Bile Acids Induce Inflammatory Genes in Hepatocytes

The American Journal of Pathology - Tập 178 - Trang 175-186 - 2011
Katryn Allen1, Hartmut Jaeschke1, Bryan L. Copple1
1Department of Pharmacology, Toxicology, and Experimental Therapeutics, University of Kansas Medical Center, Kansas City, Kansas

Tài liệu tham khảo

Li, 2004, The pathology of cholestasis, Semin Liver Dis, 24, 21, 10.1055/s-2004-823099 Qureshi, 1999, Intrahepatic cholestatic syndromes: pathogenesis, clinical features and management, Dig Dis, 17, 49, 10.1159/000016903 Setchell, 1997, Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei, Gastroenterology, 112, 226, 10.1016/S0016-5085(97)70239-7 Lindblad, 1977, Bile acid concentrations in systemic and portal serum in presumably normal man and in cholestatic and cirrhotic conditions, Scand J Gastroenterol, 12, 395, 10.3109/00365527709181679 Gujral, 2003, Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice, Hepatology, 38, 355, 10.1053/jhep.2003.50341 Ramadori, 2004, Portal tract fibrogenesis in the liver, Lab Invest, 84, 153, 10.1038/labinvest.3700030 Patel, 1995, Apoptosis and hepatobiliary disease, Hepatology, 21, 1725 Guicciardi, 2002, Bile acid-mediated hepatocyte apoptosis and cholestatic liver disease, Dig Liver Dis, 34, 387, 10.1016/S1590-8658(02)80033-0 Faubion, 1999, Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas, J Clin Invest, 103, 137, 10.1172/JCI4765 Reinehr, 2003, Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation, Gastroenterology, 125, 839, 10.1016/S0016-5085(03)01055-2 Graf, 2002, Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner, Gastroenterology, 122, 1411, 10.1053/gast.2002.32976 Yang, 2009, Switch from Mnt-Max to Myc-Max induces p53 and cyclin D1 expression and apoptosis during cholestasis in mouse and human hepatocytes, Hepatology, 49, 860, 10.1002/hep.22720 Rodrigues, 1998, A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation, J Clin Invest, 101, 2790, 10.1172/JCI1325 Marschall, 2006, Fxr(−/−) mice adapt to biliary obstruction by enhanced phase I detoxification and renal elimination of bile acids, J Lipid Res, 47, 582, 10.1194/jlr.M500427-JLR200 Wagner, 2003, Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice, Gastroenterology, 125, 825, 10.1016/S0016-5085(03)01068-0 Burkard, 2005, Differentiated quantification of human bile acids in serum by high-performance liquid chromatography-tandem mass spectrometry, J Chromatogr B Analyt Technol Biomed Life Sci, 826, 147, 10.1016/j.jchromb.2005.08.016 Sokol, 1995, Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids, Gastroenterology, 109, 1249, 10.1016/0016-5085(95)90585-5 Copple, 2010, Oxidative stress and the pathogenesis of cholestasis, Semin Liver Dis, 30, 195, 10.1055/s-0030-1253228 Gujral, 2004, Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice, Am J Physiol Gastrointest Liver Physiol, 286, G499, 10.1152/ajpgi.00318.2003 Neuman, 2002, Tumor necrosis factor-alpha and transforming growth factor-beta reflect severity of liver damage in primary biliary cirrhosis, J Gastroenterol Hepatol, 17, 196, 10.1046/j.1440-1746.2002.02672.x Yamashiki, 1998, Analysis of serum cytokine levels in primary biliary cirrhosis patients and healthy adults, J Clin Lab Anal, 12, 77, 10.1002/(SICI)1098-2825(1998)12:2<77::AID-JCLA1>3.0.CO;2-G Gulubova, 1998, Intercellular adhesion molecule-1 (ICAM-1) expression in the liver of patients with extrahepatic cholestasis, Acta Histochem, 100, 59, 10.1016/S0065-1281(98)80006-8 Sinal, 2000, Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis, Cell, 102, 731, 10.1016/S0092-8674(00)00062-3 Kim, 2006, Early growth response factor-1 is critical for cholestatic liver injury, Toxicol Sci, 90, 586, 10.1093/toxsci/kfj111 Copple, 2009, Hypoxia-inducible factor-dependent production of profibrotic mediators by hypoxic hepatocytes, Liver Int, 29, 1010, 10.1111/j.1478-3231.2009.02015.x Poltorak, 1998, Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene, Science, 282, 2085, 10.1126/science.282.5396.2085 Seki, 2007, TLR4 enhances TGF-beta signaling and hepatic fibrosis, Nat Med, 13, 1324, 10.1038/nm1663 Qiao, 2001, Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis, Mol Biol Cell, 12, 2629, 10.1091/mbc.12.9.2629 Dent, 2005, Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes, Hepatology, 42, 1291, 10.1002/hep.20942 Allen, 2010, Upregulation of early growth response factor-1 by bile acids requires mitogen-activated protein kinase signaling, Toxicol Appl Pharmacol, 243, 63, 10.1016/j.taap.2009.11.013 Wintermeyer, 2009, Invariant natural killer T cells suppress the neutrophil inflammatory response in a mouse model of cholestatic liver damage, Gastroenterology, 136, 1048, 10.1053/j.gastro.2008.10.027 Canbay, 2003, Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression, Hepatology, 38, 1188, 10.1053/jhep.2003.50472 Qin, 2005, Bile acid signaling through FXR induces intracellular adhesion molecule-1 expression in mouse liver and human hepatocytes, Am J Physiol Gastrointest Liver Physiol, 289, G267, 10.1152/ajpgi.00043.2005 Fukase, 