Bile acids: regulation of synthesis
Tóm tắt
Từ khóa
Tài liệu tham khảo
Noshiro, 1989, Molecular cloning of cDNA for cholesterol 7α-hydroxylase from rat liver microsomes. Nucleotide sequence and expression, FEBS Lett., 257, 97, 10.1016/0014-5793(89)81795-8
Li, 1990, Regulation of cholesterol 7α-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7α-hydroxylase mRNA, J. Biol. Chem., 265, 12012, 10.1016/S0021-9258(19)38501-1
Jelinek, 1990, Cloning and regulation of cholesterol 7α-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis, J. Biol. Chem., 265, 8190, 10.1016/S0021-9258(19)39056-8
Makishima, 1999, Identification of a nuclear receptor for bile acids, Science., 284, 1362, 10.1126/science.284.5418.1362
Wang, 1999, Endogenous bile acids are ligands for the nuclear receptor FXR/BAR, Mol. Cell., 3, 543, 10.1016/S1097-2765(00)80348-2
Parks, 1999, Bile acids: natural ligands for an orphan nuclear receptor, Science., 284, 1365, 10.1126/science.284.5418.1365
Zollner, 2006, Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations, Mol. Pharm., 3, 231, 10.1021/mp060010s
Nguyen, 2008, Bile acids and signal transduction: role in glucose homeostasis, Cell. Signal., 20, 2180, 10.1016/j.cellsig.2008.06.014
Keitel, 2008, Endocrine and paracrine role of bile acids, World J. Gastroenterol., 14, 5620, 10.3748/wjg.14.5620
Thomas, 2008, Targeting bile-acid signalling for metabolic diseases, Nat. Rev. Drug Discov., 7, 678, 10.1038/nrd2619
Lefebvre, 2009, Role of bile acids and bile acid receptors in metabolic regulation, Physiol. Rev., 89, 147, 10.1152/physrev.00010.2008
Eloranta, 2008, The role of FXR in disorders of bile acid homeostasis, Physiology (Bethesda)., 23, 286
Modica, 2008, Nuclear bile acid receptor FXR protects against intestinal tumorigenesis, Cancer Res., 68, 9589, 10.1158/0008-5472.CAN-08-1791
Chiang, 2002, Bile acid regulation of gene expression: roles of nuclear hormone receptors, Endocr. Rev., 23, 443, 10.1210/er.2000-0035
Chiang, 2004, Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms, J. Hepatol., 40, 539, 10.1016/j.jhep.2003.11.006
Chiang, 2005, Nuclear receptor regulation of lipid metabolism: potential therapeutics for dyslipidemia, diabetes, and chronic heart and liver diseases, Curr. Opin. Investig. Drugs., 6, 994
Watanabe, 2006, Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation, Nature., 439, 484, 10.1038/nature04330
Staudinger, 2001, The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity, Proc. Natl. Acad. Sci. USA., 98, 3369, 10.1073/pnas.051551698
Makishima, 2002, Vitamin D receptor as an intestinal bile acid sensor, Science., 296, 1313, 10.1126/science.1070477
Xie, 2001, An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids, Proc. Natl. Acad. Sci. USA., 98, 3375, 10.1073/pnas.051014398
Sonoda, 2002, Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR), Proc. Natl. Acad. Sci. USA., 99, 13801, 10.1073/pnas.212494599
Stravitz, 1995, Repression of cholesterol 7a-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes, J. Lipid Res., 36, 1359, 10.1016/S0022-2275(20)41143-5
Miyake, 2000, Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7alpha-hydroxylase, J. Biol. Chem., 275, 21805, 10.1074/jbc.C000275200
Gutierrez, 2006, Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4, Arterioscler. Thromb. Vasc. Biol., 26, 301, 10.1161/01.ATV.0000195793.73118.b4
Rao, 2002, Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes, Hepatology., 35, 307, 10.1053/jhep.2002.31104
Fang, 2004, Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes, Hepatology., 40, 961, 10.1002/hep.1840400427
Dent, 2005, Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes, Hepatology., 42, 1291, 10.1002/hep.20942
