Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective

Petrovska, 2012, Historical review of medicinal plants’ usage, Pharmacog. Rev., 6, 1, 10.4103/0973-7847.95849 Wannes, 2016, Research progress of Tunisian medicinal plants used for acute diabetes, J. Acute Dis., 5, 357, 10.1016/j.joad.2016.08.001 Prashantkumar, 2013 Anand, 2017, Phytonanotherapy for management of diabetes using green synthesis nanoparticles, J. Photochem. Photobiol. B: Biol., 173, 626, 10.1016/j.jphotobiol.2017.06.028 Zelickson, 2011, Helicobacter pylori is not the predominant etiology for peptic ulcers requiring operation, Am. Surg., 77, 1054, 10.1177/000313481107700827 Chung, 2017, Perforated peptic ulcer-an update, World J. Gastrointest. Surg., 9, 1, 10.4240/wjgs.v9.i1.1 Mehta, 2016, Ulcer-review on types, anti-ulcer drugs, anti-ulcer medicinal plants, anti-ulcer drug market, diagnostics and current global clinical trials status, Invent. Rapid Pharm. Pract., 2, 1 Kalant, 2007 Malagelada, 2007 Ferreira, 2010, Mechanisms of the gastric antiulcerogenic activity of Anacardium humile St. Hil on ethanol-induced acute gastric mucosal injury in rats, Molecules, 15, 7153, 10.3390/molecules15107153 Thirunavukkarasu, 2009, Antiulcer activity of Excoecaria agallocha bark on NSAID-induced gastric ulcer in albino rats, Glob. J. Pharmacol., 3, 123 Muralidhar, 2009, Cytoprotective effect of ulgen a polyherbal formulation against physical and chemical factor induced gastric ulcers in Wister albino rats, Am. J. Pharmacol. Toxicol., 4, 80, 10.3844/ajptsp.2009.80.84 de Carvalho, 2010, Antiulcer activity of ethanolic extract of Encholirium spectabile Mart. ex Schult & Schult f. (Bromeliaceae) in rodents, Biol Res., 43, 459, 10.4067/S0716-97602010000400011 Almeida, 2011, Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil in animal models, J. Ethnophar., 12, 630, 10.1016/j.jep.2011.01.009 Arun, 2010, Anti-ulcerogenic and ulcer healing effects of Zingiber officinale (L.) on experimental ulcer models: possible mechanism for the inhibition of acid formation, Int. J. Pharm. Res., 1, 75 Sutar, 2011, Antiulcerogenic activity of Saussurea lappa root, Int. J. Pharm. Life Sci., 2, 516 Jadhav, 2011, Evaluation of antiulcer activity of Zizyphus oenoplia (L) Mill. Root in rats, Asian J. Pharmaceut. Clin. Res., 4, 92 Londonkar, 2010, Antiulcerogenic study of different extracts of Butea frondosa Roxb in albino mice, J. Pharmacog., 1, 6 Okokon, 2009, Antiulcerogenic activity of ethanolic leaf extract of Lasianthera Africana, Afr. J. Tradit. Compl. Altern. Med., 6, 150 Jain, 2009, Antiulcerogenic effects of Gymnosporia rothiana (Celastraceae) against different experimental models, Pharmacog. Mag., 5, 100 Mazumder, 2008, Antiulcerogenic and antioxidant effects of Coccinia granids (Linn.) Voigt leaves on aspirin-induced gastric ulcer in rats, Nat. Prod. Rad., 7, 15 Minaiyan, 2005, Antiulcerogenic effect of Zataria multiflora boiss. On cysteamine induced duodenal ulcer in rats, Iran. J. Pharm. Sci., 1, 223 Fernandes, 2010, Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. Leaves against acute gastric lesion models in rodents, Biol. Res., 43, 451, 10.4067/S0716-97602010000400010 Ligha, 2009, Protection by liquorice in alcohol induced gastric mucosa damage, Pak. J. Nutr., 8, 1532, 10.3923/pjn.2009.1532.1536 Ologundudu, 