2008, Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma, Cancer Sci, 99, 1785, 10.1111/j.1349-7006.2008.00898.x Zhong, 2009, Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats, Hepatology, 50, 1524, 10.1002/hep.23189 Grotegut, 2006, Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail, EMBO J, 25, 3534, 10.1038/sj.emboj.7601213 Van Bossuyt, 1990, The role of bile acids in the development of endotoxemia during obstructive jaundice in the rat, J Hepatol, 10, 274, 10.1016/0168-8278(90)90132-B Reynolds, 1996, Gut barrier failure in experimental obstructive jaundice, J Surg Res, 62, 11, 10.1006/jsre.1996.0165 Georgiev, 2008, Characterization of time-related changes after experimental bile duct ligation, Br J Surg, 95, 646, 10.1002/bjs.6050 Gong, 2002, Liver sinusoidal endothelial cell injury by neutrophils in rats with acute obstructive cholangitis, World J Gastroenterol, 8, 342, 10.3748/wjg.v8.i2.342 Gehring, 2006, Kupffer cells abrogate cholestatic liver injury in mice, Gastroenterology, 130, 810, 10.1053/j.gastro.2005.11.015 Zhong, 2003, Polyphenols from Camellia sinensis attenuate experimental cholestasis-induced liver fibrosis in rats, Am J Physiol Gastrointest Liver Physiol, 285, G1004, 10.1152/ajpgi.00008.2003 Park, 2006, High mobility group box 1 protein interacts with multiple Toll-like receptors, Am J Physiol Cell Physiol, 290, C917, 10.1152/ajpcell.00401.2005 Tsung, 2005, The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion, J Exp Med, 201, 1135, 10.1084/jem.20042614 Gujral, 2004, Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation, Hepatology, 40, 998, 10.1002/hep.1840400431 Makishima, 1999, Identification of a nuclear receptor for bile acids, Science, 284, 1362, 10.1126/science.284.5418.1362 Dorman, 2005, Generation and functional significance of CXC chemokines for neutrophil-induced liver injury during endotoxemia, Am J Physiol Gastrointest Liver Physiol, 288, G880, 10.1152/ajpgi.00317.2004 Simonet, 1994, Long-term impaired neutrophil migration in mice overexpressing human interleukin-8, J Clin Invest, 94, 1310, 10.1172/JCI117450 Maher, 1997, Adenovirus-mediated expression of cytokine-induced neutrophil chemoattractant in rat liver induces a neutrophilic hepatitis, Hepatology, 25, 624, 10.1002/hep.510250322 Dominguez, 2009, Hepatic expression of CXC chemokines predicts portal hypertension and survival in patients with alcoholic hepatitis, Gastroenterology, 136, 1639, 10.1053/j.gastro.2009.01.056 Xu, 2004, Limited role for CXC chemokines in the pathogenesis of alpha-naphthylisothiocyanate-induced liver injury, Am J Physiol Gastrointest Liver Physiol, 287, G734, 10.1152/ajpgi.00300.2003 Yan, 2000, Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress [Erratum appeared in Nat Med 2001;7:509], Nat Med, 6, 1355, 10.1038/82168 Harja, 2004, Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation, Circ Res, 94, 333, 10.1161/01.RES.0000112405.61577.95 Pritchard, 2007, Early growth response-1 contributes to galactosamine/lipopolysaccharide-induced acute liver injury in mice, Am J Physiol Gastrointest Liver Physiol, 293, G1124, 10.1152/ajpgi.00325.2007 McMullen, 2005, Early growth response-1 transcription factor is essential for ethanol-induced fatty liver injury in mice, Gastroenterology, 128, 2066, 10.1053/j.gastro.2005.02.065 Yasoshima, 1995, Immunohistochemical analysis of adhesion molecules in the micro-environment of portal tracts in relation to aberrant expression of PDC-E2 and HLA-DR on the bile ducts in primary biliary cirrhosis, J Pathol, 175, 319, 10.1002/path.1711750310 Medina, 2005, Evidence of angiogenesis in primary biliary cirrhosis: an immunohistochemical descriptive study, J Hepatol, 42, 124, 10.1016/j.jhep.2004.09.024 Gupta, 2001, Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway, J Biol Chem, 276, 15816, 10.1074/jbc.M010878200 Rao, 1997, Activation of protein kinase C alpha and delta by bile acids: correlation with bile acid structure and diacylglycerol formation, J Lipid Res, 38, 2446, 10.1016/S0022-2275(20)30029-8 Staudinger, 2001, The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity, Proc Natl Acad Sci USA, 98, 3369, 10.1073/pnas.051551698 Kurz, 2001, Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats, Gastroenterology, 121, 407, 10.1053/gast.2001.26262 Park, 2006, TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression, Glia, 53, 248, 10.1002/glia.20278 Hiura, 1999, Activation of the human RANTES gene promoter in a macrophage cell line by lipopolysaccharide is dependent on stress-activated protein kinases and the IkappaB kinase cascade: implications for exacerbation of allergic inflammation by environmental pollutants, Clin Immunol, 90, 287, 10.1006/clim.1998.4659 Adachi, 2000, The differential role of extracellular signal-regulated kinases and p38 mitogen-activated protein kinase in eosinophil functions, J Immunol, 165, 2198, 10.4049/jimmunol.165.4.2198 Schoemaker, 2003, Resistance of rat hepatocytes against bile acid-induced apoptosis in cholestatic liver injury is due to nuclear factor-kappa B activation, J Hepatol, 39, 153, 10.1016/S0168-8278(03)00214-9