Biological detoxification of mycotoxins: a review

Annals of Microbiology - Tập 64 Số 3 - Trang 905-919 - 2014
Amal S. Hathout1, Soher E. Aly1
1Food Toxicology & Contaminants Department, National Research Centre, Cairo, Egypt

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Abrunhosa L, Serra R, Venancio A (2002) Biodegradation of ochratoxin A by fungi isolated from grapes. J Agric Food Chem 50:7493–7496

Alberts JF, Engelbrecht Y, Steyn PS, Holzapfel WH, van Zyl WH (2006) Biological degradation of aflatoxin B1 by Rhodococcus erythropolis cultures. Int J Food Microbiol 109:121–126

Angioni A, Caboni P, Garau A, Farris A, Orro D, Budroni M, Cabras P (2007) In vitro interaction between ochratoxin A and different strains of Saracchomyces cerevisiae and Kloeckera apiculata. J Agric Food Chem 55(5):2043–2048

Arai T, Tatsuya I, Koyama Y (1967) Antimicrobial activity of aflatoxins. J Bacteriol 93:59–64

Aravind KL, Patil VS, Devegowda G, Umakantha B, Ganpules P (2003) Efficacy of esterified glucomannan to counteract mycotoxicosis in naturally contaminated feed on performance and serum biochemical and hematological parameters in broilers. Poult Sci 82(4):571–576

Awad WA, Böhm J, Razzazi-Fazeli E, Faukal K, Zentek J (2004) Effects of feeding deoxynivalenol contaminated wheat on the performance of broiler chickens. The 8th Proceeding Symposium for the European Society of Veterinary Comparative Nutrition, Budapest, Hungary, pp 149–153

Awad WA, Böhm J, Razzazi-Fazeli E, Ghareeb K, Zentek J (2006) Effect of addition of a probiotic microorganism to broiler diets contaminated with deoxynivalenol on performance and histological alterations of intestinal villi of broiler chickens. Poult Sci 85:974–979

Bata A, Lasztity R (1999) Detoxification of mycotoxin contaminated food and feed by microorganisms. Trends Food Sci Technol 10:223–228

Battcock M, Azam-Ali S (1998) Fermented fruits and vegetables—a global perspective, FAO agricultural services bulletin N°134. Food and Agriculture Organization of the United Nations, Rome

Bejaoui H, Mathieu F, Taillandier P, Lebrihi A (2004) Ochratoxin A removal in synthetic and natural grape juices by selected oenological Saccharomyces strains. J Appl Microbiol 97:1038–1044

Bejaoui H, Mathieu F, Taillandier P, Lebrihi A (2006) Biodegradation of ochratoxin A by Aspergillus section Nigri species isolated from French grapes: a potential means of ochratoxin A decontamination in grape juices and musts. FEMS Microbiol 255:203–208

Bennett GA, Richard JL (1996) Influence of processing on Fusarium mycotoxins in contaminated grains. Food Technol 50(5):235–238

Binder J, Horvath EM, Schatzmayr G, Ellend N, Danner H, Krska R, Braun R (1997) Screening for deoxynivalenol-detoxifying anaerobic rumen microorganisms. Cereal Res Commun 25:343–346

Binder EM, Binder J, Ellend N, Schaffer E, Krska R, Braun R (1998) Microbiological degradation of deoxynivalenol and 3-acetyl-deoxynivalenol. In: Miraglia M, van Egmond HP, Brera C, Gilbert J (eds) Mycotoxins and phycotoxins: Developments in chemistry, toxicology and food safety. Alaken, Fort Collins, pp 279–285

Binder EM, Heidler D, Schatzmayr G, Thimm N (2000) Mycotoxins and Phycotoxins in perspective at the turn of the Millennium. In: Koe WJ, Samson RA, van Egmond HP, Gilbert J, Sabino M (eds) Proceedings of the 10th International IUPAC Symposium on Mycotoxins and Phycotoxins, Guaruja, Brazil. pp 271–277

Biomin (2011) Biomin writes history. http://www.biomin.net/en/company/milestones

Bode HB, Irschik H, Wenzel SC, Reichenbach H, Muller R, Höfle G (2003) The leupyrrins: a structurally unique family of secondary metabolites from the myxobacterium Sorangium cellulosum. J Nat Prod 66:1203–1206

Böhm J, Grajewski J, Asperger H, Cecon B, Rabus B, Razzazi E (2000) Study on biodegradation of some A- and B trichothecenes and ochratoxin A by use of probiotic microorganisms. Mycotoxin Res 16A:70–74

Bol J, Smith JE (1989) Biotransformation of aflatoxin. Food Biotechnol 3:127–144

Bolognani F, Rumney CJ, Rowland R (1997) Influence of carcinogen binding by lactic acid producing bacteria on tissue distribution and in vivo mutagenicity of dietary carcinogens. Food Chem Toxicol 35:535–545

Böswald C, Engelhardt G, Vogel H, Wallnöfer PR (1995) Metabolism of the Fusarium mycotoxins zearalenone and deoxynivalenol by yeast strains of technological relevance. Nat Toxins 3(3):138–144

