Biliary Sterol Secretion Is Not Required for Macrophage Reverse Cholesterol Transport

Bandsma, 1998, Contribution of newly synthesized cholesterol to rat plasma and bile determined by mass isotopomer distribution analysis: bile-salt flux promotes secretion of newly synthesized cholesterol into bile, Biochem. J., 329, 699, 10.1042/bj3290699

Brown, 2008, Targeted depletion of hepatic ACAT2-driven cholesterol esterification reveals a non-biliary route for fecal neutral sterol loss, J. Biol. Chem., 283, 10522, 10.1074/jbc.M707659200

Cheng, 1959, Secretion of cholesterol by intestinal mucosa in patients with complete common bile duct obstruction, Proc. Soc. Exp. Biol. Med., 101, 223, 10.3181/00379727-101-24890

Cooper, 1991, Metabolic basis of cholesterol gallstone disease, Gastroenterol. Clin. North Am., 20, 21, 10.1016/S0889-8553(21)00532-X

Deckelbaum, 1977, Failure of complete bile diversion and oral bile acid therapy in the treatment of homozygous familial hypercholesterolemia, N. Engl. J. Med., 296, 465, 10.1056/NEJM197703032960901

deGoma, 2008, Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches, J. Am. Coll. Cardiol., 51, 2199, 10.1016/j.jacc.2008.03.016

Dietschy, 1968, The role of bile salts in controlling the rate of intestinal cholesterogenesis, J. Clin. Invest., 47, 286, 10.1172/JCI105725

Glomset, 1968, The plasma lecithin:cholesterol acyltransferase reaction, J. Lipid Res., 9, 155, 10.1016/S0022-2275(20)43114-1

Grefhorst, 2002, Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles, J. Biol. Chem., 277, 34182, 10.1074/jbc.M204887200

Groen, 2001, Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL, J. Clin. Invest., 108, 843, 10.1172/JCI200112473

Jolley, 1998, Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein A-I concentration, J. Lipid Res., 39, 2143, 10.1016/S0022-2275(20)32469-X

Kruit, 2005, Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice, Gastroenterology, 128, 147, 10.1053/j.gastro.2004.10.006

Lee, 1985, Quantitative analysis of total macrophage content in adult mouse tissues. Immunohistochemical studies with monoclonal antibody F4/80, J. Exp. Med., 161, 475, 10.1084/jem.161.3.475

Lewis, 2005, New insights into the regulation of HDL metabolism and reverse cholesterol transport, Circ. Res., 96, 1221, 10.1161/01.RES.0000170946.56981.5c

Naik, 2006, Pharmacological activation of liver X receptors promotes reverse cholesterol transport in vivo, Circulation, 113, 90, 10.1161/CIRCULATIONAHA.105.560177

Pertsemlidis, 1973, Regulation of cholesterol metabolism in the dog I. Effects of complete bile diversion and of cholesterol feeding on absorption, synthesis, accumulation, and excretion rates measured during life, J. Clin. Invest., 52, 2353, 10.1172/JCI107424

Plosch, 2002, Increased heptobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1, J. Biol. Chem., 277, 33870, 10.1074/jbc.M206522200

Rader, 2009, The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis, J. Lipid Res., 50, S189, 10.1194/jlr.R800088-JLR200

Simmonds, 1967, Absorption of cholesterol from a micellar solution: intestinal perfusion studies in man, J. Clin. Invest., 46, 874, 10.1172/JCI105587

Sperry, 1927, Lipid Excretion IV. A study of the relationship of the bile to the fecal lipids with special reference to certain problems of sterol metabolism, J. Biol. Chem., 71, 351, 10.1016/S0021-9258(18)84421-0

Temel, 2007, Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentrations and is a target of ezetimibe, J. Clin. Invest., 117, 1968, 10.1172/JCI30060

van der Velde, 2007, Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice, Gastroenterology, 133, 967, 10.1053/j.gastro.2007.06.019

van der Velde, 2008, Regulation of direct transintestinal cholesterol excretion in mice, Am. J. Physiol. Gastrointest. Liver Physiol., 295, G203, 10.1152/ajpgi.90231.2008

van der Veen, 2009, Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol, J. Biol. Chem., 284, 19211, 10.1074/jbc.M109.014860

Vrins, 2009, PPARd activation leads to increased trans intestinal cholesterol efflux, J. Lipid Res., 10.1194/jlr.M800579-JLR200

Wang, 2007, Molecular regulation of macrophage reverse cholesterol transport, Curr. Opin. Cardiol., 22, 368, 10.1097/HCO.0b013e3281ec5113

Wang, 2007, Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo, J. Clin. Invest., 117, 2216, 10.1172/JCI32057

Xie, 2009, ABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouse, J. Lipid Res., 50, 1316, 10.1194/jlr.M900024-JLR200

Yu, 2002, Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion, Proc. Natl. Acad. Sci. USA, 99, 16237, 10.1073/pnas.252582399

Zhang, 2003, Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo, Circulation, 108, 661, 10.1161/01.CIR.0000086981.09834.E0