Birth Weight and Childhood Psychopathology in the ABCD Cohort: Association is Strongest for Attention Problems and is Moderated by Sex

Springer Science and Business Media LLC - 2022
Niamh Dooley1, Mary Clarke1, David Cotter1, Mary Cannon1
1Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland

Tóm tắt

AbstractMany studies have shown low birth weight is associated with psychopathology later in life, particularly attention-deficit/hyperactivity disorder (ADHD). The association is well-replicated, independent from a variety of potential familial confounds, and follows a dose–response curve (decreasing birth weight linked with increasing odds of disorder). However, the specificity of the association to attention problems is called into question by the extent of comorbidity in ADHD, and recent findings that the association is stronger for autism than ADHD. We test the relative dose–response strength of birth weight on multiple aspects of behavior to explore specificity of the effect to attention problems. We also test recent suggestions that the association between birth weight and attention problems is driven by males. Our sample consisted of 9,076 children aged 9–10 from the United States (Adolescent Brain Cognitive Development study). Outcomes included 9 problem-scales and the total problems scale from the Child Behavior Checklist (CBCL). Attention problems were the most strongly associated with birth weight after controlling for gestational age, potential familial confounds, and multiple testing, supporting the outcome-specificity of this association. Contrary to recent registry-based findings, an association between birth weight and an autism scale was not observed. Sex moderated the effect of birth weight on total problems, attention problems and aggressive behavior such that these inverse associations were strongly driven by males. Our findings have strong implications for sex-specific prediction and etiological models of childhood psychopathology.

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Tài liệu tham khảo

Aarnoudse-Moens, C. S. H., Weisglas-Kuperus, N., van Goudoever, J. B., & Oosterlaan, J. (2009). Meta-analysis of neurobehavioral outcomes in very preterm and/or very low birth weight children. Pediatrics, 124(2), 717–728.

Abel, K. M., Wicks, S., Susser, E. S., Dalman, C., Pedersen, M. G., Mortensen, P. B., et al. (2010). Birth weight, schizophrenia, and adult mental disorder: Is risk confined to the smallest babies? Archives of General Psychiatry, 67(9), 923–930.

Achenbach, T., & Rescorla, L. (2001). Manual for the ASEBA school-age forms & profiles: An integrated system of multi-informant assessment Burlington (p. 1617). University of Vermont. Research Center for Children, Youth, & Families.

American College of Obstetricians and Gynecologists. (2009). Practice Bulletin No. 107: Induction of Labor. Obstetrics and Gynecology, 114, 386–397.

Auyeung, B., Baron-Cohen, S., Wheelwright, S., & Allison, C. (2008). The autism spectrum quotient: Children’s version (AQ-Child). Journal of Autism and Developmental Disorders, 38(7), 1230–1240.

Belbasis, L., Savvidou, M. D., Kanu, C., Evangelou, E., & Tzoulaki, I. (2016). Birth weight in relation to health and disease in later life: An umbrella review of systematic reviews and meta-analyses. BMC Medicine, 14(1), 147. https://doi.org/10.1186/s12916-016-0692-5

Bhutta, A. T., Cleves, M. A., Casey, P. H., Cradock, M. M., & Anand, K. (2002). Cognitive and behavioral outcomes of school-aged children who were born preterm: A meta-analysis. Journal of the American Medical Association, 288(6), 728–737.

Brander, G., Rydell, M., Kuja-Halkola, R., de la Cruz, L. F., Lichtenstein, P., Serlachius, E., et al. (2016). Association of perinatal risk factors with obsessive-compulsive disorder: A population-based birth cohort, sibling control study. Journal of the American Medical Association: Psychiatry, 73(11), 1135–1144.

Burnett, A., Anderson, P., Cheong, J., Doyle, L., Davey, C., & Wood, S. (2011). Prevalence of psychiatric diagnoses in preterm and full-term children, adolescents and young adults: A meta-analysis. Psychological Medicine, 41(12), 2463–2474.

Caspi, A., & Moffitt, T. E. (2018). All for One and One for All: Mental Disorders in One Dimension. American Journal of Psychiatry, 175(9), 831–844. https://doi.org/10.1176/appi.ajp.2018.17121383

Class, Q. A., Rickert, M. E., Larsson, H., Lichtenstein, P., & D’Onofrio, B. M. (2014). Fetal growth and psychiatric and socioeconomic problems: Population-based sibling comparison. The British Journal of Psychiatry, 205(5), 355–361. https://doi.org/10.1192/bjp.bp.113.143693

Cross-Disorder Group of the Psychiatric Genomics Consortium. (2013). Identification of risk loci with shared effects on five major psychiatric disorders: A genome-wide analysis. The Lancet, 381(9875), 1371–1379. https://www.sciencedirect.com/science/article/pii/S0140673612621291#!