Bren U, Guengerich FP, Mavri J (2007) Guanine alkylation by the potent carcinogen aflatoxin B1: quantum chemical calculations. Chem Res Toxicol 20:1134–1140

Bruinink A, Rasonyi T, Sidler C (1998) Differences in neurotoxic effects of ochratoxin A, ochracin and ochratoxin-α in vitro. Nat Toxins 6:173–177

Bueno DJ, Casale CH, Pizzolitto RP, Salano MA, Olivier G (2006) Physical adsorptions of Aflatoxin B1 by lactic acid bacteria and Saccharomyces cerevisiae: A theoretical model. J Food Protect 70:2148–2154

Caridi A, Galvano F, Tafuri A, Ritieni A (2006a) Ochratoxin A removal during winemaking. Enzym Microb Technol 40:122–126

Caridi A, Galvano F, Tafuri A, Ritieni A (2006b) In vitro screening of Saccharomyces strains for Ochratoxin A removal from liquid medium. Ann Microbiol 56(12):135–137

Caridi A, Sidari R, Pulvirenti A, Meca G, Ritieni A (2012) Ochratoxin A adsorption phenotype: an inheritable yeast trait. J Gen Appl Microbiol 58:225–233

Castoria R, Mannina L, Durán-Patrόn R, Maffei F, Sobolev AP, De Felice DV, Pinedo-Rivilla C, Ritieni A, Ferracane R, Wright SAI (2011) Conversion of the mycotoxin patulin to the less toxic desoxypatulinic acid by the biocontrol yeast Rhodosporidium kratochvilovae strain LS11. J Agric Food Chem 59:11571–11578

Cecchini F, Morassut M, Garcia Moruno E, Di Stefano R (2006) Influence of yeast strain on ochratoxin A content during fermentation of white and red must. Food Microbiol 23(5):411–417

Çelỳk K, Denly M, Savas T (2003) Reduction of toxic effects of aflatoxin by using baker yeast (Saccharomyces cerevisiae) in growing broiler chicken diets. Rev Bras Zootec 32:615–619

Cenci G, Caldini G, Trotta F, Bosi P (2008) In vitro inhibitory activity of probiotic spore-forming bacilli against genotoxins. Lett Appl Microbiol 46:331–337

Chaurasia HK (1995) Kernel infection and aflatoxin production in peanut (Arachis hypogaea L) by Aspergillus flavus in presence of geocarpospheric bacteria. J Food Sci Technol 32:459–464

Cho KJ, Kang JS, Cho WT, Lee CH, Ha JK, Song KB (2010) In vitro degradation of zearalenone by Bacillus subtilis. Biotechnol Lett 32(12):1921–1924

Ciegler A, Lillehoj EB, Peterson RE, Hall HH (1966) Microbial detoxification of aflatoxin. Appl Microbiol 14:934–939

Coelho AR, Celli MG, Sataque Ono EY, Hoffmann FL, Pagnocca FC, Garcia S, Sabino M, Harada KI, Wosiacki G, Hirooka EY (2008) Patulin biodegradation using Pichia ohmeri and Saccharomyces cerevisiae. World Mycotoxin J 1:325–331

Cole RJ, Cox RH (1981) The aflatoxins, Handbook of toxic fungal metabolites. Academic, New York, pp 1–66

Cole RJ, Kirksez JW (1971) Aflatoxin G1 metabolism by Rhizopus species. J Agric Food Chem 19:222–223

Cole RJ, Kirksey JW, Blankenship BR (1972) Conversion of aflatoxin B1 to isomeric hydroxy compounds by Rhizopus subspecies. J Agric Food Chem 20:1100–1102

Council for Agricultural Science and Technology (2003) Mycotoxins: Risks in Plant, Animal, and Human Systems. Council for Agricultural Science and Technology, Ames, Task Force Report, No. 139

D’Souza DH, Brackett RE (1998) The role of trace metal ions in aflatoxin B1 degradation by Flavobacterium aurantiacum. J Food Protect 61:1666–1669

D’Souza DH, Brackett RE (2000) The influence of divalent cations and chelators on aflatoxin B1 degradation by Flavobacterium aurantiacum. J Food Protect 63:102–105

D’Souza DH, Brackett RE (2001) Aflatoxin B1 degradation by Flavobacterium aurantiacum in the presence of reducing conditions and seryl and sulfhydryl group inhibitors. J Food Protect 64:268–271

Del Prete V, Rodriguez H, Carrascosa AV, De Las RB, Garcia-Moruno E, Muňoz R (2007) In vitro removal of ochratoxin A by wine lactic acid bacteria. J Food Protect 70(9):2155–2160

Delcour J, Ferain T, Deghorain M, Palumbo E, Hols P (1999) The biosynthesis and functionality of the cell-wall of lactic acid bacteria. Antonie Van Leeuwenhoek 76:159–184

Detroy RW, Hesseltine CW (1968) Isolation and biological activity of a microbial conversion product of aflatoxin B1. Nature 219:967

Detroy RW, Hesseltine CW (1970) Aflatoxicol: structure of a new transformation product of aflatoxin B1. Can J Biochem 48:830–832

