Biochemical considerations in <sup>1</sup>H spectroscopy. Glutamate and glutamine; <i>Myo</i>‐inositol and related metabolites

NMR in Biomedicine - Tập 4 Số 2 - Trang 59-63 - 1991
Brian D. Ross1,2
1Also affiliated to The California Institute of Technology, Pasadena, California 91125
2Huntington Medical Research Institutes, 660 S. Fair Oaks, Pasedena, CA 91105, USA

Tóm tắt

AbstractGlutamate and glutamine, which can be clearly identified and, in part, quantified in proton spectra of the brain, play important roles in normal and pathological biochemistry. Pathways of glutamate metabolism include transamination, dehydrogenation, deamination and decarboxylation (to GABA). Glutamine is notable in hepatic encephalopathy, but is also a significant metabolic fuel in several other organs and tissues, including neoplasms. Myo‐inositol is a 6‐carbon alcohol which acquires new interest from its detection and quantitation in 1H spectra. Its role, apart from a biochemical relationship to messenger‐inositol polyphosphates, is unclear.

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NMR in Biomedicine

Tập 4 Số 2

59-63

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