Biodegradable polymerized simvastatin stimulates bone formation

Mundy, 1999, Stimulation of bone formation in vitro and in rodents by statins, Science, 286, 1946, 10.1126/science.286.5446.1946 Garrett, 2002, The role of statins as potential targets for bone formation, Arthritis Res., 4, 237, 10.1186/ar413 Shah, 2015, Novel applications of statins for bone regeneration, Natl. Sci. Rev., 2, 85, 10.1093/nsr/nwu028 Mori, 2010, Statins: candidates for promoting bone formation via BMP-2, Oral Med. Pathol., 14, 81, 10.3353/omp.14.81 Pagkalos, 2010, Simvastatin induces osteogenic differentiation of murine embryonic stem cells, J. Bone. Miner. Res., 25, 2470, 10.1002/jbmr.163 Chen, 2010, Simvastatin promotes osteoblast viability and differentiation via Ras/Smad/Erk/BMP-2 signaling pathway, Nutr. Res., 30, 191, 10.1016/j.nutres.2010.03.004 Yamashita, 2010, Simvastatin inhibits osteoclast differentiation induced by bone morphogenetic protein-2 and RANKL through regulating MAPK, AKT and Src signaling, Regul. Pept., 162, 99, 10.1016/j.regpep.2010.03.003 Moon, 2011, Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species, Exp. Mol. Med., 43, 605, 10.3858/emm.2011.43.11.067 Park, 2009, The use of simvastatin in bone regeneration, Med. Oral Patol. Oral Cir. Bucal., 14, e485 Tan, 2015, Single-dose local simvastatin injection improves implant fixation via increased angiogenesis and bone formation in an ovariectomized rat model, Med. Sci. Monit., 21, 1428, 10.12659/MSM.892247 Thylin, 2002, Effects of simvastatin gels on murine calvarial bone, J. Periodontol., 73, 1141, 10.1902/jop.2002.73.10.1141 Nyan, 2007, Bone formation with the combination of simvastatin and calcium sulfate in critical-sized rat calvarial defect, J. Pharmacol. Sci., 104, 384, 10.1254/jphs.SC0070184 Jeon, 2008, Localized intermittent delivery of simvastatin hydroxyacid stimulates bone formation in rats, J. Periodontol., 79, 1457, 10.1902/jop.2008.080004 Asafo-Adjei, 2014, Synthesis and Characterization of a Poly(ethylene glycol)-Poly(simvastatin) Diblock Copolymer, RSC. Adv., 4, 58287, 10.1039/C4RA10310F Asafo-Adjei, 2017, Tuning properties of poly(ethylene glycol)-block-poly(simvastatin) copolymers synthesized via triazabicyclodecene, React. Funct. Polym., 119, 37, 10.1016/j.reactfunctpolym.2017.07.004 Thilanga Liyanage, 2018, Biodegradable simvastatin-containing polymeric prodrugs with improved drug release, ACS. Biomater. Sci. Eng., 4, 4193, 10.1021/acsbiomaterials.8b00884 Ferrin, 2018, expression analysis of neuropeptides in oral mucosa during periodontal disease in nonhuman primates, J. Periodontol., 10.1002/JPER.17-0521 Kavalipati, 2015, Pleiotropic effects of statins, Indian J. Endocrinol. Metab., 19, 554, 10.4103/2230-8210.163106 Kisiel, 2013, Evaluation of injectable constructs for bone repair with a subperiosteal cranial model in the rat, PLoS One, 8, 10.1371/journal.pone.0071683 Takiguchi, 2009, Experimental study of bone formation ability with the periosteum on rat calvaria, J. Hard Tissue Biol., 18, 149, 10.2485/jhtb.18.149 Thomas, 2011, Infection, inflammation, and bone regeneration: a paradoxical relationship, J. Dent. Res., 90, 1052, 10.1177/0022034510393967 Morais, 2010, Biomaterials/tissue interactions: possible solutions to overcome foreign body response, AAPS. J., 12, 188, 10.1208/s12248-010-9175-3 Chung, 2016, Simvastatin reduces capsular fibrosis around silicone implants, J. Korean Med. Sci., 31, 1273, 10.3346/jkms.2016.31.8.1273 Chen, 2017, Simvastatin promotes hematoma absorption and reduces hydrocephalus following intraventricular hemorrhage in part by upregulating CD36, Transl. Stroke. Res., 8, 362, 10.1007/s12975-017-0521-y Grayson, 2004, Differential degradation rates in vivo and in vitro of biocompatible poly(lactic acid) and poly(glycolic acid) homo- and co-polymers for a polymeric drug-delivery microchip, J. Biomater. Sci. Polym. Ed., 15, 1281, 10.1163/1568562041959991 Siegel, 2006, Effect of drug type on the degradation rate of PLGA matrices, Eur. J. Pharm. Biopharm., 64, 287, 10.1016/j.ejpb.2006.06.009 Li, 1996, Hydrolytic degradation of poly (DL-lactic acid) in the presence of caffeine base, J. Control. Release, 40, 41, 10.1016/0168-3659(95)00138-7 Fong, 2014, Statins in therapy: understanding their hydrophilicity, lipophilicity, binding to 3-hydroxy-3-methylglutaryl-CoA reductase, ability to cross the blood brain barrier and metabolic stability based on electrostatic molecular orbital studies, Eur. J. Med. Chem., 85, 661, 10.1016/j.ejmech.2014.08.037 Rabin, 2012, 267 Lee, 2008, The effect of local simvastatin delivery strategies on mandibular bone formation in vivo, Biomaterials, 29, 1940, 10.1016/j.biomaterials.2007.12.045 Ruan, 2012, Mechanisms of bone anabolism regulated by statins, Biosci. Rep., 32, 511, 10.1042/BSR20110118 Maeda, 2001, Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells, Biochem. Biophys. Res. Commun., 280, 874, 10.1006/bbrc.2000.4232 Weis, 2002, Statins have biphasic effects on angiogenesis, Circulation, 105, 739, 10.1161/hc0602.103393 Aguirre, 2013, Several statins increase body and liver fat accumulation in a model of metabolic syndrome, J. Physiol. Pharmacol., 64, 281 Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S), Lancet. 344(8934) (1994) 1383-9. Rajyalakshmi, 2009, A comparative antihyperlipidemic activity of atorvastatin with simvastatin in rats, Internet. J. Pharmacol., 6, 9