Beyond vascularization: aerobic fitness is associated with N‐acetylaspartate and working memory

Brain and Behavior - Tập 2 Số 1 - Trang 32-41 - 2012
Kirk I. Erickson1,2, Andrea M. Weinstein1,2, Bradley P. Sutton3,4, Ruchika Shaurya Prakash5, Michelle W. Voss3,6, Laura Chaddock3,6, Amanda N. Szabo7, Emily L. Mailey7, Siobhan M. White7, Thomas R. Wójcicki7, Edward McAuley3,7, Arthur F. Kramer3,6
1Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA
2Department of Psychology, University of Pittsburgh, Pittsburgh, PA
3Beckman Institute for Advanced Science and Technology, University of Illinois, Champaign, IL
4Department of Bioengineering, University of Illinois, Champaign, IL
5Department of Psychology, The Ohio State University, Columbus, OH
6Department of Psychology, University of Illinois, Champaign, IL
7Department of Kinesiology and Community Health, University of Illinois, Champaign, IL

Tóm tắt

AbstractAerobic exercise is a promising form of prevention for cognitive decline; however, little is known about the molecular mechanisms by which exercise and fitness impacts the human brain. Several studies have postulated that increased regional brain volume and function are associated with aerobic fitness because of increased vascularization rather than increased neural tissue per se. We tested this position by examining the relationship between cardiorespiratory fitness and N‐acetylaspartate (NAA) levels in the right frontal cortex using magnetic resonance spectroscopy. NAA is a nervous system specific metabolite found predominantly in cell bodies of neurons. We reasoned that if aerobic fitness was predominantly influencing the vasculature of the brain, then NAA levels should not vary as a function of aerobic fitness. However, if aerobic fitness influences the number or viability of neurons, then higher aerobic fitness levels might be associated with greater concentrations of NAA. We examined NAA levels, aerobic fitness, and cognitive performance in 137 older adults without cognitive impairment. Consistent with the latter hypothesis, we found that higher aerobic fitness levels offset an age‐related decline in NAA. Furthermore, NAA mediated an association between fitness and backward digit span performance, suggesting that neuronal viability as measured by NAA is important in understanding fitness‐related cognitive enhancement. Since NAA is found exclusively in neural tissue, our results indicate that the effect of fitness on the human brain extends beyond vascularization; aerobic fitness is associated with neuronal viability in the frontal cortex of older adults.

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Brain and Behavior

Tập 2 Số 1

32-41

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