Duvick J, Bowen B, Gilliam J, Maddox J, Rood T, Wang X (2003) Fumonisin detoxification compositions and methods. US patent 6670189. Pioneer Hi- Bred International, Inc, Des Moines

El-Deeb BA (2005) Isolation and characterization of soil bacteria able to degrade zearalenone. J Bot 32:3–30

El-Nezami H, Salminen S, Ahokas J (1996) Biologic control of food carcinogen using Lactobacillus GG. Nutr Today 31:41–42

El-Nezami H, Kankaanpää P, Salminen S, Ahokas J (1998a) Ability of dairy strains of lactic acid bacteria to bind a common food carcinogen, aflatoxin B1. Food Chem Toxicol 36:321–326

El-Nezami H, Kankaanpää P, Salminen S, Ahokas J (1998b) Physicochemical alterations enhance the ability of dairy strains of lactic acid bacteria to remove aflatoxin from contaminated media. J Food Protect 61:466–468

El-Nezami H, Mykkänen H, Kankaanpää P, Salminen S, Ahokas J (2000) Ability of Lactobacillus and Propionibacterium strains to remove aflatoxin B1, from the chicken duodenum. J Food Protect 63:549–552

El-Nezami H, Chrevatidis A, Auriola S, Salminen S, Mykkänen H (2002a) Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium. Food Addit Contam 19(7):680–686

El-Nezami H, Haskard C, Salminen E, Mykkänen H, Ahokas J, Salminen S (2002b) Lactic acid bacteria and bifidobacteria reduce dietary exposure to aflatoxins. Br J Nutr 88:S119–S120

El-Nezami H, Polychronaki N, Samlminen S, Mykkänen H (2002c) Binding rather than metabolism may explain the interaction of two food-grade Lactobacillus strains with zearalenone and its derivative alpha zearalenol. Appl Environ Microbiol 68:3545–3549

El-Nezami H, Polychronaki N, Yuan Kun L, Haskard C, Juvonen R, Salminen S, Mykkänen H (2004) Chemical moieties and interactions involved in the binding of zearalenone to the surface of Lactobacillus rhamnosus strains GG. J Agric Food Chem 52(14):4577–4581

El-Nezami H, Polychronaki N, Ma J, Zhu H, Ling W, Salminen E, Juvonen R, Salminen S, Poussa T, Mykkänen H (2006) Probiotic supplementation reduces a biomarker for increased risk of liver cancer in young men from Southern China. Am J Clin Nutr 83:1199–1203

El-Sharkawy SH, Abul-Hajj YJ (1988) Microbial transformation of zearalenone. 2. Reduction, hydroxylation, and methylation products. J Org Chem 53:515–519

Faraj MK, Smith JE, Harran G (1993) Aflatoxin biodegradation: effects of temperature and microbes. Mycol Res 97:1388–1392

Fernández J, Mohedano AF, Gaya P, Medina M, Nuňez M (2000) Purification and properties of two intracellular aminopeptidases produced by Brevibacterium linens SR3. Int Dairy J 10:241–248

Freimund S, Sauter M, Rys P (2003) Efficient adsorption of the mycotoxins zearalenone and T-2 toxin on a modified yeast glucan. J Environ Sci Health B 38(3):243–255

Fuchs E, Binder EM, Heidler D, Krska R (2000) Characterization of metabolites after microbial degradation of A- and B-trichothecenes by BBSH 797. Mycotoxin Res 16A:66–69

Fuchs E, Binder EM, Heidler D, Krska R (2002) Structural characterization of metabolites after the microbial degradation of type A trichothecenes by the bacterial strain BBSH 797. Food Addit Contam 19:379–386

Fuchs S, Sontag G, Stidl R, Ehrlich V, Kundi M, Knasmuller S (2008) Detoxification of patulin and ochratoxin A, two abundant mycotoxins, by lactic acid bacteria. Food Chem Toxicol 46:1398–1407

Galtier P (2003) Toxic effects of mycotoxins. In: Lyons TP, Jacques KA (eds) Importance of biotransformation systems in nutritional biotechnology in the feed and food industries. Proceeding of the Alltech’s 19th Annual Symposium. Bath Press, Nottingham

Gratz S, Mykkänen H, Ouwehand AC, Juvonen R, Salminen S, El-Nezami H (2004) Intestinal mucus alters the ability of probiotic bacteria to bind aflatoxin B1 in vitro. Appl Environ Microbiol 70(10):6306–6308

Gratz S, Mykkänen H, El-Nezami H (2005) Aflatoxin B1 binding by a mixture of Lactobacillus and Propionibacterium: in vitro versus ex vivo. J Food Protect 68(11):2470–2474

Guan S, Ji C, Zhou T, Li J, Ma Q, Niu T (2008) Aflatoxin B1 degradation by Stenotrophomonas Maltophilia and other microbes selected using coumarin medium. Int J Mol Sci 9:1489–1503

Guan S, Zhao L, Ma Q, Zhou T, Wang N, Hu X, Ji C (2010) In vitro efficacy of Myxococcus fulvus ANSM068 to biotransform aflatoxin B1. Int J Mol Sci 11:4063–4079

