Biochemical Basis of Sestrin Physiological Activities

Trends in Biochemical Sciences - Tập 41 - Trang 621-632 - 2016
Allison Ho1, Chun-Seok Cho1, Sim Namkoong1, Uhn-Soo Cho2, Jun Hee Lee1
1Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA
2Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA

Tài liệu tham khảo

Lopez-Otin, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039 Hekimi, 2011, Taking a ‘good’ look at free radicals in the aging process, Trends Cell biol., 21, 569, 10.1016/j.tcb.2011.06.008 Johnson, 2013, mTOR is a key modulator of ageing and age-related disease, Nature, 493, 338, 10.1038/nature11861 Wu, 2013, Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression, Cell Rep., 4, 913, 10.1016/j.celrep.2013.07.030 Harrison, 2009, Rapamycin fed late in life extends lifespan in genetically heterogeneous mice, Nature, 460, 392, 10.1038/nature08221 Lee, 2013, Sestrins orchestrate cellular metabolism to attenuate aging, Cell Metab., 18, 792, 10.1016/j.cmet.2013.08.018 Budanov, 2004, Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD, Science, 304, 596, 10.1126/science.1095569 Budanov, 2008, p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling, Cell, 134, 451, 10.1016/j.cell.2008.06.028 Yang, 2013, SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans, Exp. Gerontol., 48, 371, 10.1016/j.exger.2012.12.011 Lee, 2010, Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies, Science, 327, 1223, 10.1126/science.1182228 Lee, 2012, Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3, Cell Metab., 16, 311, 10.1016/j.cmet.2012.08.004 Park, 2014, Hepatoprotective role of Sestrin2 against chronic ER stress, Nat. Commun., 5, 4233, 10.1038/ncomms5233 Bae, 2013, Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage, Cell. Metab., 17, 73, 10.1016/j.cmet.2012.12.002 Morrison, 2015, Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart, FASEB J., 29, 408, 10.1096/fj.14-258814 Tao, 2015, Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2–Akt signaling, Diabetes, 64, 1211, 10.2337/db14-0539 Ro, 2016, Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis, eLife, 5, 12204, 10.7554/eLife.12204 Kim, 2015, Sestrin2 inhibits mTORC1 through modulation of GATOR complexes, Sci. Rep., 5, 9502, 10.1038/srep09502 Chantranupong, 2014, The Sestrins interact with GATOR2 to negatively regulate the amino-acid-sensing pathway upstream of mTORC1, Cell. Rep., 9, 1, 10.1016/j.celrep.2014.09.014 Parmigiani, 2014, Sestrins inhibit mTORC1 kinase activation through the GATOR complex, Cell. Rep., 9, 1281, 10.1016/j.celrep.2014.10.019 Rhee, 2015, The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1, Free Radic. Biol. Med., 88, 205, 10.1016/j.freeradbiomed.2015.06.007 Kim, 2015, Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains, Nat. Commun., 6, 10025, 10.1038/ncomms10025 Saxton, 2016, Structural basis for leucine sensing by the Sestrin2–mTORC1 pathway, Science, 351, 53, 10.1126/science.aad2087 Wolfson, 2016, Sestrin2 is a leucine sensor for the mTORC1 pathway, Science, 351, 43, 10.1126/science.aab2674 Peng, 2014, Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling, Cell, 159, 122, 10.1016/j.cell.2014.08.038 Ye, 2015, GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2, Genes. Dev., 29, 2331, 10.1101/gad.269324.115 Budanov, 2002, Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability, Oncogene, 21, 6017, 10.1038/sj.onc.1205877 Kopnin, 2007, Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability, Cancer Res., 67, 4671, 10.1158/0008-5472.CAN-06-2466 Nogueira, 2008, Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis, Cancer Cell, 14, 458, 10.1016/j.ccr.2008.11.003 Hillas, 2000, The AhpC and AhpD antioxidant defense system of Mycobacterium tuberculosis, J. Biol. Chem., 275, 18801, 10.1074/jbc.M001001200 Bryk, 2002, Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein, Science, 295, 1073, 10.1126/science.1067798 Essler, 2009, Role of sestrin2 in peroxide signaling in macrophages, FEBS lett., 583, 3531, 10.1016/j.febslet.2009.10.017 Woo, 2009, Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins, Antioxid. Redox Signal., 11, 739, 10.1089/ars.2008.2360 Thamsen, 2011, Is overoxidation of peroxiredoxin physiologically significant?, Antioxid. Redox Signal., 14, 725, 10.1089/ars.2010.3717 Zhang, 2015, Teaching the basics of autophagy and mitophagy to redox biologists–mechanisms and experimental approaches, Redox Biol., 4, 242, 10.1016/j.redox.2015.01.003 Maiuri, 2009, Stimulation of autophagy by the p53 target gene Sestrin2, Cell Cycle, 8, 1571, 10.4161/cc.8.10.8498 Ishihara, 2013, Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury, Am. J. Physiol. Renal Physiol., 305, F495, 10.1152/ajprenal.00642.2012 Chen, 2014, Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture, Exp. Neurol., 253, 63, 10.1016/j.expneurol.2013.12.009 Hou, 2015, Sestrin2 protects dopaminergic cells against rotenone