Betanin attenuates carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio L.)

Ahmed AR, Moody AJ, Fisher A, Davies SJ (2013) Growth performance and starch utilization in common carp (Cyprinus carpio L.) in response to dietary chromium chloride supplementation. J Trace Elem Med Biol 27(1):45–51

Azeredo HM, Santos AN, Souza AC, Mendes KC, Andrade MIR (2007) Betacyanin stability during processing and storage of a microencapsulated red beetroot extract. Am J Food Tech 2(4):307–312

Bacchetta C, Cazenave J, Parma MJ, Biancucci GF (2011) Biochemical stress responses in tissues of the cichlid fish Cichlasoma dimerus exposed to a commercial formulation of endosulfan. Arch Environ Contam Toxicol 61(3):453–460

Beauchamp C, Fridovich I (1971) Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 44(1):276–287

Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72(1–2):248–254

Canistro D, Melega S, Ranieri D, Sapone A, Gustavino B, Monfrinotti M, Rizzoni M, Paolini M (2012) Modulation of cytochrome P450 and induction of DNA damage in Cyprinus carpio exposed in situ to surface water treated with chlorine or alternative disinfectants in different seasons. Mutat Res 729(1–2):81–89

Casillas E, Ames W (1986) Hepatotoxic effects of CCl4, on English sole (Parophrys vetulus): possible indicators of liver dysfunction. Comp Biochem Physiol C 84:397–400

Cederbaum AI (2010) Hepatoprotective effects of S-adenosyl-L-methionine against alcohol-and cytochrome P450 2E1-induced liver injury. World J Gastroentero 16(11):1366–1376

Chen CY, Wooster GA, Bowser PR (2004) Comparative blood chemistry and histopathology of tilapia infected with Vibrio vulnificus or Streptococcus iniae or exposed to carbon tetrachloride, gentamicin, or copper sulfate. Aquaculture 239:421–443

Cho HY, Kleeberger SR (2007) Genetic mechanisms of susceptibility to oxidative lung injury in mice. Free Radic Biol Med 42(4):433–445

Claiborne A (1985) Catalase activity. In: Greenwald RA (ed) CRC handbook of methods for oxygen radical research. CRC Press, Boca Raton, Florida

Delgado-Vargas F, Jiménez A, Paredes-López O (2000) Natural pigments: carotenoids, anthocyanins, and betalains—characteristics, biosynthesis, processing, and stability. Crit Rev Food Sci Nutr 40(3):173–289

Folmar LC, Bonomelli S, Moody T, Gibson J (1993) The effect of short-term exposure to three chemicals on the blood chemistry of the pinfish (Lagodon rhomboides). Arch Environ Contam Toxicol 24:83–86

French SW, Miyamoto K, Ohta Y, Geoffrion Y (2000) Pathogenesis of experimental alcoholic liver disease in the rat. Methods Achiev Exp Pathol 13:181–207

Gingerich WH (1982) Hepatic toxicology of fishes. In: Weber LJ (ed) Aquatic toxicology. Raven Press, New York

Gliszczyńska-Świgło A, Szymusiak H, Malinowska P (2006) Betanin, the main pigment of red beet: molecular origin of its exceptionally high free radical-scavenging activity. Food Addit Contam 23(11):1079–1087

Gray P (1964) Handbook of basic microtechnique, 3rd edn. McGraw-Hill, New York, pp 85–145

Herbach KM, Stintzing FC, Carle R (2006) Stability and color changes of thermally treated betanin, phyllocactin, and hylocerenin solutions. J Agric Food Chem 54(2):390–398

Hobbs DA, Kaffa N, George TW, Methven L, Lovegrove JA (2012) Blood pressure-lowering effects of beetroot juice and novel beetroot-enriched bread products in normotensive male subjects. Br J Nutr 108(11):2066–2074