Halttunen T, Collado MC, El-Nezami H, Meriluoto J, Salminen S (2008) Combining strains of lactic acid bacteria may reduce their toxin and heavy metal removal efficiency from aqueous solution. Lett Appl Microbiol 46:160–165

Hao YY, Brackett RE (1998) Removal of aflatoxin B1 from peanut milk inoculated with Flavobacterium aurantiacum. J Food Sci 53:1384–1386

Haskard CA, Binnion C, Ahokas J (2000) Factors affecting the sequestration of aflatoxin by Lactobacillus rhamnosus strain GG. Chem Biol Interact 128:39–49

Haskard CA, El-Nezami HS, Kankaanpää PE, Salminen S, Ahokas JT (2001) Surface binding of aflatoxin B1 by lactic acid bacteria. Appl Environ Microbiol 67:3086–3091

Hateb S, Yue T, Mohamed O (2012a) Reduction of patulin in aqueous solution by lactic acid bacteria. J Food Sci 77(4):238

Hateb S, Yue T, Mohamed O (2012b) Removal of patulin from apple juice using inactivated lactic acid bacteria. J Appl Microbiol 112(5):892–899

Hathout AS, Mohamed SR, El-Nekeety AA, Hassan NS, Aly SE, Abdel-Wahhab MA (2011) Ability of Lactobacillus casei and Lactobacillus reuteri to protect against oxidative stress in rats fed aflatoxins-contaminated diet. Toxicon 58:179–186

He P, Young LG, Forsberg C (1993) Microbially detoxified vomitoxin- contaminated corn for young pigs. J Anim Sci 71:963–967

Heidler D, Schatzmayr G (2003) A new approach to managing mycotoxins. World Poult Reed 19(2):12–15

Hernandez-Mendoza A, Guzman-de-Péna D, Garcia HS (2009) Key role of teichoic acids on aflatoxin B1 binding by probiotic bacteria. J Appl Microbiol 107:395–403

Hernandez-Mendoza A, Guzman-de-Péna D, González-Cόrdova AF, Vallejo-Cόrdova B, Garcia HS (2010) In vivo assessment of the potential protective effect of Lactobacillus casei Shirota against aflatoxin B1. Dairy Sci Technol 90:729–740

Hernandez-Mendoza A, Rivas-Jimenez L, Garcia HS (2011) Assessment of Aflatoxin B1 Binding to Lactobacillus reuteri by Microscopy and Fluorescence Techniques. Food Biotechnol 25:140–150

Hochsteiner W, Schuh M, Luger K, Baumgartner W (2000) Influence of mycotoxins contaminated feed blood parameters and milk production. Berl Munch Tierarztl Wochenschr 113:14–21

Hormisch D, Brost I, Kohring G-W, Giffhorn F, Krippenstedt RM, Stackebrandt E, Farber P, Holtzapfel WH (2004) Mycobacterium fluoranthenivorans sp. nov., a fluoranthene and aflatoxin B1 degrading bacterium from contaminated soil of a former coal gas plant. Syst Appl Microbiol 27:553–660

Hult K, Teiling A, Gatenbeck S (1976) Degradation of ochratoxin A by a ruminant. Appl Environ Microbiol 32:41–49

Hwang CA, Draughon FA (1994) Degradation of ochratoxin A by Acinetobacter calcoaceticus. J Food Protect 57:410–414

Hwang KT, Lee W, Kim GY, Lee J, Jun W (2005) The Binding of Aflatoxin B1 Modultaes the Adhesion Properties of Lactobacillus casei KCTC 3260 to a HT29 Colon Cancer Cell Line. Food Sci Biotechnol 14:866–870

Iizuka T, Jojima Y, Fudou R, Yamanaka S (1998) Isolation of myxobacteria from the marine environment. FEMS Microbiol Lett 169:317–322

Jansen R, Kunze B, Reichenbach H, Hoefle G (2003) Antibiotics from gliding bacteria. Part 93. Chondrochloren A and B, new amino styrenes from Chondromyces crocatus (Myxobacteria). Eur J Org Chem 14:2684–2689

Jard G, Liboz T, Mathieu F, Guyonvarch A, Lebrihi A (2009) Biotransformation of the mycotoxin zearalenone by a fungal strain of Aspergillus niger. ISM conference 2009, Tulln, Austria.

