Biological insights from 108 schizophrenia-associated genetic loci

Nature - Tập 511 Số 7510 - Trang 421-427 - 2014
Stephan Ripke1,2, Benjamin M. Neale1,2, Aiden Corvin3, James Walters4, Kai-How Farh2, Peter Holmans4, Phil Lee1,2, Brendan Bulik‐Sullivan1,2, David Collier5,6, Hu Zhang1,2, Tune H. Pers1,2,7, Ingrid Agartz8,9, Esben Agerbo10,11, Margot Albus, Madeline Alexander12, Silviu‐Alin Bacanu13, Martin Begemann14, Richard A. Belliveau1, Judit Bene15, Sarah E. Bergen1,8, Elizabeth Bevilacqua1, Tim B. Bigdeli13, Donald W. Black16, Richard Bruggeman17, Sven Cichon18, Randy L. Buckner2, William Byerley19, Wiepke Cahn20, Guiqing Cai21, M. Arfan Ikram22, Carrie E. Bearden23, Vaughan J. Carr24, Noa Carrera4, Stanley V. Catts25, Kimberly D. Chambert1, Raymond Chan, Ronald Y.L. Chen26, Eric Chen26, Wei Cheng27, Eric Cheung, Siow Ann Chong, C. Robert Cloninger28, David Cohen, Nadine Cohen, Paul Cormican3, N. Craddock4, James J. Crowley27, David Curtis29,30, Michael Davidson, Kenneth L. Davis21, Franziska Degenhardt31, Jurgen Del‐Favero32, Ditte Demontis10,11, Dimitris Dikeos33, Timothy G. Dinan34, Srdjan Djurovic9, Gary Donohoe35,3, Elodie Drapeau21, Jubao Duan36, Juan P. Casas37, Naser Durmishi, Peter Eichhammer38, Johan Eriksson39,40, Valentina Escott‐Price4, Laurent Essioux, Ayman H. Fanous, Martilias S. Farrell27, Maren Lang41, Lude Franke17, Robert Freedman42, Aarno Palotie23, Marion Friedl43, Joseph I. Friedman21, Menachem Fromer1,2,21, Giulio Genovese1, Lyudmila Georgieva4, Ina Giegling44,43, Paola Giusti‐Rodríguez27, Stephanie Godard45, Jacqueline I. Goldstein1,2, В. Е. Голимбет46, Srihari Gopal47, Jacob Gratten25, Lieuwe de Haan48, Christian M. Hammer14, Marian L. Hamshere4, Mark Hansen49, Thomas Hansen11, Vahram Haroutunian21, Annette M. Hartmann43, Frans Henskens50, Stefan Herms51,31, Joel N. Hirschhorn1,2, Per Hoffmann51,31, Andrea Hofman31, Mads V. Hollegaard52, David M. Hougaard52, Nakao Iwata53, Inge Joa, Antonio Julià54, René S. Kahn20, Luba Kalaydjieva55, Sena Karachanak-Yankova56, Juha Karjalainen17, David Kavanagh4, Matthew C. Keller57, James L. Kennedy58, Andrey Khrunin, Yunjung Kim27, Jānis Kloviņš59, James A. Knowles60, Bettina Konte43, Vaidutis Kučinskas61, Zita Aušrelė Kučinskienė61, Hana Kuzelova-Ptackova62, Annachiara Cagnin8, Claudine Laurent12, Jimmy Lee63, Sang Lee25, Sophie E. Legge4, Bernard Lerer, Miaoxin Li26, Tao Li64, Kung‐Yee Liang65, Jeffrey A. Lieberman66, Limborskaia Sa, Carmel M. Loughland50, Dong Liang67, Jouko Lönnqvist39, Milan Maçek62, Patrik K. E. Magnusson8, Brion S. Maher65, Reinhard Heun31, Jacques Mallet45, Sara Marsal54, Manuel Mattheisen10,11,31, Morten Mattingsdal9, Robert W. McCarley2, Colm McDonald35, Andrew M. McIntosh68, Sandra Meier41, Carin J. Meijer48, Béla Melegh15, Ingrid Melle9, Raquelle I. Mesholam‐Gately2, Andres Metspalu69, Patricia T. Michie50, Lili Milani69, Vihra Milanova56, Younes Mokrab5, Derek W. Morris35,3, Ole Mors10,11, Kieran C. Murphy70, Robin Murray6, Inez Myin‐Germeys71, Bertram Müller‐Myhsok14, Mari Nelis69, Igor Nenadić72, Deborah A. Nertney25, Gerald Nestadt65, Carolina Bonilla3, Liene Ņikitina-Zaķe59, Laura Nisenbaum5, Annelie Nordin73, Eadbhard O’Callaghan, Gianpiero L. Cavalleri1, F. Anthony O′Neill74, Sang‐Yun Oh75, Ann Olincy42, Line Olsen11, Jim van Os6,71, Christos Pantelis76, George N. Papadimitriou33, Sergi Papiol14, Elena Parkhomenko21, Michele T. Pato60, Tiina Paunio39,40, Miloš Milovančević77, Diana O. Perkins27, Olli