Blinded Patient Preference for Morphine Compared to Placebo in the Setting of Chronic Refractory Breathlessness—An Exploratory Study

Moens, 2014, Are there differences in the prevalence of palliative care-related problems in people living with advanced cancer and eight non-cancer conditions? A systematic review, J Pain Symptom Manage, 48, 660, 10.1016/j.jpainsymman.2013.11.009 Abernethy, 2008, Total dyspnoea, Curr Opin Support Palliat Care, 2, 110, 10.1097/SPC.0b013e328300cad0 Jennings, 2002, A systematic review of the use of opioids in the management of dyspnoea, Thorax, 57, 939, 10.1136/thorax.57.11.939 Oxberry, 2011, Short-term opioids for breathlessness in stable chronic heart failure: a randomized controlled trial, Eur J Heart Fail, 13, 1006, 10.1093/eurjhf/hfr068 Abernethy, 2003, Randomized, double-blind, placebo controlled cross-over, trial of sustained release morphine for the management of refractory dyspnoea, BMJ, 327, 523, 10.1136/bmj.327.7414.523 Johnson, 2002, Morphine for the relief of breathlessness in patients with chronic heart failure—a pilot study, Eur J Heart Fail, 4, 753, 10.1016/S1388-9842(02)00158-7 Currow, 2011, Once-daily opioids for chronic dyspnea: a dose increment and pharmacovigilance study, J Pain Symptom Manage, 42, 388, 10.1016/j.jpainsymman.2010.11.021 Ekström, 2014, Safety of benzodiazepines and opioids in very severe respiratory disease: national prospective study, BMJ, 348, g445, 10.1136/bmj.g445 Johnson, 2013, Opioids for chronic refractory breathlessness: patient predictors of beneficial response, Eur Respir J, 42, 758, 10.1183/09031936.00139812 Johnson, 2013, Clinically important differences in the intensity of chronic refractory breathlessness, J Pain Symptom Manage, 46, 957, 10.1016/j.jpainsymman.2013.01.011 Powers, 1999, Measurement of dyspnea in patients treated with mechanical ventilation, Am J Crit Care, 8, 254, 10.4037/ajcc1999.8.4.254 Gift, 1998, Validity of the numeric rating scale as a measure of dyspnea, Am J Crit Care, 7, 200, 10.4037/ajcc1998.7.3.200 Johnson, 2014, The relationship between two performance scales: New York Heart Association Classification and Karnofsky Performance Status Scale, J Pain Symptom Manage, 47, 652, 10.1016/j.jpainsymman.2013.05.006 Ma, 2010, Interconversion of three measures of performance status: an empirical analysis, Eur J Cancer, 46, 3175, 10.1016/j.ejca.2010.06.126 Chua, 1997, Effects of dihydrocodeine on chemosensitivity and exercise tolerance in patients with chronic heart failure, J Am Coll Cardiol, 29, 147, 10.1016/S0735-1097(96)00446-9 Krajnik, 2014, Opioid receptor bronchial tree: current science, Curr Opin Support Palliat Care, 8, 191, 10.1097/SPC.0000000000000072 Mahler, 2013, Effect of increased blood levels of β-endorphin on perception of breathlessness, Chest, 143, 1378, 10.1378/chest.12-1541 Banzett, 2015, Multidimensional Dyspnea Profile: an instrument for clinical and laboratory research, Eur Respir J, 4, 1681, 10.1183/09031936.00038914 Oxberry, 2013, Repeat dose opioids may be effective for breathlessness in chronic heart failure if given for long enough, J Palliat Med, 16, 250, 10.1089/jpm.2012.0270 Piepoli, 1996, Reproducibility of heart rate variability indices during exercise stress testing and inotrope infusion in chronic heart failure patients, Clin Sci (Lond), 91, 87, 10.1042/cs0910087supp Wilson, 2014, Patient centered decision making: use of conjoint analysis to determine risk–benefit trade-offs for preference sensitive treatment choices, J Neurol Sci, 344, 80, 10.1016/j.jns.2014.06.030 Mühlbacher, 2015, Patients' preferences: a discrete-choice experiment for treatment of non-small-cell lung cancer, Eur J Health Econ, 16, 657, 10.1007/s10198-014-0622-4 Williams, 2014, Excessive daytime sleepiness and adherence to antihypertensive medications among Blacks: analysis of the counseling African Americans to control hypertension (CAATCH) trial, Patient Prefer Adherence, 8, 283, 10.2147/PPA.S53617 Larrey, 2014, Patient adherence issues in the treatment of hepatitis C, Patient Prefer Adherence, 8, 763, 10.2147/PPA.S30339 Sloot, 2015, Side effects of analgesia may significantly reduce quality of life in symptomatic multiple myeloma: a cross-sectional prevalence study, Support Care Cancer, 23, 671, 10.1007/s00520-014-2358-1 Gregorian, 2010, Importance of side effects in opioid treatment: a trade-off analysis with patients and physicians, J Pain, 11, 1095 Schmier, 2002, Utility assessments of opioid treatment for chronic pain, Pain Med, 3, 218, 10.1046/j.1526-4637.2002.02045.x Karras, 2000, Clinically meaningful changes in quantitative measures of asthma severity, Acad Emerg Med, 7, 327, 10.1111/j.1553-2712.2000.tb02231.x Ander, 2004, Measuring the dyspnea of decompensated heart failure with a visual analog scale: how much improvement is meaningful?, Congest Heart Fail, 10, 188, 10.1111/j.1527-5299.2004.03475.x Ries, 2005, Minimally clinically important difference for the UCSD Shortness of Breath Questionnaire, Borg Scale, and Visual Analog Scale, COPD, 2, 105, 10.1081/COPD-200050655 Martins, 2015, Effects of low dose morphine on perceived sleep quality in patients with refractory breathlessness: a hypothesis generating study, Respirology Knafl, 2014, What puts heart failure patients at risk for poor medication adherence?, Patient Prefer Adherence, 8, 1007 Currow, 2012, Activity as a measure of symptom control, J Pain Symptom Manage, 44, e1, 10.1016/j.jpainsymman.2012.07.005