Bio-synthesized selenium nanoparticles ameliorate Brain oxidative stress in Parkinson disease rat models

Metabolic Brain Disease - Tập 38 - Trang 2055-2064 - 2023
Sanaz Salaramoli1,2, Hamed Amiri1,2, Hamid Reza Joshaghani3, Mahmoud Hosseini4, Seyed Isaac Hashemy2
1Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
2Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
4Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Tóm tắt

Parkinson disease (PD) is a prevalent central nervous system degenerative condition that impacts elderly people. Recent clinical and experimental study findings have established oxidative stress as one of the main pathogeneses of PD. Selenium, a trace metals with antioxidant effects, might reverse the neurobehavioral impairments and oxidative stress in rats. Thus, the goal of this study was to ascertain if Selenium Nano Particles (SeNPs) are also effective to protect brain cells from oxidative stress or not. SeNPs were synthesized utilizing Ascorbic acid and chitosan as a reducing and stabilizing agent. Next, eight groups (N: 6) of male Wistar rats were randomly assigned and injected by different dosage (0.1, 0,2, and 0.3 mg/kg) of Se and SeNP. Finally, to ascertain the protective benefits of SeNP on PD rats, behavioral evaluation, clinical symptoms, antioxidant activity, and oxidant levels were examined. According to the findings, PD rats' motor functions had developed by SeNP injection. Higher MDA levels and inhibited antioxidant activities (SOD, CAT, and GPX) in lesion group are highlighting the significant role of oxidative stress in dopaminergic neuron death and neurobehavioral abnormalities. SeNP also protect against oxidative stress as compared to the lesion group. The levels of MDA had greatly reduced while the activities of enzymes, TAC, and SeNP both had significantly increased. By enhancing antioxidant activity, administration of SeNP can reduce the hazardous consequences of oxidative stress.

Tài liệu tham khảo

Alberio T, Pippione AC, Comi C, Olgiati S, Cecconi D, Zibetti M et al (2012) Dopaminergic therapies modulate the T-CELL proteome of patients with Parkinson’s disease. IUBMB Life 64:846–852 Amin KA, Hashem KS, Alshehri FS, Awad ST, Hassan MS (2017) Antioxidant and hepatoprotective efficiency of selenium nanoparticles against acetaminophen-induced hepatic damage. Biol Trace Elem Res 175:136–145 Amiri H, Hashemy SI, Sabouri Z, Javid H, Darroudi M (2021) Green synthesized selenium nanoparticles for ovarian cancer cell apoptosis. Res Chem Intermed 47:2539–2556 Asl SS, Amiri I, Samzadeh-Kermani A, Abbasalipourkabir R, Gholamigeravand B, Shahidi S (2021) Chitosan-coated Selenium nanoparticles enhance the efficiency of stem cells in the neuroprotection of streptozotocin-induced neurotoxicity in male rats. Int J Biochem Cell Biol 141:106089 Balestrino R, Schapira A (2020) Parkinson Disease. Eur Neurol 27:27–42 Behl T, Kaur D, Sehgal A, Singh S, Sharma N, Zengin G et al (2021) Role of monoamine oxidase activity in Alzheimer’s disease: an insight into the therapeutic potential of inhibitors. Molecules 26:3724 Bellucci A, Bubacco L, Longhena F, Parrella E, Faustini G, Porrini V et al (2020) Nuclear Factor-κB dysregulation and α-synuclein pathology: Critical interplay in the pathogenesis of Parkinson’s disease. Front Aging Neurosci 12:68 Benko I, Nagy G, Tanczos B, Ungvari E, Sztrik A, Eszenyi P et al (2012) Subacute toxicity of nano-selenium compared to other selenium species in mice. Environ Toxicol Chem 31:2812–2820 Bigham M, Mohammadipour A, Hosseini M, Malvandi AM, Ebrahimzadeh-Bideskan A (2021) Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson’s disease: motor and non-motor outcomes. Metab Brain