Biochemical and tissue physiopathological evaluation of the preclinical efficacy of Solanum torvum Swartz leaves for treating oxidative impairment in rats administered a β-cell-toxicant (STZ)

DeFronzo, 2015, Type 2 diabetes mellitus, Nat. Rev. Dis. Prim., 1, 1 Janssen, 2020, Burden of disease of type 2 diabetes mellitus: cost of illness and quality of life estimated using the Maastricht study, Diabet. Med., 37, 1759, 10.1111/dme.14285 Cannon, 2018, Burden of illness in type 2 diabetes mellitus, J. Manag Care Spec. Pharm., 24, S5 Bilous, 2021 Rains, 2011, Oxidative stress, insulin signaling, and diabetes, Free Radic. Biol. Med., 50, 567, 10.1016/j.freeradbiomed.2010.12.006 West, 2000, Radicals and oxidative stress in diabetes, Diabet. Med., 17, 171, 10.1046/j.1464-5491.2000.00259.x Agada, 2020, In vitro and in vivo inhibitory effects of Carica papaya seed on α-amylase and α-glucosidase enzymes, Heliyon, 6, 10.1016/j.heliyon.2020.e03618 Wu, 2016, Myrciaria cauliflora extracts attenuate diabetic nephropathy involving the Ras signaling pathway in streptozotocin/nicotinamide mice on a high fat diet, J. Food Drug Anal., 24, 136, 10.1016/j.jfda.2015.10.001 Onikanni, 2021, Sterculia tragacantha lindl leaf extract ameliorates STZ-induced diabetes, oxidative stress, inflammation and neuronal impairment, J. Inflamm. Res., 14, 6749, 10.2147/JIR.S319673 Pickup, 2012, Management of diabetes mellitus: is the pump mightier than the pen, Nat. Rev. Endocrinol., 8, 425, 10.1038/nrendo.2012.28 Sharma, 2019, Management of diabetes mellitus in adults at the end of life: a review of recent literature and guidelines, J. Palliat. Med., 22, 1133, 10.1089/jpm.2018.0614 Calson, 2000, Miglitol and hepatotoxicity in type 2 diabetes mellitus, Am. Fam. Physician, 62, 315 Stein, 2013, A review of the efficacy and safety of oral antidiabetic drugs, Expert Opin. Drug Saf., 12, 153, 10.1517/14740338.2013.752813 Salleh, 2021, Systematic review of medicinal plants used for treatment of diabetes in human clinical trials: an ASEAN perspective, Evid. Based Complement. Altern. Med., 2021, 10.1155/2021/5570939 Yatoo, 2017, Promising antidiabetic drugs, medicinal plants and herbs: an update, Int. J. Pharmacol., 13, 732, 10.3923/ijp.2017.732.745 Jia, 2003, Antidiabetic herbal drugs officially approved in China, Phytother. Res.: Int. J. Devoted Pharmacol. Toxicol. Eval. Nat. Prod. Deriv., 17, 1127, 10.1002/ptr.1398 Park, 2013, Natural ingredients for diabetes which are approved by Korean FDA, Biomed. Res., 24 Jung, 2006, Antidiabetic agents from medicinal plants, Curr. Med. Chem., 13, 1203, 10.2174/092986706776360860 Sofowora, 1996, Research on medicinal plants and traditional medicine in Africa, J. Alter. Complement. Med., 2, 365, 10.1089/acm.1996.2.365 Tundis, 2010, Natural products as α-amylase and α-glucosidase inhibitors and their hypoglycaemic potential in the treatment of diabetes: an update, Mini Rev. Med. Chem., 10, 315, 10.2174/138955710791331007 Agrawal, 2010, Solanum torvum Sw.—a phytopharmacological review, Der Pharm. Lett., 2, 403 Yousaf, 2013, Phytochemistry and pharmacological studies on Solanum torvum Swartz, J. Appl. Pharm. Sci., 3, 152 Lim, 2013, Solanum torvum, 429 Arthan, 2002, Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum, Phytochemistry, 59, 459, 10.1016/S0031-9422(01)00417-4 Chah, 2000, Antimicrobial activity of methanolic extract of Solanum torvum fruit, Fitoterapia, 71, 187, 10.1016/S0367-326X(99)00139-2 Ndebia, 2007, Analgesic and anti-inflammatory properties of aqueous extract from leaves of Solanum torvum (Solanaceae), Afr. J. Tradit. Complement. Altern. Med., 4, 240 Panigrahi, 2014, Anticancer