Biodegradable copper–metformin nanoscale coordination polymers for enhanced chemo/chemodynamic synergistic therapy by reducing oxygen consumption to promote H2O2 accumulation

Journal of Materials Chemistry B - Tập 9 Số 8 - Trang 1988-2000
Xiangyu Meng1,2,3,4, Xuezhong Zhang1,2,3,4, Yunfeng Lei1,2,3,4, Dongwei Cao5,6,7,2,8, Zhifei Wang1,2,3,4
1Nanjing 211189
2P. R. China
3School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, Jiangsu, P. R. China
4Southeast University
5Department of Nephrology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, P. R. China
6Department of Nephrology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, P. R. China
7Nanjing
8The Affiliated Hospital of Nanjing University Medical School

Tóm tắt

A new therapeutic nanoplatform based on Dox@Cu–Met NPs was constructed, which could reduce the consumption of O2 and elevate H2O2 content for effective chemo/chemodynamic synergistic therapy.

Từ khóa


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