Curran, E. A., Cryan, J. F., Kenny, L. C., Dinan, T. G., Kearney, P. M., & Khashan, A. S. (2016). Obstetrical Mode of Delivery and Childhood Behavior and Psychological Development in a British Cohort. Journal of Autism and Developmental Disorders, 46(2), 603–614. https://doi.org/10.1007/s10803-015-2616-1

Davies, C., Segre, G., Estradé, A., Radua, J., De Micheli, A., Provenzani, U., et al. (2020). Prenatal and perinatal risk and protective factors for psychosis: A systematic review and meta-analysis. The Lancet Psychiatry, 7(5), 399–410. https://doi.org/10.1016/S2215-0366(20)30057-2

De Mola, C. L., De França, G. V. A., de Avila Quevedo, L., & Horta, B. L. (2014). Low birth weight, preterm birth and small for gestational age association with adult depression: Systematic review and meta-analysis. The British Journal of Psychiatry, 205(5), 340–347.

DiPietro, J. A., & Voegtline, K. M. (2017). The gestational foundation of sex differences in development and vulnerability. Neuroscience, 342, 4–20.

Engle, W. A., Tomashek, K. M., Wallman, C., & Committee on, F., & Newborn, A. A. o. P. . (2007). “Late-preterm” infants: A population at risk. Pediatrics, 120(6), 1390–1401. https://doi.org/10.1542/peds.2007-2952

Ficks, C. A., Lahey, B. B., & Waldman, I. D. (2013). Does low birth weight share common genetic or environmental risk with childhood disruptive disorders? Journal of Abnormal Psychology, 122(3), 842.

Garavan, H., Bartsch, H., Conway, K., Decastro, A., Goldstein, R., Heeringa, S., et al. (2018). Recruiting the ABCD sample: Design considerations and procedures. Developmental Cognitive Neuroscience, 32, 16–22.

Gargaro, B. A., Rinehart, N. J., Bradshaw, J. L., Tonge, B. J., & Sheppard, D. M. (2011). Autism and ADHD: How far have we come in the comorbidity debate? Neuroscience and Biobehavioral Reviews, 35(5), 1081–1088.

Gregory, S. G., Anthopolos, R., Osgood, C. E., Grotegut, C. A., & Miranda, M. L. (2013). Association of Autism With Induced or Augmented Childbirth in North Carolina Birth Record (1990–1998) and Education Research (1997–2007) Databases. JAMA Pediatrics, 167(10), 959–966. https://doi.org/10.1001/jamapediatrics.2013.2904

Groen-Blokhuis, M. M., Middeldorp, C. M., van Beijsterveldt, C. E., & Boomsma, D. I. (2011). Evidence for a causal association of low birth weight and attention problems. Journal of the American Academy of Child and Adolescent Psychiatry, 50(12), 1247-1254 e2. https://doi.org/10.1016/j.jaac.2011.09.007

Guastella, A. J., Cooper, M. N., White, C. R. H., White, M. K., Pennell, C. E., & Whitehouse, A. J. O. (2018). Does perinatal exposure to exogenous oxytocin influence child behavioural problems and autistic-like behaviours to 20 years of age? Journal of Child Psychology and Psychiatry, 59(12), 1323–1332. https://doi.org/10.1111/jcpp.12924

Hayward, D. A., Pomares, F., Casey, K. F., Ismaylova, E., Levesque, M., Greenlaw, K., et al. (2020). Birth weight is associated with adolescent brain development: A multimodal imaging study in monozygotic twins. Human Brain Mapping. https://doi.org/10.1002/hbm.25188

Heaman, M., Kingston, D., Chalmers, B., Sauve, R., Lee, L., & Young, D. (2013). Risk Factors for Preterm Birth and Small-for-gestational-age Births among C anadian Women. Paediatric and Perinatal Epidemiology, 27(1), 54–61.

Hill, A. B. (1965). The Environment and Disease: Association or Causation? Proceedings of the Royal Society of Medicine, 58(5), 295.

Howson, C. P., Kinney, M. V., McDougall, L., & Lawn, J. E. (2013). Born too soon: Preterm birth matters. Reproductive Health, 10(S1), S1.

Hultman, C. M., Torrang, A., Tuvblad, C., Cnattingius, S., Larsson, J. O., & Lichtenstein, P. (2007). Birth weight and attention-deficit/hyperactivity symptoms in childhood and early adolescence: A prospective Swedish twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 46(3), 370–377. https://doi.org/10.1097/01.chi.0000246059.62706.22

Jensen, C. M., & Steinhausen, H.-C. (2015). Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study. Attention Deficit and Hyperactivity Disorders, 7(1), 27–38.