Irie H, Asano-Hoshino A, Sekino Y, Nogami M, Kitagawa T, Kanda H (2010) Striking LD50 variation associated with fluctuations of CYP2E1-positive cells in hepatic lobule during chronic CCl4 exposure in mice. Virchows Arch 456(4):423–431

Jeong HG (1999) Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury. Toxicol Lett 105(3):215–222

Jeong HG, You HJ, Park SJ, Moon AR, Chung YC, Kang SK, Chun HK (2002) Hepatoprotective effects of 18β-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome p450 2E1 expression. Pharmacol Res 46(3):221–227

Jia R, Cao L, Du J, Xu P, Jeney G, Yin G (2013) The protective effect of silymarin on the carbon tetrachloride (CCl4)-induced liver injury in common carp (Cyprinus carpio). In Vitro Cell Dev Biol Anim 49:155–161

Kanner J, Harel S, Granit R (2001) Betalains a new class of dietary cationized antioxidants. J Agric Food Chem 49(11):5178–5185

Kapadia GJ, Rao GS (2012) Anticancer effects of red beet pigments. In: Neelwarne B (ed) Red beet biotechnology. Springer-Verlag, New York, pp 125–154

Koneri R, Balaraman R, Firdous KM, Kumar M (2008) Hepatoprotective effects of Momordica Cymbalaria Fenzl. against carbon tetrachloride induced hepatic injury in rats. Pharmacologyonline 1:365–374

Krajka-Kuzniak V, Paluszczak J, Szaefer H, Baer-Dubowska W (2013) Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying/antioxidant enzymes in human liver cell lines. Br J Nutr 17:1–12

Krajka-Kuźniak V, Szaefer H, Ignatowicz E, Adamska T, Baer-Dubowska W (2012) Beetroot juice protects against N-nitrosodiethylamine-induced liver injury in rats. Food Chem Toxicol 50(6):2027–2033

Krasnov A, Koskinen H, Rexroad C, Afanasyev S, Mölsä H, Oikari A (2005) Transcriptome responses to carbon tetrachloride and pyrene in the kidney and liver of juvenile rainbow trout (Oncorhynchus mykiss). Aquat Toxicol 74:70–81

Lattuca M, Malanga G, Hurtado CA, Pérez A, Calvo J, Puntarulo S (2009) Main features of the oxidative metabolism in gills and liver of Odontesthes nigricans Richardson (Pisces, Atherinopsidae). Comp Biochem Physiol B 154(4):406–411

Lee C-H, Wettasinghe M, Bolling BW, Ji L–L, Parkin KL (2005) Betalains, phase II enzyme-inducing components from red beetroot (Beta vulgaris L.) extracts. Nutr Cancer 53(1):91–103

Livrea MA, Tesoriere L (2012) Lipoperoxyl radical scavenging and antioxidative effects of red beet pigments. In: Neelwarne B (ed) Red beet biotechnology. Springer-Verlag, New York, pp 105–124

Lushchak VI (2011) Environmentally induced oxidative stress in aquatic animals. Aquat Toxicol 101(1):13–30

Murthy KNC, Manchali S (2012) Anti-diabetic potentials of red beet pigments and other constituents, red beet biotechnology. Springer, Berlin, pp 155–174

Nayak A, Das B, Kohli M, Mukherjee S (2004) The immunosuppressive effect of α-permethrin on Indian major carp, rohu (Labeo rohita Ham.). Fish Shellfish Immunol 16(1):41–50

Nemzer B, Pietrzkowski Z, Spórna A, Stalica P, Thresher W, Michałowski T, Wybraniec S (2011) Betalainic and nutritional profiles of pigment-enriched red beet root (Beta vulgaris L.) dried extracts. Food Chem 127(1):42–53

Ortiz-Ordoñez E, Uría-Galicia E, Ruiz-Picos RA, Sánchez Duran AG, Hernández Trejo Y, Sedeño-Díaz JE, López-López E (2011) Effect of yerbimat herbicide on lipid peroxidation, catalase activity, and histological damage in gills and liver of the freshwater fish goodea atripinnis. Arch Environ Contam Toxicol 61(3):443–452

