Blockade of Autoantibody-Initiated Tissue Damage by Using Recombinant Fab Antibody Fragments against Pathogenic Autoantigen

The American Journal of Pathology - Tập 176 - Trang 914-925 - 2010
Gang Wang1,2, Hideyuki Ujiie1, Akihiko Shibaki1, Wataru Nishie1, Yasuki Tateishi1, Kazuhiro Kikuchi1, Qiang Li1, James R. McMillan1,2, Hiroshi Morioka3, Daisuke Sawamura1, Hideki Nakamura1, Hiroshi Shimizu1
1Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
2Creative Research Initiative Sousei, Hokkaido University, Sapporo, Japan
3Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

Tài liệu tham khảo

Jacobson, 1997, Epidemiology and estimated population burden of selected autoimmune diseases in the United States, Clin Immunol Immunopathol, 84, 223, 10.1006/clin.1997.4412 Holers, 2003, The complement system as a therapeutic target in autoimmunity, Clin Immunol, 107, 140, 10.1016/S1521-6616(03)00034-2 Nishie, 2007, Humanization of autoantigen, Nat Med, 13, 378, 10.1038/nm1496 Liu, 1995, The role of complement in experimental bullous pemphigoid, J Clin Invest, 95, 1539, 10.1172/JCI117826 Mewar, 2006, Autoantibodies in rheumatoid arthritis: a review, Biomed Pharmacother, 60, 648, 10.1016/j.biopha.2006.09.002 D'Cruz, 2007, Systemic lupus erythematosus, Lancet, 369, 587, 10.1016/S0140-6736(07)60279-7 Girardi, 2003, Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome, J Clin Invest, 112, 1644, 10.1172/JCI200318817 Zhao, 2006, Role of FcRs in animal model of autoimmune bullous pemphigoid, J Immunol, 177, 3398, 10.4049/jimmunol.177.5.3398 Nelson, 2006, Role of different pathways of the complement cascade in experimental bullous pemphigoid, J Clin Invest, 116, 2892, 10.1172/JCI17891 Liu, 1993, A passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen BP180, J Clin Invest, 92, 2480, 10.1172/JCI116856 Liu, 2004, Bullous Pemphigoid: Using animal models to study the immunopathology, J Investig Dermatol Symp Proc, 9, 41, 10.1111/j.1087-0024.2004.00841.x Yancey, 2005, The pathophysiology of autoimmune blistering diseases, J Clin Invest, 115, 825, 10.1172/JCI200524855 Girardi, 2004, Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation, Nat Med, 10, 1222, 10.1038/nm1121 Atkinson, 2003, Complement system on the attack in autoimmunity, J Clin Invest, 112, 1639, 10.1172/JCI20309 Giudice, 1993, Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain, J Immunol, 151, 5742, 10.4049/jimmunol.151.10.5742 Wang, 2000, Humanization of a mouse monoclonal antibody neutralizing TNF-α by guided selection, J Immunol Methods, 241, 171, 10.1016/S0022-1759(00)00203-9 Barbas, 1991, Assembly of combinatorial antibody libraries on phage surfaces: The gene III site, Proc Natl Acad Sci USA, 88, 7978, 10.1073/pnas.88.18.7978 Little, 1995, Human antibody libraries in Escherichia coli, J Biotechnol, 41, 187, 10.1016/0168-1656(95)00022-I Clackson, 1991, Making antibody fragments using phage display libraries, Nature, 352, 624, 10.1038/352624a0 Wang, 2004, Cloning and characterization of antikeratin human antibodies using a semisynthetic phage antibody library, Arch Dermatol Res, 296, 270, 10.1007/s00403-004-0504-1 Marks, 1991, Bypassing immunization of human antibodies from V-gene libraries displayed on phage, J Mol Biol, 222, 581, 10.1016/0022-2836(91)90498-U Hoogenboom, 2005, Selecting and screening recombinant antibody libraries, Nat Biotechnol, 23, 1105, 10.1038/nbt1126 Fairley, 2005, Mapping the binding sites of anti-BP180 immunoglobulin E autoantibodies in bullous pemphigoid, J Invest Dermatol, 125, 467, 10.1111/j.0022-202X.2005.23853.x Shimizu, 1994, Demonstration of desmosomal antigens by electron microscopy using cryofixed and cryosubstituted skin with silver-enhanced gold probe, J Histochem Cytochem, 42, 687, 10.1177/42.5.8157937 McMillan, 2006, Colocalization of multiple laminin isoforms predominantly beneath hemidesmosomes in the upper lamina densa of the epidermal basement membrane, J Histochem Cytochem, 54, 109, 10.1369/jhc.5A6701.2005 Nonaka, 2000, The extracellular domain of BPAG2 has a loop structure in the carboxy terminal flexible tail in vivo, J Invest Dermatol, 115, 889, 10.1046/j.1523-1747.2000.00136.x Khumalo, 2005, Interventions for bullous pemphigoid, Cochrane Database Syst Rev, CD002292 Schumann, 2000, The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases, Am J Pathol, 156, 685, 10.1016/S0002-9440(10)64772-4 Ishiko, 1993, J Clin Invest, 91, 1608, 10.1172/JCI116368 Stanley, 1995, Autoantibodies against adhesion molecules and structures in blistering skin diseases, J Exp Med, 181, 1, 10.1084/jem.181.1.1 Kobayashi, 2002, BP180 ELISA using bacterial recombinant NC16a protein as a diagnostic and monitoring tool for bullous pemphigoid, J Dermatol Sci, 30, 224, 10.1016/S0923-1811(02)00109-3 Tsuji-Abe, 2005, Correlation of clinical severity and ELISA indices for the NC16A domain of BP180 measured using BP180 ELISA kit in bullous pemphigoid, J Dermatol Sci, 37, 145, 10.1016/j.jdermsci.2004.10.007 Zillikens, 1997, Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies, J Invest Dermatol, 109, 573, 10.1111/1523-1747.ep12337492 Sitaru, 2002, Autoantibodies to bullous pemphigoid antigen 180 induce dermal-epidermal separation in cryosections of human skin, J Invest Dermatol, 118, 664, 10.1046/j.1523-1747.2002.01720.x