Biologically modified PHEMA beads for hemoperfusion: Preliminary studies

Polyhydroxyethylmethacrylate (PHEMA) beads were prepared by phase separation polymerization. Hydroxyl groups on PHEMA beads were activated with CNBr at alkaline pH. Adsorption of heparin, blood proteins (i.e. albumin, fibrinogen and γ-globulin), protein A, HIgG and DNA on these beads were studied. Preparation and activation procedures are given here. The preliminary results of these studies are also reported.