toxicity through AMPK-dependent autophagy activation, Mol. Cell. Biol., 35, 2740, 10.1128/MCB.00285-15 Ro, 2014, Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species, Proc. Natl. Acad. Sci. U.S.A., 111, 7849, 10.1073/pnas.1401787111 Papadia, 2008, Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses, Nat. Neurosci., 11, 476, 10.1038/nn2071 Yang, 2014, Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production, Hypertension, 64, 825, 10.1161/HYPERTENSIONAHA.114.03840 Suzuki, 2013, Toward clinical application of the Keap1–Nrf2 pathway, Trends Pharmacol. Sci., 34, 340, 10.1016/j.tips.2013.04.005 Komatsu, 2010, The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1, Nat. Cell Biol., 12, 213, 10.1038/ncb2021 Lau, 2010, A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62, Mol. Cell. Biol., 30, 3275, 10.1128/MCB.00248-10 Ro, 2014, Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1, FEBS J., 281, 3816, 10.1111/febs.12905 Ichimura, 2013, Phosphorylation of p62 activates the Keap1–Nrf2 pathway during selective autophagy, Mol. Cell, 51, 618, 10.1016/j.molcel.2013.08.003 Buitrago-Molina, 2013, The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice, Hepatology, 58, 1143, 10.1002/hep.26412 Jain, 2010, p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription, J. Biol. Chem., 285, 22576, 10.1074/jbc.M110.118976 Shin, 2012, Nrf2-ARE pathway regulates induction of Sestrin-2 expression, Free Radic. Biol. Med., 53, 834, 10.1016/j.freeradbiomed.2012.06.026 Reed, 2011, Lipid peroxidation and neurodegenerative disease, Free Radic. Biol. Med., 51, 1302, 10.1016/j.freeradbiomed.2011.06.027 Davi, 2005, Lipid peroxidation in diabetes mellitus, Antioxid. Redox Signal., 7, 256, 10.1089/ars.2005.7.256 Zhang, 2014, Cardiovascular diseases: oxidative damage and antioxidant protection, Eur. Rev. Med. Pharmacol. Sci., 18, 3091 Feng, 2005, The coordinate regulation of the p53 and mTOR pathways in cells, Proc. Natl. Acad. Sci. U.S.A., 102, 8204, 10.1073/pnas.0502857102 Ben-Sahra, 2013, Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death, Cell Death Differ., 20, 611, 10.1038/cdd.2012.157 Hong-Brown, 2015, Adamts1 mediates ethanol-induced alterations in collagen and elastin via a FoxO1–sestrin3–AMPK signaling cascade in myocytes, J. Cell. Biochem., 116, 91, 10.1002/jcb.24945 Eid, 2013, Sestrin 2 and AMPK connect hyperglycemia to Nox4-dependent endothelial nitric oxide synthase uncoupling and matrix protein expression, Mol. Cell. Biol., 33, 3439, 10.1128/MCB.00217-13 Kim, 2015, Identification of an AMPK phosphorylation site in Drosophila TSC2 (gigas) that regulate cell growth, Int. J. Mol. Sci., 16, 7015, 10.3390/ijms16047015 Sanli, 2012, Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells, PloS ONE, 7, e32035, 10.1371/journal.pone.0032035 Dokudovskaya, 2015, SEA you later alli-GATOR–a dynamic regulator of the TORC1 stress response pathway, J. Cell Sci., 128, 2219, 10.1242/jcs.168922 Bar-Peled, 2013, A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1, Science, 340, 1100, 10.1126/science.1232044 Chen, 2011, Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase, Nucleic Acids Res., 39, 235, 10.1093/nar/gkq763 Chen, 2010, FoxOs inhibit mTORC1 and activate Akt by inducing the expression of Sestrin3 and Rictor, Dev. Cell, 18, 592, 10.1016/j.devcel.2010.03.008 Bruning, 2013, Nelfinavir and bortezomib inhibit mTOR activity via ATF4-mediated sestrin-2 regulation, Mol. Oncol., 7, 1012, 10.1016/j.molonc.2013.07.010 Eagle, 1961, The intracellular amino acid concentrations required for protein synthesis in cultured human cells, J. Biol. Chem., 236, 2039, 10.1016/S0021-9258(18)64126-2 Baydoun, 1990, Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells, Biochem. Biophys. Res. Commun., 173, 940, 10.1016/S0006-291X(05)80876-9 Gallinetti, 2013, Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR, Biochem. J., 449, 1, 10.1042/BJ20121098 Kimball, 2016, Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation, Cellular signalling, 10.1016/j.cellsig.2016.03.008 Linares, 2015, Amino acid activation of mTORC1 by a PB1-domain-driven kinase complex cascade, Cell Rep., 12, 1339, 10.1016/j.celrep.2015.07.045 Moscat, 2011, Feedback on fat: p62–mTORC1–autophagy connections, Cell, 147, 724, 10.1016/j.cell.2011.10.021 Duran, 2011, p62 is a key regulator of nutrient sensing in the mTORC1 pathway, Mol. Cell, 44, 134, 10.1016/j.molcel.2011.06.038 Dann, 2007, mTOR complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer, Trends Mol. Med., 13, 252, 10.1016/j.molmed.2007.04.002 Huang, 2008, The TSC1–TSC2 complex is required for proper activation of mTOR complex 2, Mol. Cell. Biol., 28, 4104, 10.1128/MCB.00289-08 Budanov, 2010, Stressin’ Sestrins take an aging fight, EMBO Mol. Med., 2, 388, 10.1002/emmm.201000097 Gwinn, 2008, AMPK phosphorylation of raptor mediates a metabolic checkpoint, Mol. Cell., 30, 214, 10.1016/j.molcel.2008.03.003