activity of ethanolic extract of Solanum torvum sw, Int. J. Pharm. Pharm. Sci., 6, 93 Kadam, 2019, Protective effect of Solanum torvum on monosodium glutamate-induced hepatotoxicity and nephrotoxicity in rats, Indian J. Nat. Prod. Resour., 10, 31 Loganayaki, 2010, Antioxidant activity of two traditional Indian vegetables: Solanum nigrum L. and Solanum torvum L, Food Sci. Biotechnol., 19, 121, 10.1007/s10068-010-0017-y Gandhi, 2011, Solanum torvum Swartz. fruit containing phenolic compounds shows antidiabetic and antioxidant effects in streptozotocin induced diabetic rats, Food Chem. Toxicol., 49, 2725, 10.1016/j.fct.2011.08.005 Gandhi, 2011, Antihyperglycemic activity and antidiabetic effect of methyl caffeate isolated from Solanum torvum Swartz. fruit in streptozotocin induced diabetic rats, Eur. J. Pharmacol., 670, 623, 10.1016/j.ejphar.2011.09.159 Kusirisin, 2009, Effect of polyphenolic compounds from Solanum torvum on plasma lipid peroxidation, superoxide anion and cytochrome P450 2E1 in human liver microsomes, Med. Chem., 5, 583, 10.2174/157340609790170443 Singleton, 1999, [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent, Methods Enzymol., 152, 10.1016/S0076-6879(99)99017-1 Chang, 2002, Estimation of total flavonoid content in propolis by two complementary colorimetric methods, J. Food Drug Anal., 10 Ghorai, N.; Chakraborty, S.; Gucchait, S.; Saha, S.K.; Biswas, S. Estimation of total Terpenoids concentration in plant tissues using a monoterpene, Linalool as standard reagent. 2012. Chassagne, 1996, Identification and quantification of passion fruit cyanogenic glycosides, J. Agric. Food Chem., 44, 3817, 10.1021/jf960381t Oyaizu, 1986, Studies on products of browning reaction antioxidative activities of products of browning reaction prepared from glucosamine, Jpn. J. Nutr. Diet., 44, 307, 10.5264/eiyogakuzashi.44.307 Tsado, 2016, Antioxidants and antimicrobial activities of methanol extract of Newbouldia laevis and Crateva adansonii, J. Pharm. Allied Health Sci., 6, 14 Moore, 1998, Measurement of lipid peroxidation, Free Radic. Res., 28, 659, 10.3109/10715769809065821 Worthington, K. Alpha amylase Worthington enzyme manual (pp. 36–41). Lakewood, NJ: Worthington Biochemical Corporation.[Google Scholar] 1993. Cirillo, 1962, Mechanism of glucose transport across the yeast cell membrane, J. Bacteriol., 84, 485, 10.1128/jb.84.3.485-491.1962 Etuk, 2010, Animals models for studying diabetes mellitus, Agric. Biol. J. N Am., 1, 130 Shittu, 2014, Effects of methanol extract of Musca domestica larvae on antioxidants enzymes in T. Brucei infected rats, Niger. J. Biochem. Mol. Biol., 29, 1 Ibrahim, J.; Kabiru, A.Y.; Abdulrasheed-Adeleke, T.; Lawal, B.; Adewuyi, A.H. Antioxidant and hepatoprotective potentials of curcuminoid isolates from turmeric (Curcuma longa) rhizome on CCl₄-induced hepatic damage in Wistar rats. 2020. Adesina, 2020, Antiplasmodial effect and sub-acute toxicity of alkaloid, flavonoid and phenolic extracts of Sida acuta leaf on Plasmodium berghei-infected animals, J. Taibah Univ. Sci., 14, 943, 10.1080/16583655.2020.1790912 Kum-Tatt, 1974, A new colorimetric method for the determination of glutathione in erythrocytes, Clin. Chim. Acta, 53, 153, 10.1016/0009-8981(74)90093-X Shagirtha, 2017, Neuroprotective efficacy of hesperetin against cadmium induced oxidative stress in the brain of rats, Toxicol. Ind. Health, 33, 454, 10.1177/0748233716665301 Kakkar, P.; Das, B.; Viswanathan, P. A modified spectrophotometric assay of superoxide dismutase. 