Kariuki, S. M., Abubakar, A., Murray, E., Stein, A., & Newton, C. R. J. C. (2016). Evaluation of psychometric properties and factorial structure of the pre-school child behaviour checklist at the Kenyan Coast. Child and Adolescent Psychiatry and Mental Health, 10(1), 1. https://doi.org/10.1186/s13034-015-0089-9

Keskinen, E., Miettunen, J., Koivumaa-Honkanen, H., Mäki, P., Isohanni, M., & Jääskeläinen, E. (2013). Interaction between parental psychosis and risk factors during pregnancy and birth for schizophrenia—the Northern Finland 1966 Birth Cohort study. Schizophrenia Research, 145(1–3), 56–62.

Lahti, M., Eriksson, J., Heinonen, K., Kajantie, E., Lahti, J., Wahlbeck, K., et al. (2015). Late preterm birth, post-term birth, and abnormal fetal growth as risk factors for severe mental disorders from early to late adulthood. Psychological Medicine, 45(5), 985–999.

Lang, J. M., Lieberman, E., & Cohen, A. (1996). A comparison of risk factors for preterm labor and term small-for-gestational-age birth. Epidemiology, 369–376.

Laplante, F., Brake, W. G., Chehab, S. L., & Sullivan, R. M. (2012). Sex differences in the effects of perinatal anoxia on dopamine function in rats. Neuroscience Letters, 506(1), 89–93.

Larsen, J. K., Bendsen, B. B., Foldager, L., & Munk-Jørgensen, P. (2010). Prematurity and low birth weight as risk factors for the development of affective disorder, especially depression and schizophrenia: A register study. Acta Neuropsychiatrica, 22(6), 284–291.

Leyfer, O. T., Folstein, S. E., Bacalman, S., Davis, N. O., Dinh, E., Morgan, J., et al. (2006). Comorbid psychiatric disorders in children with autism: Interview development and rates of disorders. Journal of Autism and Developmental Disorders, 36(7), 849–861.

Lindström, K., Lindblad, F., & Hjern, A. (2009). Psychiatric morbidity in adolescents and young adults born preterm: A Swedish national cohort study. Pediatrics, 123(1), e47-53. https://doi.org/10.1542/peds.2008-1654

Liuhanen, J., Suvisaari, J., Kajantie, E., Miettunen, J., Sarin, A.-P., Järvelin, M.-R., et al. (2018). Interaction between compound genetic risk for schizophrenia and high birth weight contributes to social anhedonia and schizophrenia in women. Psychiatry Research, 259, 148–153.

MacDorman, M. F., Declercq, E., & Zhang, J. (2010). Obstetrical intervention and the singleton preterm birth rate in the United States from 1991–2006. American Journal of Public Health, 100(11), 2241–2247.

Martin, J. A., Hamilton, B. E., Sutton, P. D., Ventura, S. J., Mathews, T., Kirmeyer, S., et al. (2010). Births: final data for 2007.

Mathewson, K. J., Chow, C. H., Dobson, K. G., Pope, E. I., Schmidt, L. A., & Van Lieshout, R. J. (2017). Mental health of extremely low birth weight survivors: A systematic review and meta-analysis. Psychological Bulletin, 143(4), 347.

Mirza, M. A., Ritzel, R., Xu, Y., McCullough, L. D., & Liu, F. (2015). Sexually dimorphic outcomes and inflammatory responses in hypoxic-ischemic encephalopathy. Journal of Neuroinflammation, 12(1), 32. https://doi.org/10.1186/s12974-015-0251-6

Momany, A. M., Kamradt, J. M., & Nikolas, M. A. (2018). A Meta-Analysis of the Association Between Birth Weight and Attention Deficit Hyperactivity Disorder. Journal of Abnormal Child Psychology, 46(7), 1409–1426. https://doi.org/10.1007/s10802-017-0371-9

Momany, A. M., Kamradt, J. M., Ullsperger, J. M., Elmore, A. L., Nigg, J. T., & Nikolas, M. A. (2017). Sex moderates the impact of birth weight on child externalizing psychopathology. Journal of Abnormal Psychology, 126(2), 244–256. https://doi.org/10.1037/abn0000238

Murray, E., Matijasevich, A., Santos, I. S., Barros, A. J., Anselmi, L., Barros, F. C., et al. (2015). Sex differences in the association between foetal growth and child attention at age four: Specific vulnerability of girls. Journal of Child Psychology and Psychiatry, 56(12), 1380–1388.