Jard G, Liboz T, Mathieu F, Guyonvarćh A, Lebrihi A (2011) Review of mycotoxin reduction in food and feed: from prevention in the field to detoxification by adsorption or transformation. Food Addit Contam Part A 28(11):1590–1609

Jespersen L (2003) Occurrence and taxonomic characteristics of strains of Saccharomyces cerevisiae predominant in African indigenous fermented foods and beverages. FEMS Yeast Res 3:191–200

Kabak B, Var I (2004) Binding of aflatoxin M1 by Lactobacillus and Bifidobacterium strains. Milchwissenschaft 59:301–303

Kabak B, Var I (2008) Factors affecting the removal of aflatoxin M1 from food model by Lactobacillus and Bifidobacterium strains. J Environ Sci Health B 43:617–624

Kabak B, Dobson ADW, Var I (2006) Strategies to prevent mycotoxin contamination of food and animal feed: A review. Crit Rev Food Sci Nutr 46:593–619

Kankaanpää P, Tuomola E, El-Nezami H, Ahokas J, Salminen SJ (2000) Binding of aflatoxin B1 alters the adhesion properties of Lactobacillus rhamnosus strain GG innCaco-2 model. J Food Protect 63:412–414

Karaman M, Basmacioglu H, Ortatatli M, Oguz H (2005) Evaluation of the detoxifying effect of yeast glucomannan on aflatoxicosis in broilers as assessed by gross examination and histopathology. Br Poult Sci 46(3):394–400

Karlovsky P (2011) Biological detoxification of the mycotoxin deoxynivalenol and its use in genetically engineered crops and feed additives. Appl Microbiol Biotechnol 91:491–504

Khanafari A, Soudi H, Miraboulfathi M, Osboo RK (2007) A in vitro investigation of aflatoxin B1 biological control by Lactobacillus plantarum. Pak J Biol Sci 10(15):2553–2556

Kirk O, Borchert TV, Fuglsang CC (2002) Industrial enzyme applications. Curr Opin Biotechnol 13:345–351

Knasmuller S, Steinkellner H, Hirschl AM, Rabot S, Nobis EC, Kassie F (2001) Impact of bacteria in dairy products and of the intestinal microflora on genotoxic and carcinogenic effects of heterocyclic aromatic amines. Mutat Res 480–481:129–138

Knol W, Bol J, Huis in’t Veld JHJ (1990) Detoxification of aflatoxin B1 in feeds by Rhizopus oryzae in solid state. In: Zeuthen P, Cheftel JC, Eriksson C, Gormley TR, Linko P, Paulus K (eds) Food biotechnology, vol 2. Elsevier Applied Science, London, pp 132–136

Kollöffel B, Meile L, Teuber M (1999) Analysis of Brevibacteria on the surface of Gruyere cheese detected by in situ hybridization and by colony hybridization. Lett Appl Microbiol 29:317–322

Kubicek C, Rohr M (1985) Citric acid fermentation. CRC Crit Rev Biotechnol 3(4):331–373

Kunze B, Reichenbach H, Mueller R, Höfle G (2005) Aurafuron A and B, new bioactive polyketides from Stigmatella aurantiaca and Archangium gephyra (myxobacteria). Fermentation, isolation, physico-chemical properties, structure and biological activity. J Antibiot 58:244–251

Kusumaningtyas E, Widiastuti R, Maryam R (2006) Reduction of aflatoxin B1 in chicken feed by using Saccharomyces cerevisiae, Rhizopus oligosporus, and their combination. Mycopathologia 162:307–311

Lahtinen SJ, Haskard CA, Ouwehand AC, Salminen SJ, Ahokas JT (2004) Binding of aflatoxin B1 to cell wall components of Lactobacillus rhamnosus strain GG. Food Addit Contam 21:158–164

Lankaputhra WEV, Shah NP (1998) Antimutagenic properties of probiotic bacteria and of organic acids. Mutat Res 397:169–182

Lee YK, El-Nezami H, Haskard CA, Gratz S, Puong KY, Salminen S, Mykkänen H (2003) Kinetics of adsorption and desorption of aflatoxin B1 by viable and nonviable bacteria. J Food Protect 66:426–430

Leibold T, Sasse F, Reichenbach H, Höfle G (2004) Cyrmenins, novel antifungal peptides containing a nitrogen-Linked β-methoxyacrylate pharmacophore: isolation and structural elucidation. Eur J Org Chem 2:431–435

Lillehoj EB, Ciegler BA, Hall HH (1967) Aflatoxin B1 uptake by Flavobacterium aurantiacum and resulting toxic effects. J Bacteriol 93:464–471

Line JE, Brackett RE (1995) Role of toxin concentration and second carbon source in microbial transformation of aflatoxin B1 by Flavobacterium aurantiacum. J Food Protect 58:1042–1044

Line JE, Brackett RE, Willikinson RE (1994) Evidence for degradation of aflatoxin B1 by Flavobacterium aurantiacum. J Food Protect 57:788–791

Mann R, Rehm HJ (1976) Degradation products from aflatoxin B1 by Corynebacterium rubrum, Aspergillus niger, Trichoderma viride and Mucor ambiguus. Eur J Appl Microbiol 2:297–306

Mirocha CJ, Schauerhamer B, Christensen CM, Niku-Paavola ML, Nummi M (1979) Incidence of zearalenol (Fusarium mycotoxin) in animal feed. Appl Environ Microbiol 38:749–750

Mishra HN, Das C (2003) A review on biological control and metabolism of aflatoxin. Crit Rev Food Sci Nutr 43:245–264

Mokoena MP, Chelule PK, Gqaleni N (2005) Reduction of fumonisin B1 and zearalenone by lactic acid bacteria in fermented maize meal. J Food Protect 68:2095–2099

