Biology of Acinetobacter baumannii: Pathogenesis, Antibiotic Resistance Mechanisms, and Prospective Treatment Options
Tóm tắt
Từ khóa
Tài liệu tham khảo
Acosta, 2011, Multidrug-resistant Acinetobacter baumannii Harboring OXA-24 carbapenemase, Spain, Emerg. Infect Dis., 17, 1064, 10.3201/eid/1706.091866
Adams, 2008, Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii, J. Bacteriol., 190, 8053, 10.1128/JB.00834-08
Adams, 2009, Resistance to colistin in Acinetobacter baumannii associated with mutations in the PmrAB two-component system, Antimicrob. Agents Chemother., 53, 3628, 10.1128/AAC.00284-09
Afzal-Shah, 2001, Characterization of OXA-25, OXA-26, and OXA-27, molecular class D β-lactamases associated with carbapenem resistance in clinical isolates of Acinetobacter baumannii, Antimicrob. Agents Chemother., 45, 583, 10.1128/AAC.45.2.583-588.2001
Al-Agamy, 2016, First Detection of GES-5 Carbapenemase-Producing Acinetobacter baumannii Isolate, Microb. Drug Resist, 10.1089/mdr.2016.0152
Al Atrouni, 2016, Wide spread of OXA-23-producing carbapenem-resistant Acinetobacter baumannii belonging to clonal complex II in different hospitals in Lebanon, Int. J. Infect. Dis., 52, 29, 10.1016/j.ijid.2016.09.017
Aly, 2016, High prevalence of the PER-1 gene among carbapenem-resistant Acinetobacter baumannii in Riyadh, Saudi Arabia, Eur. J. Clin. Microbiol. Infect Dis., 35, 1759, 10.1007/s10096-016-2723-8
Anthony, 2008, Clinical and microbiological outcomes of serious infections with multidrug-resistant gram-negative organisms treated with tigecycline, Clin. Infect. Dis., 46, 567, 10.1086/526775
Antunes, 2011, Deciphering the multifactorial nature of Acinetobacter baumannii pathogenicity, PLoS ONE, 6, e22674, 10.1371/journal.pone.0022674
Antunes, 2012, In vitro and in vivo antimicrobial activities of gallium nitrate against multidrug-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 56, 5961, 10.1128/AAC.01519-12
Aranda, 2011, Acinetobacter baumannii RecA protein in repair of DNA damage, antimicrobial resistance, general stress response, and virulence, J. Bacteriol., 193, 3740, 10.1128/JB.00389-11
Aranda, 2014, Role of Acinetobacter baumannii UmuD homologs in antibiotic resistance acquired through DNA damage-induced mutagenesis, Antimicrob. Agents Chemother., 58, 1771, 10.1128/AAC.02346-13
Arivett, 2015, Antimicrobial activity of Gallium Protoporphyrin IX against Acinetobacter baumannii strains displaying different antibiotic resistance phenotypes, Antimicrob. Agents Chemother., 59, 7657, 10.1128/AAC.01472-15
Arroyo, 2011, The pmrCAB operon mediates polymyxin resistance in Acinetobacter baumannii ATCC 17978 and clinical isolates through phosphoethanolamine modification of lipid A, Antimicrob. Agents Chemother., 55, 3743, 10.1128/AAC.00256-11
Asahara, 2016, Protective effect of a synbiotic against multidrug-resistant Acinetobacter baumannii in a Murine Infection Model, Antimicrob. Agents Chemother., 60, 3041, 10.1128/AAC.02928-15
Aydemir, 2013, Colistin vs. the combination of colistin and rifampicin for the treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia, Epidemiol. Infect., 141, 1214, 10.1017/S095026881200194X
Bae, 2016, In vitro synergistic activity of antimicrobial agents in combination against clinical isolates of colistin-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 6774, 10.1128/AAC.00839-16
Bakour, 2014, Characterization of Acinetobacter baumannii clinical isolates carrying blaOXA-23carbapenemase and 16S rRNA methylase armA genes in Yemen, Microb. Drug Resist., 20, 604, 10.1089/mdr.2014.0018
Barksdale, 2016, Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii, BMC Microbiol., 16, 189, 10.1186/s12866-016-0799-z
Basler, 2013, Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions, Cell, 152, 884, 10.1016/j.cell.2013.01.042
Bassetti, 2008, Colistin and rifampicin in the treatment of multidrug-resistant Acinetobacter baumannii infections, J. Antimicrob. Chemother., 61, 417, 10.1093/jac/dkm509
Batirel, 2014, Comparison of colistin-carbapenem, colistin-sulbactam, and colistin plus other antibacterial agents for the treatment of extremely drug-resistant Acinetobacter baumannii bloodstream infections, Eur. J. Clin. Microbiol. Infect. Dis., 33, 1311, 10.1007/s10096-014-2070-6
Beceiro, 2011, Phosphoethanolamine modification of lipid A in colistin-resistant variants of Acinetobacter baumannii mediated by the pmrAB two-component regulatory system, Antimicrob. Agents Chemother., 55, 3370, 10.1128/AAC.00079-11
Beceiro, 2013, Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?, Clin. Microbiol. Rev., 26, 185, 10.1128/CMR.00059-12
Bentancor, 2012a, Identification of Ata, a multifunctional trimeric autotransporter of Acinetobacter baumannii, J. Bacteriol., 194, 3950, 10.1128/JB.06769-11
Bentancor, 2012b, Evaluation of the trimeric autotransporter Ata as a vaccine candidate against Acinetobacter baumannii infections, Infect. Immun., 80, 3381, 10.1128/IAI.06096-11
Bergogne-Berezin, 1996, Acinetobacter spp. as nosocomial pathogens: microbiological, clinical, and epidemiological features, Clin. Microbiol Rev, 9, 148, 10.1128/CMR.9.2.148
Bernstein, 1998, Mechanisms of therapeutic activity for gallium, Pharmacol. Rev, 50, 665
Bhuiyan, 2016, Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis, Proc. Natl. Acad. Sci. U.S.A., 113, 9599, 10.1073/pnas.1523116113
Biancofiore, 2007, Colistin, meropenem and rifampin in a combination therapy for multi-drug-resistant Acinetobacter baumannii multifocal infection. A case report, Minerva. Anestesiol, 73, 181
Biglari, 2016, Antimicrobial resistance mechanisms and genetic diversity of multidrug-resistant Acinetobacter baumannii isolated from a teaching hospital in Malaysia, Microb. Drug Resist, 10.1089/mdr.2016.0130
Blanchard, 2014, Identification of Acinetobacter baumannii serum-associated antibiotic efflux pump inhibitors, Antimicrob. Agents Chemother., 58, 6360, 10.1128/AAC.03535-14
Bogaerts, 2010, GES extended-spectrum β-lactamases in Acinetobacter baumannii isolates in Belgium, Antimicrob. Agents Chemother., 54, 4872, 10.1128/AAC.00871-10
Boll, 2015, Reinforcing lipid A acylation on the cell surface of Acinetobacter baumannii promotes cationic antimicrobial peptide resistance and desiccation survival, MBio, 6, e00478, 10.1128/mBio.00478-15
Bonnin, 2011a, Genetic diversity of carbapenem-hydrolysing β-lactamases in Acinetobacter baumannii from Romanian hospitals, Clin. Microbiol. Infect., 17, 1524, 10.1111/j.1469-0691.2011.03622.x
Bonnin, 2012, Dissemination of New Delhi metallo-β-lactamases-1-producing Acinetobacter baumannii in Europe, Clin. Microbiol. Infect., 18, E362, 10.1111/j.1469-0691.2012.03928.x
Bonnin, 2011b, PER-7, an extended-spectrum β-lactamases with increased activity toward broad-spectrum cephalosporins in Acinetobacter baumannii, Antimicrob. Agents Chemother., 55, 2424, 10.1128/AAC.01795-10
Borgeaud, 2015, The type VI secretion system of Vibrio cholerae fosters horizontal gene transfer, Science., 347, 63, 10.1126/science.1260064
Bou, 2000a, Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of β-lactamases, J. Clin. Microbiol, 38, 3299, 10.1128/JCM.38.9.3299-3305.2000
Bou, 2000, Cloning, nucleotide sequencing, and analysis of the gene encoding an AmpC β-lactamases in Acinetobacter baumannii, Antimicrob. Agents Chemother, 44, 428, 10.1128/AAC.44.2.428-432.2000
Bou, 2000b, OXA-24, a novel class D β-lactamases with carbapenemase activity in an Acinetobacter baumannii clinical strain, Antimicrob. Agents Chemother, 44, 1556, 10.1128/AAC.44.6.1556-1561.2000
Boucher, 2009, Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America, Clin. Infect. Dis., 48, 1, 10.1086/595011
Bowler, 2016, In vitro activity of fusidic acid-containing combinations against carbapenem-resistant Acinetobacter baumannii clinical strains, Antimicrob. Agents Chemother., 60, 5101, 10.1128/AAC.01124-16
Briers, 2014, Engineered endolysin-based “Artilysins” to combat multidrug-resistant gram-negative pathogens, MBio, 5, e01379, 10.1128/mBio.01379-14
Brigante, 2012, Emergence and spread of a multidrug-resistant Acinetobacter baumannii clone producing both the carbapenemase OXA-23 and the 16S rRNA methylase ArmA, J. Med. Microbiol., 61, 653, 10.1099/jmm.0.040980-0
Brown, 2005, Characterisation of OXA-51, a novel class D carbapenemase found in genetically unrelated clinical strains of Acinetobacter baumannii from Argentina, Clin. Microbiol. Infect., 11, 15, 10.1111/j.1469-0691.2004.01016.x
Cai, 2012, Colistin resistance of Acinetobacter baumannii: clinical reports, mechanisms and antimicrobial strategies, J. Antimicrob. Chemother., 67, 1607, 10.1093/jac/dks084
Camarena, 2010, Molecular mechanisms of ethanol-induced pathogenesis revealed by RNA-sequencing, PLoS Pathog., 6, e1000834, 10.1371/journal.ppat.1000834
Candel, 2010, A combination of tigecycline, colistin, and meropenem against multidrug-resistant Acinetobacter baumannii bacteremia in a renal transplant recipient: pharmacodynamic and microbiological aspects, Rev. Esp. Quimioter, 23, 103
Cannon, 2014, The risk of seizures among the carbapenems: a meta-analysis, J. Antimicrob. Chemother., 69, 2043, 10.1093/jac/dku111
Carruthers, 2013, Acinetobacter baumannii utilizes a type VI secretion system for bacterial competition, PLoS ONE, 8, e59388, 10.1371/journal.pone.0059388
Castanheira, 2014, Update on Acinetobacter species: mechanisms of antimicrobial resistance and contemporary in vitro activity of minocycline and other treatment options, Clin. Infect. Dis, 59, S367, 10.1093/cid/ciu706
Catel-Ferreira, 2011, Structure-function relationships of CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii, J. Antimicrob. Chemother., 66, 2053, 10.1093/jac/dkr267
Centers for Disease Prevention, 2004, Acinetobacter baumannii infections among patients at military medical facilities treating injured U.S. service members, 2002–2004, MMWR Morb. Mortal. Wkly. Rep, 53, 1063
Cerqueira, 2014, A global virulence regulator in Acinetobacter baumannii and its control of the phenylacetic acid catabolic pathway, J. Infect. Dis., 210, 46, 10.1093/infdis/jiu024
Chagas, 2014, Characterization of carbapenem-resistant Acinetobacter baumannii in Brazil (2008-2011): countrywide spread of OXA-23-producing clones (CC15 and CC79), Diagn. Microbiol. Infect. Dis., 79, 468, 10.1016/j.diagmicrobio.2014.03.006