Pietiläinen39,40, Joseph Piven30, Andrew Pocklington4, John Powell6, Alkes L. Price1,2, Ann E. Pulver65, Shaun Purcell21, Digby Quested78, Soumya Raychaudhuri11, Abraham Reichenberg21, Mark Reimers13, Alexander Richards4, Joshua L. Roffman2, Panos Roussos21, Douglas M. Ruderfer4,21, Veikko Salomaa39, Marc De Hert36, Ulrich Schall50, Christian Schubert79, Thomas G. Schulze41,80, Sibylle G. Schwab81, Edward M. Scolnick1, Rodney J. Scott50, Larry J. Seidman2, Jianxin Shi82, Engilbert Sigurðsson83, Teimuraz Silagadze84, Jeremy M. Silverman21, Kang Sim, P. A. Slominsky, Jordan W. Smoller1,2, Hon‐Cheong So26, Chris C. A. Spencer78, Eli A. Stahl1,21, Hreinn Stefánsson85, Stacy Steinberg85, Elisabeth Stögmann86, Richard E. Straub, Eric Strengman20, Janice M. Fullerton41, T. Scott Stroup66, Mythily Subramaniam, Jaana Suvisaari39, Dragan M. Švrakić28, Jin Szatkiewicz27, Erik Söderman8, Srinivas Thirumalai, Драга Тончева56, Sarah Tosato87, Juha Veijola88, John L. Waddington70, Dermot Walsh, Dai Wang47, Qiang Wang64, Bradley T. Webb13, Mark Weiser, Dieter B. Wildenauer55, Nigel Williams4, Stephanie Williams27, Stephanie H. Witt41, Aaron R. Wolen13, Emily H.M. Wong26, Brandon Wormley13, Hualin Simon Xi79, Clement C. Zai58, Xuebin Zheng89, Fritz Zimprich86, Naomi R. Wray25, Kári Stefánsson85, Peter M. Visscher25, Rolf Adolfsson73, Ole A. Andreassen9, Douglas H. R. Blackwood68, Elvira Bramon30, Joseph D. Buxbaum21, Anders D. Børglum10,11, Ariel Darvasi90, Enrico Domenici, Agnes A. Steixner-Kumar14, Tõnu Esko1,2,69, Pablo V. Gejman36, Gill Livingston3, Hugh Gurling30, Eva C. Schulte8, Assen Jablensky55, Erik G. Jönsson8,9, Kenneth S. Kendler13, George Kirov4, Jo Knight58, Todd Lencz91,92, Douglas F. Levinson12, Qingqin S. Li47, Jing Liu89,63, Anil K. Malhotra91,92, Steven A. McCarroll1,2, Andrew McQuillin30, Jennifer L. Moran1, Preben Bo Mortensen10,11, Bryan Mowry25, Markus M. Noethen31, Urban Ösby23,20, Michael J. Owen4, Carlos N. Pato60, Tracey L. Petryshen1,2, Daniëlle Posthuma93,94, Marcella Rietschel41, Brien P. Riley13, Dan Rujescu44,43, Pak C. Sham26, Pamela B. Mahon21, Jens R. Wendland79, Jian Yang11,95, Mark J. Daly1,2, Jing Wu8,27
1Broad Institute, Cambridge, United States
2Harvard University, Cambridge, United States
3Trinity College Dublin, Dublin, Ireland
4Cardiff University, Cardiff, United Kingdom
5Eli Lilly (United States), Indianapolis, United States
6King's College London, London, United Kingdom
7Technical University of Denmark, Kongens Lyngby, Denmark
8Karolinska Institutet, Stockholm, Sweden
9University of Oslo, Oslo, Norway
10Aarhus University, Aarhus, Denmark
11Lundbeck (Denmark), Copenhagen, Denmark
12Stanford University, Stanford, United States
13Virginia Commonwealth University, Richmond, United States
14Max Planck Society, Munich, Germany
15University of Pecs, Pécs, Hungary
16University of Iowa, Iowa City, United States
17University of Groningen, Groningen, Netherlands
18Louisiana State University, Baton Rouge, United States
19University of California, San Francisco, San Francisco, United States
20Utrecht University, Utrecht, The Netherlands
21Icahn School of Medicine at Mount Sinai, New York, United States
22Inserm, Paris, France
23University of California, Los Angeles, Los Angeles, United States
24UNSW Sydney, Sydney, Australia
25University of Queensland, Brisbane, Australia
26University of Hong Kong, Hong Kong, Hong Kong
27University of North Carolina at Chapel Hill, Chapel Hill, United States