1984. Sinha, 1972, Colorimetric assay of catalase, Anal. Biochem., 47, 389, 10.1016/0003-2697(72)90132-7 Friedewald, 1972, Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, Clin. Chem., 18, 499, 10.1093/clinchem/18.6.499 Delanghe, 2011, Creatinine determination according to Jaffe-what does it stand for?, NDT, 4, 83 Searle, 1984, The Berthelot or indophenol reaction and its use in the analytical chemistry of nitrogen. A review, Analyst, 109, 549, 10.1039/an9840900549 Suvarna, 2018 Ndako, 2021, Polar extracts from Gymnosporia senegalensis (syn. Maytenus senegalensis) root bark, its effects on nociception, edema, and malarial infection, Phytomedicine, 1 Onikanni, 2022, Therapeutic efficacy of Clompanus pubescens leaves fractions via downregulation of neuronal cholinesterases/Na+-K+ATPase/IL-1 β, and improving the neurocognitive and antioxidants status of streptozotocin-induced diabetic rats, Biomed. Pharmacother., 148, 10.1016/j.biopha.2022.112730 Hanwell, 2012, Avogadro: an advanced semantic chemical editor, visualization, and analysis platform, J. Chemin., 4, 17, 10.1186/1758-2946-4-17 Lawal, 2021, Pharmacoinformatics and preclinical studies of NSC765690 and NSC765599, potential STAT3/CDK2/4/6 inhibitors with antitumor activities against NCI60 human tumor cell lines, Biomedicines, 9, 92, 10.3390/biomedicines9010092 Lawal, 2022, Identification of a novel immune-inflammatory signature of COVID-19 infections, and evaluation of pharmacokinetics and therapeutic potential of RXn-02, a novel small-molecule derivative of quinolone, Comput. Biol. Med., 148, 10.1016/j.compbiomed.2022.105814 Lawal, 2021, mTOR/EGFR/iNOS/MAP2K1/FGFR/TGFB1 are druggable candidates for N-(2,4-Difluorophenyl)-2′,4′-Difluoro-4-Hydroxybiphenyl-3-Carboxamide (NSC765598), with consequent anticancer implications, Front. Oncol., 11 Lawal, 2022, Leveraging bulk and single-cell RNA sequencing data of NSCLC tumor microenvironment and therapeutic potential of NLOC-15A, a novel multi-target small molecule, Front. Immunol., 13 Ajiboye, 2016, Inhibitory effect on key enzymes relevant to acute type-2 diabetes and antioxidative activity of ethanolic extract of Artocarpus heterophyllus stem bark, J. Acute Dis., 5, 423, 10.1016/j.joad.2016.08.011 Shim, 2003, Inhibitory effect of aqueous extract from the gall of Rhus chinensis on alpha-glucosidase activity and postprandial blood glucose, J. Ethnopharmacol., 85, 283, 10.1016/S0378-8741(02)00370-7 Lawal, 2022, Preclinical anti-inflammatory and antioxidant effects of Azanza garckeana in STZ-induced glycemic-impaired rats, and pharmacoinformatics of it major phytoconstituents, Biomed. Pharmacother., 152, 10.1016/j.biopha.2022.113196 Ibrahim, 2014, Anti-oxidative activity and inhibition of key enzymes linked to type 2 diabetes (α-glucosidase and α-amylase) by Khaya senegalensis, Acta Pharm., 64, 311, 10.2478/acph-2014-0025 Saidu, 2017, Starch hydrolysis, polyphenol contents, and in vitro alpha amylase inhibitory properties of some Nigerian foods as affected by cooking, Front. Nutr., 4 Thilagam, 2013, α-Glucosidase and α-amylase inhibitory activity of Senna surattensis, J. Acupunct. Meridian Stud., 6, 24, 10.1016/j.jams.2012.10.005 Roy, 2015, Assessing glucose uptake through the yeast hexose transporter 1 (Hxt1), PLoS One, 10, 10.1371/journal.pone.0121985 Pitchaipillai, 2016, In vitro antidiabetic activity of ethanolic leaf extract of bruguiera Cylindrica L.