Chang, 2005, Species-level identification of isolates of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex by sequence analysis of the 16S-23S rRNA gene spacer region, J. Clin. Microbiol., 43, 1632, 10.1128/JCM.43.4.1632-1639.2005
Chang, 2012, Clonal spread of multidrug-resistant Acinetobacter baumannii in eastern Taiwan, J. Microbiol. Immunol. Infect., 45, 37, 10.1016/j.jmii.2011.09.019
Cheah, 2016, Colistin and polymyxin B dosage regimens against Acinetobacter baumannii: differences in activity and the emergence of resistance, Antimicrob. Agents Chemother., 60, 3921, 10.1128/AAC.02927-15
Chen, 2006, Predictive biomarkers for drug-resistant Acinetobacter baumannii isolates with blaTEM-1, AmpC-type bla and integrase 1 genotypes, J. Microbiol. Immunol. Infect, 39, 372
Chen, 2014, Decreased susceptibility to tigecycline in Acinetobacter baumannii mediated by a mutation in trm encoding SAM-dependent methyltransferase, J. Antimicrob. Chemother., 69, 72, 10.1093/jac/dkt319
Chen, 2010, Emergence and distribution of plasmids bearing the blaOXA-51-like gene with an upstream ISAba1 in carbapenem-resistant Acinetobacter baumannii isolates in Taiwan, Antimicrob. Agents Chemother., 54, 4575, 10.1128/AAC.00764-10
Chen, 2008, Acquisition of a plasmid-borne blaOXA-58 gene with an upstream IS1008 insertion conferring a high level of carbapenem resistance to Acinetobacter baumannii, Antimicrob. Agents Chemother., 52, 2573, 10.1128/AAC.00393-08
Chen, 2011, Emergence of NDM-1-producing Acinetobacter baumannii in China, J. Antimicrob. Chemother., 66, 1255, 10.1093/jac/dkr082
Chihi, 2016, GES-11-producing Acinetobacter baumannii clinical isolates from Tunisian hospitals: long-term dissemination of GES-type carbapenemases in North Africa, J. Glob. Antimicrob. Resist., 5, 47, 10.1016/j.jgar.2016.03.005
Chin, 2015, A PmrB-regulated deacetylase required for lipid A modification and polymyxin resistance in Acinetobacter baumannii, Antimicrob. Agents Chemother., 59, 7911, 10.1128/AAC.00515-15
Chiu, 2016, In vitro activity of SecA inhibitors in combination with carbapenems against carbapenem-hydrolysing class D β-lactamase-producing Acinetobacter baumannii, J. Antimicrob. Chemother., 71, 3441, 10.1093/jac/dkw331
Cho, 2009, Genetic basis of resistance to aminoglycosides in Acinetobacter spp. and spread of armA in Acinetobacter baumannii sequence group 1 in Korean hospitals, Diagn. Microbiol. Infect. Dis, 64, 185, 10.1016/j.diagmicrobio.2009.02.010
Choi, 2008a, Acinetobacter baumannii outer membrane protein A targets the nucleus and induces cytotoxicity, Cell. Microbiol., 10, 309, 10.1111/j.1462-5822.2007.01041.x
Choi, 2005, Outer membrane protein 38 of Acinetobacter baumannii localizes to the mitochondria and induces apoptosis of epithelial cells, Cell Microbiol., 7, 1127, 10.1111/j.1462-5822.2005.00538.x
Choi, 2008b, Acinetobacter baumannii invades epithelial cells and outer membrane protein A mediates interactions with epithelial cells, BMC Microbiol., 8, 216, 10.1186/1471-2180-8-216
Chu, 2001, IMP-4, a novel metallo-β-lactamase from nosocomial Acinetobacter spp. collected in Hong Kong between 1994 and 1998, Antimicrob. Agents Chemother, 45, 710, 10.1128/AAC.45.3.710-714.2001
Chung, 2016, Combination therapy with polymyxin B and netropsin against clinical isolates of multidrug-resistant Acinetobacter baumannii, Sci. Rep., 6, 28168, 10.1038/srep28168
Cirioni, 2016, Colistin enhances therapeutic efficacy of daptomycin or teicoplanin in a murine model of multiresistant Acinetobacter baumannii sepsis, Diagn. Microbiol. Infect. Dis., 86, 392, 10.1016/j.diagmicrobio.2016.09.010
Cirz, 2007, Controlling mutation: intervening in evolution as a therapeutic strategy, Crit. Rev. Biochem. Mol. Biol., 42, 341, 10.1080/10409230701597741
Cisneros, 2002, Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment, Clin. Microbiol. Infect, 8, 687, 10.1046/j.1469-0691.2002.00487.x
Clemmer, 2011, Genetic analysis of surface motility in Acinetobacter baumannii, Microbiology, 157, 2534, 10.1099/mic.0.049791-0
Corbin, 2008, Metal chelation and inhibition of bacterial growth in tissue abscesses, Science, 319, 962, 10.1126/science.1152449
Cordoba, 2015, In vitro activities of novel antimicrobial combinations against extensively drug-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 59, 7316, 10.1128/AAC.00493-15
Corvec, 2003, AmpC cephalosporinase hyperproduction in Acinetobacter baumannii clinical strains, J. Antimicrob. Chemother., 52, 629, 10.1093/jac/dkg407
Corvec, 2007, Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA−23 in Acinetobacter baumannii, Antimicrob. Agents Chemother., 51, 1530, 10.1128/AAC.01132-06
Coyne, 2011, Efflux-mediated antibiotic resistance in Acinetobacter spp, Antimicrob. Agents Chemother., 55, 947, 10.1128/AAC.01388-10
Coyne, 2010, Overexpression of resistance-nodulation-cell division pump AdeFGH confers multidrug resistance in Acinetobacter baumannii, Antimicrob. Agents Chemother., 54, 4389, 10.1128/AAC.00155-10
Croxatto, 2012, Applications of MALDI-TOF mass spectrometry in clinical diagnostic microbiology, FEMS Microbiol. Rev., 36, 380, 10.1111/j.1574-6976.2011.00298.x
Curcio, 2008, Tigecycline for Acinetobacter baumannii infection: other considerations, Clin. Infect. Dis, 46, 1797, 10.1086/588051
Damier-Piolle, 2008, AdeIJK, a resistance-nodulation-cell division pump effluxing multiple antibiotics in Acinetobacter baumannii, Antimicrob. Agents Chemother., 52, 557, 10.1128/AAC.00732-07
Davison, 2016, Diversity in a polymicrobial community revealed by analysis of viromes, endolysins and CRISPR spacers, PLoS ONE, 11, e0160574, 10.1371/journal.pone.0160574
de Breij, 2010, Do biofilm formation and interactions with human cells explain the clinical success of Acinetobacter baumannii?, PLoS ONE, 5, e10732, 10.1371/journal.pone.0010732
Defraine, 2016, Efficacy of artilysin Art-175 against resistant and persistent Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 3480, 10.1128/AAC.00285-16
del Mar Tomas, 2005, Cloning and functional analysis of the gene encoding the 33- to 36-kilodalton outer membrane protein associated with carbapenem resistance in Acinetobacter baumannii, Antimicrob. Agents Chemother., 49, 5172, 10.1128/AAC.49.12.5172-5175.2005
Deng, 2014, Molecular epidemiology and mechanisms of tigecycline resistance in clinical isolates of Acinetobacter baumannii from a Chinese university hospital, Antimicrob. Agents Chemother., 58, 297, 10.1128/AAC.01727-13
de Sa Cavalcanti, 2016, High frequency of OXA-253-producing Acinetobacter baumannii in different hospitals in Recife, Brazil: a new threat?, Antimicrob. Agents Chemother., 61, e01309, 10.1128/AAC.01309-16
Dhabaan, 2015, Imipenem treatment induces expression of important genes and phenotypes in a resistant Acinetobacter baumannii isolate, Antimicrob. Agents Chemother., 60, 1370, 10.1128/AAC.01696-15
Dijkshoorn, 1996, Comparison of outbreak and nonoutbreak Acinetobacter baumannii strains by genotypic and phenotypic methods, J. Clin. Microbiol, 34, 1519, 10.1128/JCM.34.6.1519-1525.1996
Dizbay, 2010, In vitro synergistic activity of tigecycline and colistin against XDR-Acinetobacter baumannii, J. Antibiot. (Tokyo), 63, 51, 10.1038/ja.2009.117
Doi, 2015, Acinetobacter baumannii: evolution of antimicrobial resistance-treatment options, Semin. Respir. Crit. Care Med., 36, 85, 10.1055/s-0034-1398388
Doi, 2004, Spread of novel aminoglycoside resistance gene aac(6′)-Iad among Acinetobacter clinical isolates in Japan, Antimicrob. Agents Chemother., 48, 2075, 10.1128/AAC.48.6.2075-2080.2004
Donnarumma, 2010, Molecular characterization of acinetobacter isolates collected in intensive care units of six hospitals in Florence, Italy, during a 3-year surveillance program: a population structure analysis, J. Clin. Microbiol., 48, 1297, 10.1128/JCM.01916-09
Dortet, 2016, First occurrence of OXA-72-producing Acinetobacter baumannii in Serbia, Antimicrob. Agents Chemother., 60, 5724, 10.1128/AAC.01016-16
Dubois, 2009, CTX-M β-lactamase production and virulence of Escherichia coli K1, Emerg. Infect. Dis., 15, 1988, 10.3201/eid1512.090928
Dubrovskaya, 2015, Risk factors for nephrotoxicity onset associated with polymyxin B therapy, J. Antimicrob. Chemother., 70, 1903, 10.1093/jac/dkv014
Dupont, 2005, Identification of an OprD homologue in Acinetobacter baumannii, J. Proteome. Res., 4, 2386, 10.1021/pr050143q
Elhosseiny, 2015, Acinetobacter baumannii universal stress protein A plays a pivotal role in stress response and is essential for pneumonia and sepsis pathogenesis, Int. J. Med. Microbiol., 305, 114, 10.1016/j.ijmm.2014.11.008
Elhosseiny, 2016, The secretome of Acinetobacter baumannii ATCC 17978 type II secretion system reveals a novel plasmid encoded phospholipase that could be implicated in lung colonization, Int. J. Med. Microbiol., 306, 633, 10.1016/j.ijmm.2016.09.006
Ellis, 2010, Virulence and immunomodulatory roles of bacterial outer membrane vesicles, Microbiol. Mol. Biol. Rev., 74, 81, 10.1128/MMBR.00031-09
Endimiani, 2007, Spread in an Italian hospital of a clonal Acinetobacter baumannii strain producing the TEM-92 extended-spectrum β-lactamase, Antimicrob. Agents Chemother., 51, 2211, 10.1128/AAC.01139-06
Erridge, 2007, Acinetobacter baumannii lipopolysaccharides are potent stimulators of human monocyte activation via Toll-like receptor 4 signalling, J. Med. Microbiol., 56, 165, 10.1099/jmm.0.46823-0
Espinal, 2011, Dissemination of an NDM-2-producing Acinetobacter baumannii clone in an Israeli rehabilitation center, Antimicrob. Agents Chemother., 55, 5396, 10.1128/AAC.00679-11
Evans, 2007, Eleven novel OXA-51-like enzymes from clinical isolates of Acinetobacter baumannii, Clin. Microbiol. Infect., 13, 1137, 10.1111/j.1469-0691.2007.01828.x
Fajardo Bonin, 2014, Identification of immunogenic proteins of the bacterium Acinetobacter baumannii using a proteomic approach, Proteomics Clin. Appl., 8, 916, 10.1002/prca.201300133
Fan, 2016, Activity of colistin in combination with meropenem, tigecycline, fosfomycin, fusidic acid, rifampin or sulbactam against extensively drug-resistant Acinetobacter baumannii in a murine thigh-infection model, PLoS ONE, 11, e0157757, 10.1371/journal.pone.0157757
Fang, 2016, Molecular characterization of carbapenemase genes in Acinetobacter baumannii in China, Genet. Mol. Res., 15, gmr7432, 10.4238/gmr.15017432