Fang, 2007, Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling, Mol. Pharmacol., 71, 1122, 10.1124/mol.106.032060
Gupta, 2004, Deoxycholic acid activates the c-Jun N-terminal kinase pathway via FAS receptor activation in primary hepatocytes: role of acidic sphingomyelinase-mediated ceramide generation in FAS receptor activation, J. Biol. Chem., 279, 5821, 10.1074/jbc.M310979200
Han, 2004, Bile acids enhance the activity of the insulin receptor and glycogen synthase in primary rodent hepatocytes, Hepatology., 39, 456, 10.1002/hep.20043
Kawamata, 2003, A G protein-coupled receptor responsive to bile acids, J. Biol. Chem., 278, 9435, 10.1074/jbc.M209706200
Maruyama, 2002, Identification of membrane-type receptor for bile acids (M-BAR), Biochem. Biophys. Res. Commun., 298, 714, 10.1016/S0006-291X(02)02550-0
Keitel, 2007, The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells, Hepatology., 45, 695, 10.1002/hep.21458
Katsuma, 2005, Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1, Biochem. Biophys. Res. Commun., 329, 386, 10.1016/j.bbrc.2005.01.139
Russell, 2003, The enzymes, regulation, and genetics of bile acid synthesis, Annu. Rev. Biochem., 72, 137, 10.1146/annurev.biochem.72.121801.161712
Hofmann, 2004, Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity, Drug Metab. Rev., 36, 703, 10.1081/DMR-200033475
Hofmann, 2008, Bile acids: chemistry, pathochemistry, biology, pathobiology, and therapeutics, Cell. Mol. Life Sci., 65, 2461, 10.1007/s00018-008-7568-6
Monte, 2009, Bile acids: chemistry, physiology, and pathophysiology, World J. Gastroenterol., 15, 804, 10.3748/wjg.15.804
Pandak, 1996, Hep G2 cells: a model for studies on regulation of human cholesterol 7α-hydroxylase at the molecular level, Am. J. Physiol., 270, G401
Baker, 2000, One or more labile proteins regulate the stability of chimeric mRNAs containing the 3′-untranslated region of cholesterol 7α-hydroxylase mRNA, J. Biol. Chem., 275, 19985, 10.1074/jbc.M002351200
Agellon, 1997, The 3′-untranslated region of the mouse cholesterol 7α-hydroxylase mRNA contains elements responsive to post-transcriptional regulation by bile acids, Biochem. J., 328, 393, 10.1042/bj3280393
Crestani, 1998, Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors, J. Lipid Res., 39, 2192, 10.1016/S0022-2275(20)32474-3
Li, 2006, Bile acids and cytokines inhibit the human cholesterol 7α-hydroxylase gene via the JNK/c-jun pathway in human liver cells, Hepatology., 43, 1202, 10.1002/hep.21183
Li, 2006, Insulin regulation of cholesterol 7α-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c, J. Biol. Chem., 281, 28745, 10.1074/jbc.M605815200
Song, 2006, Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7a1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis, Hepatology., 43, 117, 10.1002/hep.20919
Song, 2007, Hepatocyte growth factor signaling pathway inhibits cholesterol 7α-hydroxylase and bile acid synthesis in human hepatocytes, Hepatology., 46, 1993, 10.1002/hep.21878
Song, 2009, Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression, Hepatology., 49, 297, 10.1002/hep.22627
Chiang, 1994, Identification and characterization of a putative bile acid responsive element in cholesterol 7α-hydroxylase gene promoter, J. Biol. Chem., 269, 17502, 10.1016/S0021-9258(17)32469-9
Janowski, 1996, An oxysterol signalling pathway mediated by the nuclear receptor LXRα, Nature., 383, 728, 10.1038/383728a0
Lehmann, 1997, Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway, J. Biol. Chem., 272, 3137, 10.1074/jbc.272.6.3137
Peet, 1998, Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha, Cell., 93, 693, 10.1016/S0092-8674(00)81432-4
Chiang, 2001, Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα), Gene., 262, 257, 10.1016/S0378-1119(00)00518-7
