Ma trận nhạy cảm sinh học trong việc phân phối thuốc
Tóm tắt
Trong nhiều năm qua, lĩnh vực phân phối thuốc đã tập trung vào (1) kiểm soát sự giải phóng của một liệu pháp và (2) nhắm mục tiêu liệu pháp đến một loại tế bào cụ thể. Những nỗ lực nghiên cứu này chủ yếu tập trung vào việc phát triển các polyme phân hủy mới và các phương tiện phân phối thuốc có gắn phân tử. Sự quan tâm gần đây đối với các vật liệu sinh học phản ứng với môi trường đã mở ra những phương pháp mới để kích hoạt sự giải phóng thuốc và định vị liệu pháp tại một vị trí cụ thể. Những vật liệu sinh học mới này, thường được gọi là "thông minh" hoặc "thông dụng", có khả năng phân phối một tác nhân liệu pháp dựa trên các tín hiệu từ môi trường hoặc kích thích từ xa. Các vật liệu nhạy cảm với kích thích có thể tạo ra một liều liệu pháp có hiệu quả mà không có tác dụng phụ không mong muốn. Các polyme phản ứng với các kích thích khác nhau, chẳng hạn như pH, ánh sáng, nhiệt độ, siêu âm, từ tính, hoặc các phân tử sinh học đã được nghiên cứu như là những phương tiện tiềm năng cho việc phân phối thuốc. Bài đánh giá này mô tả những tiến bộ gần đây nhất trong các hệ thống phân phối thuốc "thông minh" phản ứng với một hoặc nhiều kích thích.
Từ khóa
Tài liệu tham khảo
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