Nosarti, C., Reichenberg, A., Murray, R. M., Cnattingius, S., Lambe, M. P., Yin, L., et al. (2012). Preterm birth and psychiatric disorders in young adult life. Archives of General Psychiatry, 69(6), E1-8. https://doi.org/10.1001/archgenpsychiatry.2011.1374

Oberg, A. S., D’Onofrio, B. M., Rickert, M. E., Hernandez-Diaz, S., Ecker, J. L., Almqvist, C., et al. (2016). Association of Labor Induction With Offspring Risk of Autism Spectrum Disorders. JAMA Pediatrics, 170(9), e160965–e160965. https://doi.org/10.1001/jamapediatrics.2016.0965

Ooi, Y. P., Rescorla, L., Ang, R. P., Woo, B., & Fung, D. S. (2011). Identification of autism spectrum disorders using the Child Behavior Checklist in Singapore. Journal of Autism and Developmental Disorders, 41(9), 1147–1156. https://doi.org/10.1007/s10803-010-1015-x

Pettersson, E., Larsson, H., D'Onofrio, B., Almqvist, C., & Lichtenstein, P. (2019). Association of Fetal Growth With General and Specific Mental Health Conditions. Journal of the American Medical Association: Psychiatry. https://doi.org/10.1001/jamapsychiatry.2018.4342

Pettersson, E., Sjölander, A., Almqvist, C., Anckarsäter, H., D’Onofrio, B. M., Lichtenstein, P., et al. (2015). Birth weight as an independent predictor of ADHD symptoms: A within-twin pair analysis. Journal of Child Psychology and Psychiatry, 56(4), 453–459.

Polderman, T. J., Derks, E. M., Hudziak, J. J., Verhulst, F. C., Posthuma, D., & Boomsma, D. I. (2007). Across the continuum of attention skills: A twin study of the SWAN ADHD rating scale. Journal of Child Psychology and Psychiatry, 48(11), 1080–1087.

R Core Team (2019). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. https://www.R-project.org/

Raju, T. N., Higgins, R. D., Stark, A. R., & Leveno, K. J. (2006). Optimizing care and outcome for late-preterm (near-term) infants: A summary of the workshop sponsored by the National Institute of Child Health and Human Development. Pediatrics, 118(3), 1207–1214.

Rao, P. A., & Landa, R. J. (2014). Association between severity of behavioral phenotype and comorbid attention deficit hyperactivity disorder symptoms in children with autism spectrum disorders. Autism, 18(3), 272–280.

Rice, F., Lewis, A., Harold, G., van den Bree, M., Boivin, J., Hay, D. F., et al. (2007). Agreement between maternal report and antenatal records for a range of pre and peri-natal factors: The influence of maternal and child characteristics. Early Human Development, 83(8), 497–504.

Selzam, S., Coleman, J. R. I., Caspi, A., Moffitt, T. E., & Plomin, R. (2018). A polygenic p factor for major psychiatric disorders. Translational Psychiatry, 8(1), 205. https://doi.org/10.1038/s41398-018-0217-4

Smith, A. L., Alexander, M., Rosenkrantz, T. S., Sadek, M. L., & Fitch, R. H. (2014). Sex differences in behavioral outcome following neonatal hypoxia ischemia: Insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic brain injury. Experimental Neurology, 254, 54–67. https://doi.org/10.1016/j.expneurol.2014.01.003

Smith, T. F., Schmidt-Kastner, R., McGeary, J. E., Kaczorowski, J. A., & Knopik, V. S. (2016). Pre- and Perinatal Ischemia-Hypoxia, the Ischemia-Hypoxia Response Pathway, and ADHD Risk. Behavior Genetics, 46(3), 467–477. https://doi.org/10.1007/s10519-016-9784-4

Spong, C. Y. (2013). Defining “term” pregnancy: Recommendations from the Defining “Term” Pregnancy Workgroup. Journal of the American Medical Association, 309(23), 2445–2446.

Tzoulaki, I., Jarvelin, M.-R., Hartikainen, A.-L., Leinonen, M., Pouta, A., Paldanius, M., et al. (2008). Size at birth, weight gain over the life course, and low-grade inflammation in young adulthood: Northern Finland 1966 Birth Cohort study. European Heart Journal, 29(8), 1049–1056.

Vu, H. D., Dickinson, C., & Kandasamy, Y. (2018). Sex difference in mortality for premature and low birth weight neonates: A systematic review. American Journal of Perinatology, 35(08), 707–715.

Wiles, N. J., Peters, T. J., Heron, J., Gunnell, D., Emond, A., & Lewis, G. (2006). Fetal growth and childhood behavioral problems: Results from the ALSPAC cohort. American Journal of Epidemiology, 163(9), 829–837. https://doi.org/10.1093/aje/kwj108

Yoshimasu, K., Barbaresi, W. J., Colligan, R. C., Voigt, R. G., Killian, J. M., Weaver, A. L., et al. (2012). Childhood ADHD is strongly associated with a broad range of psychiatric disorders during adolescence: A population-based birth cohort study. Journal of Child Psychology and Psychiatry, 53(10), 1036–1043.

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