Agellon, 2002, Dietary cholesterol fails to stimulate the human cholesterol 7α-hydroxylase gene (CYP7A1) in transgenic mice, J. Biol. Chem., 277, 20131, 10.1074/jbc.C200105200
Chen, 2002, Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet, J. Biol. Chem., 277, 42588, 10.1074/jbc.M205117200
Stroup, 1997, Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene CYP7A, Am. J. Physiol., 273, G508
De Fabiani, 2003, Coordinated control of cholesterol catabolism to bile acids and of gluconeogenesis via a novel mechanism of transcription regulation linked to the fasted-to-fed cycle, J. Biol. Chem., 278, 39124, 10.1074/jbc.M305079200
Shin, 2003, PGC-1α activates CYP7A1 and bile acid biosynthesis, J. Biol. Chem., 278, 50047, 10.1074/jbc.M309736200
Lundasen, 2003, Leptin induces the hepatic high density lipoprotein receptor scavenger receptor B type I (SR-BI) but not cholesterol 7α-hydroxylase (Cyp7a1) in leptin-deficient (ob/ob) mice, J. Biol. Chem., 278, 43224, 10.1074/jbc.M302645200
Galman, 2005, Bile acid synthesis in humans has a rapid diurnal variation that is asynchronous with cholesterol synthesis, Gastroenterology., 129, 1445, 10.1053/j.gastro.2005.09.009
Rizzo, 2005, Role of FXR in regulating bile acid homeostasis and relevance for human diseases, Curr. Drug Targets Immune Endocr. Metabol. Disord., 5, 289, 10.2174/1568008054863781
Chiang, 2000, FXR responds to bile acids and represses cholesterol 7α-hydroxylase gene (CYP7A1) transcription, J. Biol. Chem., 275, 10918, 10.1074/jbc.275.15.10918
Yang, 2002, On the mechanism of bile acid inhibition of rat sterol 12α- hydroxylase gene (CYP8B1) transcription: roles of alpha-fetoprotein transcription factor and hepatocyte nuclear factor 4alpha, Biochim. Biophys. Acta., 1583, 63, 10.1016/S1388-1981(02)00186-5
Chen, 2003, Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha), Gene., 313, 71, 10.1016/S0378-1119(03)00631-0
Sanyal, 2007, Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis, Proc. Natl. Acad. Sci. USA., 104, 15665, 10.1073/pnas.0706736104
Inoue, 2004, Hepatocyte nuclear factor 4alpha is a central regulator of bile acid conjugation, J. Biol. Chem., 279, 2480, 10.1074/jbc.M311015200
Hunt, 2000, The peroxisome proliferator-activated receptor α (PPARα) regulates bile acid biosynthesis, J. Biol. Chem., 275, 28947, 10.1074/jbc.M002782200
Pineda Torra, 2003, Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor, Mol. Endocrinol., 17, 259, 10.1210/me.2002-0120
Marrapodi, 2000, Peroxisome proliferator-activated receptor alpha (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription, J. Lipid Res., 41, 514, 10.1016/S0022-2275(20)32398-1
Quinn, 2005, Expression and regulation of sterol 27-hydroxylase (CYP27A1) in human macrophages: a role for RXR and PPARgamma ligands, Biochem. J., 385, 823, 10.1042/BJ20041776
Solaas, 2004, Differential regulation of cytosolic and peroxisomal bile acid amidation by PPAR alpha activation favors the formation of unconjugated bile acids, J. Lipid Res., 45, 1051, 10.1194/jlr.M300291-JLR200
Duez, 2008, Regulation of bile acid synthesis by the nuclear receptor Rev-erbα, Gastroenterology., 135, 689, 10.1053/j.gastro.2008.05.035
Preitner, 2002, The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator, Cell., 110, 251, 10.1016/S0092-8674(02)00825-5
Yin, 2005, The orphan nuclear receptor Rev-erbalpha recruits the N-CoR/histone deacetylase 3 corepressor to regulate the circadian Bmal1 gene, Mol. Endocrinol., 19, 1452, 10.1210/me.2005-0057
Yin, 2006, Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock, Science., 311, 1002, 10.1126/science.1121613
Raghuram, 2007, Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta, Nat. Struct. Mol. Biol., 14, 1207, 10.1038/nsmb1344
