Biodegradable polymeric nanoparticles as drug delivery devices

Journal of Controlled Release - Tập 70 Số 1-2 - Trang 1-20 - 2001
Kumaresh S. Soppimath1, Tejraj M. Aminabhavi1, Anandrao R. Kulkarni1, Walter E. Rudzinski2
1Department of Chemistry, Polymer Research Group, Karnatak University, Dharwad 580 003, India
2Department of Chemistry, Southwest Texas State University, San Marcos, TX 78666 USA

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Kreuter, 1994, Nanoparticles, 219

1981

Langer, 2000, Biomaterials in drug delivery and tissue engineering: One laboratory’s experience, Acc. Chem. Res., 33, 94, 10.1021/ar9800993

Lanza, 1997, Principles of Tissue Engineering, 405

Peppas, 1995, Recent advances on the use of biodegradable microparticles and nanoparticles in the controlled drug delivery, Int. J. Pharm., 116, 1, 10.1016/0378-5173(94)00324-X

Zimmer, 1995, Microspheres and nanoparticles used in ocular drug delivery systems, Adv. Drug. Deliv. Rev., 16, 61, 10.1016/0169-409X(95)00017-2

Couvreur, 1986

Raney, 2000, Biomimetic transport, rational drug delivery, Biochem. Pharmacol., 59, 105, 10.1016/S0006-2952(99)00316-0

Uhrich, 1999, Polymeric systems for controlled drug release, Chem. Rev., 99, 3181, 10.1021/cr940351u

Monfardini, 1998, Stabilization of substances in circulation, Bioconjug. Chem., 9, 418, 10.1021/bc970184f

Torchilin, 1998, Polymer-coated long-circulating microparticulate pharmaceuticals, J. Microencapsul., 15, 1, 10.3109/02652049809006831

Wise, 1979, Lactide/glycolide acid polymers, 237

Jackanicz, 1973, Poly lactic acid as a biodegradable carrier for contraceptive steroids, Contraception, 8, 227, 10.1016/0010-7824(73)90033-4

Andersson, 1976, An injectable sustained release fertility control system, Contraception, 13, 375, 10.1016/S0010-7824(76)80047-9

Pitt, 1979, Sustained release drug delivery systems II: factors affecting release rate for poly(ϵ-caprolactone) and related biodegradable polyesters, J. Pharm. Sci., 68, 1534, 10.1002/jps.2600681219

Pitt, 1980, Biodegradable drug delivery systems based on aliphatic polyesters: application to contraceptives and narcotic antagonists, 19

Calvo, 1996, Comparative in vitro evaluation of several colloidal systems, nanoparticles, nanocapsules and nanoemulsions as ocular drug carriers, J. Pharm. Sci., 85, 530, 10.1021/js950474+

Lescure, 1994, Preparation and characterization of novel poly(methylidene malonate 2.1.2.)-made nanoparticles, Pharm. Res., 9, 1270, 10.1023/A:1018986226557

Farrugia, 1999, Gelatin behavior in dilute aqueous solutions: Designing a nanoparticulate formulations, J. Pharm. Pharmacol., 51, 643, 10.1211/0022357991772925

Fernandez-Urrusuno, 1999, Enhancement of nasal absorption of insulin using chitosan nanopartilces, Pharm. Res., 16, 1576, 10.1023/A:1018908705446

Aynie, 1998, Alginate nanoparticles as a novel carrier for antisense oligonucleotide, 5

Vauthier, 1991, Methodology of ultradispersed polymer system, S.T.P. Pharm. Sci., 1, 109

Allemann, 1993, Drug-loaded nanoparticles-Preparation methods and drug targeting issues, Eur. J. Pharm., 39, 173

Couvreur, 1995, Controlled drug delivery with nanoparticles: Current possibilities and future trends, Eur. J. Pharm., 41, 2

Alonso, 1996, Nanoparticulate drug carrier technology, 203

Scholes, 1993, The preparation of sub-500 nm poly(lactide-co-glycolide) microspheres for site-specific drug delivery, J. Control. Rel., 25, 145, 10.1016/0168-3659(93)90103-C

Zambaux, 1998, Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by double emulsion method, J. Control. Rel., 50, 31, 10.1016/S0168-3659(97)00106-5

Niwa, 1993, Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with d,l-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method and the drug release behavior, J. Control. Rel., 25, 89, 10.1016/0168-3659(93)90097-O