Fernandez-Cuenca, 2011, Attenuated virulence of a slow-growing pandrug-resistant Acinetobacter baumannii is associated with decreased expression of genes encoding the porins CarO and OprD-like, Int. J. Antimicrob. Agents, 38, 548, 10.1016/j.ijantimicag.2011.08.002
Fernando, 2012, Growth phase-dependent expression of RND efflux pump- and outer membrane porin-encoding genes in Acinetobacter baumannii ATCC 19606, J. Antimicrob. Chemother., 67, 569, 10.1093/jac/dkr519
Fiester, 2016, Iron-regulated phospholipase C activity contributes to the cytolytic activity and virulence of Acinetobacter baumannii, PLoS ONE, 11, e0167068, 10.1371/journal.pone.0167068
Flores-Diaz, 2016, Bacterial sphingomyelinases and phospholipases as virulence factors, Microbiol. Mol. Biol. Rev., 80, 597, 10.1128/MMBR.00082-15
Fonseca, 2013, Carbapenem-resistant Acinetobacter baumannii from Brazil: role of carO alleles expression and blaOXA-23 gene, BMC Microbiol., 13, 245, 10.1186/1471-2180-13-245
Fournier, 2006, The epidemiology and control of Acinetobacter baumannii in health care facilities, Clin. Infect. Dis., 42, 692, 10.1086/500202
Fournier, 2006, Comparative genomics of multidrug resistance in Acinetobacter baumannii, PLoS Genet., 2, e7, 10.1371/journal.pgen.0020007
Fulnecky, 2005, Amikacin and colistin for treatment of Acinetobacter baumannii meningitis, J. Infect., 51, e249, 10.1016/j.jinf.2005.04.003
Gaddy, 2012, Role of acinetobactin-mediated iron acquisition functions in the interaction of Acinetobacter baumannii strain ATCC 19606T with human lung epithelial cells, Galleria mellonella caterpillars, and mice, Infect. Immun., 80, 1015, 10.1128/IAI.06279-11
Gaddy, 2009, The Acinetobacter baumannii 19606 OmpA protein plays a role in biofilm formation on abiotic surfaces and in the interaction of this pathogen with eukaryotic cells, Infect. Immun., 77, 3150, 10.1128/IAI.00096-09
Gales, 2003, Emergence of an IMP-like metallo-enzyme in an Acinetobacter baumannii clinical strain from a Brazilian teaching hospital, Diagn. Microbiol. Infect. Dis, 45, 77, 10.1016/S0732-8893(02)00500-X
Gallego, 2001, Carriage of class 1 integrons and antibiotic resistance in clinical isolates of Acinetobacter baumannii from northern Spain, J. Med. Microbiol., 50, 71, 10.1099/0022-1317-50-1-71
Garcia-Quintanilla, 2015, Lipopolysaccharide loss produces partial colistin dependence and collateral sensitivity to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii, Int. J. Antimicrob. Agents, 46, 696, 10.1016/j.ijantimicag.2015.07.017
Garcia-Salguero, 2015, Can plazomicin alone or in combination be a therapeutic pption against carbapenem-resistant Acinetobacter baumannii?, Antimicrob. Agents Chemother., 59, 5959, 10.1128/AAC.00873-15
Gebhardt, 2015, Joint transcriptional control of virulence and resistance to antibiotic and environmental stress in Acinetobacter baumannii, MBio, 6, e01660, 10.1128/mBio.01660-15
Gehrlein, 1991, Imipenem resistance in Acinetobacter baumanii is due to altered penicillin-binding proteins, Chemotherapy, 37, 405, 10.1159/000238887
Geisinger, 2015, Antibiotic modulation of capsular exopolysaccharide and virulence in Acinetobacter baumannii, PLoS Pathog., 11, e1004691, 10.1371/journal.ppat.1004691
Giannouli, 2009, Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii strains in intensive care units of multiple Mediterranean hospitals, J. Antimicrob. Chemother., 63, 828, 10.1093/jac/dkp032
Gogou, 2011, Evolution of multidrug-resistant Acinetobacter baumannii clonal lineages: a 10 year study in Greece (2000–09), J. Antimicrob. Chemother., 66, 2767, 10.1093/jac/dkr390
Goic-Barisic, 2011, Outbreak in Croatia caused by a new carbapenem-resistant clone of Acinetobacter baumannii producing OXA-72 carbapenemase, J. Hosp. Infect., 77, 368, 10.1016/j.jhin.2010.12.003
Gonzalez-Villoria, 2016, A multicenter study in Mexico finds Acinetobacter baumannii clinical isolates belonging to clonal complexes 636B (113B) and 92B harboring OXA-72, OXA-239, and OXA-469, Antimicrob. Agents Chemother., 60, 2587, 10.1128/AAC.02042-15
Gordon, 2009, A review of clinical and microbiological outcomes following treatment of infections involving multidrug-resistant Acinetobacter baumannii with tigecycline, J. Antimicrob. Chemother., 63, 775, 10.1093/jac/dkn555
Gordon, 2010, Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance, Int. J. Antimicrob. Agents, 35, 219, 10.1016/j.ijantimicag.2009.10.024
Hagihara, 2014, In vitro pharmacodynamics of polymyxin B and tigecycline alone and in combination against carbapenem-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 58, 874, 10.1128/AAC.01624-13
Hammerstrom, 2015, Acinetobacter baumannii repeatedly evolves a hypermutator phenotype in response to tigecycline that effectively surveys evolutionary trajectories to resistance, PLoS ONE, 10, e0140489, 10.1371/journal.pone.0140489
Hamouda, 2010, Characterization of epidemiologically unrelated Acinetobacter baumannii isolates from four continents by use of multilocus sequence typing, pulsed-field gel electrophoresis, and sequence-based typing of blaOXA-51-like genes, J. Clin. Microbiol., 48, 2476, 10.1128/JCM.02431-09
Harding, 2016, Medically relevant Acinetobacter species require a type II secretion system and specific membrane-associated chaperones for the export of multiple substrates and full virulence, PLoS Pathog., 12, e1005391, 10.1371/journal.ppat.1005391
Hasani, 2016, Frequency of aminoglycoside-modifying enzymes and ArmA among different sequence groups of Acinetobacter baumannii in Iran, Microb. Drug Resist., 22, 347, 10.1089/mdr.2015.0254
Hassan, 2016, Pangenome and immuno-proteomics analysis of Acinetobacter baumannii strains revealed the core peptide vaccine targets, BMC Genomics., 17, 732, 10.1186/s12864-016-2951-4
Hawley, 2007, Development of colistin-dependent Acinetobacter baumannii-Acinetobacter calcoaceticus complex, Antimicrob. Agents Chemother., 51, 4529, 10.1128/AAC.01115-07
He, 2015, In vitro and in vivo analysis of antimicrobial agents alone and in combination against multi-drug resistant Acinetobacter baumannii, Front. Microbiol., 6, 507, 10.3389/fmicb.2015.00507
He, 2015, Biofilm formation caused by clinical Acinetobacter baumannii isolates is associated with overexpression of the AdeFGH efflux pump, Antimicrob. Agents Chemother., 59, 4817, 10.1128/AAC.00877-15
Heritier, 2003, Genetic and functional analysis of the chromosome-encoded carbapenem-hydrolyzing oxacillinase OXA-40 of Acinetobacter baumannii, Antimicrob. Agents Chemother, 47, 268, 10.1128/AAC.47.1.268-273.2003
Heritier, 2005a, Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii, Antimicrob. Agents Chemother., 49, 4174, 10.1128/AAC.49.10.4174-4179.2005
Heritier, 2005b, Contribution of acquired carbapenem-hydrolyzing oxacillinases to carbapenem resistance in Acinetobacter baumannii, Antimicrob. Agents Chemother., 49, 3198, 10.1128/AAC.49.8.3198-3202.2005
Heritier, 2006, Cephalosporinase over-expression resulting from insertion of ISAba1 in Acinetobacter baumannii, Clin. Microbiol. Infect., 12, 123, 10.1111/j.1469-0691.2005.01320.x
Higgins, 2012, Molecular epidemiology of Acinetobacter baumannii bloodstream isolates obtained in the United States from 1995 to 2004 using rep-PCR and multilocus sequence typing, J. Clin. Microbiol., 50, 3493, 10.1128/JCM.01759-12
Higgins, 2013, OXA-235, a novel class D β-lactamase involved in resistance to carbapenems in Acinetobacter baumannii, Antimicrob. Agents Chemother., 57, 2121, 10.1128/AAC.02413-12
Higgins, 2009, OXA-143, a novel carbapenem-hydrolyzing class D β-lactamase in Acinetobacter baumannii, Antimicrob. Agents Chemother., 53, 5035, 10.1128/AAC.00856-09
Higgins, 2004, Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii, J. Antimicrob. Chemother., 54, 821, 10.1093/jac/dkh427
Hiraki, 2013, Successful treatment of skin and soft tissue infection due to carbapenem-resistant Acinetobacter baumannii by ampicillin-sulbactam and meropenem combination therapy, Int. J. Infect. Dis., 17, e1234, 10.1016/j.ijid.2013.05.002
Hogg, 1998, In-vitro activity of the combination of colistin and rifampicin against multidrug-resistant strains of Acinetobacter baumannii, J Antimicrob Chemother
Hong, 2013, Co-existence of blaOXA-23 and armA in multidrug-resistant Acinetobacter baumannii isolated from a hospital in South Korea, J. Med. Microbiol., 62, 836, 10.1099/jmm.0.055384-0
Hong, 2016, High rate of colistin dependence in Acinetobacter baumannii, J. Antimicrob. Chemother., 71, 2346, 10.1093/jac/dkw121
Hood, 2010, Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations, Antimicrob. Agents Chemother., 54, 1029, 10.1128/AAC.00963-09
Hood, 2012, Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration, PLoS Pathog., 8, e1003068, 10.1371/journal.ppat.1003068
Hornsey, 2010, AdeABC-mediated efflux and tigecycline MICs for epidemic clones of Acinetobacter baumannii, J. Antimicrob. Chemother., 65, 1589, 10.1093/jac/dkq218
Hornsey, 2011, Whole-genome comparison of two Acinetobacter baumannii isolates from a single patient, where resistance developed during tigecycline therapy, J. Antimicrob. Chemother., 66, 1499, 10.1093/jac/dkr168
Hornsey, 2011, In vivo efficacy of glycopeptide-colistin combination therapies in a Galleria mellonella model of Acinetobacter baumannii infection, Antimicrob. Agents Chemother., 55, 3534, 10.1128/AAC.00230-11
Hou, 2015, Drug-resistant gene of blaOXA-23, blaOXA-24, blaOXA-51and blaOXA-58 in Acinetobacter baumannii, Int. J. Clin. Exp. Med, 8, 13859
Houang, 2003, Significance of genomic DNA group delineation in comparative studies of antimicrobial susceptibility of Acinetobacter spp, Antimicrob. Agents Chemother, 47, 1472, 10.1128/AAC.47.4.1472-1475.2003
Hu, 2013, Diversity in the major polysaccharide antigen of Acinetobacter baumannii assessed by DNA sequencing, and development of a molecular serotyping scheme, PLoS ONE, 8, e70329, 10.1371/journal.pone.0070329
Hu, 2007, An OXA-66/OXA-51-like carbapenemase and possibly an efflux pump are associated with resistance to imipenem in Acinetobacter baumannii, Antimicrob. Agents Chemother., 51, 3844, 10.1128/AAC.01512-06
Huang, 2014, Immunization against multidrug-resistant Acinetobacter baumannii effectively protects mice in both pneumonia and sepsis models, PLoS ONE, 9, e100727, 10.1371/journal.pone.0100727