Burris, 2008, Nuclear hormone receptors for heme: REV-ERBα and REV-ERBbeta are ligand-regulated components of the mammalian clock, Mol. Endocrinol., 22, 1509, 10.1210/me.2007-0519
Wang, 2008, Bifunctional role of Rev-erbalpha in adipocyte differentiation, Mol. Cell. Biol., 28, 2213, 10.1128/MCB.01608-07
Yin, 2007, Rev-erbα, a heme sensor that coordinates metabolic and circadian pathways, Science., 318, 1786, 10.1126/science.1150179
Kawamoto, 2006, Effects of fasting and re-feeding on the expression of Dec1, Per1, and other clock-related genes, J Biochem., 140, 401, 10.1093/jb/mvj165
Noshiro, 1990, Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7α-hydroxylase, FEBS Lett., 268, 137, 10.1016/0014-5793(90)80992-R
Noshiro, 1990, Rat liver cholesterol 7α-hydroxylase. Pretranslational regulation for circadian rhythm, J. Biol. Chem., 265, 10036, 10.1016/S0021-9258(19)38775-7
Chiang, 1990, Regulation of cholesterol 7 alpha-hydroxylase in the liver. Purification of cholesterol 7α-hydroxylase and the immunochemical evidence for the induction of cholesterol 7α-hydroxylase by cholestyramine and circadian rhythm, J. Biol. Chem., 265, 3889, 10.1016/S0021-9258(19)39677-2
Mueller, 1990, DBP, a liver enriched transcriptional activator is expressed late in ontogeny and its tissue specificity is determined post-transcriptionally, Cell., 61, 279, 10.1016/0092-8674(90)90808-R
Wuarin, 1990, Expression of the liver enriched transcription activator protein DBP follows a stringent circadian rhythm, Cell., 63, 1257, 10.1016/0092-8674(90)90421-A
Lavery, 1993, Circadian transcription of the cholesterol 7α-hydroxylase gene may involve the liver-enriched bZIP protein DBP, Genes Dev., 7, 1871, 10.1101/gad.7.10.1871
Yamada, 2000, Circadian rhythms of sterol 12alpha-hydroxylase, cholesterol 7α- hydroxylase and DBP involved in rat cholesterol catabolism, Biol. Chem., 381, 1149, 10.1515/BC.2000.142
Noshiro, 2007, Multiple mechanisms regulate circadian expression of the gene for cholesterol 7α-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis, J. Biol. Rhythms., 22, 299, 10.1177/0748730407302461
Noshiro, 2004, Rhythmic expression of DEC1 and DEC2 in peripheral tissues: DEC2 is a potent suppressor for hepatic cytochrome P450s opposing DBP, Genes Cells., 9, 317, 10.1111/j.1356-9597.2004.00722.x
Ananthanarayanan, 2001, Human bile salt export pump (BSEP) promoter is transactivated by the farnesoid X receptor/bile acid receptor (FXR/BAR), J. Biol. Chem., 276, 28857, 10.1074/jbc.M011610200
Jansen, 2003, Genetic cholestasis, causes and consequences for hepatobiliary transport, Liver Int., 23, 315, 10.1034/j.1478-3231.2003.00856.x
Carlton, 2004, Molecular basis of intrahepatic cholestasis, Ann. Med., 36, 606, 10.1080/07853890410018916
Dawson, 2003, Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice, J. Biol. Chem., 278, 33920, 10.1074/jbc.M306370200
Li, 2005, FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade, Am. J. Physiol. Gastrointest. Liver Physiol., 288, G60, 10.1152/ajpgi.00170.2004
Tu, 2000, FXR, a bile acid receptor and biological sensor, Trends Cardiovasc. Med., 10, 30, 10.1016/S1050-1738(00)00043-8
Dawson, 2005, The heteromeric organic solute transporter α-β, Ostα-Ostß, is an ileal basolateral bile acid transporter, J. Biol. Chem., 280, 6960, 10.1074/jbc.M412752200
Ballatori, 2005, OSTα-OSTβ: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia, Hepatology., 42, 1270, 10.1002/hep.20961
Ballatori, 2008, Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver, Am. J. Physiol. Gastrointest. Liver Physiol., 295, G179, 10.1152/ajpgi.90319.2008
Rao, 2008, The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis, Proc. Natl. Acad. Sci. USA., 105, 3891, 10.1073/pnas.0712328105