Wehrle, 1995, The Influence of process parameters on the PLA nanoparticle size distribution evaluated by means of factorial design, J. Pharm. Biopharm., 41, 19

Murakami, 1996, Preparation of poly(d,l-lactide-co-glycolide) latex for surface modifying material by a double coacervation method, Proced. Intern. Symp. Control. Rel. Bioact. Mater., 23, 361

Birnbaum, 2000, Controlled release of β-estradiol from PLAGA microparticles: The effect of organic phase solvent on encapsulation and release, J. Control. Rel., 65, 375, 10.1016/S0168-3659(99)00219-9

Bodmeier, 1988, Solvent selection in the preparation of poly(d,l-lactide) microspheres prepared by the solvent evaporation method, Int. J. Pharm., 43, 179, 10.1016/0378-5173(88)90073-7

Arshaday, 1991, Preparation of porous and nonporous biodegradable polymeric hollow microspheres, J. Control. Rel., 17, 1

Allemann, 1992, Preparation of aqueous polymeric nanodispersions by a reversible salting-out process: influence of process parameters on particle size, Int. J. Pharm., 87, 247, 10.1016/0378-5173(92)90249-2

Allemann, 1993, Invitro extended-release properties of drug-loaded poly(d,l-lactic) acid nanoparticles produced by a salting-out procedure, Pharm. Res., 10, 1732, 10.1023/A:1018970030327

Leroux, 1995, New approach for the preparation of nanoparticles by an emulsification–diffusion method, Eur. J. Pharm. Biopharm., 41, 14

Quintanar, 1998, Influence of the stabilizer coating layer on the purification and freeze drying of poly (dl-lactic acid) nanoparticles prepared by emulsification-diffusion technique, J. Microencapsulation, 15, 107, 10.3109/02652049809006840

Tom, 1991, Particle formation with supercritical fluids — a review, J. Aerosol Sci., 22, 555, 10.1016/0021-8502(91)90013-8

Randolph, 1993, Sub-micron-sized biodegradable particles of poly(l-lactic acid) via the gas antisolvent spray precipitation process, Biotechnol. Prog., 9, 429, 10.1021/bp00022a010

L. Benedetti, A. Bertucco, M. Lora, P. Pallado, in: Atti del 3° Congresso I fluidi Supercriticai e le Loro Applicazioni, I. Kikic and P. Alessi (Eds.), Trieste, 1995, p. 221.

Mishima, 2000, Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent, AIChE J., 46, 857, 10.1002/aic.690460418

Tom, 1991, Formation of bioerodiable polymeric microspheres and microparticles by rapid expansion of supercritical solution, Biotechnol. Prog., 7, 403, 10.1021/bp00011a004

Tom, 1994, Preparation of poly(l-lactic acid) and composite poly(l-lactic acid)-pyrene by rapid expansion of supercritical solution, J. Supercrit. Fluids, 7, 9, 10.1016/0896-8446(94)90003-5

Mawson, 1994, Formation of poly(1,1,2,2-tetrahydroperfluorodecyl acrylate) submicron fibers and particles from supercritical carbon dioxide solutions, Macromolecules, 28, 3182, 10.1021/ma00113a021

Pani, 1968, The degradation of n-butyl alpha-cyanoacrylate tissue adhesive, II, Surgery, 63, 481

Leonarda, 1970, Hemostatic application of alpha cyanoacrylates: bonding mechanism and physiological degradation of bonds, 185

Couvreur, 1978, Les perspectives d’utilisation des formes microdispersés comme vecteurs intracellulaires, Pharm. Acta Helv., 53, 341

Couvreur, 1979, Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphology and sorptive properties, J. Pharm. Pharmacol., 31, 331, 10.1111/j.2042-7158.1979.tb13510.x

Behan, 1999, A study of the factors affecting the formation of poly(n-butylcyanoacrylate) nanoparticles, Proced. Intern. Symp. Control. Rel. Bioact. Mater., 26, 1134

Lherm, 1992, Alkylcynoacrylate drug carriers: II. Cytotoxicity of cyanoacrylate nanoparticles with different alkyl chain length, Int. J. Pharm., 84, 13, 10.1016/0378-5173(92)90210-S