Mokoena MP, Chelule PK, Gqaleni N (2006) The toxicity and decreased concentration of aflatoxin B in natural lactic acid fermented maize meal. J Appl Microbiol 100(4):773–777

Molnar O, Schatzmayr G, Fuchs E, Prillinger H (2004) Trichosporon mycotoxinivorans sp. nov., a new yeast species useful in biological detoxification of various mycotoxins. Syst Appl Microbiol 27:661–671

Moss MO (1998) Recent studies of mycotoxins. J Appl Microbiol Symp Suppl 84:62S–76S

Moss MO, Long MT (2002) Fate of patulin in the presence of the yeast Saccharomyces cerevisiae. Food Addit Contam 19:387–399

Motomura M, Toyomasu T, Mizuno K, Shinozawa T (2003) Purification and characterization of an aflatoxin degradation enzyme from Pleurotus ostreatus. Microbiol Res 158:237–242

Nadathur SR, Gould SJ, Baklynsli AT (1994) Antimutagenicity of fermented milk. J Dairy Sci 77:3287–3295

Nakazato M, Morozumi S, Saito K, Fujinuma K, Nishima T, Kasai N (1990) Inter conversion of Aflatoxin B1 and Aflatoxicol by Several Fungi. Appl Environ Microbiol 56:1465–1470

Niderkorn V (2007) Activites de biotransformation et de séquestration des fusariotoxines chez les bacteries fermentaires pour la détoxification des ensilages de mais. Thèse de Doctorat, Université Blaise Pascal, Clermont-Ferrand-Theix, France

Niderkorn V, Boudra H, Morgavi DP (2006) Binding of Fusarium mycotoxins by fermentative bacteria in vitro. Appl Environ Microbiol 101:849–856

Niderkorn V, Morgavi DP, Pujos E, Tissandier A, Boudra H (2007) Screening of fermentative bacteria for their ability to bind and biotransform deoxynivalenol, zearalenone and fumonisins in an in vitro simulated corn silage model. Food Addit Contam 24(4):406–415

Niderkorn V, Morgavi DP, Aboab B, Lemaire M, Boudra H (2009) Cell wall component and mycotoxin moieties involved in the binding of fumonisin B1and B2 by lactic acid bacteria. J Appl Microbiol 106:977–985

Nout MJR (1989) Effect of Rhizopus and Neurospora spp. on growth of Aspergillus flavus and A. parasiticus and accumulation of aflatoxin B1 in groundnut. Mycol Res 93:518–523

Oluwafemi F, Kumar M, Bandyopadhyay R, Ogunbanwo T, Ayanwande KB (2010) Bio-detoxification of aflatoxin B1 in artificially contaminated maize grains using lactic acid bacteria. Toxin Rev 29(3–4):115–122

Onraedt A, Soetaert W, Vandamme E (2005) Industrial importance of the genus Brevibacterium. Biotechnol Lett 27:527–605

Orrhage K, Sillerstrom E, Gustafsson JA, Nord CE, Rafter J (1994) Binding of mutagenic heterocyclic amines by intestinal and lactic acid bacteria. Mutat Res 311:239–248

Özkaya Ş (2001) Ülkemizde Aflatoksin Sorunu Yaşanan Bazı Gıdalarda AFB1’in Azaltılması veya Giderilmesinde Flavobacterium aurantiacum’ unnEtkinliğinin Araştırılması. Hacettepe Üniversitesi Fen Bilimleri Enstitüsü Gıda Mühendisliği Anabilim Dalı. Doktora Tezi. Ankara. 86s.

Özpinar H, Augonyte G, Drochner W (1999) Inactivation of ochratoxin in ruminal fluid with variation of pH-value and fermentation parameters in an in vitro system. Environ Toxicol Pharmacol 7:1–9

Parent-Massin D (2004) Haematotoxicity of trichothecenes. Toxicol Lett 153:75–81

Peltonen K, El-Nezami H, Salminen S, Ahokas J (2000) Binding of aflatoxin B1 by probiotic bacteria. J Sci Food Agric 80:1941–1945

Peltonen K, El-Nezami H, Haskard C, Ahokas J, Salminen S (2001) Aflatoxin B1 binding by dairy strains of lactic acid bacteria and bifidobacteria. J Dairy Sci 84:2152–2156

Petchkongkaew A, Taillandier P, Gasaluck P, Lebrihi A (2008) Isolation of Bacillus spp. from Thai fermented soybean (Thua-nao): screening for aflatoxin B1 and ochratoxin A detoxification. J Appl Microbiol 104:1495–1502

Pierides M, El-Nezami H, Peltonen K, Salminen S, Ahokas J (2000) Ability of dairy strains of lactic acid bacteria to bind aflatoxin M1 in a food model. J Food Protect 63:645–650

Piotrowska M, Zakowska Z (2000) The biodegradation of ochratoxin A in food products by lactic acid bacteria and baker’s yeast. Food Biotechnol 17:307–310

Piotrowska M, Zakowska Z (2005) The limitation of ochratoxin A by lactic acid bacteria strains. Pol J Microbiol 54:279–286