Park CM, Cha YS, Youn HJ, Cho CW, Song YS (2010) Amelioration of oxidative stress by dandelion extract through CYP2E1 suppression against acute liver injury induced by carbon tetrachloride in Sprague-Dawley rats. Phytother Res 24(9):1347–1353

Pena-Llopis S, Pena J, Sancho E, Fernandez-Vega C, Ferrando M (2001) Glutathione-dependent resistance of the European eel Anguilla anguilla to the herbicide molinate. Chemosphere 45(4):671–681

Pena-Llopis S, Ferrando MD, Peña JB (2003) Fish tolerance to organophosphate-induced oxidative stress is dependent on the glutathione metabolism and enhanced by N-acetylcysteine. Aquat Toxicol 65(4):337–360

Preiser JC (2012) Oxidative stress. J Parenter Enteral Nutr 36(2):147–154

Saleem M, Alam A, Sultana S (2000) Attenuation of benzoyl peroxide-mediated cutaneous oxidative stress and hyperproliferative response by the prophylactic treatment of mice with spearmint (Mentha spicata). Food Chem Toxicol 38(10):939–948

Sreekanth D, Arunasree M, Roy KR, Chandramohan Reddy T, Reddy GV, Reddanna P (2007) Betanin a betacyanin pigment purified from fruits of Opuntia ficus-indica induces apoptosis in human chronic myeloid leukemia Cell line-K562. Phytomedicine 14(11):739–746

Stintzing FC, Herbach KM, Mosshammer MR, Carle R, Yi W, Sellappan S, Akoh CC, Bunch R, Felker P (2005) Color, betalain pattern, and antioxidant properties of cactus pear (Opuntia spp.) clones. J Agric Food Chem 53(2):442–451

Szaefer H, Krajka-Kuźniak V, Ignatowicz E, Adamska T, Baer-Dubowska W (2013) Evaluation of the effect of beetroot juice on DMBA-induced damage in liver and mammary gland of female Sprague–Dawley Rats. Phytother Res doi. doi: 10.1002/ptr.4951 (Epub ahead of print)

Takayanagi T, Sasaki H, Kawashima A, Mizuochi Y, Hirate H, Sugiura T, Azami T, Asai K, Sobue K (2011) A new enteral diet, mhn-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride–induced hepatitis. JPEN J Parenter Enteral Nutr 35(4):516–522

Wang T, Sun NL, Zhang WD, Li HL, Lu GC, Yuan BJ, Jiang H, She JH, Zhang C (2008) Protective effects of dehydrocavidine on carbon tetrachloride-induced acute hepatotoxicity in rats. J Ethnopharmacol 117:300–308

Wolf JC, Wolfe MJ (2005) A brief overview of nonneoplastic hepatic toxicity in fish. Toxicol Pathol 33(1):75–85

Wroblewska M, Juskiewicz J, Wiczkowski W (2011) Physiological properties of beetroot crisps applied in standard and dyslipidaemic diets of rats. Lipids Health Dis 10(1):1–8

Yin G, Cao L, Xu P, Jeney G, Nakao M, Lu C (2011) Hepatoprotective and antioxidant effects of Glycyrrhiza glabra extract against carbon tetrachloride (CCl4)-induced hepatocyte damage in common carp (Cyprinus carpio). Fish Physiol Biochem 37(1):209–216

Zhang J, Shen H, Xu T, Wang X, Li W, Gu Y (2003) Effects of long-term exposure of low-level diesel oil on the antioxidant defense system of fish. Bull Environ Contam Toxicol 71(2):234–239

Zhang X, Xie P, Li D, Tang R, Lei H, Zhao Y (2009) Time-dependent oxidative stress responses of crucian carp (Carassius auratus) to intraperitoneal injection of extracted microcystins. Bull Environ Contam Toxicol 82(5):574–578