De Keyser, 1989, Synthesis of 14C labeled acrylic derivatives: diethyl [3-14C] methylidenemalonate and isobutyl [3-14C] cyanoacrylate, J. Lable. Comp. Radiopharm., 27, 909, 10.1002/jlcr.2580270807

De Keyser, 1991, Poly(diethyl methylidenemalonate) nanoparticles as a potential drug carrier: preparation, distribution and elimination after intravenous and peroral administration to mice, J. Pharm. Sci., 80, 67, 10.1002/jps.2600800117

Mabela, 1993, Development of poly(dialkyl methylidenemalonate) nanoparticles as drug carriers, Int. J. Pharm., 92, 71, 10.1016/0378-5173(93)90265-H

Breton, 1994, New poly(methylidene malonate 2.1.2) nanoparticles: Recent developments, Vol. 4, 161

Lescure, 1994, Preparation and charecterization of novel poly(methylidene malonoate 2.1.2.)-made nanoparticles, Pharm. Res., 11, 1270, 10.1023/A:1018986226557

Breton, 1998, Physico-chemical characterization, preparation and performance of poly(methylidene malonate 2.1.2) nanoparticles, Biomaterials, 19, 271, 10.1016/S0142-9612(97)00243-3

N. Bru-Magniez, X. Guillon, P. Breton, P. Couvreur, F. Lescure, C. Roques-Carmes, G. Riess, Method for preparing malonate methylidene nanoparticles, nanoparticles optionally containing one or several biologically active molecules, International Patent PCT WO 98/18455, 1998.

N. Bru-Magniez, V. Larras, G. Riess, P. Breton, P. Couvreur, C. Roques-Carmes, Novel surfactant copolymers based on methylidene malonate, International Patent PCT WO 99/38898, 1999.

Mitra, 1998, pH and thermoresponsive hydrogel nanoparticles, Proc. Intern. Symp. Control. Rel. Bioact. Mater., 25, 234

Mitra, 1998, Long circulating RES evading hydrophilic nanoparticles, Proc. Intern. Symp. Control. Rel. Bioact Mater., 25, 168

Gref, 1994, Biodegradable long circulating polymeric nanospheres, Science, 18, 1600, 10.1126/science.8128245

M. Amiji, K. Park, in: S.W. Shalaby, Y. Ikada, R. Langer, J. Williams, (Eds.), Polymers of Biological Significance, ACS Symp. Ser. 540, Washington, DC, 1994.

Calvo, 1997, Novel hydrophilic chitosan and chitosan/polyethylene oxide nanoparticles as protein carriers, J. Appl. Polym. Sci., 63, 125, 10.1002/(SICI)1097-4628(19970103)63:1<125::AID-APP13>3.0.CO;2-4

Calvo, 1997, Chitosan and chitosan/ethylene oxide–propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines, Pharm. Res., 14, 1431, 10.1023/A:1012128907225

Fernandez-urrusuno, 1999, Enhancement of nasal absorption of insulin using chitosan nanoparticles, Pharm. Res., 16, 1576, 10.1023/A:1018908705446

P. Calvo A.S. Boughaba, M. Appel, E. Fattal, M.J. Alonso, P. Couvreur, Oligonucleotide–chitosan nanoparticles as new gene therapy vector, Proc. 2nd World Meeting APGI/APV Paris, 1998, pp. 1111–1112.

Mao, 1996, DNA–chitosan nanoparticles for the gene delivery, Proc. Intern. Symp. Control. Release. Bioact. Mater., 23, 401

Ray, 1999, Oral immunization with DNA–chitosan nanoparticles, Proc. Intern. Symp. Control. Release. Bioact. Mater., 26, 348

Truong-Le, 1997, Delivery of DNA vaccine using gelatin–DNA nanoparticles, Proc. Intern. Symp. Control. Rel. Bioact. Mater., 24, 39

Tian, 1999, Formulation and biological activity of antineoplastic proteoglycans derived from Mycobacterium vaccae in chitosan nanoparticles, J. Pharm. Pharmacol., 51, 151, 10.1211/0022357991772268

Tokumitsu, 1999, Chitosan–gadopenteic acid complex nanoparticles for gadolinium neutron-capture therapy of cancer: preparation by novel emulsion–droplet coalescence technique and characterization, Pharm. Res., 16, 1830, 10.1023/A:1018995124527

Vautheir, 1998, Pharmacokinetic and tissue disposition of oligonucleotide associated with alginate nanoparticles, Proc. Intern. Symp. Control. Rel. Bioact. Mater., 25, 228