Dis 36:927–937 Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O (2012) Oxidative stress and antioxidant defense. World Allergy Organ J 5:9–19 Bisht N, Phalswal P, Khanna PK (2022) Selenium nanoparticles: a review on synthesis and biomedical applications. Materials Advances 3:1415–1431 Chand K, Jiao C, Lakhan MN, Shah AH, Kumar V, Fouad DE et al (2021) Green synthesis, characterization and photocatalytic activity of silver nanoparticles synthesized with Nigella Sativa seed extract. Chem Phys Lett 763:138218 Cheung RCF, Ng TB, Wong JH, Chan WY (2015) Chitosan: an update on potential biomedical and pharmaceutical applications. Mar Drugs 13:5156–5186 Damier P, Hirsch E, Zhang P, Agid Y, Javoy-Agid F (1993) Glutathione peroxidase, glial cells and Parkinson’s disease. Neuroscience 52:1–6 Dawood MA, Basuini MFE, Yilmaz S, Abdel-Latif HM, Kari ZA, Abdul Razab MKA et al (2021) Selenium nanoparticles as a natural antioxidant and metabolic regulator in aquaculture: A review. Antioxidants 10:1364 de Farias CC, Maes M, Bonifácio KL, Bortolasci CC, de Souza NA, Brinholi FF et al (2016) Highly specific changes in antioxidant levels and lipid peroxidation in Parkinson’s disease and its progression: disease and staging biomarkers and new drug targets. Neurosci Lett 617:66–71 Diko CS, Zhang H, Lian S, Fan S, Li Z, Qu Y (2020) Optimal synthesis conditions and characterization of selenium nanoparticles in Trichoderma sp WL-Go culture broth. Mater Chem Phys 246:122583 Draper H, Dhanakoti S, Hadley M, Piche L (2019) Malondialdehyde in biological systems. CRC Press, Cellular antioxidant defense mechanisms, pp 97–109 Forman HJ, Zhang H (2021) Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy. Nat Rev Drug Discovery 20:689–709 García DS, de Deus FT, Castro ES, Borrué C, Mata M, Vila BS et al (2019) Non-motor symptoms burden, mood, and gait problems are the most significant factors contributing to a poor quality of life in non-demented Parkinson’s disease patients: Results from the COPPADIS Study Cohort. Parkinsonism Relat Disord 66:151–157 Gupta RK, Patel AK, Shah N, Choudhary AK, Jha UK, Yadav UC et al (2014) Oxidative stress and antioxidants in disease and cancer: a review. Asian Pac J Cancer Prev 15:4405–4409 Hussain I, Singh N, Singh A, Singh H, Singh S (2016) Green synthesis of nanoparticles and its potential application. Biotech Lett 38:545–560 Jeevitha D, Amarnath K (2013) Chitosan/PLA nanoparticles as a novel carrier for the delivery of anthraquinone: Synthesis, characterization and in vitro cytotoxicity evaluation. Colloids Surf, B 101:126–134 Jia X, Li N, Chen J (2005) A subchronic toxicity study of elemental Nano-Se in Sprague-Dawley rats. Life Sci 76:1989–2003 Kazemi M, Akbari A, Zarrinfar H, Soleimanpour S, Sabouri Z, Khatami M et al (2020) Evaluation of antifungal and photocatalytic activities of gelatin-stabilized selenium oxide nanoparticles. J Inorg Organomet Polym Mater 30:3036–3044 Kazemi M, Akbari A, Sabouri Z, Soleimanpour S, Zarrinfar H, Khatami M et al (2021) Green synthesis of colloidal selenium nanoparticles in starch solutions and investigation of their photocatalytic, antimicrobial, and cytotoxicity effects. Bioprocess Biosyst Eng 44:1215–1225 Krukouskaya T, Sinevich E, Zagorsky S, Melnov S, Golovach M (2013) Multielement profiles of children in urban environmental context. Ecol Urban Areas 2013:610 Lee HM, Koh S-B (2015) Many faces of Parkinson’s disease: non-motor symptoms of Parkinson’s disease. J Movement Disord 8:92 Levy OA, Malagelada C, Greene LA (2009) Cell death pathways in Parkinson’s disease: proximal triggers, distal effectors, and final steps. Apoptosis 14:478–500 Li Z, Yao Q, Tian Y, Jiang Y, Xu M, Wang H et al (2022) Trehalose protects against cisplatin-induced cochlear hair cell damage by activating TFEB-mediated autophagy. Biochem Pharmacol 197:114904 Li J, Wuliji O, Li W, Jiang Z-G, Ghanbari HA (2013) Oxidative stress and neurodegenerative disorders. Int J Mol Sci 14:24438–75 Liang P, Qian D, Zhenfeng G, Yongyi C, Yi S, Liang L (2021) Biological selenium nano-particles modify immune responses of macrophages exposed to bladder tumor antigens. J Cluster Sci 32:1623–1633 Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D et al (2018) Oxidative stress, aging, and diseases. Clin Interv Aging 13:757 Martínez Y, Li X, Liu G, Bin P, Yan W, Más D et al (2017) The role of methionine on metabolism, oxidative stress, and diseases. Amino Acids 49:2091–2098 Mohan CO, Gunasekaran S, Ravishankar C (2019) Chitosan-capped gold nanoparticles for indicating temperature abuse in frozen stored products. npj Science of Food 3:2 Nguyen NT, Nguyen NT, Nguyen VA (2020) In situ synthesis and characterization of ZnO/chitosan nanocomposite as an adsorbent for removal of Congo red from aqueous solution. Adv Polym Technol 2020:1–8 Percário S, da Silva Barbosa A, Varela ELP, Gomes ARQ, Ferreira MES, de Nazaré Araújo Moreira T et al (2020) Oxidative stress in parkinson’s disease: Potential benefits of antioxidant supplementation. Oxidative Med Cell Longev 2020:2360872 Phan TTV, Phan DT, Cao XT, Huynh T-C, Oh J (2021) Roles of chitosan in green synthesis of metal nanoparticles for biomedical applications. Nanomaterials 11:273 Ramamurthy C, Sampath KS, Arunkumar P, Kumar MS, Sujatha V, Premkumar K et al (2013) Green synthesis and characterization of selenium nanoparticles and its augmented cytotoxicity with doxorubicin on cancer cells. Bioprocess Biosyst Eng 36:1131–1139 Salaramoli S, Joshaghani H, Hashemy SI (2022) Selenium effects on oxidative stress-induced calcium signaling pathways in Parkinson’s disease. Indian J Clin Biochem 37:257–266 Shehabeldine A, Hasanin M (2019) Green synthesis of hydrolyzed starch–chitosan nano-composite as drug delivery system to gram negative bacteria. Environ Nanotechnol Monitoring Manag 12:100252 Sobolev O, Gutyj B, Petryshak R, Pivtorak J, Kovalskyi Y, Naumyuk A et al (2018) Biological role of selenium in the organism of animals and humans. Ukrainian J Ecol 8:654–665 Thirumavalavan M, Huang K-L, Lee J-F (2013) Preparation and morphology studies of nano zinc oxide obtained using native and modified chitosans. Materials 6:4198–4212 Trist BG, Hare DJ, Double KL (2019) Oxidative stress in the aging substantia nigra and the etiology of Parkinson’s disease. Aging Cell 18:e13031 Trojanowski JQ, LEE VMY (2003) Parkinson’s disease and related α-synucleinopathies are brain amyloidoses. Ann New York Acad Sci 991:107–10 Usman MS, Ibrahim NA, Shameli K, Zainuddin N, Yunus WMZW (2012) Copper nanoparticles mediated by chitosan: synthesis and characterization via chemical methods. Molecules 17:14928–14936 Vyas J, Rana S (2017) Antioxidant activity and green synthesis of selenium nanoparticles using allium sativum extract. Int J Phytomedicine 9:634–641 Younesian O, Khodabakhshi B, Abdolahi N, Norouzi A, Behnampour N, Hosseinzadeh S et al (2022) Decreased Serum Selenium Levels of COVID-19 Patients in Comparison with Healthy Individuals. Biol Trace Elem Res 200:1562–1567 Yue D, Zeng C, Okyere SK, Chen Z, Hu Y (2021) Glycine nano-selenium prevents brain oxidative stress and neurobehavioral abnormalities caused by MPTP in rats. J Trace Elem Med Biol 64:126680 Zafar KS, Siddiqui A, Sayeed I, Ahmad M, Salim S, Islam F (2003) Dose-dependent protective effect of selenium in rat model of Parkinson’s disease: neurobehavioral and neurochemical evidences. J Neurochem 84:438–446