2008, The anti-ulcerogenic activity of aqueous extract of carica papaya fruit on aspirin—induced ulcer in rats, Int. J. Toxicol., 5, 2 Raju, 2009, Evaluation of antiulcer activity of methanolic extract of Terminalia chebula fruits in experimental rats, J. Pharm. Sci. Res., 1, 101 Bighettia, 2005, Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip, Phytomedicine, 12, 72, 10.1016/j.phymed.2003.09.006 Nwafor, 2005, Antiulcerogenic and antidiarrhoeal potentials of methanolic extract of Pausinystalia macroceras stem-bark in rats, Nig. J. Nat. Prod. Med., 9, 63 Garcia-Barrantes, 2011, Anti-ulcerogenic properties of Quassia amara L (Simaroubaceae) standardized extracts in rodent models, J. Ethnophar., 12, 904, 10.1016/j.jep.2011.01.052 Karbalay-Doust, 2009, Antiulcerogenic effects of Matricaria chamomilla extract in experimental gastric ulcer in mice, Iran. J. Med. Sci., 34, 198 Molina, 2005, Therapeutic effect of D-002 (Abexol) on gastric ulcer induced experimentally in rats, J. Med. Food, 8, 59, 10.1089/jmf.2005.8.59 Sa´nchez, 2010, Pharmacological and toxicological evaluation of Rhizophora mangle L, as a potential antiulcerogenic drug: chemical composition of active extract, J. Pharmacog. Phytother., 2, 56 Londonkar, 2009, Studies on activity of various extracts of Mentha arvensis Linn. against drug induced gastric ulcer in mammals, World J. Gastrointest. Oncol., 1, 82, 10.4251/wjgo.v1.i1.82 Malairajan, 2008, Evaluation of anti-ulcer activity of Polyalthia longifolia (Sonn) Thwaites in experimental animals, Ind. J. Pharmacol., 40, 126, 10.4103/0253-7613.42306 Sanmugapriya, 2007, Antiulcerogenic potential of Strychnos potatorum Linn seeds on aspirin plus pyloric ligation-induced ulcers in experimental rats, Int. J. Phytother. Phytopharmacol., 14, 360 Awaad, 2006, Antiulcerogenic activity of Alhagi maurorum, Pharm. Biol., 44, 292, 10.1080/13880200600714160 Cola-Miranda, 2006, Antiulcerogenic activity of Indigofera truxillensis Kunth, Biota Neotropica, 6, 10.1590/S1676-06032006000300004 Coelho, 2006, Phytochemical study and antiulcerogenic activity of Syngonanthus bisulcatus (Eriocaulaceae), Braz. J. Pharm. Sci., 42, 413 Wahida, 2007, Antiulcerogenic activity of Zizyphus lotus (L.) extracts, J. Ethnopharmacol., 112, 228, 10.1016/j.jep.2007.02.024 Anosike, 2010, Anti-inflammatory and antiulcerogenic effect of ethanol extract of coconut (Cocos nucifera) on experimental rats, Afr. J. Food Agri. Nutr. Dev., 10, 4286 Shanthi, 2010, Antiulcerogenic activities of the methanolic extract of Cissus quadrangularis in wistar, Int. J. Toxicol., 7, 1559 Mahmood, 2010, Anti-ulcerogenic activity of Gynura procumbens leaf extract against experimentally-induced gastric lesions in rats, J. Med. Plants Res., 4, 685 Sachin, 2009, Antiulcer activity of methanol extract of Erythrina indica lam. Leaves in experimental animals, Pharmacog. Res., 1, 396 Hiruma-Lima, 2009, Antiulcerogenic action of ethanolic extract of the resin from Virola surinamensis Warb. (Myristicaceae), J. Ethnophar., 122, 406, 10.1016/j.jep.2008.12.023 Nunes, 2009, Antiulcerogenic activity of Combretum leprosum, Pharmazie, 64, 58 Jain, 2009, Antiulcerogenic effects of Spathodea falcata against different experimental models, Asian J. Pharm. Clin. Res., 2, 54 Abdulla, 2009, Evaluation of the anti-ulcer activities of Morus alba