Frankenberg, 2006, Regulation of the mouse organic solute transporter α-β, Ostα-Ostβ, by bile acids, Am. J. Physiol. Gastrointest. Liver Physiol., 290, G912, 10.1152/ajpgi.00479.2005
Boyer, 2006, Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTα-OSTβ in cholestasis in humans and rodents, Am. J. Physiol. Gastrointest. Liver Physiol., 290, G1124, 10.1152/ajpgi.00539.2005
Denson, 2001, The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp, Gastroenterology., 121, 140, 10.1053/gast.2001.25503
Kullak-Ublick, 2000, Mechanisms of cholestasis, Clin. Liver Dis., 4, 357, 10.1016/S1089-3261(05)70114-8
Trauner, 1998, Molecular pathogenesis of cholestasis, N. Engl. J. Med., 339, 1217, 10.1056/NEJM199810223391707
Goodwin, 2000, A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis, Mol. Cell., 6, 517, 10.1016/S1097-2765(00)00051-4
Lu, 2000, Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors, Mol. Cell., 6, 507, 10.1016/S1097-2765(00)00050-2
Zhang, 2001, Transcriptional regulation of the human sterol 12α-hydroxylase gene (CYP8B1): roles of hepatocyte nuclear factor 4α (HNF4α) in mediating bile acid repression, J. Biol. Chem., 276, 41690, 10.1074/jbc.M105117200
Del Castillo-Olivares, 2004, Role of FTF/LRH-1 on bile acid biosynthesis. A known nuclear receptor activator that can act as a suppressor of bile acid biosynthesis, J. Biol. Chem., 279, 16813, 10.1074/jbc.M400646200
Boulias, 2005, Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP, EMBO J., 24, 2624, 10.1038/sj.emboj.7600728
Boulias, 2004, Functional role of G9a-induced histone methylation in small heterodimer partner-mediated transcriptional repression, Nucleic Acids Res., 32, 6096, 10.1093/nar/gkh947
Kemper, 2004, Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP, Mol. Cell. Biol., 24, 7707, 10.1128/MCB.24.17.7707-7719.2004
Fang, 2007, Coordinated recruitment of histone methyltransferase G9a and other chromatin modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism, Mol. Cell. Biol., 27, 1407, 10.1128/MCB.00944-06
Mitro, 2007, Insights in the regulation of cholesterol 7α-hydroxylase gene reveal a target for modulating bile acid synthesis, Hepatology., 46, 885, 10.1002/hep.21819
Mataki, 2007, Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1, Mol. Cell. Biol., 27, 8330, 10.1128/MCB.00852-07
Lee, 2008, Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis, Mol. Endocrinol., 22, 1345, 10.1210/me.2007-0565
Kerr, 2002, Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis, Dev. Cell., 2, 713, 10.1016/S1534-5807(02)00154-5
Wang, 2002, Redundant pathways for negative feedback regulation of bile Acid production, Dev. Cell., 2, 721, 10.1016/S1534-5807(02)00187-9
Huang, 2006, Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration, Science., 312, 233, 10.1126/science.1121435
Zhang, 2009, Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration, Mol. Endocrinol., 23, 137, 10.1210/me.2008-0198
Holt, 2003, Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis, Genes Dev., 17, 1581, 10.1101/gad.1083503
Inagaki, 2005, Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis, Cell Metab., 2, 217, 10.1016/j.cmet.2005.09.001
Kim, 2007, Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine, J. Lipid Res., 48, 2664, 10.1194/jlr.M700330-JLR200
Pandak, 1995, Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7α-hydroxylase in rats with biliary fistulas, Gastroenterology., 108, 533, 10.1016/0016-5085(95)90083-7
Ito, 2005, Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho, J. Clin. Invest., 115, 2202, 10.1172/JCI23076
Yu, 2000, Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4, J. Biol. Chem., 275, 15482, 10.1074/jbc.275.20.15482
Yu, 2005, Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids, J. Biol. Chem., 280, 17707, 10.1074/jbc.M411771200