Huang, 2016, Immunization with a 22-kDa outer membrane protein elicits protective immunity to multidrug-resistant Acinetobacter baumannii, Sci. Rep., 6, 20724, 10.1038/srep20724
Hujer, 2005, Identification of a new allelic variant of the Acinetobacter baumannii cephalosporinase, ADC-7 β-lactamase: defining a unique family of class C enzymes, Antimicrob. Agents Chemother., 49, 2941, 10.1128/AAC.49.7.2941-2948.2005
Iwashkiw, 2012, Identification of a general O-linked protein glycosylation system in Acinetobacter baumannii and its role in virulence and biofilm formation, PLoS Pathog., 8, e1002758, 10.1371/journal.ppat.1002758
Jacobs, 2010, Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis, Infect. Immun., 78, 1952, 10.1128/IAI.00889-09
Jara, 2015, Novobiocin inhibits the antimicrobial resistance acquired through DNA damage-induced mutagenesis in Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 637, 10.1128/AAC.01810-15
Jaruratanasirikul, 2016, Population pharmacokinetics and pharmacodynamics modeling to optimize dosage regimens of sulbactam in critically ill patients with severe sepsis caused by Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 7236, 10.1128/AAC.01669-16
Jeon, 2015, Structural basis for carbapenem-hydrolyzing mechanisms of carbapenemases conferring antibiotic resistance, Int. J. Mol. Sci., 16, 9654, 10.3390/ijms16059654
Jeon, 2016, In vivo application of bacteriophage as a potential therapeutic agent to control OXA-66-like carbapenemase-producing Acinetobacter baumannii strains belonging to sequence type 357, Appl. Environ. Microbiol., 82, 4200, 10.1128/AEM.00526-16
Jeong, 2009, Loss of the 29-kilodalton outer membrane protein in the presence of OXA-51-like enzymes in Acinetobacter baumannii is associated with decreased imipenem susceptibility, Microb. Drug Resist., 15, 151, 10.1089/mdr.2009.0828
Jeong, 2005, Investigation of a nosocomial outbreak of Acinetobacter baumannii producing PER-1 extended-spectrum β-lactamase in an intensive care unit, J. Hosp. Infect., 59, 242, 10.1016/j.jhin.2004.09.025
Jin, 2011, Acinetobacter baumannii secretes cytotoxic outer membrane protein A via outer membrane vesicles, PLoS ONE, 6, e17027, 10.1371/journal.pone.0017027
Johnson, 2015, Acinetobacter baumannii is dependent on the type II secretion system and its substrate LipA for lipid utilization and in vivo fitness, J. Bacteriol., 198, 711, 10.1128/JB.00622-15
Jones, 2015, Fatal outbreak of an emerging clone of extensively drug-resistant Acinetobacter baumannii with enhanced virulence, Clin. Infect. Dis., 61, 145, 10.1093/cid/civ225
Jun, 2013, Acinetobacter baumannii outer membrane vesicles elicit a potent innate immune response via membrane proteins, PLoS ONE, 8, e71751, 10.1371/journal.pone.0071751
Juttukonda, 2016, Acinetobacter baumannii coordinates urea metabolism with metal import to resist host-mediated metal limitation, MBio, 7, e01475, 10.1128/mBio.01475-16
Kalin, 2014, Comparison of colistin and colistin/sulbactam for the treatment of multidrug resistant Acinetobacter baumannii ventilator-associated pneumonia, Infection., 42, 37, 10.1007/s15010-013-0495-y
Kaplan, 2011, Antibiotic-induced biofilm formation, Int. J. Artif. Organs., 34, 737, 10.5301/ijao.5000027
Karthikeyan, 2010, Coexistence of blaOXA-23 with blaNDM-1 and armA in clinical isolates of Acinetobacter baumannii from India, J. Antimicrob. Chemother., 65, 2253, 10.1093/jac/dkq273
Kenyon, 2013, Variation in the complex carbohydrate biosynthesis loci of Acinetobacter baumannii genomes, PLoS ONE, 8, e62160, 10.1371/journal.pone.0062160
Kim, 2010, Prevalence and diversity of carbapenemases among imipenem-nonsusceptible Acinetobacter isolates in Korea: emergence of a novel OXA-182, Diagn. Microbiol. Infect. Dis., 68, 432, 10.1016/j.diagmicrobio.2010.07.014
Kim, 2009, Serum resistance of Acinetobacter baumannii through the binding of factor H to outer membrane proteins, FEMS Microbiol. Lett., 301, 224, 10.1111/j.1574-6968.2009.01820.x
Kim, 2012, Carbapenem-resistant Acinetobacter baumannii: diversity of resistant mechanisms and risk factors for infection, Epidemiol. Infect., 140, 137, 10.1017/S0950268811000744
Knight, 2016, Mutations decreasing intrinsic β-lactam resistance are linked to cell division in the nosocomial pathogen Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 3751, 10.1128/AAC.00361-16
Kobayashi, 2001, Novel macrolide-specific ABC-type efflux transporter in Escherichia coli, J. Bacteriol., 183, 5639, 10.1128/JB.183.19.5639-5644.2001
Koeleman, 1998, Comparison of amplified ribosomal DNA restriction analysis, random amplified polymorphic DNA analysis, and amplified fragment length polymorphism fingerprinting for identification of Acinetobacter genomic species and typing of Acinetobacter baumannii, J. Clin. Microbiol, 36, 2522, 10.1128/JCM.36.9.2522-2529.1998
Koeleman, 2001, Antibiotic resistance is a major risk factor for epidemic behavior of Acinetobacter baumannii, Infect. Control Hosp Epidemiol., 22, 284, 10.1086/501901
Koenigs, 2016, CipA of Acinetobacter baumannii is a novel plasminogen binding and complement inhibitory protein, J. Infect. Dis., 213, 1388, 10.1093/infdis/jiv601
Koenigs, 2015, Translation elongation factor Tuf of Acinetobacter baumannii is a plasminogen-binding protein, PLoS ONE, 10, e0134418, 10.1371/journal.pone.0134418
Koh, 2007, IMP-4 and OXA beta-lactamases in Acinetobacter baumannii from Singapore, J. Antimicrob. Chemother., 59, 627, 10.1093/jac/dkl544
Koh, 2012, Acinetobacter calcoaceticus-Acinetobacter baumannii complex species in clinical specimens in Singapore, Epidemiol. Infect., 140, 535, 10.1017/S0950268811001129
Kohlenberg, 2009, Outbreak of carbapenem-resistant Acinetobacter baumannii carrying the carbapenemase OXA-23 in a German university medical centre, J. Med. Microbiol., 58, 1499, 10.1099/jmm.0.012302-0
Konstantinidis, 2016, Immunomodulatory role of clarithromycin in Acinetobacter baumannii infection via formation of neutrophil extracellular traps, Antimicrob. Agents Chemother., 60, 1040, 10.1128/AAC.02063-15
Koomanachai, 2009, Pharmacodynamic evaluation of tigecycline against Acinetobacter baumannii in a murine pneumonia model, J. Antimicrob. Chemother., 63, 982, 10.1093/jac/dkp056
Korotkov, 2012, The type II secretion system: biogenesis, molecular architecture and mechanism, Nat. Rev. Microbiol., 10, 336, 10.1038/nrmicro2762
Kostoulias, 2015, Impact of a cross-kingdom signaling molecule of Candida albicans on Acinetobacter baumannii physiology, Antimicrob. Agents Chemother., 60, 161, 10.1128/AAC.01540-15
Krizova, 2013, TEM-1 β-lactamase as a source of resistance to sulbactam in clinical strains of Acinetobacter baumannii, J. Antimicrob. Chemother., 68, 2786, 10.1093/jac/dkt275
Kulp, 2010, Biological functions and biogenesis of secreted bacterial outer membrane vesicles, Annu. Rev. Microbiol., 64, 163, 10.1146/annurev.micro.091208.073413
Kumar, 2016, Identification of a novel NDM variant, blaNDM−3, from a multidrug-resistant Acinetobacter baumannii, Infect. Control. Hosp. Epidemiol., 37, 747, 10.1017/ice.2016.66
Kuo, 2016, Clonal spread of blaOXA-72-carrying Acinetobacter baumannii sequence type 512 in Taiwan, Int. J. Antimicrob. Agents, 48, 111, 10.1016/j.ijantimicag.2016.04.020
Kuo, 2010, Distribution of blaOXA-carrying imipenem-resistant Acinetobacter spp. in 3 hospitals in Taiwan, Diagn. Microbiol. Infect. Dis, 66, 195, 10.1016/j.diagmicrobio.2009.09.013
Kuo, 2007, Multidrug-resistant Acinetobacter baumannii bacteraemia: clinical features, antimicrobial therapy and outcome, Clin. Microbiol. Infect., 13, 196, 10.1111/j.1469-0691.2006.01601.x
Kuo, 2012, Emergence of extensively drug-resistant Acinetobacter baumannii complex over 10 years: nationwide data from the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program, BMC Infect Dis., 12, 200, 10.1186/1471-2334-12-200
Kusradze, 2016, Characterization and testing the efficiency of Acinetobacter baumannii phage vB-GEC_Ab-M-G7 as an antibacterial agent, Front. Microbiol., 7, 1590, 10.3389/fmicb.2016.01590
Kwon, 2009, Proteome analysis of outer membrane vesicles from a clinical Acinetobacter baumannii isolate, FEMS Microbiol. Lett., 297, 150, 10.1111/j.1574-6968.2009.01669.x
La Scola, 2006, Sequencing of the rpoB gene and flanking spacers for molecular identification of Acinetobacter species, J. Clin. Microbiol., 44, 827, 10.1128/JCM.44.3.827-832.2006
Lee, 2008, Antimicrobial effects of varied combinations of meropenem, sulbactam, and colistin on a multidrug-resistant Acinetobacter baumannii isolate that caused meningitis and bacteremia, Microb. Drug Resist., 14, 233, 10.1089/mdr.2008.0840
Lee, 2013a, Strategies to minimize antibiotic resistance, Int. J. Environ. Res. Public Health., 10, 4274, 10.3390/ijerph10094274
Lee, 2013b, Lipid a biosynthesis of multidrug-resistant pathogens - a novel drug target, Curr. Pharm. Des, 19, 6534, 10.2174/13816128113199990494
Lee, 2015, Quantitative proteomic view associated with resistance to clinically important antibiotics in Gram-positive bacteria: a systematic review, Front. Microbiol., 6, 828, 10.3389/fmicb.2015.00828
Lee, 2016, Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: epidemiology, Genetic Context, Treatment Options, and Detection Methods, Front. Microbiol., 7, 895, 10.3389/fmicb.2016.00895
Lee, 2007, Differences in phenotypic and genotypic traits against antimicrobial agents between Acinetobacter baumannii and Acinetobacter genomic species 13TU, J. Antimicrob. Chemother., 59, 633, 10.1093/jac/dkm007
Lee, 2015, Urgent need for β-lactam-β-lactamase inhibitors, Lancet Infect. Dis., 15, 876, 10.1016/S1473-3099(15)00143-7
Lee, 2016, How to minimise antibiotic resistance, Lancet Infect. Dis., 16, 17, 10.1016/S1473-3099(15)00467-3
Lee, 2010, Acinetobacter baumannii outer membrane protein A induces dendritic cell death through mitochondrial targeting, J. Microbiol., 48, 387, 10.1007/s12275-010-0155-1
Lee, 2005, Novel acquired metallo-β-lactamase gene, blaSIM-1, in a class 1 integron from Acinetobacter baumannii clinical isolates from Korea, Antimicrob. Agents Chemother., 49, 4485, 10.1128/AAC.49.11.4485-4491.2005
Lee, 2008, Molecular characterisation of the metallo-β-lactamase genes in imipenem-resistant Gram-negative bacteria from a university hospital in southern Taiwan, Int. J. Antimicrob. Agents, 32, 475, 10.1016/j.ijantimicag.2008.07.009