extracts in experimentally-induced gastric ulcer in rats, Biomed. Res., 20, 35 Chatterjee, 2014, l-theanine healed NSAID-induced gastric ulcer by modulating pro/antioxidant balance in gastric ulcer margin, J. Nat. Med., 68, 699, 10.1007/s11418-014-0852-x Khanavi, 2012, Pharmacological and histological effects of Centaurea bruguierana ssp. belangerana on indomethacin-induced peptic ulcer in rats, J. Nat. Med., 66, 343, 10.1007/s11418-011-0598-7 Mahattanadul, 2006, Effects of curcumin on reflux esophagitis in rats, J. Nat. Med., 60, 198, 10.1007/s11418-006-0036-4 Xiao, 2002, Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice, J. Clin. Invest., 110, 955, 10.1172/JCI0215918 Ohsaki, 1999, Microanalysis of a selective potent anti-Helicobacter pylori compound in a Brazilian medicinal plant Myroxylon peruiferum and the activity of analogues, Bioorg. Med. Chem. Lett., 9, 1109, 10.1016/S0960-894X(99)00141-9 Fukai, 2002, Anti-Helicobacter pylori flavonoids from Licorice extract, Life Sci., 71, 1449, 10.1016/S0024-3205(02)01864-7 Li, 2005, In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases, J. Ethnophar., 98, 329, 10.1016/j.jep.2005.01.020 Yang, 1997, Genetic analysis of the cytotoxin-associated gene and the vacuolating toxin gene in Helicobacter pylori strains isolated from Taiwanese patients, Am. J. Gastroenterol., 92 Matsuda, 2003, Effects of sesquiterpenes and amino acid-sesquiterpene conjugates from the roots of Saussurea lappa on inducible nitric oxide synthase and heat shock protein in lipopolysaccharide-activated macrophages, Bioorg. Med. Chem., 11, 709, 10.1016/S0968-0896(02)00471-6 Cowan, 1999, Plant products as antimicrobial agents, Clin. Microbiol. Rev., 12, 564, 10.1128/CMR.12.4.564 Park, 1997, Anti-Helicobacter pylori effect of costunolide isolated from the stem bark of Magnolia sieboldii, Arch. Pharm. Res., 20, 275, 10.1007/BF02976157 Ohta, 1999, In vitro inhibition of the growth of Helicobacter pylori by oil-macerated garlic constituents, Antimicrob. Agents Chemother., 43, 1811, 10.1128/AAC.43.7.1811 Gadhi, 1999, Antibacterial activity of Aristolochia paucinervis Pomel, J. Ethnophar., 67, 87, 10.1016/S0378-8741(98)00212-8 Adesanwo, 2009, Antisecretory and antiulcerogenic activities of the stem bark extract of Melaleuca bracteata and isolation of principles, J. Med. Plants Res., 3, 822 Agrawal, 2010, Anti-ulcer activity of Smithia conferta in various animal, J. Saudi Chem. Soc., 14, 307, 10.1016/j.jscs.2010.04.011 Dias, 2012, A historical overview of natural products in drug discovery, Metabolites, 2, 303, 10.3390/metabo2020303 Ota, 2017, An overview of herbal products and secondary metabolites used for management of type two diabetes, Front. Pharmacol., 8, 10.3389/fphar.2017.00436 Vilar, 2017, Molecular docking and drug discovery in β-adrenergic receptors, Curr. Med. Chem., 24, 4340, 10.2174/0929867324666170724101448 Adamsson, 2017, Gastric expression of IL-17A and IFNγ in Helicobacter pylori infected individuals is related to symptoms, Cytok, 99, 30, 10.1016/j.cyto.2017.06.013 Jaiswal, 2014, A comparative tissue-specific metabolite analysis and determination of protodioscin content in Asparagus species used in traditional Chinese medicine and ayurveda by use of laser microdissection UHPLC–QTOF/MS and LC–MS/MS, Phytochem. Anal., 25, 514, 10.1002/pca.2522