Lundasen, 2006, Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man, J. Intern. Med., 260, 530, 10.1111/j.1365-2796.2006.01731.x
Schaap, 2009, High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis, Hepatology., 49, 1228, 10.1002/hep.22771
Li, 2004, Mechanism of rifampicin and pregnane X receptor (PXR) inhibition of human cholesterol 7α-hydroxylase gene (CYP7A1) transcription, Am. J. Physiol. Gastrointest. Liver Physiol., 288, G74, 10.1152/ajpgi.00258.2004
Han, 2009, Mechanism of vitamin D receptor inhibition of cholesterol 7α-hydroxylase gene transcription in human hepatocytes, Drug Metab. Dispos., 37, 469, 10.1124/dmd.108.025155
Owsley, 2003, Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7α-hydroxylase gene, Biochem. Biophys. Res. Commun., 304, 191, 10.1016/S0006-291X(03)00551-5
Li, 2007, PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine, J. Lipid Res., 48, 373, 10.1194/jlr.M600282-JLR200
Miao, 2006, Functional inhibitory cross-talk between car and HNF-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha, J. Biol. Chem., 281, 14537, 10.1074/jbc.M510713200
Gupta, 2001, Down-regulation of cholesterol 7α-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway, J. Biol. Chem., 276, 15816, 10.1074/jbc.M010878200
Jahan, 2005, Cytokine regulation of human sterol 12α-hydroxylase (CYP8B1) gene, Am. J. Physiol. Gastrointest. Liver Physiol., 288, G685, 10.1152/ajpgi.00207.2004
Myung, 2007, Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-β-dependent hepatic stellate cell activation, Biochem. Biophys. Res. Commun., 353, 1091, 10.1016/j.bbrc.2006.12.157
Li, 2007, A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7α-hydroxylase gene, Gastroenterology., 133, 1660, 10.1053/j.gastro.2007.08.042
Wilkinson, 2005, A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene, Mol. Cell. Biol., 25, 1200, 10.1128/MCB.25.3.1200-1212.2005
Cordenonsi, 2007, Integration of TGF-β and Ras/MAPK signaling through p53 phosphorylation, Science., 315, 840, 10.1126/science.1135961
Maeda, 2002, Repression of hepatocyte nuclear factor 4α tumor suppressor p53: involvement of the ligand-binding domain and histone deacetylase activity, Mol. Endocrinol., 16, 402
Li, 2008, Transforming growth factor beta 1, tumor necrosis factor a, and insulin signaling crosstalk in regulation of the rat cholesterol 7α-hydroxylase gene expression, J. Lipid Res., 49, 1981, 10.1194/jlr.M800140-JLR200
Dueland, 1991, Regulation of cholesterol and bile acid homeostasis in bile-obstructed rats, Biochem. J., 280, 373, 10.1042/bj2800373
Boyer, 2005, Nuclear receptor ligands: rational and effective therapy for chronic cholestatic liver disease?, Gastroenterology., 129, 735, 10.1016/j.gastro.2005.06.053
Zollner, 2009, Nuclear receptors as therapeutic targets in cholestatic liver diseases, Br. J. Pharmacol., 156, 7, 10.1111/j.1476-5381.2008.00030.x
Fiorucci, 2005, Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor (FXR) ligand, in estrogen induced cholestasis, J. Pharmacol. Exp. Ther., 313, 604, 10.1124/jpet.104.079665
Pellicciari, 2007, Nongenomic actions of bile acids. Synthesis and preliminary characterization of 23- and 6,23-alkyl-substituted bile acid derivatives as selective modulators for the G-protein coupled receptor TGR5, J. Med. Chem., 50, 4265, 10.1021/jm070633p
Gilat, 2001, Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in inbred mice, Lipids., 36, 1135, 10.1007/s11745-001-0824-3
Leikin-Frenkel, 2004, Faecal sterol output is increased by arachidyl amido cholanoic acid (Aramchol) in rats, Biochem. Soc. Trans., 32, 131, 10.1042/bst0320131
Leikin-Frenkel, 2008, Treatment of preestablished diet-induced fatty liver by oral fatty acid-bile acid conjugates in rodents, Eur. J. Gastroenterol. Hepatol., 20, 1205