon injury-induced neointima formation in a rat carotid artery model, J Biol Chem, 280, 14700, 10.1074/jbc.M500322200 Han, 2006, Serum deprivation results in redifferentiation of human umbilical vascular smooth muscle cells, Am J Physiol Cell Physiol, 291, 50, 10.1152/ajpcell.00524.2005 Morla, 2000, Control of smooth muscle cell proliferation and phenotype by integrin signaling through focal adhesion kinase, Biochem Biophys Res Comm, 272, 298, 10.1006/bbrc.2000.2769 Taylor, 2001, Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells, Mol Cell Biol, 21, 1565, 10.1128/MCB.21.5.1565-1572.2001 Schaller, 1994, Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src, Mol Cell Biol, 14, 1680, 10.1128/MCB.14.3.1680 Xi, 2003, Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic domain in inside-out and outside-in signaling, J Cell Biol, 162, 329, 10.1083/jcb.200303120 Ren, 1999, Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton, Eur Mol Biol Organization J, 18, 578, 10.1093/emboj/18.3.578 Taylor, 2000, A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes, J Biol Chem, 275, 19250, 10.1074/jbc.M909099199