Lee, 2011, A novel insertion sequence, ISAba10, inserted into ISAba1 adjacent to the blaOXA-23 gene and disrupting the outer membrane protein gene carO in Acinetobacter baumannii, Antimicrob. Agents Chemother., 55, 361, 10.1128/AAC.01672-09
Lee, 2013, Clinical outcomes of tigecycline alone or in combination with other antimicrobial agents for the treatment of patients with healthcare-associated multidrug-resistant Acinetobacter baumannii infections, Eur. J. Clin. Microbiol Infect Dis., 32, 1211, 10.1007/s10096-013-1870-4
Lees-Miller, 2013, A common pathway for O-linked protein-glycosylation and synthesis of capsule in Acinetobacter baumannii, Mol. Microbiol., 89, 816, 10.1111/mmi.12300
Lenhard, 2016a, High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii, J. Antimicrob. Chemother., 72, 153, 10.1093/jac/dkw355
Lenhard, 2016b, Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii, Int. J. Antimicrob. Agents, 48, 719, 10.1016/j.ijantimicag.2016.07.024
Li, 2016, Rapid multiplexed phenotypic screening identifies drug resistance functions for three novel efflux pumps in Acinetobacter baumannii, J. Antimicrob. Chemother., 71, 1223, 10.1093/jac/dkv460
Li, 2015, Tigecycline resistance in Acinetobacter baumannii mediated by frameshift mutation in plsC, encoding 1-acyl-sn-glycerol-3-phosphate acyltransferase, Eur. J. Clin. Microbiol. Infect. Dis., 34, 625, 10.1007/s10096-014-2272-y
Li, 2016, Development and evaluation of species-specific PCR for detection of nine Acinetobacter species, Ann. Clin. Lab. Sci, 46, 270
Li, 2016, Abrp, a new gene, confers reduced susceptibility to tetracycline, glycylcine, chloramphenicol and fosfomycin classes in Acinetobacter baumannii, Eur. J. Clin. Microbiol. Infect. Dis., 35, 1371, 10.1007/s10096-016-2674-0
Li, 2015, Clonal dissemination of extensively drug-resistant Acinetobacter baumannii producing an OXA-23 β-lactamase at a teaching hospital in Shanghai, China, J. Microbiol. Immunol. Infect., 48, 101, 10.1016/j.jmii.2014.04.005
Li, 2015, Outer membrane vesicles isolated from two clinical Acinetobacter baumannii strains exhibit different toxicity and proteome characteristics, Microb. Pathog., 81, 46, 10.1016/j.micpath.2015.03.009
Liang, 2011, Activities of colistin- and minocycline-based combinations against extensive drug resistant Acinetobacter baumannii isolates from intensive care unit patients, BMC Infect. Dis., 11, 109, 10.1186/1471-2334-11-109
Liao, 2015, Acinetobacter baumannii extracellular OXA-58 is primarily and selectively released via outer membrane vesicles after Sec-dependent periplasmic translocation, Antimicrob. Agents Chemother., 59, 7346, 10.1128/AAC.01343-15
Lin, 2012, Inhibition of LpxC protects mice from resistant Acinetobacter baumannii by modulating inflammation and enhancing phagocytosis, MBio, 3, e00312, 10.1128/mBio.00312-12
Lin, 2013, Acinetobacter baumannii rOmpA vaccine dose alters immune polarization and immunodominant epitopes, Vaccine, 31, 313, 10.1016/j.vaccine.2012.11.008
Lin, 2011a, Molecular epidemiology and antimicrobial resistance determinants of multidrug-resistant Acinetobacter baumannii in five proximal hospitals in Taiwan, Jpn. J. Infect. Dis, 64, 222, 10.7883/yoken.64.222
Lin, 2010, Role of integrons in antimicrobial susceptibility patterns of Acinetobacter baumannii, Jpn. J. Infect. Dis, 63, 440, 10.7883/yoken.63.440
Lin, 2011b, Emergence and dissemination of blaOXA-23-carrying imipenem-resistant Acinetobacter sp. in a regional hospital in Taiwan, J. Microbiol. Immunol. Infect., 44, 39, 10.1016/j.jmii.2011.01.008
Lin, 2014, Antimicrobial resistance in Acinetobacter baumannii: from bench to bedside, World J. Clin. Cases., 2, 787, 10.12998/wjcc.v2.i12.787
Lin, 2015, The role of the two-component system BaeSR in disposing chemicals through regulating transporter systems in Acinetobacter baumannii, PLoS ONE, 10, e0132843, 10.1371/journal.pone.0132843
Lin, 2014, Role of the BaeSR two-component system in the regulation of Acinetobacter baumannii adeAB genes and its correlation with tigecycline susceptibility, BMC Microbiol., 14, 119, 10.1186/1471-2180-14-119
Lin, 2013, Molecular epidemiology of integron-associated antimicrobial gene cassettes in the clinical isolates of Acinetobacter baumannii from northern Taiwan, Ann. Lab. Med., 33, 242, 10.3343/alm.2013.33.4.242
Liou, 2014, The sensor kinase BfmS mediates virulence in Acinetobacter baumannii, J. Microbiol. Immunol. Infect., 47, 275, 10.1016/j.jmii.2012.12.004
Liu, 2014, Prevalence and mapping of a plasmid encoding a type IV secretion system in Acinetobacter baumannii, Genomics., 104, 215, 10.1016/j.ygeno.2014.07.011
Liu, 2016, Characterization of surface antigen protein 1 (SurA1) from Acinetobacter baumannii and its role in virulence and fitness, Vet. Microbiol., 186, 126, 10.1016/j.vetmic.2016.02.018
Liu, 2014, Efficacy and safety of polymyxins for the treatment of Acinectobacter baumannii infection: a systematic review and meta-analysis, PLoS ONE, 9, e98091, 10.1371/journal.pone.0098091
Liu, 2016, Synergistic killing by meropenem and colistin combination of carbapenem-resistant Acinetobacter baumannii isolates from Chinese patients in an in vitro pharmacokinetic/pharmacodynamic model, Int. J. Antimicrob. Agents, 48, 559, 10.1016/j.ijantimicag.2016.07.018
Liu, 2015, Detection of AmpC β-lactamases in Acinetobacter baumannii in the Xuzhou region and analysis of drug resistance, Exp. Ther. Med., 10, 933, 10.3892/etm.2015.2612
Lolans, 2006, Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40, Antimicrob. Agents Chemother., 50, 2941, 10.1128/AAC.00116-06
Lomovskaya, 1992, Emr, an Escherichia coli locus for multidrug resistance, Proc. Natl. Acad. Sci. U.S.A, 89, 8938, 10.1073/pnas.89.19.8938
Luke, 2010, Identification and characterization of a glycosyltransferase involved in Acinetobacter baumannii lipopolysaccharide core biosynthesis, Infect. Immun., 78, 2017, 10.1128/IAI.00016-10
Luo, 2012, Active and passive immunization protects against lethal, extreme drug resistant-Acinetobacter baumannii infection, PLoS ONE, 7, e29446, 10.1371/journal.pone.0029446
Lu, 2009, Diversity of carbapenem resistance mechanisms in Acinetobacter baumannii from a Taiwan hospital: spread of plasmid-borne OXA-72 carbapenemase, J. Antimicrob. Chemother., 63, 641, 10.1093/jac/dkn553
Magnet, 2001, Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454, Antimicrob. Agents Chemother., 45, 3375, 10.1128/AAC.45.12.3375-3380.2001
Mak, 2009, Antibiotic resistance determinants in nosocomial strains of multidrug-resistant Acinetobacter baumannii, J. Antimicrob. Chemother., 63, 47, 10.1093/jac/dkn454
Marchand, 2004, Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system, Antimicrob. Agents Chemother., 48, 3298, 10.1128/AAC.48.9.3298-3304.2004
Martinez-Guitian, 2016, Synergy between colistin and the signal peptidase inhibitor MD3 is dependent on the mechanism of colistin resistance in Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 4375, 10.1128/AAC.00510-16
Martinez, 2016, Genetic environment of the KPC gene in Acinetobacter baumannii ST2 clone from Puerto Rico and genomic insights into its drug resistance, J. Med. Microbiol., 65, 784, 10.1099/jmm.0.000289
McConnell, 2013, Acinetobacter baumannii: human infections, factors contributing to pathogenesis and animal models, FEMS Microbiol. Rev., 37, 130, 10.1111/j.1574-6976.2012.00344.x
McConnell, 2011, Outer membrane vesicles as an acellular vaccine against Acinetobacter baumannii, Vaccine, 29, 5705, 10.1016/j.vaccine.2011.06.001
McQueary, 2012, Extracellular stress and lipopolysaccharide modulate Acinetobacter baumannii surface-associated motility, J. Microbiol., 50, 434, 10.1007/s12275-012-1555-1
Megeed, 2016, Investigation of the virulence factors and molecular characterization of the clonal relations of multidrug-resistant Acinetobacter baumannii isolates, J. AOAC Int, 10.5740/jaoacint.16-0139
Mendes, 2009, Emergence and widespread dissemination of OXA-23, -24/40 and -58 carbapenemases among Acinetobacter spp. in Asia-Pacific nations: report from the SENTRY Surveillance Program, J. Antimicrob. Chemother., 63, 55, 10.1093/jac/dkn434
Mendes, 2010, Comprehensive assessment of tigecycline activity tested against a worldwide collection of Acinetobacter spp. (2005–2009), Diagn. Microbiol. Infect. Dis, 68, 307, 10.1016/j.diagmicrobio.2010.07.003
Menegucci, 2016, Strategies for the treatment of polymyxin B-resistant Acinetobacter baumannii infections, Int. J. Antimicrob. Agents, 47, 380, 10.1016/j.ijantimicag.2016.02.007
Merino, 2010, OXA-24 carbapenemase gene flanked by XerC/XerD-like recombination sites in different plasmids from different Acinetobacter species isolated during a nosocomial outbreak, Antimicrob. Agents Chemother., 54, 2724, 10.1128/AAC.01674-09
Moffatt, 2010, Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production, Antimicrob. Agents Chemother., 54, 4971, 10.1128/AAC.00834-10
Moland, 2008, In vitro activity of tigecycline against multidrug-resistant Acinetobacter baumannii and selection of tigecycline-amikacin synergy, Antimicrob. Agents Chemother., 52, 2940, 10.1128/AAC.01581-07
Montero, 2004, Antibiotic combinations for serious infections caused by carbapenem-resistant Acinetobacter baumannii in a mouse pneumonia model, J. Antimicrob. Chemother., 54, 1085, 10.1093/jac/dkh485
Moon, 2012, Acinetobacter baumannii outer membrane protein A modulates the biogenesis of outer membrane vesicles, J. Microbiol., 50, 155, 10.1007/s12275-012-1589-4
Mosqueda, 2013, Globally expanding carbapenemase finally appears in Spain: nosocomial outbreak of Acinetobacter baumannii producing plasmid-encoded OXA-23 in Barcelona, Spain, Antimicrob. Agents Chemother., 57, 5155, 10.1128/AAC.01486-13
Motaouakkil, 2006, Colistin and rifampicin in the treatment of nosocomial infections from multiresistant Acinetobacter baumannii, J. Infect., 53, 274, 10.1016/j.jinf.2005.11.019
Moubareck, 2009, GES-11, a novel integron-associated GES variant in Acinetobacter baumannii, Antimicrob. Agents Chemother., 53, 3579, 10.1128/AAC.00072-09
Mougous, 2006, A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus, Science, 312, 1526, 10.1126/science.1128393
Moya, 2008, Benefit of having multiple ampD genes for acquiring β-lactam resistance without losing fitness and virulence in Pseudomonas aeruginosa, Antimicrob. Agents Chemother., 52, 3694, 10.1128/AAC.00172-08