Jung, 2000, Sulfobutylated poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) facilitate the preparation of small negatively charged biodegradable nanospheres for protein delivery, J. Control. Rel., 67, 157, 10.1016/S0168-3659(00)00201-7

Breitenbach, 1999, Self-assembling colloidal carriers for protein delivery: nanoparticulate polymer protein conjugates with novel water soluble biodegradable comb polyesters, Proc. Intern. Symp. Control. Release. Bioact. Mater., 26, 159

Breitenbach, 1999, Oral and nasal administration of tetanus toxoid loaded nanoparticles consisting of novel charged biodegradable polyesters for mucosal vaccination, Proc. Intern. Symp. Control. Release. Bioact. Mater., 26, 348

Alenso, 1991, Approaches to improve the association of amikacin sulphate to poly(cyanoacrylate) nanoparticles, Int. J. Pharm., 68, 69, 10.1016/0378-5173(91)90128-B

Ueda, 1998, Influence of the preparation methods on the drying release behavior of loperamide-loaded nanoparticles, J. Microencapsulation, 15, 361, 10.3109/02652049809006863

Couvreur, 1979, Adsorption of antineoplastic drugs to polyalkylcyanoacrylate nanoparticles and their release in calf serum, J. Pharm. Sci., 68, 1521, 10.1002/jps.2600681215

Radwan, 1995, In vitro evaluation of polyisobutylcyanoacrylate nanoparticles as a controlled drug carrier for theophylline, Drug Dev. Ind. Pharm., 21, 2371, 10.3109/03639049509070875

Egea, 1994, Entrapment of cisplatin into biodegradable polyalkylcyanoacrylate nanoparticles, Farmaco, 49, 211

Chukwu, 1999, Loading some psychopharmacologic agents onto poly(butyl-cyanoacrylate) nanoparticles-a means of targeting to the brain and improving therapeutic efficiency, Proced. Intern. Symp. Control. Rel. Bioact. Mater., 26, 1148

Vora, 1993, Investigation of the relative affinity of doxorubicin for neutral and negatively charged particulate carriers, Drug Dev. Ind. Pharm., 19, 759, 10.3109/03639049309062981

Martin, 1994, Study of the binding mechanisms of drugs onto polyalkylcyanoacrylate nanoparticles, J. Pharm. Belg., 49, 498

Benoit, 1994, Adsorption of beta-blocker onto polyisobutylcyanoacrylate nanoparticles measured by depletion and dielectric method, Pharm. Res., 11, 585, 10.1023/A:1018935103900

Yoo, 1999, Biodegradable nanoparticles containing doxorubicin–PLGA conjugate for sustained release, Pharm. Res., 16, 1114, 10.1023/A:1018908421434

Washington, 1990, Drug release from microdisperse systems. A critical review, Int. J. Pharm., 58, 1, 10.1016/0378-5173(90)90280-H

Magenheim, 1991, Nanoparticle characterization: a comprehensive physicochemical approach, S.T.P. Pharm. Sci., 1, 221

El-Samaligly, 1986, Polyalkylcyanoacrylate nanocapsules, J. Pharm. Pharmacol., 38, 216, 10.1111/j.2042-7158.1986.tb04547.x

LeRay, 1994, End-chain radiolabeling and in vitro stability studies of radiolabeled poly(hydroxy) nanoparticles, J. Pharm. Sci., 83, 845, 10.1002/jps.2600830618

Fresta, 1995, Pefloxacin mesilate- and ofloxacin-loaded polyethylcyanoacrylate nanoparticles; characterization of the colloidal drug carrier formulation, J. Pharm. Sci., 84, 895, 10.1002/jps.2600840721

Cavallaro, 1994, Entrapment of β-lactams antibiotics in polyethylcyanoacrylate nanoparticles: studies on the possible in vivo application of this colloidal delivery system, Int. J. Pharm., 111, 31, 10.1016/0378-5173(94)90399-9

Leavy, 1990, Drug release from submicron O/W emulsion: A new in vitro kinetic evaluation model, Int. J. Pharm., 66, 29, 10.1016/0378-5173(90)90381-D

Jalil, 1990, Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties, J. Microencapsul., 7, 297, 10.3109/02652049009021842