Raju MVLN, Devegowda G (2000) Influence of esterified-glucomannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to individual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). Br Poult Sci 41:640–650

Reichenbach H (2001) Myxobacteria, producers of noval bioactive substances. J Indian Microbiol Biotechnol 27:149–156

Reichenbach H, Dworkin M (1992) The myxobacteria, the prokaryote. Spriger-Verlag, New York, pp 3418–3487

Reichenbach H, Hoefle G (1993) Production of bioactive secondary metabolites. Myxobact Am Soc Microbiol, Washington DC, pp 347–397

Richard JL (2007) Some major mycotoxins and their mycotoxicoses—an overview. Int J Food Microbiol 119:3–10

Ringot D, Lerzy B, Bonhoure JP, Auclair E, Orial E, Larondelle Y (2005) Effect of temperature on vitro ochratoxin A biosynthesis onto yeast cell wall derivatives. Process Biochem 40:3008–3016

Rodriguez H, Reveron I, Doria F, Costantini A, De Las RB, Muňoz R, Garcia-Moruno E (2011) Degradation of Ochratoxin A by Brevibacterium Species. J Agric Food Chem 59:10755–10760

Sakai M, Miyauchi K, Kato N, Masai E, Fukuda M (2003) 2- Hydroxypenta-2, 4-dienoate metabolic pathway genes in a strong polychlorinated biphenyl degrader, Rhodococcus sp. strain RHA1. Appl Environ Microbiol 69:327–433

Schallmey M, Singh A, Ward OP (2004) Developments in the use of Bacillus species for industrial production. Can J Microbiol 50:1–17

Schatzmayr G, Schatzmayr D, Pichler E, Taubel M, Loibner AP, Binder EM (2006) A novel approach to deactivate ochratoxin A. In: Njapau H, Trujillo S, van Egmond H, Park D (eds) Mycotoxins and phycotoxins: Advances in determination, toxicology and exposure management. Academic Publishers, Wageningen, pp 279–290

Shahin AAM (2007) Removal of aflatoxin B1 from contaminated liquid media by dairy lactic acid bacteria. Int J Agric Biol 9:71–75

Shantha T (1999) Fungal degradation of aflatoxin B1. Nat Toxins 7:175–178

Shapira R (2004) Detection and control. In Qinghua Wu, Alena Jezkova, Zonghui Yuan, Lucie Pavlikova, Vlastimil Dohna, and Kamil Biological degradation of aflatoxins. Drug Metab Rev 41(1):1–7

Shetty PH, Hald B, Jespersen L (2007) Surface binding of aflatoxin B1 by Saccharomyces cerevisiae strains with potential decontaminating abilities in indigenous fermented foods. Int J Food Microbiol 113:41–46

Shima J, Takase S, Takahashi Y, Iwai Y, Fujimoto H, Yamazaki M, Ochi K (1997) Novel detoxification of the trichothecene mycotoxin deoxynivalenol by a soil bacterium isolated by enrichment culture. Appl Environ Microbiol 63(10):3825–3830

Skrinjar M, Rasić JL, Stojicić V (1996) Lowering of ochratoxin A level in milk by yoghurt bacteria and Bifidobacteria. Folia Microbiol (Praha) 41(1):26–28

Smiley RD, Draughon FA (2000) Preliminary evidence that degradation of aflatoxin B1 by Flavobacterium aurantiacum is enzymatic. J Food Protect 63(3):415–418

Sørhaug T (1981) Comparison of peptide-hydrolases from six strains of Brevibacterium linens. Milchwissenschaft 36:137–139

Soriano JM, Gonzalez L, Catala AI (2005) Mechanism of action of sphingolipids and their metabolites in the toxicity of fumonisin B1. Prog Lipid Res 44:345–356

Stidl R, Fuchs S, Koller V, Marian B, Sontag G, Ehrlich V, Knasmueller S (2007) DNA-protective properties of lactic acid bacteria. In: Durackova Z, Slamenova D (eds), Synthetic and Natural Compounds in Cancer Therapy and Prevention. Bratislava, Slovakia

Stidl R, Sontag G, Koller V, Knasmüller S (2008) Binding of heterocyclic aromatic amines by lactic acid bacteria: results of a comprehensive screening trial. Mol Nutr Food Res 52(3):322–329

Stinton EE, Osman SF, Bills DD (1979) Water soluble products from patulin during alcoholic fermentation of apple juice. J Food Sci 44: 788,789,796

Sundstøl-Eriksen G, Pettersson H, Lundh T (2004) Comparative cytotoxicity of deoxynivalenol, nivalenol, their acetylated derivatives and de-epoxy metabolites. Food Chem Toxicol 42(4):619–624

Sweeney MJ, Dobson ADW (1998) Mycotoxin production by Aspergillus, Fusarium and Penicillium species. Int J Food Microbiol 43:141–158

Sweeney MJ, Dobson AD (1999) Molecular biology of mycotoxin biosynthesis. FEMS Microbiol Lett 175:149–163

Tejada-Castaneda ZI, Avila-Gonzalez E, Casaubon-Huguenin MT, Cervantes-Olivares RA, Vasquez-Pelaez C, Hernandez-Baumgarten EM, Moreno-Martinez E (2008) Bio-detoxification of aflatoxin-contaminated chick feed. Poult Sci 87:1569–1576