Mugnier, 2010, Worldwide dissemination of the blaOXA-23 carbapenemase gene of Acinetobacter baumannii, Emerg. Infect. Dis., 16, 35, 10.3201/eid1601.090852
Mussi, 2005, Acquisition of resistance to carbapenems in multidrug-resistant clinical strains of Acinetobacter baumannii: natural insertional inactivation of a gene encoding a member of a novel family of b-barrel outer membrane proteins, Antimicrob. Agents Chemother., 49, 1432, 10.1128/AAC.49.4.1432-1440.2005
Mussi, 2007, CarO, an Acinetobacter baumannii outer membrane protein involved in carbapenem resistance, is essential for L-ornithine uptake, FEBS Lett., 581, 5573, 10.1016/j.febslet.2007.10.063
Muthusamy, 2016, In vitro activities of polymyxins and rifampicin against carbapenem resistant Acinetobacter baumannii at a tertiary care hospital from south India, J. Clin. Diagn. Res, 10.7860/JCDR/2016/19968.8535
Mutlu Yilmaz, 2012, Efficacy of tigecycline/colistin combination in a pneumonia model caused by extensively drug-resistant Acinetobacter baumannii, Int. J. Antimicrob. Agents, 40, 332, 10.1016/j.ijantimicag.2012.06.003
Naas, 2006, VEB-1 Extended-spectrum β-lactamase-producing Acinetobacter baumannii, France, Emerg. Infect. Dis., 12, 1214, 10.3201/eid1208.051547
Naas, 2005, Outbreak of carbapenem-resistant Acinetobacter baumannii producing the carbapenemase OXA-23 in a tertiary care hospital of Papeete, French Polynesia, J. Clin. Microbiol., 43, 4826, 10.1128/JCM.43.9.4826-4829.2005
Naas, 2007, Panresistant extended-spectrum β-lactamase SHV-5-producing Acinetobacter baumannii from New York City, J. Antimicrob. Chemother., 60, 1174, 10.1093/jac/dkm366
Nagano, 2004, Nosocomial transmission of CTX-M-2 β-lactamase-producing Acinetobacter baumannii in a neurosurgery ward, J. Clin. Microbiol., 42, 3978, 10.1128/JCM.42.9.3978-3984.2004
Nairn, 2016, The Response of Acinetobacter baumannii to Zinc Starvation, Cell Host Microbe., 19, 826, 10.1016/j.chom.2016.05.007
Navia, 2002, Characterization of an integron carrying a new class D β-lactamase (OXA-37) in Acinetobacter baumannii, Microb. Drug Resist., 8, 261, 10.1089/10766290260469516
Navon-Venezia, 2007, High tigecycline resistance in multidrug-resistant Acinetobacter baumannii, J. Antimicrob. Chemother., 59, 772, 10.1093/jac/dkm018
Nemec, 2004, Diversity of aminoglycoside-resistance genes and their association with class 1 integrons among strains of pan-European Acinetobacter baumannii clones, J. Med. Microbiol., 53, 1233, 10.1099/jmm.0.45716-0
Nepka, 2016, In vitro bactericidal activity of trimethoprim-sulfamethoxazole alone and in combination with colistin, against carbapenem-resistant Acinetobacter baumannii clinical isolates, Antimicrob. Agents Chemother, 10.1128/AAC.01082-16
Ni, 2016, Effects of efflux pump inhibitors on colistin resistance in multidrug-resistant Gram-negative gacteria, Antimicrob. Agents Chemother., 60, 3215, 10.1128/AAC.00248-16
Norton, 2013, Antibiotic resistance acquired through a DNA damage-inducible response in Acinetobacter baumannii, J. Bacteriol., 195, 1335, 10.1128/JB.02176-12
Nowak-Zaleska, 2016, Correlation between the number of Pro-Ala repeats in the EmrA homologue of Acinetobacter baumannii and resistance to netilmicin, tobramycin, imipenem and ceftazidime, J. Glob. Antimicrob. Resist., 7, 145, 10.1016/j.jgar.2016.09.004
Ozbek, 2010, Postantibiotic effects of tigecycline, colistin sulfate, and levofloxacin alone or tigecycline-colistin sulfate and tigecycline-levofloxacin combinations against Acinetobacter baumannii, Chemotherapy, 56, 466, 10.1159/000321015
Pachon-Ibanez, 2010, Efficacy of rifampin and its combinations with imipenem, sulbactam, and colistin in experimental models of infection caused by imipenem-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 54, 1165, 10.1128/AAC.00367-09
Pachon-Ibanez, 2004, Activity of tigecycline (GAR-936) against Acinetobacter baumannii strains, including those resistant to imipenem, Antimicrob. Agents Chemother., 48, 4479, 10.1128/AAC.48.11.4479-4481.2004
Pailhories, 2016, First case of OXA-24-producing Acinetobacter baumannii in cattle from Reunion Island, France, Int. J. Antimicrob. Agents, 48, 763, 10.1016/j.ijantimicag.2016.09.005
Pankuch, 2008, Activity of meropenem with and without ciprofloxacin and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii, Antimicrob. Agents Chemother., 52, 333, 10.1128/AAC.00689-07
Pannek, 2006, Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-b-naphthylamide, J. Antimicrob. Chemother., 57, 970, 10.1093/jac/dkl081
Pantopoulou, 2007, Colistin offers prolonged survival in experimental infection by multidrug-resistant Acinetobacter baumannii: the significance of co-administration of rifampicin, Int. J. Antimicrob. Agents, 29, 51, 10.1016/j.ijantimicag.2006.09.009
Papa, 2009, Molecular epidemiology of carbapenem-resistant Acinetobacter baumannii in a newly established Greek hospital, Microb. Drug Resist., 15, 257, 10.1089/mdr.2009.0060
Park, 2015, Effect of carbonyl cyanide 3-chlorophenylhydrazone (CCCP) on killing Acinetobacter baumannii by colistin, J. Microbiol., 53, 53, 10.1007/s12275-015-4498-5
Parra Millan, 2016, Efficacy of lysophosphatidylcholine in combination with antimicrobial agents against Acinetobacter baumannii in experimental murine peritoneal sepsis and pneumonia models, Antimicrob. Agents Chemother., 60, 4464, 10.1128/AAC.02708-15
Pasteran, 2006, Emergence of PER-2 and VEB-1a in Acinetobacter baumannii strains in the Americas, Antimicrob. Agents Chemother., 50, 3222, 10.1128/AAC.00284-06
Peck, 2012, In vitro time-kill studies of antimicrobial agents against blood isolates of imipenem-resistant Acinetobacter baumannii, including colistin- or tigecycline-resistant isolates, J. Med. Microbiol., 61, 353, 10.1099/jmm.0.036939-0
Peleg, 2007, Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii, Antimicrob. Agents Chemother., 51, 2065, 10.1128/AAC.01198-06
Peleg, 2008, Acinetobacter baumannii: emergence of a successful pathogen, Clin. Microbiol. Rev., 21, 538, 10.1128/CMR.00058-07
Pelletier, 2013, Unique structural modifications are present in the lipopolysaccharide from colistin-resistant strains of Acinetobacter baumannii, Antimicrob. Agents Chemother., 57, 4831, 10.1128/AAC.00865-13
Penwell, 2012, The Acinetobacter baumannii entA gene located outside the acinetobactin cluster is critical for siderophore production, iron acquisition and virulence, PLoS ONE, 7, e36493, 10.1371/journal.pone.0036493
Perez, 2016, The FhaB/FhaC two-partner secretion system is involved in adhesion of Acinetobacter baumannii AbH12O-A2 strain, Virulence, 10.1080/21505594.2016.1262313
Perez, 2007, Global challenge of multidrug-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 51, 3471, 10.1128/AAC.01464-06
Petrosillo, 2005, Combined colistin and rifampicin therapy for carbapenem-resistant Acinetobacter baumannii infections: clinical outcome and adverse events, Clin. Microbiol. Infect., 11, 682, 10.1111/j.1469-0691.2005.01198.x
Pfeifer, 2011, Molecular characterization of blaNDM−1 in an Acinetobacter baumannii strain isolated in Germany in 2007, J. Antimicrob. Chemother., 66, 1998, 10.1093/jac/dkr256
Phee, 2015, Colistin and fusidic acid, a novel potent synergistic combination for treatment of multidrug-resistant Acinetobacter baumannii infections, Antimicrob. Agents Chemother., 59, 4544, 10.1128/AAC.00753-15
Pichardo, 2010, Efficacy of tigecycline vs. imipenem in the treatment of experimental Acinetobacter baumannii murine pneumonia, Eur. J. Clin. Microbiol. Infect. Dis., 29, 527, 10.1007/s10096-010-0890-6
Pires, 2015, In vitro activity of the novel antimicrobial peptide dendrimer G3KL against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa, Antimicrob. Agents Chemother., 59, 7915, 10.1128/AAC.01853-15
Ploy, 1994, Detection of aac(6′)-I genes in amikacin-resistant Acinetobacter spp. by PCR, Antimicrob. Agents Chemother, 38, 2925, 10.1128/AAC.38.12.2925
Poirel, 2005a, Genetic environment and expression of the extended-spectrum β-lactamase blaPER-1 gene in gram-negative bacteria, Antimicrob. Agents Chemother., 49, 1708, 10.1128/AAC.49.5.1708-1713.2005
Poirel, 2007, Identification of the novel narrow-spectrum β-lactamase SCO-1 in Acinetobacter spp. from Argentina, Antimicrob. Agents Chemother., 51, 2179, 10.1128/AAC.01600-06
Poirel, 2008, Carbapenem-resistant Acinetobacter baumannii isolates from Tunisia producing the OXA-58-like carbapenem-hydrolyzing oxacillinase OXA-97, Antimicrob. Agents Chemother., 52, 1613, 10.1128/AAC.00978-07
Poirel, 2005b, OXA-58, a novel class D β-lactamase involved in resistance to carbapenems in Acinetobacter baumannii, Antimicrob. Agents Chemother., 49, 202, 10.1128/AAC.49.1.202-208.2005
Poirel, 2009, ISCR2, another vehicle for blaVEB gene acquisition, Antimicrob. Agents Chemother., 53, 4940, 10.1128/AAC.00414-09
Pongpech, 2010, Antibacterial activity of carbapenem-based combinations againts multidrug-resistant Acinetobacter baumannii, J. Med. Assoc. Thai, 93, 161
Potron, 2011, Genetic features of CTX-M-15-producing Acinetobacter baumannii from Haiti, Antimicrob. Agents Chemother., 55, 5946, 10.1128/AAC.05124-11
Potron, 2009, Genetic and biochemical characterization of the first extended-spectrum CARB-type b-lactamase, RTG-4, from Acinetobacter baumannii, Antimicrob. Agents Chemother., 53, 3010, 10.1128/AAC.01164-08
Pournaras, 2006, Outbreak of multiple clones of imipenem-resistant Acinetobacter baumannii isolates expressing OXA-58 carbapenemase in an intensive care unit, J. Antimicrob. Chemother., 57, 557, 10.1093/jac/dkl004
Principe, 2013, In vitro activity of doripenem in combination with various antimicrobials against multidrug-resistant Acinetobacter baumannii: possible options for the treatment of complicated infection, Microb. Drug Resist., 19, 407, 10.1089/mdr.2012.0250
Principe, 2009, In vitro activity of tigecycline in combination with various antimicrobials against multidrug resistant Acinetobacter baumannii, Ann. Clin. Microbiol. Antimicrob., 8, 18, 10.1186/1476-0711-8-18
Principe, 2014, Epidemic diffusion of OXA-23-producing Acinetobacter baumannii isolates in Italy: results of the first cross-sectional countrywide survey, J. Clin. Microbiol., 52, 3004, 10.1128/JCM.00291-14