28Washington University in St. Louis, St Louis, United States
29Queen Mary University of London, London, United Kingdom
30University College London, London, United Kingdom
31University of Bonn Bonn, Germany
32University of Antwerp, Antwerp, Belgium
33National and Kapodistrian University of Athens, Athens, Greece
34University College Cork, Cork, Ireland
35Ollscoil na Gaillimhe – University of Galway, Galway, Ireland
36University of Chicago, Chicago, United States
37University of London, London, United Kingdom
38University of Regensburg, Regensburg, Germany
39Finnish Institute for Health and Welfare, Helsinki, Finland
40University of Helsinki, Helsinki, Finland
41Heidelberg University, Heidelberg, Germany
42University of Colorado Denver, Denver, United States
43Martin Luther University Halle-Wittenberg, Halle, Germany
44Ludwig-Maximilians-Universität München, Munich, Germany
45Université Paris Cité, Paris, France
46Russian Academy of Sciences, Moscow, Russia
47Janssen Belgium, Beerse, Belgium
48University of Amsterdam, Amsterdam, Netherlands
49Illumina (United States), San Diego, United States
50University of Newcastle Australia, Newcastle, Australia
51University of Basel, Basel, Switzerland
52Statens Serum Institut, Copenhagen, Denmark
53Fujita Health university, Toyoake, Japan
54Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain
55University of Western Australia, Perth, Australia
56Medical University of Sofia, Sofia, Bulgaria
57University of Colorado Boulder, Boulder, United States
58University of Toronto, Toronto, Canada
59Latvian Biomedical Research and Study Centre, Riga, Latvia
60University of Southern California, Los Angeles, United States
61Vilnius University, Vilnius, Lithuania
62Charles University, Prague, Czechia
63National University of Singapore, Singapore, Singapore
64Sichuan University, Chengdu, China
65Johns Hopkins University, Baltimore, United States
66Columbia University, New York, United States
67Pomeranian Medical University, Szczecin, Poland
68University of Edinburgh, Edinburgh, United Kingdom
69University of Tartu, Tartu, Estonia
70Royal College of Surgeons in Ireland, Dublin, Ireland
71Maastricht University, Maastricht, Netherlands
72Friedrich Schiller University Jena, Jena, Germany
73Umeå University, Umeå, Sweden
74Queen’s University Belfast, Belfast, United Kingdom
75Lawrence Berkeley National Laboratory, Berkeley, United States
76University of Melbourne, Melbourne, Australia
77University of Belgrade, Belgrade, Serbia
78University of Oxford, Oxford, United Kingdom
79Pfizer (United States), New York, United States
80University of Göttingen, Göttingen, Germany
81Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany
82National Institutes of Health, Bethesda, United States
83University of Iceland, Reykjavik, Iceland
84Tbilisi State Medical University, Tbilisi, Georgia
85deCODE Genetics (Iceland), Reykjavik, Iceland
86Medical University of Vienna, Vienna, Austria
87University of Verona, Verona, Italy
88University of Oulu, Oulu, Finland
89Agency for Science, Technology and Research, Singapore, Singapore
90Hebrew University of Jerusalem, Jerusalem, Israel
91Hofstra University, Hempstead, United States
92Northwell Health, New Hyde Park, United States
93Erasmus University Rotterdam, Rotterdam, Netherlands
94Vrije Universiteit Amsterdam, Amsterdam, Netherlands
95University of Copenhagen, Copenhagen, Denmark

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