Magenheim, 1993, A new in vitro technique for the evaluation of drug release profiles from colloidal carriers-ultrafiltration technique at low pressure, Int. J. Pharm., 94, 115, 10.1016/0378-5173(93)90015-8

Rodrigues Jr, 1995, Premaquine-loaded poly(lactide) nanoparticles: physicochemical study and acute tolerance in mice, Int. J. Pharm., 126, 253, 10.1016/0378-5173(95)04135-4

Polakovic, 1999, Lidocaine loaded biodegradable nanospheres. II. modeling of drug release, J. Control. Rel., 60, 169, 10.1016/S0168-3659(99)00012-7

Lu, 1999, A method of the preparation of polymeric nanocapsules without stabilizer, J. Control. Rel., 61, 107, 10.1016/S0168-3659(99)00112-1

Muller, 1993, Surface modification of i.v. injectable biodegradable nanoparticles with poloxamer polymers and poloxamine 908, Int. J. Pharm., 89, 25, 10.1016/0378-5173(93)90304-X

Van Oss, 1978, Phagocytosis as a surface phenomenon, Annu. Rev. Microbiol., 32, 19, 10.1146/annurev.mi.32.100178.000315

Allemann, 1997, Kinetics of blood component-adsorption on poly(d,l-lactide) nanoparticles: Evidence of compliment C3 component involvement, J. Biomed. Mater. Res., 37, 229, 10.1002/(SICI)1097-4636(199711)37:2<229::AID-JBM12>3.0.CO;2-9

Blunk, 1996, Kinetics of plasma protein adsorption on model particles for controlled drug delivery and drug targeting, Eur. J. Pharm. Biopharm., 42, 262

Thode, 1997, Determination of plasma protein adsorption on magnetic iron oxide: sample preparation, Pharm. Res., 14, 905, 10.1023/A:1012104017761

Thode, 1997, Influence of sample preparation on plasma protein adsorption patterns on polysaccharide-stabilized iron oxide particles and end-terminal microsequencing of unknown proteins, J. Drug Target., 5, 35, 10.3109/10611869708995856

Lück, 1998, Plasma protein adsorption on biodegradable microspheres consisting of poly(d,l-lactide-co-glycolide), poly(l-lactide) or ABA triblock copolymers containing poly(oxyethylene), J. Control. Rel., 55, 107, 10.1016/S0168-3659(98)00030-3

Gref, 1995, The controlled intravenous delivery of drugs using PEG-coated sterically stabilized nanospheres, Adv. Drug Deliv. Rev., 16, 215, 10.1016/0169-409X(95)00026-4

Peracchia, 1999, Visualization of in vitro protein-rejecting properties of PEGylated stealth® polycyanoacrylate nanoparticles, Biomaterials, 20, 1269, 10.1016/S0142-9612(99)00021-6

Ratner, 1987, Biomaterial surface, J. Biomed. Mat. Res. Appl. Biomat., 21, 59

Carstensen, 1991, Adsorption of ethoxylated surfactants on nanoparticles. I. Characterization by hydrophilic interaction chromatography, Int. J. Pharm., 67, 29, 10.1016/0378-5173(91)90262-M

Gref, 1994, Biodegradable long-circulating polymeric nanoparticles, Science, 263, 1600, 10.1126/science.8128245

Joen, 1991, Protein-surface interactions in the presence of polyethylene oxide. I. Simplified theory, J. Colloid. Interf. Sci., 142, 149, 10.1016/0021-9797(91)90043-8

Bazile, 1995, Stealth Me-PEG–PLA nanoparticles avoid uptake by the mononuclear phagocyte system, J. Pharm. Sci., 84, 493, 10.1002/jps.2600840420

Tobio, 1998, Stealth PLA–PEG nanoparticles as protein carriers for nasal administration, Pharm. Res., 15, 270, 10.1023/A:1011922819926

Gref, 1999, Polyoxyethylene-coated nanospheres: effect of coating on zeta potential and phagocytosis, Polymer Int., 48, 251, 10.1002/(SICI)1097-0126(199904)48:4<251::AID-PI104>3.0.CO;2-4

Govender, 2000, PLA–PEG nanoparticles for site specific delivery: drug incorporation studies, J. Control. Rel., 64, 269

Kim, 1998, Preparation and characterization of biodegradable nanospheres composed of methoxy poly(ethylene glycol) and dl-lactide block copolymer as novel drug carriers, J. Control. Rel., 56, 197, 10.1016/S0168-3659(98)00083-2