Pukatzki, 2006, Identification of a conserved bacterial protein secretion system in Vibrio cholerae using the Dictyostelium host model system, Proc. Natl. Acad. Sci. U.S.A., 103, 1528, 10.1073/pnas.0510322103
Qi, 2008, Characterization of genetic diversity of carbapenem-resistant Acinetobacter baumannii clinical strains collected from 2004 to 2007, J. Clin. Microbiol., 46, 1106, 10.1128/JCM.01877-07
Quale, 2003, Molecular epidemiology and mechanisms of carbapenem resistance in Acinetobacter baumannii endemic in New York City, Clin. Infect. Dis., 37, 214, 10.1086/375821
Quinteira, 2007, Molecular epidemiology of imipenem-resistant Acinetobacter haemolyticus and Acinetobacter baumannii isolates carrying plasmid-mediated OXA-40 from a Portuguese hospital, Antimicrob. Agents Chemother., 51, 3465, 10.1128/AAC.00267-07
Rafailidis, 2007, Ampicillin/sulbactam: current status in severe bacterial infections, Drugs, 67, 1829, 10.2165/00003495-200767130-00003
Rajamohan, 2010, Molecular and functional characterization of a novel efflux pump, AmvA, mediating antimicrobial and disinfectant resistance in Acinetobacter baumannii, J. Antimicrob. Chemother., 65, 1919, 10.1093/jac/dkq195
Rakin, 2012, Hunger for iron: the alternative siderophore iron scavenging systems in highly virulent Yersinia, Front. Cell. Infect. Microbiol., 2, 151, 10.3389/fcimb.2012.00151
Ramirez, 2010a, Naturally competent Acinetobacter baumannii clinical isolate as a convenient model for genetic studies, J. Clin. Microbiol., 48, 1488, 10.1128/JCM.01264-09
Ramirez, 2010b, Novel insights about class 2 integrons from experimental and genomic epidemiology, Antimicrob. Agents Chemother., 54, 699, 10.1128/AAC.01392-08
Rao, 2016a, Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies, J. Antimicrob. Chemother., 71, 3148, 10.1093/jac/dkw293
Rao, 2016b, Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii, Int. J. Antimicrob. Agents, 48, 331, 10.1016/j.ijantimicag.2016.06.006
Ravasi, 2011, ISAba825, a functional insertion sequence modulating genomic plasticity and blaOXA-58 expression in Acinetobacter baumannii, Antimicrob. Agents Chemother., 55, 917, 10.1128/AAC.00491-10
Reid, 2005, The importance of guidelines in the development and application of probiotics, Curr. Pharm. Des, 11, 11, 10.2174/1381612053382395
Repizo, 2015, Differential Role of the T6SS in Acinetobacter baumannii Virulence, PLoS ONE, 10, e0138265, 10.1371/journal.pone.0138265
Ribera, 2003a, Partial characterization of a transposon containing the tet(A) determinant in a clinical isolate of Acinetobacter baumannii, J. Antimicrob. Chemother., 52, 477, 10.1093/jac/dkg344
Ribera, 2003b, Presence of the Tet M determinant in a clinical isolate of Acinetobacter baumannii, Antimicrob. Agents Chemother, 47, 2310, 10.1128/AAC.47.7.2310-2312.2003
Riccio, 2000, Characterization of the metallo-β-lactamase determinant of Acinetobacter baumannii AC-54/97 reveals the existence of blaIMP allelic variants carried by gene cassettes of different phylogeny, Antimicrob. Agents Chemother, 44, 1229, 10.1128/AAC.44.5.1229-1235.2000
Ritchie, 2014, A review of intravenous minocycline for treatment of multidrug-resistant Acinetobacter infections, Clin. Infect. Dis, 59, S374, 10.1093/cid/ciu613
Robledo, 2010, Detection of KPC in Acinetobacter spp. in Puerto Rico, Antimicrob. Agents Chemother., 54, 1354, 10.1128/AAC.00899-09
Roca, 2009, CraA, a major facilitator superfamily efflux pump associated with chloramphenicol resistance in Acinetobacter baumannii, Antimicrob. Agents Chemother., 53, 4013, 10.1128/AAC.00584-09
Rodriguez-Bano, 2008, Biofilm formation in Acinetobacter baumannii: associated features and clinical implications, Clin. Microbiol. Infect., 14, 276, 10.1111/j.1469-0691.2007.01916.x
Rodriguez, 2010, In vitro antimicrobials activity against endemic Acinetobacter baumannii multiresistant clones, J. Infect. Dev. Ctries, 4, 164, 10.3855/jidc.604
Rodriguez, 2015, In vitro activity of minocycline alone or in combination in multidrug-resistant Acinetobacter baumannii isolates, J. Med. Microbiol., 64, 1196, 10.1099/jmm.0.000147
Rodriguez-Rubio, 2016, ‘Artilysation’ of endolysin lambdaSa2lys strongly improves its enzymatic and antibacterial activity against streptococci, Sci. Rep., 6, 35382, 10.1038/srep35382
Rosenfeld, 2012, Expression of the resistance-nodulation-cell division pump AdeIJK in Acinetobacter baumannii is regulated by AdeN, a TetR-type regulator, Antimicrob. Agents Chemother., 56, 2504, 10.1128/AAC.06422-11
Ruiz, 2015, Crystal Structure of Hcp from Acinetobacter baumannii: a Component of the Type VI Secretion System, PLoS ONE, 10, e0129691, 10.1371/journal.pone.0129691
Ruiz, 2007, High prevalence of carbapenem-hydrolysing oxacillinases in epidemiologically related and unrelated Acinetobacter baumannii clinical isolates in Spain, Clin. Microbiol. Infect., 13, 1192, 10.1111/j.1469-0691.2007.01825.x
Rumbo, 2011, Horizontal transfer of the OXA-24 carbapenemase gene via outer membrane vesicles: a new mechanism of dissemination of carbapenem resistance genes in Acinetobacter baumannii, Antimicrob. Agents Chemother., 55, 3084, 10.1128/AAC.00929-10
Rumbo, 2014, The Acinetobacter baumannii Omp33-36 porin is a virulence factor that induces apoptosis and modulates autophagy in human cells, Infect. Immun., 82, 4666, 10.1128/IAI.02034-14
Rumbo, 2016, Assessment of antivirulence activity of several D-amino acids against Acinetobacter baumannii and Pseudomonas aeruginosa, J. Antimicrob. Chemother., 71, 3473, 10.1093/jac/dkw342
Russo, 2013, The K1 capsular polysaccharide from Acinetobacter baumannii is a potential therapeutic target via passive immunization, Infect. Immun., 81, 915, 10.1128/IAI.01184-12
Russo, 2010, The K1 capsular polysaccharide of Acinetobacter baumannii strain 307-0294 is a major virulence factor, Infect. Immun., 78, 3993, 10.1128/IAI.00366-10
Russo, 2009, Penicillin-binding protein 7/8 contributes to the survival of Acinetobacter baumannii in vitro and in vivo, J. Infect. Dis., 199, 513, 10.1086/596317
Russo, 2016, The response regulator BfmR is a potential drug target for Acinetobacter baumannii, mSphere, 1, e00082, 10.1128/mSphere.00082-16
Ruzin, 2007, AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus-Acinetobacter baumannii complex, J. Antimicrob. Chemother., 59, 1001, 10.1093/jac/dkm058
Saha, 2013, Microbial siderophores: a mini review, J. Basic Microbiol., 53, 303, 10.1002/jobm.201100552
Sahly, 2008, Extended-spectrum β-lactamase production is associated with an increase in cell invasion and expression of fimbrial adhesins in Klebsiella pneumoniae, Antimicrob. Agents Chemother., 52, 3029, 10.1128/AAC.00010-08
Sakoulas, 2016, Classical β-lactamase inhibitors potentiate the activity of daptomycin against methicillin-resistant Staphylococcus aureus and colistin against Acinetobacter baumannii, Antimicrob. Agents Chemother., 61, e01745, 10.1128/AAC.01745-16
Sandri, 2013, Population pharmacokinetics of intravenous polymyxin B in critically ill patients: implications for selection of dosage regimens, Clin. Infect. Dis., 57, 524, 10.1093/cid/cit334
Santimaleeworagun, 2011, In vitro activity of colistin or sulbactam in combination with fosfomycin or imipenem against clinical isolates of carbapenem-resistant Acinetobacter baumannii producing OXA-23 carbapenemases, Southeast Asian J. Trop. Med. Public Health, 42, 890
Schroder, 2013, Opposing effects of aminocoumarins and fluoroquinolones on the SOS response and adaptability in Staphylococcus aureus, J. Antimicrob. Chemother, 68, 529, 10.1093/jac/dks456
Sechi, 2004, PER-1 type β-lactamase production in Acinetobacter baumannii is related to cell adhesion, Med. Sci. Monit
Segal, 2004, Genetic environment and transcription of ampC in an Acinetobacter baumannii clinical isolate, Antimicrob. Agents Chemother, 48, 612, 10.1128/AAC.48.2.612-614.2004
Sharma, 2016, Fosfomycin resistance in Acinetobacter baumannii is mediated by efflux through a major facilitator superfamily (MFS) transporter-AbaF, J. Antimicrob. Chemother., 72, 68, 10.1093/jac/dkw382
Sheng, 2011, Comparative in vitro antimicrobial susceptibilities and synergistic activities of antimicrobial combinations against carbapenem-resistant Acinetobacter species: Acinetobacter baumannii versus Acinetobacter genospecies 3 and 13TU, Diagn. Microbiol. Infect. Dis., 70, 380, 10.1016/j.diagmicrobio.2011.03.003
Shin, 2015, Synergistic effect of oleanolic acid on aminoglycoside antibiotics against Acinetobacter baumannii, PLoS ONE, 10, e0137751, 10.1371/journal.pone.0137751
Shneider, 2013, PAAR-repeat proteins sharpen and diversify the type VI secretion system spike, Nature, 500, 350, 10.1038/nature12453
Siroy, 2005, Channel formation by CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii, Antimicrob. Agents Chemother., 49, 4876, 10.1128/AAC.49.12.4876-4883.2005
Skalweit, 2016, Bulgecin A as a β-lactam enhancer for carbapenem-resistant Pseudomonas aeruginosa and carbapenem-resistant Acinetobacter baumannii clinical isolates containing various resistance mechanisms, Drug Des. Devel. Ther., 10, 3013, 10.2147/DDDT.S110193
Smani, 2013, Association of the outer membrane protein Omp33 with fitness and virulence of Acinetobacter baumannii, J. Infect. Dis., 208, 1561, 10.1093/infdis/jit386
Smani, 2014, Role of OmpA in the multidrug resistance phenotype of Acinetobacter baumannii, Antimicrob. Agents Chemother., 58, 1806, 10.1128/AAC.02101-13
Smani, 2012, Role of fibronectin in the adhesion of Acinetobacter baumannii to host cells, PLoS ONE, 7, e33073, 10.1371/journal.pone.0033073
Smith, 2007, A molecular Swiss army knife: OmpA structure, function and expression, FEMS Microbiol. Lett., 273, 1, 10.1111/j.1574-6968.2007.00778.x
Smolyakov, 2003, Nosocomial multi-drug resistant Acinetobacter baumannii bloodstream infection: risk factors and outcome with ampicillin-sulbactam treatment, J. Hosp. Infect, 54, 32, 10.1016/S0195-6701(03)00046-X
Songer, 1997, Bacterial phospholipases and their role in virulence, Trends Microbiol., 5, 156, 10.1016/S0966-842X(97)01005-6
Song, 2008, Colistin and rifampicin combination in the treatment of ventilator-associated pneumonia caused by carbapenem-resistant Acinetobacter baumannii, Int. J. Antimicrob. Agents, 32, 281, 10.1016/j.ijantimicag.2008.04.013
