Bipartite mechanism for laminin-integrin interactions: Identification of the integrin-binding site in LG domains of the laminin α chain

Pozzi, 2017, The nature and biology of basement membranes, Matrix Biol., 57–58, 1, 10.1016/j.matbio.2016.12.009 Yamada, 2015, Molecular basis of laminin-integrin interactions, Curr. Top. Membr., 76, 197, 10.1016/bs.ctm.2015.07.002 Hohenester, 2019, Structural biology of laminins, Essays Biochem., 63, 285, 10.1042/EBC20180075 Domogatskaya, 2012, Functional diversity of laminins, Annu. Rev. Cell Dev. Biol., 28, 523, 10.1146/annurev-cellbio-101011-155750 Takagi, 2007, Structural basis for ligand recognition by integrins, Curr. Opin. Cell Biol., 19, 557, 10.1016/j.ceb.2007.09.002 Mould, 2004, Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?, Curr. Opin. Cell Biol., 16, 544, 10.1016/j.ceb.2004.07.003 Ziober, 1993, Alternative extracellular and cytoplasmic domains of the integrin α7 subunit are differentially expressed during development, J. Biol. Chem., 268, 26773, 10.1016/S0021-9258(19)74380-4 Nishiuchi, 2006, Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant α3β1, α6β1, α7β1 and α6β4 integrins, Matrix Biol., 25, 189, 10.1016/j.matbio.2005.12.001 von der Mark, 2007, Distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of α7 integrins define specificity for laminin isoforms, J. Mol. Biol., 371, 1188, 10.1016/j.jmb.2007.05.074 Sonnenberg, 1990, Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that α6β1 but not α6β4 functions as a major receptor for fragment E8, J. Cell Biol., 110, 2145, 10.1083/jcb.110.6.2145 Ido, 2006, Probing the integrin-binding site within the globular domain of laminin-511 with the function-blocking monoclonal antibody 4C7, Matrix Biol., 25, 112, 10.1016/j.matbio.2005.10.003 Ido, 2007, The requirement of the glutamic acid residue at the third position from the carboxyl termini of the laminin γ chains in integrin binding by laminins, J. Biol. Chem., 282, 11144, 10.1074/jbc.M609402200 Ido, 2008, Laminin isoforms containing the γ3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the γ1 and γ2 chains, J. Biol. Chem., 283, 28149, 10.1074/jbc.M803553200 Kikkawa, 2007, The LG1-3 tandem of laminin α5 harbors the binding sites of Lutheran/basal cell adhesion molecule and α3β1/α6β1 integrins, J. Biol. Chem., 282, 14853, 10.1074/jbc.M611706200 Xiong, 2002, Crystal structure of the extracellular segment of integrin αVβ3 in complex with an Arg-Gly-Asp ligand, Science, 296, 151, 10.1126/science.1069040 Emsley, 2000, Structural basis of collagen recognition by integrin α2β1, Cell, 101, 47, 10.1016/S0092-8674(00)80622-4 Pulido, 2017, Crystal structure of the heterotrimeric integrin-binding region of laminin-111, Structure, 25, 530, 10.1016/j.str.2017.01.002 Takizawa, 2017, Mechanistic basis for the recognition of laminin-511 by α6β1 integrin, Sci. Adv., 3, 10.1126/sciadv.1701497 Delwel, 1995, An alternatively spliced exon in the extracellular domain of the human α6 integrin subunit-functional analysis of the α6 integrin variants, Cell Adhes. Commun., 3, 143, 10.3109/15419069509081283 Humphries, 2003, Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble, Trends Biochem. Sci., 28, 313, 10.1016/S0968-0004(03)00112-9 Taniguchi, 2017, Probing the acidic residue within the integrin binding site of laminin-511 that interacts with the metal ion-dependent adhesion site of α6β1 integrin, Biochem. Biophys. Res. Commun., 487, 525, 10.1016/j.bbrc.2017.04.051 Takagi, 2004, Structural basis for ligand recognition by RGD (Arg-Gly-Asp)-dependent integrins, Biochem. Soc. Trans., 32, 403, 10.1042/bst0320403 Takagi, 2003, Structure of integrin α5β1 in complex with fibronectin, EMBO J., 22, 4607, 10.1093/emboj/cdg445 Mould, 2003, Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis, J. Biol. Chem., 278, 39993, 10.1074/jbc.M304627200 Nagae, 2012, Crystal structure of α5β1 integrin ectodomain: atomic details of the fibronectin receptor, J. Cell Biol., 197, 131, 10.1083/jcb.201111077 Sato, 2009, Molecular basis of the recognition of nephronectin by integrin α8β1, J. Biol. Chem., 284, 14524, 10.1074/jbc.M900200200 Taniguchi, 2009, The C-terminal region of laminin β chains modulates the integrin binding affinities of laminins, J. Biol. Chem., 284, 7820, 10.1074/jbc.M809332200 Takagi, 2001, C-terminal opening mimics 'inside-out' activation of integrin α5β1, Nat. Struct. Biol., 8, 412, 10.1038/87569 Madeira, 2019, The EMBL-EBI search and sequence analysis tools APIs in 2019, Nucleic Acids Res., 47, W636, 10.1093/nar/gkz268