–glucose uptake by yeast cells method, Int. Biol. Biomed. J., 2, 171 Yang, 2011, Oxidative stress and diabetes mellitus, Clin. Chem. Lab. Med., 49, 1773, 10.1515/cclm.2011.250 Lawal, 2017, African natural products with potential antioxidants and hepatoprotectives properties: a review, Clin. Phytosci., 2, 1, 10.1186/s40816-016-0037-0 Habig, 1974, Glutathione S-transferases: the first enzymatic step in mercapturic acid formation, J. Biol. Chem., 249, 7130, 10.1016/S0021-9258(19)42083-8 Adisa, 2019, Alterations of antioxidant status and mitochondrial succinate dehydrogenase activity in the liver of wistar strain albino rats treated with by ethanol extracts of annona senegalensis pers (annonaceae) stem bark, Toxicol. Res., 35, 13, 10.5487/TR.2019.35.1.013 Bhatti, 2022, Oxidative stress in the pathophysiology of type 2 diabetes and related complications: current therapeutics strategies and future perspectives, Free Radic. Biol. Med., 10.1016/j.freeradbiomed.2022.03.019 Mishra, 2022, Hypoglycemic activity of methanol fraction of solanum torvum (Swartz) fruits in normal and Streptozotocin induced Hyperglycemic rat models, Res. J. Pharm. Technol., 15, 1443, 10.52711/0974-360X.2022.00239 Petersen, 2017, Regulation of hepatic glucose metabolism in health and disease, Nat. Rev. Endocrinol., 13, 572, 10.1038/nrendo.2017.80 Sathishsekar, 2005, Antioxidant properties of Momordica charantia (bitter gourd) seeds on Streptozotocin induced diabetic rats, Asia Pac. J. Clin. Nutr., 14, 153 Mohan, 2013, Antidiabetic and antioxidant properties of Triticum aestivum in streptozotocin-induced diabetic rats, Adv. Pharmacol. Sci., 2013 Ramachandraiahgari, 2012, Protective role of ethanolic extract of Aloe vera antioxidant properties on liver and kidney of streptozotocin-induced diabetic rats, Dig. J. Nanomater. Biostruct., 7, 175 Iyer, 1992, Studies on the effect of dry Sundakai (Solanum torvum) powder supplementation on lipid profile, glycated proteins and amino acids in non-insulin dependent diabetic patients, Plant Foods Hum. Nutr., 42, 175, 10.1007/BF02196470 Shittu, 2015, Alteration in biochemical indices following chronic administration of methanolic extract of Nigeria bee propolis in Wistar rats, Asian Pac. J. Trop. Dis., 5, 654, 10.1016/S2222-1808(15)60907-0 Yusuf, 2018, In-vitro antioxidants, antimicrobial and toxicological evaluation of Nigerian Zingiber officinale, Clin. Phytosci., 4, 1, 10.1186/s40816-018-0070-2 Maikai, 2020, Protective roles of crude and fractions of A. senegalensise carpel against alloxan-induced hyperglycemia and hyperlipidemia in rats, Comp. Clin. Pathol., 29, 327, 10.1007/s00580-019-03063-1 Nigam, 2011, Serum lipid profile: fasting or non-fasting?, Indian J. Clin. Biochem., 26, 96, 10.1007/s12291-010-0095-x Bhatt, 2015, Fatty liver disease in diabetes mellitus, Hepatobiliary Surg. Nutr., 4, 101 Eze, 2012, Effect of ethanolic leaf extract of" mucunapruriens"(fabaceae) on lipid profile inalloxan-induced diabetic wistar rats, Br. J. Pharmacol. Toxicol., 3, 102 Tappy, 2021, Metabolism of sugars: a window to the regulation of glucose and lipid homeostasis by splanchnic organs, Clin. Nutr., 40, 1691, 10.1016/j.clnu.2020.12.022 Mohamed, 2016, Mechanisms of diabetes-induced liver damage: the role of oxidative stress and inflammation, Sultan Qaboos Univ. Med. J., 16, e132, 10.18295/squmj.2016.16.02.002 Yang, 2022, Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease, Int. J. Mol. Sci., 23, 774, 10.3390/ijms23020774 Matyas, 2021, Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications, Nat. Rev. Cardiol., 18, 117, 10.1038/s41569-020-0433-5 Molecular Docking of Bioactive Compounds Against BRCA and COX Proteins. Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 2016, 71, 181–183. Alozieuwa, 2022, Luteolin-rich extract of Thespesia garckeana F. Hoffm. (Snot Apple) contains potential drug-like candidates and modulates glycemic and oxidoinflammatory aberrations in experimental animals, Oxid. Med. Cell. Longev., 2022, 10.1155/2022/1215097