Srinivasan, 2009, Role of AbeS, a novel efflux pump of the SMR family of transporters, in resistance to antimicrobial agents in Acinetobacter baumannii, Antimicrob. Agents Chemother., 53, 5312, 10.1128/AAC.00748-09
Srinivasan, 2015, Functional characterization of AbeD, an RND-type membrane transporter in antimicrobial resistance in Acinetobacter baumannii, PLoS ONE, 10, e0141314, 10.1371/journal.pone.0141314
Stahl, 2015, Acinetobacter baumannii virulence is mediated by the concerted action of three phospholipases D, PLoS ONE, 10, e0138360, 10.1371/journal.pone.0138360
Stoeva, 2008, Clonal spread of carbapenem-resistant OXA-23-positive Acinetobacter baumannii in a Bulgarian university hospital, Clin. Microbiol. Infect., 14, 723, 10.1111/j.1469-0691.2008.02018.x
Su, 2012, Increase of carbapenem-resistant Acinetobacter baumannii infection in acute care hospitals in Taiwan: association with hospital antimicrobial usage, PLoS ONE, 7, e37788, 10.1371/journal.pone.0037788
Sugawara, 2012, OmpA is the principal nonspecific slow porin of Acinetobacter baumannii, J. Bacteriol., 194, 4089, 10.1128/JB.00435-12
Sun, 2016, Single amino acid substitution Gly186Val in AdeS restores tigecycline susceptibility of Acinetobacter baumannii, J. Antimicrob. Chemother., 71, 1488, 10.1093/jac/dkw002
Sun, 2012, A truncated AdeS kinase protein generated by ISAba1 insertion correlates with tigecycline resistance in Acinetobacter baumannii, PLoS ONE, 7, e49534, 10.1371/journal.pone.0049534
Su, 2005, AbeM, an H+-coupled Acinetobacter baumannii multidrug efflux pump belonging to the MATE family of transporters, Antimicrob. Agents Chemother., 49, 4362, 10.1128/AAC.49.10.4362-4364.2005
Tada, 2014, Dissemination of 16S rRNA methylase ArmA-producing Acinetobacter baumannii and emergence of OXA-72 carbapenemase coproducers in Japan, Antimicrob. Agents Chemother., 58, 2916, 10.1128/AAC.01212-13
Taitt, 2014, Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities, Antimicrob. Agents Chemother., 58, 767, 10.1128/AAC.01897-13
Thandar, 2016, Novel engineered peptides of a phage lysin as effective antimicrobials against multidrug-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 2671, 10.1128/AAC.02972-15
Thummeepak, 2016, Enhanced antibacterial activity of Acinetobacter baumannii bacteriophage OABP-01 endolysin (LysABP-01) in combination with colistin, Front. Microbiol., 7, 1402, 10.3389/fmicb.2016.01402
Timurkaynak, 2006, In vitro activities of non-traditional antimicrobials alone or in combination against multidrug-resistant strains of Pseudomonas aeruginosa and Acinetobacter baumannii isolated from intensive care units, Int. J. Antimicrob. Agents, 27, 224, 10.1016/j.ijantimicag.2005.10.012
Tipton, 2016, An ompR/envZ two-component system ortholog regulates phase variation, osmotic tolerance, motility, and virulence in Acinetobacter baumannii strain AB5075, J. Bacteriol, 10.1128/JB.00705-16
Tognim, 2006, Dissemination of IMP-1 metallo- beta -lactamase-producing Acinetobacter species in a Brazilian teaching hospital, Infect. Control Hosp. Epidemiol., 27, 742, 10.1086/504356
Tomaras, 2003, Attachment to and biofilm formation on abiotic surfaces by Acinetobacter baumannii: involvement of a novel chaperone-usher pili assembly system, Microbiology, 149, 3473, 10.1099/mic.0.26541-0
Tomaras, 2008, Characterization of a two-component regulatory system from Acinetobacter baumannii that controls biofilm formation and cellular morphology, Microbiology, 154, 3398, 10.1099/mic.0.2008/019471-0
Touchon, 2014, The genomic diversification of the whole Acinetobacter genus: origins, mechanisms, and consequences, Genome Biol. Evol., 6, 2866, 10.1093/gbe/evu225
Traglia, 2014, Whole-genome sequence analysis of the naturally competent Acinetobacter baumannii clinical isolate A118, Genome Biol. Evol., 6, 2235, 10.1093/gbe/evu176
Traglia, 2016, Serum Albumin and Ca2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 4920, 10.1128/AAC.00529-16
Trebosc, 2016, A novel genome-editing platform for drug-resistant Acinetobacter baumannii reveals an AdeR-unrelated tigecycline resistance mechanism, Antimicrob. Agents Chemother., 60, 7263, 10.1128/AAC.01275-16
Tsakris, 2008, Clusters of imipenem-resistant Acinetobacter baumannii clones producing different carbapenemases in an intensive care unit, Clin. Microbiol. Infect., 14, 588, 10.1111/j.1469-0691.2008.01996.x
Tsakris, 2006, VIM-1 metallo-β-lactamase in Acinetobacter baumannii, Emerg. Infect. Dis, 12, 981, 10.3201/eid1206.051097
Tsakris, 2007, Identification of a novel blaOXA-51 variant, blaOXA-92, from a clinical isolate of Acinetobacter baumannii, Clin. Microbiol. Infect., 13, 348, 10.1111/j.1469-0691.2006.01598.x
Tsuji, 2016, Paradoxical effect of polymyxin B: high drug exposure amplifies resistance in Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 3913, 10.1128/AAC.02831-15
Turner, 2003, The activity of meropenem and comparators against Acinetobacter strains isolated from European hospitals, 1997–2000, Clin. Microbiol. Infect, 9, 563, 10.1046/j.1469-0691.2003.00591.x
Turton, 2006a, The role of ISAba1 in expression of OXA carbapenemase genes in Acinetobacter baumannii, FEMS Microbiol. Lett., 258, 72, 10.1111/j.1574-6968.2006.00195.x
Turton, 2006b, Identification of Acinetobacter baumannii by detection of the blaOXA-51-like carbapenemase gene intrinsic to this species, J. Clin Microbiol., 44, 2974, 10.1128/JCM.01021-06
Umland, 2012, In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media, MBio, 3, e00113, 10.1128/mBio.00113-12
Vahaboglu, 2006, High prevalence of OXA-51-type class D β-lactamases among ceftazidime-resistant clinical isolates of Acinetobacter spp.: co-existence with OXA-58 in multiple centres, J. Antimicrob. Chemother., 58, 537, 10.1093/jac/dkl273
Valenzuela, 2007, Horizontal gene transfer in a polyclonal outbreak of carbapenem-resistant Acinetobacter baumannii, J. Clin. Microbiol., 45, 453, 10.1128/JCM.01971-06
Vijayakumar, 2016, Molecular characterization of invasive carbapenem-resistant Acinetobacter baumannii from a tertiary care hospital in south India, Infect. Dis. Ther., 5, 379, 10.1007/s40121-016-0125-y
Vilacoba, 2013, Emergence and spread of plasmid-borne tet(B)::ISCR2 in minocycline-resistant Acinetobacter baumannii isolates, Antimicrob. Agents Chemother., 57, 651, 10.1128/AAC.01751-12
Vila, 1997, Cloning and nucleotide sequence analysis of a gene encoding an OXA-derived β-lactamase in Acinetobacter baumannii, Antimicrob. Agents Chemother, 41, 2757, 10.1128/AAC.41.12.2757
Vila, 1995, Mutation in the gyrA gene of quinolone-resistant clinical isolates of Acinetobacter baumannii, Antimicrob. Agents Chemother, 39, 1201, 10.1128/AAC.39.5.1201
Vincent, 2009, International study of the prevalence and outcomes of infection in intensive care units, JAMA, 302, 2323, 10.1001/jama.2009.1754
Voulgari, 2016, First report of an NDM-1 metallo-β-lactamase-producing Acinetobacter baumannii clinical isolate in Greece, Int. J. Antimicrob. Agents, 48, 761, 10.1016/j.ijantimicag.2016.09.006
Wang, 2007, Molecular epidemiology of clinical isolates of carbapenem-resistant Acinetobacter spp. from Chinese hospitals. Antimicrob, Agents Chemother., 51, 4022, 10.1128/AAC.01259-06
Wang, 2014, Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung, MBio, 5, e01163, 10.1128/mBio.01163-14
Wareham, 2011, In vitro activity of teicoplanin combined with colistin versus multidrug-resistant strains of Acinetobacter baumannii, J. Antimicrob. Chemother., 66, 1047, 10.1093/jac/dkr069
Weber, 2015a, Pathogenic Acinetobacter: from the Cell Surface to Infinity and Beyond, J. Bacteriol., 198, 880, 10.1128/JB.00906-15
Weber, 2015b, A multidrug resistance plasmid contains the molecular switch for type VI secretion in Acinetobacter baumannii, Proc. Natl. Acad. Sci. U.S.A., 112, 9442, 10.1073/pnas.1502966112
Weber, 2013, Genomic and functional analysis of the type VI secretion system in Acinetobacter, PLoS ONE, 8, e55142, 10.1371/journal.pone.0055142
Wormser, 1982, Co-trimoxazole (trimethoprim-sulfamethoxazole): an updated review of its antibacterial activity and clinical efficacy, Drugs, 24, 459, 10.2165/00003495-198224060-00002
Wright, 2014, New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis, MBio, 5, e00963, 10.1128/mBio.00963-13
Wu, 2016, In vivo protein interaction network analysis reveals porin-localized antibiotic inactivation in Acinetobacter baumannii strain AB5075, Nat. Commun., 7, 13414, 10.1038/ncomms13414
Yamamoto, 2011, Interspecies dissemination of a novel class 1 integron carrying blaIMP−19 among Acinetobacter species in Japan, J. Antimicrob. Chemother., 66, 2480, 10.1093/jac/dkr336
Yang, 2015, Antibacterial activity of a novel peptide-modified lysin against Acinetobacter baumannii and Pseudomonas aeruginosa, Front. Microbiol., 6, 1471, 10.3389/fmicb.2015.01471
Yang, 2016, In vivo and in vitro efficacy of minocycline-based combination therapy for minocycline-resistant Acinetobacter baumannii, Antimicrob. Agents Chemother., 60, 4047, 10.1128/AAC.02994-15
Yokoyama, 2015, Population pharmacokinetic-pharmacodynamic target attainment analysis of sulbactam in patients with impaired renal function: dosing considerations for Acinetobacter baumannii infections, J. Infect. Chemother., 21, 284, 10.1016/j.jiac.2014.12.005
Yum, 2002, Molecular characterization of metallo-β-lactamase-producing Acinetobacter baumannii and Acinetobacter genomospecies 3 from Korea: identification of two new integrons carrying the blaVIM-2 gene cassettes, J. Antimicrob. Chemother, 49, 837, 10.1093/jac/dkf043
Yu, 2007, Widespread occurrence of aminoglycoside resistance due to ArmA methylase in imipenem-resistant Acinetobacter baumannii isolates in China, J. Antimicrob. Chemother., 60, 454, 10.1093/jac/dkm208
Zavascki, 2007, Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review, J. Antimicrob. Chemother., 60, 1206, 10.1093/jac/dkm357
Zhang, 2016, Mucosal immunization with purified OmpA elicited protective immunity against infections caused by multidrug-resistant Acinetobacter baumannii, Microb. Pathog., 96, 20, 10.1016/j.micpath.2016.04.019
Zhu, 2009, A novel aminoglycoside-modifying enzyme gene aac(6′)-Ib in a pandrug-resistant Acinetobacter baumannii strain, J. Hosp. Infect., 73, 184, 10.1016/j.jhin.2009.05.012
Zimbler, 2012, Stress response and virulence functions of the Acinetobacter baumannii NfuA Fe-S scaffold protein, J. Bacteriol., 194, 2884, 10.1128/JB.00213-12