Peracchia, 1999, Stealth® PEGylated polycyanoacrylate nanoparticles for intravenous administration and spleenic targeting, J. Control. Rel., 60, 121, 10.1016/S0168-3659(99)00063-2

Gessnerl, 1999, Plasma protein adsorption on poly(ethylene-glycol) (PEG) modified polystyrene nanoparticles: influence of PEG surface density, Proc. Intern. Symp. Control. Rel. Bioact. Mater., 26, 597

Peracchia, 1997, PEG-coated injectable nanospheres prepared from amphiphilic diblock and multiblock copolymers: investigation of drug encapsulation and release characteristics, J. Control. Rel., 46, 223, 10.1016/S0168-3659(96)01597-0

Peracchia, 1996, PEG–PIBCA nanoparticles with different PEG-coating configurations formed by chemical coupling of PEG, Proced. Intern. Symp. Control. Rel. Bioact. Mater., 23, 395

Peracchia, 1997, Development of sterically stabilized poly(isobutyl-2-cyanoacrylate) nanoparticles by chemical coupling of poly(ethylene glycol), J. Biomed. Mater. Res., 34, 317, 10.1002/(SICI)1097-4636(19970305)34:3<317::AID-JBM6>3.0.CO;2-N

Peracchia, 1998, PEGylated nanoparticles from a novel methoxypolyethylene glycol cyanoacrylate–hexadecyl cyanoacrylate amphiphilic copolymer, Pharm. Res., 15, 550, 10.1023/A:1011973625803

Peracchia, 1997, Compliment consumption by poly(ethylene glycol) in different conformations chemically coupled to poly(isobutyl-2-cyanoacrylate) nanoparticles, Life Sci., 61, 741, 10.1016/S0024-3205(97)00539-0

Jaeghere, 1999, Formulation and lyoprotection of poly(lactic acid-co-ethylene oxide) nanoparticles: Influence on the physical stability and in vitro cell uptake, Pharm. Res., 16, 859, 10.1023/A:1018826103261

Vittaz, 1996, Effect of PEO surface density on long-circulating PLA–PEO nanoparticles which are very low complement activators, Biomaterials, 17, 1575, 10.1016/0142-9612(95)00322-3

Ha, 1999, Poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) (Plunoric)/poly(ϵ-caprolactone) (PCL) amphiphilic block copolymeric nanospheres I. Preparation and characterization, J. Control. Rel., 62, 381, 10.1016/S0168-3659(99)00167-4

Storm, 1995, Surface modification of nanoparticles to oppose uptake by the mononuclear system, Adv. Drug Deliv. Rev., 17, 31, 10.1016/0169-409X(95)00039-A

Illum, 1983, Effect of the nonionic surfactant poloxamer 338 on the fate and deposition of polystyrene microspheres following intravenous administration, J. Pharm. Sci., 72, 1086, 10.1002/jps.2600720933

Illum, 1984, The organ uptake of intravenously administered colloidal particles can be altered using a non-ionic surfactant (poloxamer 338), FEBS Letts., 167, 79, 10.1016/0014-5793(84)80836-4

Rudt, 1993, In vitro phagocytosis assay of nano- and microparticles by chemiluminescence. III. Uptake of differently sized surface-modified particles, and its correlation to particle properties and in vivo distribution, Eur. J. Pharm. Sci., 1, 31, 10.1016/0928-0987(93)90015-3

Illum, 1993, The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block copolymer poloxamine 908, Int. J. Pharm., 89, 25

Moghimi, 1997, Single dose of iv injected poloxamine coated long-circulating particle triggers macrophage clearance of subsequent doses in rats, Clin. Sci., 93, 371, 10.1042/cs0930371

Demoy, 1999, Spleen capture of nanoparticles: Influence of animal species and surface characteristics, Pharm. Res., 16, 37, 10.1023/A:1018858409737

Shinoda, 1999, Nanosphere coated with lactosyl-polystyrene polymer as a targeting carrier to hepatocytes, Drug Deliv., 6, 147, 10.1080/107175499266896

Cho, 1997, Simple preparation of nanoparticles coated with carbohydrate-carrying polymers, Biomaterials, 18, 323, 10.1016/S0142-9612(96)00138-X