Teniola OD, Addo PA, Brost IM, Färber P, Jany K-D, Alberts JF, Van Zyl WH, Steyn PS, Holzapfel WH (2005) Degradation of aflatoxin B1 by cell-free extracts of Rhodococcus erythropolis and Mycobacterium fluoranthenivorans sp. nov. Int J Food Microbiol 105:111–117

Tinyiro SE, Yao W, Sun X, Wokadala C, Wang S (2011) Scavenging of zearalenone by Bacillus strains—in vitro. Res J Microbiol 6(3):304–309

Tuomola EM, Ouwehand AC, Salminen SJ (2000) Chemical, physical and enzymatic pretreatments of probiotic lactobacilli alter their adhesion to human intestinal mucus glycoproteins. Int J Food Microbiol 60:75–81

Turbic A, Ahokas JT, Haskard CA (2002) Selective in vitro binding of dietary mutagens, individually or in combination, by lactic acid bacteria. Food Addit Contam 19:144–152

Var I, Erginkaya Z, Kabak B (2009) Reduction of ochratoxin A levels in white wine by yeast treatments. J Inst Brew 115(1):30–34

Varga J, Toth B (2005) Novel strategies to control mycotoxins in feeds: a review. Acta Vet Hung 53:189–203

Varga J, Rigo K, Teren J (2000) Degradation of ochratoxin A by Aspergillus species. Int J Food Microbiol 59:1–7

Varga J, Peteri Z, Tabori K, Teren J (2005) Degradation of ochratoxin-A and other mycotoxins by Rhizopus isolates. Int J Food Microbiol 99:321–328

Vekiru E, Hametner C, Mitterbauer R, Rechthaler J, Adam G, Schatzmayr G, Krska R, Schuhmacher R (2010) Cleavage of Zearalenone by Trichosporon mycotoxinivorans to a novel non-estrogenic metabolite. Appl Environ Microbiol 76(7):2353–2359

Ward OP (1989) Fermentation biotechnology. Prentice Hall, Englewood Cliffs

Wegst W, Lingens F (1983) Bacterial degradation of ochratoxin A. FEMS Microbiol Lett 17:341–344

Xiao H, Madhyastha S, Marquardt RR, Li S, Vodela JK, Frohlich AA, Kemppainen BW (1996) Toxicity of ochratoxin A, its opened lactone form and several of its analogs: structure-activity relationships. Toxicol Appl Pharmacol 137(2):182–192

Yamada A, Kishi H, Sugihama K, Hatta T, Nakamura K, Masai E, Fukuda M (1998) Two nearly identical aromatic compound hydrolase genes in a strong polychlorinated biphenyl degrader, Rhodococcus sp. Strain RHA1. Appl Environ Microbiol 64:2006–2012

Yiannikouris A, André G, Buléon A, Jeminet G, Canet I, François J, Bertin G, Jouany JP (2004a) Comprehensive conformational study of key interactions involved in zearalenone complexation with β-D-glucans. Biomacromolecules 5(6):2176–2185

Yiannikouris A, Francois J, Poughon L, Dussap CG, Bertin G, Jeminet G, Jouany JP (2004b) Adsorption of Zearalenone by beta-D-glucans in the Saccharomyces cerevisiae cell wall. J Food Protect 67:1195–1200

Yiannikouris A, Francois J, Poughon L, Dussap CG, Bertin G, Jeminet G, Jouany JP (2004c) Alkali extraction of beta-d-glucans from Saccharomyces cerevisiae cell wall and study of their adsorptive properties toward zearalenone. J Agric Food Chem 52:3666–3673

Yiannikouris A, François J, Poughon L, Dussap C-G, Jeminet G, Bertin G, Jouany JP (2004d) Complexation of zearalenone with β-D-glucans isolated from the cell wall of Saccharomyces cerevisiae: study of the influence of pH on model β-D-glucans. J Food Protect 67(12):2741–2746

Young JC, Zhou T, Yu H, Zhu H, Gong J (2007) Degradation of trichothecene mycotoxins by chicken intestinal microbes. Food Chem Toxicol 45:136–143

Zhang XB, Ohta Y (1991) Binding of mutagens by fractions of the cell wall skeleton of lactic acid bacteria on mutagens. J Dairy Sci 74:1477–1481

Zhao LH, Guan S, Gao X, Ma QG, Lei YP, Bai XM, Ji C (2010) Preparation, purification and characteristics of an aflatoxin degradation enzyme from Myxococcus fulvus ANSM068. J Appl Microbiol 110:147–155

Zinedine A, Faid M, Benlemlih M (2005) In vitro reduction of aflatoxin B1 by strains of lactic acid bacteria isolated from Moroccan sourdough bread. Int J Agric Biol 7:67–70

Zjalic S, Reverberi M, Ricelli A, Granito VM, Fanelli C, Fabbri AA (2006) Trametes versicolor: a possible tool for aflatoxin control. Int J Food Microbiol 107:243–249