Maruyama, 1997, Nanoparticle DNA carrier with poly(l-lysine) grafted polysaccharide copolymer and poly(d,l-lactic acid), Bioconjug. Chem., 8, 735, 10.1021/bc9701048

Duchene, 1999, Cyclodextrins and carrier systems, J. Control. Rel., 62, 263, 10.1016/S0168-3659(99)00046-2

Raeissi, 1989, In vitro characterization of blood–brain barrier permeability to delta sleep-inducing peptide, J. Pharm. Pharmacol., 41, 848, 10.1111/j.2042-7158.1989.tb06385.x

Zlokovich, 1989, The in vivo approaches for studying peptide interaction at the blood–brain barrier, Peptides, 10, 249

Schroeder, 1996, Nanoparticles, a drug carrier system to pass the blood–brain barrier, permit central analgesic effects of i.v. dalargin injections, Brain Res., 710, 121, 10.1016/0006-8993(95)01375-X

Schroeder, 1998, A efficacy of oral dalargin-loaded nanoparticle delivery across the blood–brain barrier, Peptide, 19, 777, 10.1016/S0196-9781(97)00474-9

Alyautdin, 1995, Analgesic activity of the hexapeptide dalargin adsorbed on the surface of polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles, Eur. J. Pharm. Biopharm., 41, 44

Borchardt, 1994, Uptake of surfactant-coated poly(methyl methacrylate)-nanoparticles by bovine brain microvessel endothelial cell monolayers, Int. J. Pharmacol., 110, 29, 10.1016/0378-5173(94)90372-7

Troster, 1990, Modification of the body distribution of poly(methyl methacrylate) nanoparticles in rats by coating with surfactants, Int. J. Pharm., 61, 85, 10.1016/0378-5173(90)90047-8

Steiniger, 1999, The influence of polysorbate 80-coated nanoparticles on bovine brain capillary endothelial cells in vitro, Proced. Intern. Symp. Control. Rel. Bioact. Mater., 26, 790

Olivier, 1999, Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity, Pharm. Res., 16, 1836, 10.1023/A:1018947208597

Gulyaev, 1999, Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles, Pharm. Res., 16, 1564, 10.1023/A:1018983904537

Alyautdin, 1997, Delivery of lopermide across the blood–brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles, Pharm. Res., 14, 25, 10.1023/A:1012098005098

Alyautdin, 1998, Significant entry of tubocurarin into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles: in situ brain perfusion study, J. Microencapsulation, 15, 67, 10.3109/02652049809006836

Schroeder, 1998, Nanoparticle technology for delivery of drugs across the blood–brain-barrier, J. Pharm. Sci., 87, 1305, 10.1021/js980084y

Couvreur, 1993, Nano- and microparticles for the delivery of peptides and proteins, Adv. Drug Deliv. Rev., 5, 141, 10.1016/0169-409X(93)90046-7

Uchida, 1996, Instability of bovine insulin in poly(lactide-co-glycolide) (PLGA) microspheres, Chem. Pharm. Bull., 44, 235, 10.1248/cpb.44.235

Lin, 1997, A novel biodegradable system based on gelatin NPs and poly(lactic-co-glycolic acid) microspheres for protein and peptide drug delivery, J. Pharm. Sci., 86, 891, 10.1021/js970084i

Wang, 1999, A heterogeneously structured composite based on poly(lactic-co-glycolic acid) microspheres and poly(vinyl alcohol) hydrogel nanoparticles for long-term protein drug delivery, Pharm. Res., 16, 1430, 10.1023/A:1018911411381

Gasper, 1998, Formulation of l-aspargainase-loaded poly(lactide-co-glycolide) nanoparticles: influence of polymer properties on enzyme loading, activity and in vitro release, J. Control. Rel., 52, 53, 10.1016/S0168-3659(97)00196-X

Fishbein, 2000, Nanoparticulate delivery system of a tyrphostin for the treatment of restenosis, J. Control. Rel., 65, 221, 10.1016/S0168-3659(99)00244-8

Kawashima, 1999, Pulmonary delivery of insulin with nebulized dl-lactide/glycolide copolymer (PLGA) nanospheres to prolong hypoglycemic effect, J. Control. Rel., 62, 279, 10.1016/S0168-3659(99)00048-6

Carino, 2000, Nanosphere based oral insulin delivery, J. Control. Rel., 65, 261, 10.1016/S0168-3659(99)00247-3